31 replies to this topic

[albedo]

The main equation in the text, refer to it for the explication of symbols and interpretation of this model of aging and supportive data:

Screenshot 2024-11-03 103234.png

 

In other words, where the effects of aging are coming from:

 Screenshot 2024-11-06 140619.png   17.93KB   0 downloads

 

Will the model be adopted more broadly in the community and will more evidence support it? At the end of the paper and since its pre-print version, the authors quoted a number of additional supportive research:

 

 Screenshot 2024-11-06 141104.png   58.8KB   0 downloads
 

[Castiel]

I am not sure this is an fruitful line of enquiry. Of course a body cannot be maintained against entropy indefinitely. But entropy doesn't care if it wins in 10 years or 1000 years, but that makes a big difference to me. 

There are trees lasting thousands of years, and some organisms last for tens of thousands of years.

 

Humans have even created ways to store information reliably for billions of years.   I do believe indefinite extension is possible.

 

Regards entropy and aging, a similar theory existed before, the rate of living or free radical theory of aging.  This theory was later superseded by the membrane pacemaker theory of aging.  Membrane pacemaker theory of aging can explain the exceptions to the free radical theory of aging well.

 

As can be seen calorie restriction lowers membrane peroxidation index, making membranes more resistant to damage.  High metabolism species like birds that have higher than expected lifespan for their metabolic rate, also have more resistant membranes.  And when looking at their membrane peroxidation index their maximum lifespan is as expected from membrane resilience.

Metabolism and longevity: Is there a role for membrane fatty acids?

https://academic.oup...943?login=false

 

If the peroxidation index is low enough for the given metabolic rate, even multicentury agelessness is possible.

The extreme longevity of Arctica islandica is associated with increased peroxidation resistance in mitochondrial membranes

https://pubmed.ncbi....h.gov/22708840/

 

There are two avenues of approach that can be taken based on this information, finding substances that alter peroxidation index regulation  such as CR mimetics, or other compounds that change gene regulation of peroxidation index.  

 

Or alternative find molecules that protect membranes from damage, such as astaxanthin which did well in the ITP.  What's more some sources suggest the blood levels achieved in ITP are similar to those attainable by humans with a few 10s of mg.   Further research is needed, but it is not inconceivable that higher doses of astaxanthin could have even bigger effects on lifespan.  

Edited by Castiel, Yesterday, 07:21 AM.