7 replies to this topic

[JohnGioLuca]

Does anyone know the main difference between the two? I contacted a few websites who say the Endocalyx is the newer updated version of Arterosil but that may be for their profit benefits. If you look at the ingredients in each, it appears that the original patented formula in Arterosil was
Rhamnan sulfate derived from the green seaweed Monostroma nitidum. In Endocalyx it appears the main compound is “ The type of brown seaweed used in Endocalyx is Laminaria Japonica. An extract is produced which is certified to have
a minimum extract rate of 85% of the compound fucoidan sulfate. ”

Does anyone know what the better formula is if your goal is overall cardiovascular health? Thank you.

[frederickson]

good question. i personally prefer arterosil, which is the original product in the category, has more research on the finished product, and has a far stronger scientific team supporting their formulations and research.

[JohnGioLuca]

good question. i personally prefer arterosil, which is the original product in the category, has more research on the finished product, and has a far stronger scientific team supporting their formulations and research.

Excellent thanks! Have you found another supplement or way to just use the extract that does all the heavy lifting in that formula as the proprietary blend of everything else doesn’t seem very important?

Edited by JohnGioLuca, 25 March 2023 - 04:11 PM.

[Mr Spock]

The main ingredient,fucoidan sulfate, seems to be the one that does " the heavy lifting", and which is readily available. A quick search on Pubmed suggests that is the one with some research backing it.

Adding glucosamine sulfate, would also help. This way it would probably work out cheaper than buying this product.

[FHC_guy]

It is my understanding that Arterosil was the first glycocalyx (support) product on the market. The original formulator then sold the company and later started the company that developed Endocalyx Pro. This new company also sells the device to test one’s glycocalyx and supplementing with their Endocalyx Pro product appears to increase the glycocalyx based on testing results.

 

There is also a third product brought to market by Ortho Molecular Products. Originally the product was called Glycocalyx Pro and was a three capsule per serving formulation. They then renamed the product RegeneVasc and it’s now a two capsule per serving. It looks like they switched out the Glucosomine Sulfate Potassium Chloride with Chondroitin Sulfate Sodium to be able to fit into two capsules. The price remained the same.

 

Recently, I discovered a forth product developed by one of the scientists that worked with the guy who came up with Aterosil. This forth product is called ReVasca. You can find it at: glycocalyx.com

 

All four of these products average around $100 per month unless you take advantage of the subscription service and then you can get some of them down to around $80 a month.

 

I agree with the previous poster. It appears that Fucoidan Sulfate (derived from Seaweed) appears to be the heavy lifter. You can watch the videos below to learn more about the glycocalyx and what constitutes it:

 

https://www.youtube....h?v=GWDcnrYNRQI

 

Below is my poor man’s version of supplements for Glycocalyx support which costs less than half of the four products mentioned above. If anyone else would like to add their recommendations for a piece meal approach please feel free to add to the discussion.

 

Doctor's Best Fucoidan 70% - 60 Veggie Caps: $27.29 per month. Two capsules contains 420 mg of Fucoidan.

 

NOW Chondroitin Sulfate -- 600 mg - 120 Capsules: $5.35 per month. One capsule contains 600 mg of Chondroitin Sulfate Sodium.

 

Force Factor Hyaluronic Acid -- 200 mg - 60 Vegetable Capsules: $4.27 per month

 

Total cost: $36.91 per month.

 

 

Tags: Glycocalyx, Endothelial, Endothelium.

 

[Mr Spock]

It is my understanding that Arterosil was the first glycocalyx (support) product on the market. The original formulator then sold the company and later started the company that developed Endocalyx Pro. This new company also sells the device to test one’s glycocalyx and supplementing with their Endocalyx Pro product appears to increase the glycocalyx based on testing results.

 

There is also a third product brought to market by Ortho Molecular Products. Originally the product was called Glycocalyx Pro and was a three capsule per serving formulation. They then renamed the product RegeneVasc and it’s now a two capsule per serving. It looks like they switched out the Glucosomine Sulfate Potassium Chloride with Chondroitin Sulfate Sodium to be able to fit into two capsules. The price remained the same.

 

Recently, I discovered a forth product developed by one of the scientists that worked with the guy who came up with Aterosil. This forth product is called ReVasca. You can find it at: glycocalyx.com

 

All four of these products average around $100 per month unless you take advantage of the subscription service and then you can get some of them down to around $80 a month.

 

I agree with the previous poster. It appears that Fucoidan Sulfate (derived from Seaweed) appears to be the heavy lifter. You can watch the videos below to learn more about the glycocalyx and what constitutes it:

 

https://www.youtube....h?v=GWDcnrYNRQI

 

Below is my poor man’s version of supplements for Glycocalyx support which costs less than half of the four products mentioned above. If anyone else would like to add their recommendations for a piece meal approach please feel free to add to the discussion.

 

Doctor's Best Fucoidan 70% - 60 Veggie Caps: $27.29 per month. Two capsules contains 420 mg of Fucoidan.

 

NOW Chondroitin Sulfate -- 600 mg - 120 Capsules: $5.35 per month. One capsule contains 600 mg of Chondroitin Sulfate Sodium.

 

Force Factor Hyaluronic Acid -- 200 mg - 60 Vegetable Capsules: $4.27 per month

 

Total cost: $36.91 per month.

 

 

Tags: Glycocalyx, Endothelial, Endothelium.

 This is looks like a good stack.

 

Couple of points which we should address:

 

a) Is chondroitin sulfate similar in its MOA to  Glucosomine Sulfate ?

 

b) Hyaluronic acid comes in 2 forms, one is low molecular weight and the other is high molecular weight. Which form is best and which have thy used I'm not sure.

[ironfistx]

It is my understanding that Arterosil was the first glycocalyx (support) product on the market. The original formulator then sold the company and later started the company that developed Endocalyx Pro. This new company also sells the device to test one’s glycocalyx and supplementing with their Endocalyx Pro product appears to increase the glycocalyx based on testing results.

 

There is also a third product brought to market by Ortho Molecular Products. Originally the product was called Glycocalyx Pro and was a three capsule per serving formulation. They then renamed the product RegeneVasc and it’s now a two capsule per serving. It looks like they switched out the Glucosomine Sulfate Potassium Chloride with Chondroitin Sulfate Sodium to be able to fit into two capsules. The price remained the same.

 

Recently, I discovered a forth product developed by one of the scientists that worked with the guy who came up with Aterosil. This forth product is called ReVasca. You can find it at: glycocalyx.com

 

All four of these products average around $100 per month unless you take advantage of the subscription service and then you can get some of them down to around $80 a month.

 

I agree with the previous poster. It appears that Fucoidan Sulfate (derived from Seaweed) appears to be the heavy lifter. You can watch the videos below to learn more about the glycocalyx and what constitutes it:

 

https://www.youtube....h?v=GWDcnrYNRQI

 

Below is my poor man’s version of supplements for Glycocalyx support which costs less than half of the four products mentioned above. If anyone else would like to add their recommendations for a piece meal approach please feel free to add to the discussion.

 

Doctor's Best Fucoidan 70% - 60 Veggie Caps: $27.29 per month. Two capsules contains 420 mg of Fucoidan.

 

NOW Chondroitin Sulfate -- 600 mg - 120 Capsules: $5.35 per month. One capsule contains 600 mg of Chondroitin Sulfate Sodium.

 

Force Factor Hyaluronic Acid -- 200 mg - 60 Vegetable Capsules: $4.27 per month

 

Total cost: $36.91 per month.

 

 

Tags: Glycocalyx, Endothelial, Endothelium.

 

420mg of Fucoidan per serving.

 

If you look at Life Extension's fucoidan you see it has 88.5mg (85% standardization).  They say this is equivalent to a Japanese daily serving.  So is 420 a lot?

 

Based on this reddit thread, https://www.reddit.c...vid_connection/, Endocalyx Pro has 106.25mg per capsule (4 capsules per serving).  So that's about 424mg (85% extraction rate), BUT then they go on to say it's 524 per serving, so maybe that's not including the pecentage.

 

According to this thread, https://www.reddit.c...s_every_vendor/ fucoidan is "is bad thing."

 

I have found lots of posts of people using it for cancer.  Is it safe to take if you do not have cancer?

 

 

[ironfistx]

Here are the ingredients:

 

endocalyx pro: glucosamine sulfate (vegetarian), fucoidan (luminaria japonica) extract, olive leaf extract, artichoke leaf extract, grape seed extract, hyaluronic acid, superoxide dismustase 5000, catalase

 

Here are the ingredients in

Arterosil: Green seaweed (Monostroma nitidum) extract [MonitumRS] grape (seed and skin) extract, green tea (leaf) extract, grape pomace (fruit) extract, tomato (fruit), carrot (root) juice, bilberry (fruit), broccoli (aerial parts), green cabbage (leaf), onion (bulb), garlic (bulb), grapefruit (fruit), asparagus (stalks), papaya (fruit), pineapple (fruit), strawberry (fruit), apple (fruit), apricot (fruit), wild cherry (fruit), mandarin orange (fruit), blackcurrant (fruit), olive (fruit) extract, cucumber (fruit)

 

I asked ChatGPT about these ingredients (replies below).

 

Before we do that, I tried to figure out what is in Endocalyx Pro, because it says 2475mg.  So going from the normal doses of the ingredients they have, I would estimate:

 

Glucosamine: 1000mg

 

Fucoidan: 424mg (from the post above)

 

Olive leaf extract: 400mg

 

Artichoke extract: 250mg

 

Grape Seed extract: 100mg

 

Hyaluronic acid: 100mg

 

SOD: 100mg

 

Catalyse: 50mg

 

That's nearly 2400mg, which is about what the dose says.

 

Do not quote me on any of this.

 

I estiamted in order, assuming the first mentioned has the highest weight, etc.

 

 

I think that Arterosil is basically just green seaweed extract and a bunch of fruit, so you could probably replicate that by getting the extract, using grape seed and skin extract, green tea extract and eating fruits.  I've never seen grape skin extract before, though.

 

 

Thank you for providing the detailed ingredients for Endocalyx Pro and Arterosil. Both supplements contain various bioactive compounds and plant extracts that are intended to support cardiovascular health and endothelial function. Below is a breakdown of the key ingredients in each and their potential benefits:

Endocalyx Pro Ingredients:

1. Glucosamine Sulfate (Vegetarian)

   • Role: Known primarily for supporting joint health, glucosamine also helps maintain the integrity of the glycocalyx, the protective layer of endothelial cells. It has anti-inflammatory properties that may support vascular health.
   • Potential Benefit: Promotes vascular health by supporting the endothelial cell structure.

2. Fucoidan (Laminaria japonica) Extract

   • Role: Fucoidan is a type of polysaccharide found in brown seaweed. It is believed to have anti-inflammatory, antioxidant, and anti-coagulant properties, which may help protect the endothelial cells and improve blood vessel function.
   • Potential Benefit: Supports endothelial health, reduces inflammation, and may help with blood circulation.

3. Olive Leaf Extract

   • Role: Rich in antioxidants, particularly oleuropein, olive leaf extract has been shown to have anti-inflammatory and cardiovascular protective effects. It can help support healthy blood pressure and reduce oxidative stress.
   • Potential Benefit: Improves cardiovascular function by reducing inflammation and oxidative stress.

4. Artichoke Leaf Extract

   • Role: Artichoke leaf extract is known for supporting liver health, but it also has antioxidant properties that can protect the endothelial lining of blood vessels.
   • Potential Benefit: Supports detoxification and has cardiovascular benefits due to its antioxidant properties.

5. Grape Seed Extract

   • Role: Rich in proanthocyanidins, grape seed extract has powerful antioxidant effects, particularly in supporting vascular health. It can help improve circulation and reduce oxidative stress.
   • Potential Benefit: Improves blood vessel function and protects against oxidative damage.

6. Hyaluronic Acid

   • Role: Known for its ability to retain moisture, hyaluronic acid also plays a role in maintaining the structure of the endothelial cells and the glycocalyx. It helps with cell hydration and tissue repair.
   • Potential Benefit: Supports endothelial health and hydration, which may improve vascular integrity.

7. Superoxide Dismutase (5000 units)

   • Role: SOD is a powerful antioxidant enzyme that neutralizes harmful free radicals like superoxide. By reducing oxidative stress, SOD helps protect endothelial cells from damage.
   • Potential Benefit: Reduces oxidative damage and supports healthy vascular function.

8. Catalase

   • Role: Catalase is another antioxidant enzyme that helps break down hydrogen peroxide into water and oxygen, further reducing oxidative stress.
   • Potential Benefit: Reduces oxidative damage to the endothelium and supports overall cardiovascular health.

Arterosil Ingredients:

1. Green Seaweed (Monostroma nitidum) Extract [MonitumRS]

   • Role: Monostroma nitidum is a type of green seaweed that is rich in polysaccharides. It is believed to support the health and repair of the endothelial glycocalyx.
   • Potential Benefit: Improves endothelial function and the structural integrity of the glycocalyx, which may support vascular health.

2. Grape (Seed and Skin) Extract

   • Role: Grape seed and skin extracts are rich in polyphenols, particularly resveratrol, which have antioxidant, anti-inflammatory, and vasoprotective properties.
   • Potential Benefit: Protects blood vessels from oxidative damage, improves circulation, and supports overall heart health.

3. Green Tea (Leaf) Extract

   • Role: Green tea is rich in catechins, which are powerful antioxidants that help reduce inflammation and oxidative stress. It may also improve endothelial function.
   • Potential Benefit: Supports cardiovascular health by improving circulation and reducing oxidative stress.

4. Grape Pomace (Fruit) Extract

   • Role: Grape pomace (the leftover material from winemaking) is rich in antioxidants, especially flavonoids and resveratrol, that help protect blood vessels.
   • Potential Benefit: Offers antioxidant protection to the endothelial lining, promoting vascular health.

5. Tomato (Fruit) Extract

   • Role: Tomatoes are high in lycopene, an antioxidant that supports cardiovascular health by improving endothelial function and reducing oxidative stress.
   • Potential Benefit: Reduces the risk of cardiovascular disease by protecting blood vessels from damage.

6. Carrot (Root) Juice

   • Role: Carrots contain beta-carotene and other antioxidants that can help reduce oxidative stress and improve vascular function.
   • Potential Benefit: Supports overall heart health and endothelial function.

7. Bilberry (Fruit)

   • Role: Bilberry is known for its high anthocyanin content, which has strong antioxidant and anti-inflammatory properties, promoting vascular health.
   • Potential Benefit: Improves circulation and supports endothelial health.

8. Broccoli (Aerial Parts)

   • Role: Rich in sulforaphane, broccoli has antioxidant and anti-inflammatory effects, supporting vascular health and endothelial function.
   • Potential Benefit: Reduces oxidative stress and supports cardiovascular health.

9. Green Cabbage (Leaf)

   • Role: Contains antioxidants, particularly vitamin C, that help protect the endothelial lining from oxidative damage.
   • Potential Benefit: Contributes to overall cardiovascular health.

10. Onion (Bulb)

• Role: Onions contain sulfur compounds that have antioxidant and anti-inflammatory effects, supporting healthy blood vessels.
• Potential Benefit: Supports cardiovascular function and reduces oxidative stress.

11. Garlic (Bulb)

• Role: Garlic is known for its cardiovascular benefits, including reducing cholesterol, improving blood circulation, and protecting against oxidative stress.
• Potential Benefit: Improves blood circulation and reduces inflammation in blood vessels.

12. Grapefruit (Fruit)

• Role: Grapefruit contains antioxidants such as flavonoids and vitamin C, which help protect blood vessels and improve circulation.
• Potential Benefit: Supports cardiovascular health and reduces oxidative stress.

13. Asparagus (Stalks)

• Role: Asparagus is rich in antioxidants and fiber, which support endothelial health and reduce inflammation.
• Potential Benefit: Supports cardiovascular function and reduces oxidative stress.

14. Papaya (Fruit)

• Role: Papaya contains antioxidants such as vitamin C and beta-carotene, which protect against oxidative damage and support heart health.
• Potential Benefit: Reduces oxidative stress and supports cardiovascular health.

15. Pineapple (Fruit)

• Role: Pineapple contains bromelain, an enzyme with anti-inflammatory properties that supports vascular health.
• Potential Benefit: Reduces inflammation and supports overall cardiovascular health.

16. Strawberry (Fruit)

• Role: Strawberries are rich in antioxidants like vitamin C and anthocyanins, which support vascular health.
• Potential Benefit: Improves endothelial function and reduces oxidative stress.

17. Apple (Fruit)

• Role: Apples contain polyphenols and fiber that support cardiovascular health and reduce inflammation.
• Potential Benefit: Promotes heart health and improves blood vessel function.

18. Apricot (Fruit)

• Role: Apricots are rich in antioxidants, particularly vitamin C, which can support endothelial health.
• Potential Benefit: Reduces oxidative stress and supports cardiovascular health.

19. Wild Cherry (Fruit)

• Role: Wild cherries contain antioxidants that support vascular health and reduce oxidative damage.
• Potential Benefit: Protects blood vessels from damage.

20. Mandarin Orange (Fruit)

• Role: Rich in vitamin C and flavonoids, mandarin oranges provide antioxidant protection to the endothelium.
• Potential Benefit: Supports heart health by reducing oxidative stress.

21. Blackcurrant (Fruit)

• Role: Blackcurrants are high in anthocyanins and vitamin C, which have antioxidant and anti-inflammatory effects.
• Potential Benefit: Supports cardiovascular health and endothelial function.

22. Olive (Fruit) Extract

• Role: Olive extract contains oleuropein, which has antioxidant, anti-inflammatory, and vascular-protective effects.
• Potential Benefit: Supports endothelial health and reduces inflammation in blood vessels.

23. Cucumber (Fruit)

• Role: Cucumber is high in water content and antioxidants, supporting overall hydration and endothelial function.
• Potential Benefit: Improves vascular health and helps with hydration.

Key Differences:

• Endocalyx Pro focuses more on glycocalyx support (through ingredients like glucosamine sulfate, fucoidan, and hyaluronic acid), as well as antioxidant support (through grape seed extract, SOD, and catalase).
• Arterosil uses a broader range of fruits, vegetables, and plant extracts to provide antioxidants and promote vascular health, with a particular emphasis on green seaweed extract (MonitumRS), which supports the endothelial glycocalyx.

Conclusion:

Both Endocalyx Pro and Arterosil aim to support endothelial health and cardiovascular function, but they do so using different approaches and ingredients. Endocalyx Pro focuses more on specific ingredients for glycocalyx support and antioxidants like SOD and catalase, while Arterosil relies heavily on a wide variety of plant-based extracts and seaweed to improve vascular health and protect against oxidative stress.

As with any supplement, it's important to consult with a healthcare provider to determine which one may be more suitable for your needs, especially if you have underlying health conditions or are taking medications.