8 replies to this topic

[Michael Lustgarten]

https://www.youtube....h?v=RmiQ0fb_Fug

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[osris]

I've just seen this video after seeing your other niacin video before. This is even better news. 

 

Did your epigenetic pace of aging improve on this lower dose?

[Michael Lustgarten]

That test is scheduled for next Monday...

[osris]

I'll keep a look out for when you post about it.

 

 

[osris]

I asked ChatGPT about your experience with 600 mg of niacin, and your concerns that it was negatively affecting your epigenetic pacing. I asked it to write an article about it. I find it reassuring. Here it is:

 

Title: "Navigating the NAD Boost: Exploring Personal Observations on Niacin and Epigenetic Aging"

 

 

Introduction

 

In the quest for better health and potential anti-aging strategies, individuals often explore various supplements and interventions. One such avenue involves the use of niacin, also known as vitamin B3, to boost Nicotinamide Adenine Dinucleotide (NAD) levels. Recently, a person shared their experiences on YouTube, shedding light on their use of niacin and raising intriguing concerns about the potential impact on their epigenetic pace of aging.

 

Niacin and NAD

 

Niacin is a crucial B-vitamin that plays a role in cellular processes, and it exists in two main forms: nicotinic acid and niacinamide. Niacin is believed to boost NAD levels, which in turn has been associated with various cellular functions and potential anti-aging effects. The person in question reported that a daily intake of 60 mg of niacin raised their NAD levels significantly.

 

Concerns about Epigenetic Pace of Aging

 

In an interesting twist, the individual expressed concerns about the potential negative impact of high-dose niacin on their epigenetic pace of aging. They shared that after taking a higher dose of 600 mg of niacin, their blood test results showed a drastic increase in NAD levels. However, they also reported sending off their blood for epigenetic analysis on the same day and receiving results suggesting a reduction in their epigenetic pace of aging.

 

Analyzing the Claims

 

The claims raise important questions about the interplay between niacin supplementation, NAD levels, and the epigenetic clock. The person's self-observations and the reported results, while intriguing, highlight the complexity of individual responses to supplements and the need for further scientific investigation.

 

Understanding Epigenetics

 

Epigenetics is a field that explores changes in gene expression that are not related to alterations in the DNA sequence. The epigenetic clock, which estimates biological age based on DNA methylation patterns, is a tool used to assess the pace of aging at the molecular level. While promising, the implications of the epigenetic clock for overall health and longevity are still under investigation.

 

Navigating Personal Experiences

 

Individual anecdotes can provide valuable insights, but it's crucial to interpret them with caution. The concerns raised by this individual highlight the need for more comprehensive research on the relationship between niacin, NAD levels, and the epigenetic pace of aging. Personal responses to supplements can vary widely, and individual observations may not necessarily translate into universal conclusions.

 

The Role of Scientific Research

 

Scientific understanding of niacin's effects on NAD levels and its potential impact on aging is an evolving area of research. While some studies suggest positive effects, more research is needed to establish clear connections and determine optimal dosages.

 

Conclusion

 

The personal observations shared by this individual offer a glimpse into the complexity of supplement use and its potential effects on molecular aging processes. As the field of epigenetics continues to advance, and more research is conducted on the interplay between niacin, NAD, and the epigenetic clock, individuals should approach health decisions with a critical mindset. Consulting with healthcare professionals and relying on evidence from well-designed scientific studies remain essential for making informed choices about health and longevity.

 

 

[osris]

I've started a thread to discuss your video:

https://www.longecit...-pace-of-aging/

[Michael Lustgarten]

NMN vs Nicotinic Acid: Which Is Better For Increasing NAD?

 

https://www.youtube....h?v=SwggBuuamCk

 

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[osris]

Hope the results are definitive. 

 

But don't worry if they are not. See article below by ChatGPT:

 

Is Epigenetic Analysis Always Reliable

 

 

Epigenetic analysis has become a powerful tool in understanding gene regulation and cellular processes. However, the reliability of such analyses is contingent upon various factors, encompassing methodologies, sample quality, experimental design, and more.

 

Factors Influencing the Reliability of Epigenetic Analysis

 

1. Methodology:

 

Different techniques are employed in epigenetic analysis, such as bisulfite sequencing, chromatin immunoprecipitation (ChIP), and RNA sequencing. The reliability hinges on the accuracy and specificity of the chosen method. Each technique has its strengths and limitations, and researchers must carefully select the one that aligns with their specific goals.

 

2. Sample Quality:

 

The quality of biological samples (DNA, RNA, or chromatin) is pivotal. Contaminated or degraded samples can compromise the reliability of results. Rigorous sample preparation protocols and quality control measures are essential to ensure the integrity of the data.

 

3. Data Analysis:

 

Accurate data analysis is critical for reliable results. The bioinformatics tools and pipelines used for processing and interpreting epigenetic data must be validated and suitable for the chosen experimental design. Robust statistical methods are crucial for drawing meaningful conclusions.

 

4. Reproducibility:

 

Reproducibility is a hallmark of scientific reliability. Experiments should be meticulously designed and conducted to enable other researchers to replicate the results independently. Ensuring the consistency of findings across different laboratories adds strength to the reliability of the analysis.

 

5. Experimental Controls:

 

Proper experimental controls are necessary to distinguish genuine changes from artifacts or technical issues. The inclusion of appropriate controls helps validate the observed alterations, ensuring that they are indeed linked to the experimental conditions being tested.

 

6. Cell Type Specificity:

 

Epigenetic patterns can vary among different cell types. Researchers must consider the specific cell type under investigation and employ suitable controls to account for cellular heterogeneity. Failure to do so can lead to misinterpretation of results.

 

7. Validation:

 

Results obtained through epigenetic analysis should ideally undergo validation using independent methods or in different experimental systems. This step is crucial for confirming the reliability of the observed epigenetic changes and strengthening the robustness of the findings.

 

Supplementation Decisions Based on Epigenetic Analysis

 

Deciding whether to take a supplement solely based on epigenetic analysis is intricate. While epigenetic analysis can offer valuable insights into gene regulation, several considerations should be taken into account:

 

1. Limited Understanding:

 

Our understanding of the relationship between specific epigenetic changes and health outcomes is still evolving. Caution should be exercised when interpreting epigenetic data, and associations found in research may not always imply causation.

 

2. Individual Variation:

 

Epigenetic patterns and responses to supplements can vary among individuals. What is considered a "normal" epigenetic profile may differ from person to person, and factors such as genetics, lifestyle, and overall health should be considered.

 

3. Holistic Approach:

 

Health decisions, including supplement choices, should be approached holistically. Factors such as diet, exercise, lifestyle, and existing health conditions play a crucial role. A balanced diet rich in nutrients from whole foods is generally recommended.

 

4. Professional Guidance:

 

Before deciding on supplementation based on epigenetic analysis or any other factors, consulting with a healthcare professional is advisable. They can assess individual needs, consider potential risks, and provide personalized advice based on a more comprehensive understanding of one's health.

 

5. Quality of Evidence:

 

Consider the quality and quantity of evidence supporting the relationship between a specific supplement and its purported benefits. Rigorous studies, including randomized controlled trials and peer-reviewed research, provide more reliable evidence.

 

6. Risks and Side Effects:

 

Supplements can have side effects and interact with medications. It's essential to be aware of potential risks and discuss them with a healthcare provider before making decisions about supplementation.

 

NAD Levels and the Complexity of Aging

 

In addition to these considerations, the relationship between NAD levels and the epigenetic pace of aging adds another layer of complexity. While NAD is recognized for its potential in supporting cellular health and longevity, its direct impact on the specific regulation of the epigenetic pace of aging is not fully understood. The intricate interplay between NAD, sirtuins, and other cellular pathways contributes to the complexity of aging, a process influenced by numerous factors. As research in longevity science progresses, the understanding of these relationships will likely evolve, emphasizing the need for a comprehensive and nuanced approach to decisions regarding both epigenetic analysis and supplementation.

 

 

 

[Gal220]

check out this thread

https://www.longecit...an-you-find-it/