6 replies to this topic

[smithx]

Effect of phosphodiesterase type 5 inhibitors on major adverse cardiovascular events and overall mortality in a large nationwide cohort of men with erectile dysfunction and cardiovascular risk factors: A retrospective, observational study based on healthcare claims and national death index data
https://academic.oup...842?login=false

 

 

Phosphodiesterase type 5 inhibitor–exposed men had a 25% lower incidence of overall mortality (HR 0.75; 95% CI 0.65-0.87; P < .001). Men without coronary artery disease (CAD) but with CV risk factors at baseline showed a similar pattern.

[ironfistx]

Having sex makes them happier? Then they live longer? Just kidding.

Edited by ironfistx, 19 January 2023 - 03:53 AM.

[smithx]

One possibility is that older men who are having a lot of sex are already in better condition because they also get more exercise. Or it may just be the Viagra.

[ironfistx]

I think the concept of the study was that viagra increases lifespan but has nothing to do with sex.

[Harkijn]

Ever since this was published

https://roguehealtha...-drug/#comments

I have been taking small amounts of  generic Sildenafil  almost daily, not for ED but it lowers my blood pressure which stubbornly remains in the high normal  range without it.

 

See also  https://pubmed.ncbi....h.gov/19627292/

 

Not too long ago here in Longecity there was a thread on Cialis which is the original brand name for tadalafil, another PDE inhibitor

[AgeVivo]

I am preparing a female mouse lifespan test at home on sildenafil ( https://www.longecit...e-2#entry921120 ). For now my mice are a few months old so the experiment will start in a year and the results will be known in 2.5 years.

I was able to gather sildenafil but I need to organize the placebo now - any view ?

 

This to confirm or not what is seen in human data --which might be correlation not causation (though I don't think -- I was longly shown that sildenafil produce some cerebrospinal liquid flow and increase vigilance, so it is likely good for neurodegeneration, in addition to be likely good for the vascular system in general. Anti pde3 were also shown to have anticancer effects but it is unclear with anti pde5.

 

I may as well do it with males but then with no placebo (as I would see males that take sildenafil...)

Edited by AgeVivo, 21 January 2023 - 04:07 PM.

[Kevnzworld]

Nitric oxide!