• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults

biomarkers

  • Please log in to reply
No replies to this topic

#1 johnhemming

  • Member
  • 322 posts
  • 123
  • Location:Birmingham, UK

Posted 30 September 2022 - 06:02 PM


https://www.thelance...3964(22)00474-1

 

Much the same as many others really.

 

 

Findings As few as 8-15 variables predicted longevity at 2-, 5- and 10-years with predictive performance (area under receiver operator characteristic curve) of 0¢76 (95% CIs 0¢69, 0¢83), 0¢76 (0¢72, 0¢81) and 0¢66 (0¢61, 0¢71), respectively. Numbers of small high-density lipoprotein particles, younger age, and fewer pack years of cigarette smoking were the strongest determinants of longevity at 2-, 5- and 10-years, respectively. Physical function was a prominent predictor of longevity at all time horizons. Age and cognitive function contributed to predictions at 5 and 10 years. Age was not among the local 2-year prediction variables (although significant in univariable analysis), thus establishing that age is not a direct cause of 2-year longevity in the context of measured factors in our data that determine longevity.

 


  • like x 1





Also tagged with one or more of these keywords: biomarkers

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users