There are several ways to reduce serotonin neurotransmission in the brain:
Pharmacological targets:
- Antagonize 5-HT receptors (5-HT1b, 5-HT2a, 5-HT2c, 5-HT3, etc) directly
- Agonize 5-HT1a autoreceptors (which inhibit neurotransmission at other serotonin receptors)
- Increase SERT (serotonin transporter) activity
- Increase MAO-A activity
- Lower the activity of the two main serotonin synthesis enzymes, tryptophan hydroxylase & aromatic L-amino acid decarboxylase, (However, I'm not sure if there are drugs that actually target this)
Non-pharmacological:
- Follow a low-tryptophan diet
Are there any other mechanisms I'm missing here that would lead to lower serotonin neurotransmission?
Thank you,
