5 replies to this topic

[TRUGAN]

Interesting...  Manganese supplement.

 

https://newatlas.com...-vessel-plaque/

 

Edited by TRUGAN, 03 November 2023 - 04:32 AM.

[boylan]

I wonder what the optimum dose would be?

 

https://www.ncbi.nlm...les/PMC5907490/

 

5. Mn and Atherosclerosis

Atherosclerosis is the disease of the arterial wall, characterized by cholesterol accumulation, and culminates in potentially life-threatening conditions, such as heart attack, stroke, and angina [87]. Recent evidence suggests that atherosclerosis is a chronic inflammatory disease of the blood vessel wall [88–90]. Oxidized low-density lipoprotein (oxLDL) and endothelium dysfunction play a key role in the pathogenesis of atherosclerosis [91, 92]. Accumulation of oxLDL in the arterial wall is a characteristic feature of disease progression [88].

Previous studies have demonstrated that the roles of oxLDL and endothelium dysfunction are closely related to the imbalance of oxidative stress and inflammation in the pathogenic process of atherosclerosis [9, 10, 93, 94]. Mitochondrial DNA damage may result from reactive species production in vascular tissues and may in turn be an early event in the initiation of atherosclerotic lesions [95]. MnSOD was reported to reduce the oxLDL-induced apoptosis of macrophages [87, 96], protect against endothelial dysfunction [97, 98], and inhibit the oxidation of LDL by endothelial cells [9]. Furthermore, the association of decreased activity of MnSOD with atherogenesis has suggested that analysis of Mn content in the vascular wall matrix may be one of prospective methods for the diagnosis of early stages of atherosclerosis [99].

Several studies indicated that Mn supplementation could reduce high glucose-induced monocyte adhesion to endothelial cells and endothelial dysfunction and also lower blood levels of ICAM-1 and cholesterol [48, 49], elicit anti-inflammatory effects in endothelial cells [100], and potentially prevent or delay the progression of atherosclerosis. Little is known about the Mn concentration in atherosclerosis patient samples. It has been observed that the difference between the Mn contents of normal and atherosclerotic aortic tissue was not significant [101]. However, in epidemiologic studies, higher blood Mn levels were found in senior citizens aged 61–100 years with atherosclerosis compared to those without [60]. The same result was found in individuals aged 30–62 years [102].

 

 

 

Open in a separate window

Go to:

 

 

[Drumchops]

I'm wondering about dosage as well. Nothing in the article regarding dosage.

[Mind]

 

 

If the results transfer to human subjects, it could mean a new path toward clearing our blood vessels of the plaques that are a major contributor to cardiovascular disease

 

Big if - in the quote above. This type of supplementation might utterly fail in humans considering the positive correlation between high manganese levels and atherosclerosis. 

 

 

 

 However, in epidemiologic studies, higher blood Mn levels were found in senior citizens aged 61–100 years with atherosclerosis compared to those without

 

Plus you don't want to overdo Mn supplementation because of toxicity issues.

[HBRU]

I read that Manganese put to senesence otherwise cancer cells... this can be good. So maybe once a month a megadosis of 50 mg can be a good idea. It's quite toxic for brain, so in that moment better take other calming supplements as Taurine, Glycine... Melatonine, Theanine. And sleep. Of course just my ideas.
I read that Manganese put to senesence otherwise cancer cells... this can be good. So maybe once a month a megadosis of 50 mg can be a good idea. It's quite toxic for brain, so in that moment better take other calming supplements as Taurine, Glycine... Melatonine, Theanine. And sleep. Of course just my ideas.

[Daniel Cooper]

It's a shame we have conflicting research here. I hate to leave a potentially useful treatment on the table because I can't decide if it's helpful or hurtful.