DHA:
http://www.clinicalt...how/NCT00060749DMAE, Carnosine, ALCAR:
http://www.smart-dru...ine-article.htmAntioxidants:
Antioxidants Reduce The Accumulation Of Lipofuscin In Mature Brains
As we grow older, the ability of our brain cells to generate energy diminishes significantly. In addition, the amount of glutathione and cellular antioxidant enzymes in these brain cells also decreases, thus allowing for a larger accumulation of free radicals. In humans, the larger accumulation of free radicals permits lipid peroxidation, which can result in an increase of the pigment called lipofuscin in the brain. This is the same pigment that causes “liver” or “age” spots in the skin that are often associated with aging.
Many neuroscientists now believe that lipofuscin accumulation contributes to loss of healthy mental function and absentmindedness that is often experienced with aging. Studies indicate that by maintaining diets high in antioxidants, experimental animals develop fewer lipofuscin pigments in their brains with aging.
Mental acuity is crucial in sustaining our overall quality of life. Harsh environmental factors, certain lifestyle choices as well as dietary choices, all make it more imperative that we provide our brains with adequate nutritional support.
http://www.sciencebo...ctives.137.htmlLipofuscin accumulation inside the cells is a marker for any membrane damage.
Causes:
Vitamin A and Vitamin E deficiency
Ischemia
Free radical damage
Proteolytic reactions
Increased intake of PUFAs
Senility associated reduction of protelolytic pathways
Certain chemicals
Drugs that induce Lipofuscinosis:
Phenothiazines
Phenacetin
Leupeptin ( protease inhibitor)
Clofibrate
Phthalates
Amiodarone
Rifabutin ( Antitubercular agent)
Avasimibe
