I asked ChatGPT to design a supplement regime that takes into account the theories of David Sinclair and Aubrey de Grey, and this is what it came up with:
Designing a supplement regime that integrates elements from both David Sinclair's and Aubrey de Grey's theories on longevity involves combining supplements that target key pathways related to aging and repair various types of cellular damage. Here is a comprehensive supplement regime that reflects insights from both approaches:
David Sinclair's Approach
1. NAD+ Precursors:
- Nicotinamide Riboside (NR): Increases NAD+ levels, which support cellular energy production and activate sirtuins.
- Nicotinamide Mononucleotide (NMN): Another NAD+ precursor that supports similar benefits as NR.
2. Sirtuin Activators:
- Resveratrol: A polyphenol found in red wine that activates sirtuins, particularly SIRT1, which is involved in cellular stress resistance and longevity.
- Pterostilbene: A compound similar to resveratrol but with potentially better bioavailability and stability.
3. Epigenetic Modifiers:
- Fisetin: A flavonoid that may help clear senescent cells and improve cellular function.
- Quercetin: Another flavonoid with anti-inflammatory and senolytic properties, which may help eliminate senescent cells.
4. Mitochondrial Support:
- Coenzyme Q10 (CoQ10): Supports mitochondrial function and energy production.
- Alpha-Lipoic Acid (ALA): An antioxidant that supports mitochondrial health and energy metabolism.
Aubrey de Grey's Approach
1. Cell and Tissue Repair:
- Collagen Peptides: Support the extracellular matrix and tissue repair.
- Hyaluronic Acid: Helps maintain skin hydration and supports extracellular matrix integrity.
2. Antioxidants:
- Vitamin C: A powerful antioxidant that helps neutralize free radicals and supports collagen synthesis.
- Vitamin E: Another potent antioxidant that protects cell membranes from oxidative damage.
3. Anti-inflammatory Agents:
- Omega-3 Fatty Acids: Reduce inflammation and support overall cellular health.
- Curcumin: The active compound in turmeric, which has strong anti-inflammatory and antioxidant properties.
4. DNA Repair and Protection:
- Folate: Supports DNA synthesis and repair.
- Vitamin B12: Works with folate in DNA repair and supports overall cellular health.
- Zinc: Essential for DNA repair and immune function.
5. Senolytics:
- Fisetin and Quercetin: Already mentioned under Sinclair's approach but also relevant here for clearing senescent cells.
- Dasatinib: A pharmaceutical that has shown senolytic effects in research, though its use should be monitored by a healthcare professional.
Integrative Regime:
Combining these insights, here is a potential daily supplement regime:
1. Morning:
- Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN)
- Resveratrol or Pterostilbene
- Vitamin C
- Omega-3 Fatty Acids
- Folate and Vitamin B12
2. Midday:
- Coenzyme Q10 (CoQ10)
- Alpha-Lipoic Acid (ALA)
- Curcumin
- Quercetin
3. Evening:
- Fisetin
- Collagen Peptides
- Hyaluronic Acid
- Vitamin E
- Zinc
Notes and Considerations
- Lifestyle Factors: In addition to supplements, consider integrating lifestyle changes such as intermittent fasting, regular exercise, and a balanced diet rich in fruits, vegetables, and healthy fats.
- Medical Supervision: Always consult with a healthcare provider before starting any new supplement regime, especially if combining multiple supplements or if there are underlying health conditions.
- Quality and Dosage: Ensure the supplements are of high quality and taken in appropriate dosages as per medical advice.
- Adjustments: Personalize the regime based on individual health needs and response to supplements.
By combining these supplements, you can address both the metabolic and epigenetic pathways highlighted by Sinclair and the cellular damage repair emphasized by de Grey, potentially providing a more comprehensive strategy for promoting longevity and healthy aging.
