Courtesy of Steve H in the news forum
https://www.lifespan...on-in-killifish
"By injuring the brains of aged, treated fish and treated controls, the researchers found that removing senescent cells did indeed restore some of the animals’ regenerative abilities. Interestingly, the number of quiescent, non-dividing glial cells did not change. However, the number of dividing progenitor cells, the cells that lead to regeneration and replenishment ot tissues, was significantly increased by senolytics. The number of freshly created neurons was nearly doubled in the treated animals."
Thoughts on this?
So perhaps either the senolytics D+Q themselves appear through some mechanism encouraging progenitor division or might it be that the population of progenitor cells adjusts directly to the population of senescent cells - the programed death model - senescent cells are the marker of aging and the progenitor cell population adjusts down accordingly. With a sudden big reduction in senescent cells the organism is signalled as biologically younger, and the number of progenitor cells adjusts to that senescent cell level related age? Or just that through mass replacement, there is a sudden spike in demand?
