3 replies to this topic

[ambivalent]

https://www.ncbi.nlm...es/PMC10919985/

 

 

UDCA a bile acid, is closely related to the more familiar TUDCA. 

 

Interestingly and oddly the paper doesn't seem too interested in the CRP findings and appears to contradict the data in the discussion. 

 

"Nevertheless, the results of this study revealed that lipid status remained unaffected, along with the inflammatory parameters (IL-6 and CRP)."

 

Yet there is clear, dramatic improvement in the data of CRP - indeed the paper states:

 

"Inflammatory parameters did not change significantly. A significant decrease in the intragroup change was found in CRP (1.4 (2.3) vs. 1.9 (2.4); p < 0.05) compared to baseline values in the UDCA group."

 

IL-6 appears reduced too, but the "deltas" didn't pick it up.

 

https://www.ncbi.nlm...port=objectonly

 

 

Improvements in glucose, HB1AC, waste circumference, blood pressure, cholesterol. 

 

https://www.ncbi.nlm...port=objectonly

 

https://www.ncbi.nlm...port=objectonly

 

 

Markers of superoxide dismutase, catalase, and glutathione all increased in the UDCA group:

 

https://www.ncbi.nlm...85/figure/fig3/

 

 

And so, unsurprisingly, oxidative stress markers improved too:

 

https://www.ncbi.nlm...85/figure/fig2/

 

 

 

Summary:

 

 

"The study demonstrated that an eight-week UDCA administration had beneficial effects on anthropometric status, liver function, and diastolic blood pressure in patients with T2DM. UDCA significantly improved BMI, diastolic blood pressure, liver enzymes (ALT and GGT), and oxidative stress parameters, thus potentially attenuating the progression and complications of diabetes."

 

 

NB There is an interview with Professor Steer on longecity where UDCA is discussed. Note too the P3 trials for TUDCA on ALS failed, despite two very promising P2 trials. 

 

https://www.longecit...eases-and-udca/

 

 

 

Edited by ambivalent, 16 July 2024 - 04:34 PM.

[Mind]

Pretty amazing results. Where can we procure UDCA? Something endogenous that produces such positive results should be on everyone's radar.

[ambivalent]

Hi Mind,

 

UDCA isn't as readily available as TUDCA - I don't see any on amazon - but it can be purchased at online pharmacies at around what looks like twice the cost of TUDCA. 

 

 

 

Here is a clinical study on obesity with TUDCA:

 

https://diabetesjour...prove-Liver-and

 

"Hepatic and muscle insulin sensitivity increased by ∼30% (P < 0.05) after treatment with TUDCA but did not change after placebo therapy."  

[ambivalent]

Here is the full TUDCA-obesity paper - similar dosing to the UDCA trial but over 4 weeks rather than 8. 

 

https://www.ncbi.nlm...les/PMC2911053/

 

CRP - is improved signifcantly (5.4 - 4.4 mg/L) but the data obviously not statistically reliable with the placebo group improving (5.7 - 5mg/L)

 

 https://www.ncbi.nlm...port=objectonly

 

nb CRP levels in the UDCA study were much lower from the outset (2.3, 2.4 mg/L in the UDCA trial compared to 5.4, 5.7 mg/L in the TUDCA trial). 

 

 

 

 

Edited by ambivalent, 19 July 2024 - 02:15 PM.