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Hacking Aging - Genomic Failure Hypothesis

epigenetics

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#1 johnhemming

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Posted 08 April 2024 - 03:12 PM



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#2 Mind

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Posted 09 April 2024 - 06:36 PM

Another detailed video about DNA damage and aging. Thanks for sharing.

 

One thing I am a little dismayed about is that we are still discussing "the theory of aging" and what is the root cause. I think there should be more testing/clinical research and less theorizing, if we want to make progress.



#3 johnhemming

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Posted 09 April 2024 - 06:50 PM

This hypothesis is being tested in Homo Sapiens.   However, it remains that we do need to identify a mechanism (or more than one mechanism) that actually causes aging.



#4 Mind

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Posted 10 April 2024 - 04:56 PM

This hypothesis is being tested in Homo Sapiens.   However, it remains that we do need to identify a mechanism (or more than one mechanism) that actually causes aging.

 

Very true. My point is that I think we could get at the "root causes" through more and varied clinical trials. A large number of small and cheap trials could reveal important aging insights in a short period of time. It just seems that a significant portion of the "brain trust" dedicated to rejuvenation is engaged in too much theorizing and the writing of new white papers.



#5 johnhemming

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Posted 11 April 2024 - 05:56 AM

In the end we need to identify a mechanism so that any inverventions are additive rather than cancelling each other out.

 

Personally I think the hypothesis detailed in the video is correct and the experimental results seem to justify that view.  However, only time will tell.

 

One difficulty in funding research is that funders wish a high probability of success which tends to reduce innovation.

 

 

 

 







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