24 replies to this topic

[TheFountain]

So I started Methylene Blue about 2 weeks ago. 

 

I am starting out really slow. 

 

10 drops a day in water, on an empty stomach.

 

I finally started peeing blue. Not a dark deep blue but just a kind of very light clear blue. 

 

So far I am noticing a pretty significant difference in my skin tone. I am proud of this fact because I have been on a fairly consistent skincare regimen, to varying effective results. And this is definitely adding a lot of vibrancy to my skin tone. 

 

I am now waiting for the more prominent effects which I heard take longer and higher dosages. Such as stronger cognitive disposition as well as greater energy.

 

I presume this is months down the line or even half a year.

 

I am slowly upping my dose because I am afraid of the corresponding anxiety that results in diving in headlong too fast.

 

Please share your results and how blue is your piss?

[Blueflash]

10 drops might not be a slow start? I have heard of great cognitive benefits from micromolar dosing. Maybe 1 drop every two hours. I take 10 MG sublingual along with caffeine before the gym, and the cardio boost is just phenomenal. Noticing improved memory in the last 2 months of increased dosage.It turns my urine a slight green. I also cramp easier with a higher dose. Truly a miracle molecule. I heard mention of a study on Alzheimer patients taking 8-16 MG per day. Supposedly, there was an 85% success rate. Lots of info on the Ray Peat forum.

[TheFountain]

10 drops might not be a slow start? I have heard of great cognitive benefits from micromolar dosing. Maybe 1 drop every two hours. I take 10 MG sublingual along with caffeine before the gym, and the cardio boost is just phenomenal. Noticing improved memory in the last 2 months of increased dosage.It turns my urine a slight green. I also cramp easier with a higher dose. Truly a miracle molecule. I heard mention of a study on Alzheimer patients taking 8-16 MG per day. Supposedly, there was an 85% success rate. Lots of info on the Ray Peat forum.

 

Tjhis Longevitist on Youtube called Claudiaglows told she uses 30 drops every day, in the morning, in an empty stomach. 

 

I was like WTF?

 

She said she "started slow" also at around 5-10 drops a day in the beginning. But I know it increases serotonin uptake, so I wonder what those effects earlier in the day will be. 

 

How long have you been on the stuff? I might try 5 drops, separated by a few hours each. Like 5 drops morning, 5 drops afternoon, then perhaps 5 drops at mid evening. 

[Blueflash]

I have been using methylene blue for a couple years now. In the past, I could not tolerate more than a couple drops. It would affect my mind in a negative way. Just felt off. I'm 59 now, seems to be about the time our aging takes a step change. I suspect it's the increased oxidative stress of aging that allowed me to recently increase the dosage, but this is just a guess. For malaria, some take hundreds of milligrams. But you are right about serotonin being raised in some people. Always wise to start low.

[mbdrinker]

I would find better stuff for euphoria than mb unless you do want to become impotent. I guess cannabis is even less harmful even if smoked. It just kills balls. And man without balls is no longer a man

[TheFountain]

I would find better stuff for euphoria than mb unless you do want to become impotent. I guess cannabis is even less harmful even if smoked. It just kills balls. And man without balls is no longer a man

 

Direct evidence? My balls are fine

[yucca06]

Do you feel MB could be used with ca-AKG ? I guess it should give a considerable mitochondrial boost ?

[mbdrinker]

Direct evidence? My balls are fine

Find info on the net about it killing cells producing sperm. I guess i met it on this very site. I myself like mb psychodelic effects but had to quit it because of that info. Also you can read about any serotonergic ads causing libido death. As i have guessed it's because serotonin as a reward is to be released during sex but you break that survival mechanism by sero ads. No one has yet debated that guess. So it seems more and more logical.

[yucca06]

Find info on the net about it killing cells producing sperm. I guess i met it on this very site. I myself like mb psychodelic effects but had to quit it because of that info. Also you can read about any serotonergic ads causing libido death. As i have guessed it's because serotonin as a reward is to be released during sex but you break that survival mechanism by sero ads. No one has yet debated that guess. So it seems more and more logical.

 

...never had such morning woods since I take it( was already fine before, and I'm 56)...sometimes it looks like even priapism from about 04:00 to 06:00 AM and it makes me wake up...don't read alarming stuff, just try slowly, and you'll see.

 

(I take : 20 to 25mg late afternoon)

Edited by yucca06, 26 June 2023 - 01:07 PM.

[Sandra Jenkins]

Hello forum members,

 

The effects of Methylene Blue have garnered interest among the longevity community. While I'm not a medical professional, I can provide some insights on the topic.

 

Methylene Blue has been studied for its potential cognitive and anti-aging benefits. Some research suggests it may enhance memory, improve mitochondrial function, and exhibit antioxidant properties. However, it's important to note that individual experiences and outcomes may vary.

 

Regarding your question, I'd also like to mention Wellabs products. Wellabs offers a diverse range of high-quality supplements that can support various aspects of health and well-being. Their products include options for immunity, digestion, energy, brain health, and more. However, it's essential to consult with healthcare professionals and consider your specific needs before trying any new products.

 

Remember, when considering the use of Methylene Blue or any other supplement, it's advisable to discuss it with a qualified healthcare provider who can provide personalized advice based on your medical history and individual circumstances.

 

If you have any further questions or need more information, feel free to ask.

[frederickson]

methylene blue is actually used to TREAT priapism, so i find your experiences very interesting. 

 

i have also been concerned about the adverse impact on erections, due to the fact that methylene blue is a potent nitric oxide inhibitor.

[mbdrinker]

Exactly it's nitric oxide inhibitor and that oxide is needed for erection and i also confirm adverse effect on libido and sex organs themselves. Otherwise i would be drinking it for psychodelic pleasures. I have come across recently on info about valdoxan ad pills based on agomelatin which binds to melatonin receptors and also releases dopamine. They promise to improve libido, treat depression, restore sleep. Any experiences on that? As no seratonin involved should be good for libido

[EliotH]

I just ordered some but haven't received it yet. I have seen claims that MB hormetic - it might do one thing at low doses and the opposite at higher doses. Like it is an antioxidant at low doses and pro-oxidant at high doses. Many people leaving reviews on Amazon seem to be taking around 4-8 drops at .5mg per drop.

[TheFountain]

I just ordered some but haven't received it yet. I have seen claims that MB hormetic - it might do one thing at low doses and the opposite at higher doses. Like it is an antioxidant at low doses and pro-oxidant at high doses. Many people leaving reviews on Amazon seem to be taking around 4-8 drops at .5mg per drop.

 

What company did you order from? My regular company is OOS at the moment. Which ticks me off. 

[EliotH]

What company did you order from? My regular company is OOS at the moment. Which ticks me off. 

 

I got this one from Amazon. Next time I might try powder from CZTL if I can find it again. I had a link yesterday but can't find it today.

 

https://www.amazon.com/dp/B0BC2GGYYS

[TheFountain]

I got this one from Amazon. Next time I might try powder from CZTL if I can find it again. I had a link yesterday but can't find it today.

 

https://www.amazon.com/dp/B0BC2GGYYS

It all seems to be here

 

https://cztl.bz/

[johnhemming]

AIUI it makes mitochondria produce more ATP by acting as an alternative electron transport.  I have seen suggested longevity dosage in the range of 10-50mg.  As it has a 4 hour half life it may be something to take in the morning and say around noon.  I have not tried it myself, but I intend to.

 

 

"In the mitochondria, MB plays a remarkable role, owing to its capacity as a catalytic redox

cycler. MB receives electrons from NADH through complex I, converting it to the colorless

reduced counterpart leucomethylene blue (leucoMB) (Fig. 1). LeucoMB directly transfers

these electrons to cytochrome c, re-oxidizing to MB in the process, ready to begin the cycle

anew. Even during complex I inhibition via rotenone MB can bypass ETC blockage at

complex I and III, promoting respiration [23] (Fig. 2). Oxidative damage, a cause and

consequence of mitochondrial dysfunction, impairs primarily complex IV as well as

complex I [24]. This blockage is also bypassed by MB, as it can significantly increase the

activity of complex IV. Expression of complex IV subunits is subsequently upregulated,

perhaps through induction of nuclear respiratory factor 1 (Nrf1) which was found to be

elevated in aged mice treated with MB [25–27]. This increase may be related to PTEN

inactivation by modest increases of H2O2 production or by inhibition of GSK-3, increasing

NRF1 expression downstream of the NRF2/ARE pathway [27–29]."

Edited by johnhemming, 12 August 2023 - 02:36 PM.

[TheFountain]

I have been using methylene blue for a couple years now. In the past, I could not tolerate more than a couple drops. It would affect my mind in a negative way. Just felt off. I'm 59 now, seems to be about the time our aging takes a step change. I suspect it's the increased oxidative stress of aging that allowed me to recently increase the dosage, but this is just a guess. For malaria, some take hundreds of milligrams. But you are right about serotonin being raised in some people. Always wise to start low.

Not sure if it's age dependent since you're like 20 years older than me but I do know that I was recently off it again for a couple weeks then started up again.

 

I noticed a difference in my overall well being and energy levels.

 

As someone who is convinced the Covid Vaccine fucked me up I am looking for every angle I can to reverse the effects of that untested vaccine (tested on the public actually) that I can get. 

 

MB seems like a step in the proper direction

[Blueflash]

Not sure if it's age dependent since you're like 20 years older than me but I do know that I was recently off it again for a couple weeks then started up again.

I noticed a difference in my overall well being and energy levels.

As someone who is convinced the Covid Vaccine fucked me up I am looking for every angle I can to reverse the effects of that untested vaccine (tested on the public actually) that I can get.

MB seems like a step in the proper direction

[Blueflash]

I've heard from more than one source that NAC could help rid the body of some of those components injected into you. For myself, NAC seemed to deplete some minerals, so start low dose and consider taking breaks too.

[mbdrinker]

I don't take that crap anymore and have better penile erection. Won't take anymore and recommend anyone do the same. The best thing nowadays would be producing home wine and smoking something natural. I currently smoke black tea but no more than one pipe per day. It seems to have strong vessel widening effect and no more pipes are allowabale. What they sell currently in shops is not real tobacco and not real wine but some artificial crap. So people be clever and don't listen to their evil promotions from zion elders. They want to destroy our race by crappy substances. I respect Dorian Yaets and his experiments. Puto kaput!

[mbdrinker]

If you are over 40-45 perhaps you have noticedthat vessels on hands become kind of protruding over hand surface. So after one  pipe of black tea protrusion goes away completely. The effect develops almost within minutes. In the past linen oil did that for me but no longer helps. Smoking tea is stronger in this aspect!

[mbdrinker]

In spite of their antismoking promotions we must be philosophical. It has just occured to me that smoking can act as heart training since it speeds up pulse which happens during crappy sports like running but without damage to joints. So indeed smoking must be reassessed. I bet natural alcohol has also tons of positive effects besides deactivating covid vaccinal crap, killing bacteria and so on.

[mbdrinker]

As i am jobless i have managed to escape their crappy vaccination and so 50% of russians. I guess the evil ones were not content with their results in russia and that freedom convoy in canada was amazing stuff. If not that artificial war from the dwarf bustard it may be that convoy would have spread all over the world!

[TheFountain]

I've heard from more than one source that NAC could help rid the body of some of those components injected into you. For myself, NAC seemed to deplete some minerals, so start low dose and consider taking breaks too.

 

Been taking NAC again since shortly after getting that Vaccine. 

 

I am telling you, as soon as I got that Vaccine, my energy levels dropped significantly and have not yet fully returned. I have moments here and moments there of bursts of energy but for the most part it did something to me. Maybe I need to focus on supplements that assist ATP?