3 replies to this topic

[C0rt3x]

Hi,

 

I am seeking some help for my mother, she is 85 and was diagnosed with alzheimers this year, she currently takes 10mg of aricept daily but she is getting very agitated and confused. I would like to give her some additional help, and I was thinking of alpha GPC, now I know you should not take choline with an acetylcholinesterase inhibitor but there was a randomised controlled trial where patients with alzheimer's were given Donepezil (10mg) and alpha GPC  (1200mg) daily, and it improved their mood disorders.

 

What would you suggest that I could try with her? I was thinking of lion's mane but confused as to which of the three types to use:

 

Lion's mane with 40% polysaccharides

Lion's mane with 4% triterpenoids

Lion's mane with 25% beta glucans

 

I know there is no cure but if I can help ease the condition, I would be grateful.

 

Thank you.

 

[Turnbuckle]

See this post: https://www.longecit...ndpost&p=919066

[C0rt3x]

Thank you

[ambivalent]

Well you might well consider giving fisetin a go - there are a lot of preclinical trials on a range of neurloglical disorders, inlcuding one clinical trial on stroke outcomes:

 

https://www.ncbi.nlm...es/PMC7990461/#

 

Also there is a fisetin dervied drug being trialled, which should announce phase 1 results soon, which would be something of an endorsement:

 

https://www.technolo...-testing-354533

 

 

https://www.salk.edu...ng-study-shows/

 

The other drug mentioned as well as CMS121, is J145 dervived from curcumin which too is due a phase 2 readout. It is suggested that the benefits were gained through anti-aging effects.

 

If experimenting with both or either then bioavaialability is key - I have found mixing with olive oil to be effective and taking and am currently experimenting with a cheap brand of lipsomal fisetin + quercitin combination.

 

Earlier this year there was a post on reddit by a guy who had seen his white hair turn grey, further down in the post he was asked about any mental effects. This was his reply:

 

"Not really. But it's had a HUGE effect on my mother-in-law. She's been having alzheimers memory problems for years but in the last 2 she's had severe mood swings sometimes resulting in rage, paranoia and violent behavior - to the point in the last 6 months my father in law couldnt leave her at home alone.

She started taking 500mg daily and within two weeks her moods completely stabilized to the point where my FIL could go back to his usual 3-4 days/week golfing again.

It's one month later and my wife says her mothers memory has improved to the point she's not telling her the same thing over and over in the phone conversations they have during the week and that she sounds "totally normal now" on the phone.

It's third hand information filtered through my wife so take it with a grain of salt... I'm not in El Paso to directly observe my MIL. My FIL did say to my wife the fisetin is a 'miracle' drug for them. I get the impression he was so desperate he'd try almost anything."

 

(https://www.reddit.c..._white_back_to/)

 

So perhaps worth a try and you may not have to wait too long to see an improvement. 

Edited by ambivalent, 08 November 2022 - 05:14 PM.