9 replies to this topic

[Michael Lustgarten]

https://www.youtube....h?v=A8z-722SjFw

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[albedo]

Thank you Michael. Useful as always. Quick remarks: hs-CRP highly sensitive to inflammation is not listed and RDW is not in the Quest labs. Yes, RDW has largest statistical weight in Levine 2018 mortality risk assessor paper, likely related to the well-known correlation with CVD risk but I always wondered if and how the 9 biomarkers in her paper are directly comparable between each other: probably the study you posted gives some insight as published in 2029 just after Levine. Have you ever studied this aspect in more details?

Edited by albedo, 02 August 2024 - 10:31 AM.

[johnhemming]

I think the issue with RDW is that it does not vary that much.   Hence any variation has to have quite a bit of weight.

[Michael Lustgarten]

I think the issue with RDW is that it does not vary that much.   Hence any variation has to have quite a bit of weight.

 

In my case, RDW has varied from 11.6 - 13.6 since 2015 (50 tests), which is a relatively wide range

[johnhemming]

Yes, but if you compare it to how much say CRP can vary.   2/11.6 is only 17%.   CRP can go up by many multiples. 

[albedo]

Yes, but if you compare it to how much say CRP can vary.   2/11.6 is only 17%.   CRP can go up by many multiples. 

 

Yes but that is typical in the case of infection, e.g. seen once with me going from ~0.3 to 50 for the high sensitivity CRP during a flu. I think here we are focusing on sub-clinical values slowly changing with age, IMHO. Using the weight in Levine's to assess the clinical importance of a biomarkers when compared to the other 8 out of the regressions is not appropriate and you nee to use other tools, maybe SHAP?
 

[albedo]

Epistemic considerations are becoming more and more important as the field matures, e.g.

 

Kriukov D, Kuzmina E, Efimov E, Dylov DV, Khrameeva EE. Epistemic uncertainty challenges aging clock reliability in predicting rejuvenation effects. Aging Cell. Published online July 28, 2024:e14283.

 

[johnhemming]

Yes, but that is for the methylation clocks.

[DukeNukem]

I put a lot of weight on these three markers:

Uric acid (you really want it below 4.0)
A1c (best below 5.0)
Trigs (best below 65)

And perhaps the most important all-around indicator of health: 
VO2 max (you want to be in the good to excellent range for your age/sex)

The more feeble you are, the closer you are to death. Having a high VO2 max level keeps you from being feeble. I'm 63, and my VO2 max score is 55, putting me in the "superior" category for my age (or the "excellent" category for the 20-29 yr old range). I do this, btw, with super minimal time doing cardio work. I do one all-out max effort sprint on a spin cycle three days a week, just one all out 12 second workout three times a week. And with zero warm-up. My total time on the spin bike is under one minute per session, or under three mins per week, and I'm getting a far far better cardiorespiratory benefit that people who spend 90 minutes on a treadmill jogging their little hearts out.

Additionally, having ample skeleton muscle is also super important to maximizing your longevity. Again, it comes down to: don't become feeble, unless dying soon is your goal.

[albedo]

I put a lot of weight on these three markers:

Uric acid (you really want it below 4.0)
A1c (best below 5.0)
Trigs (best below 65)

And perhaps the most important all-around indicator of health: 
VO2 max (you want to be in the good to excellent range for your age/sex)

The more feeble you are, the closer you are to death. Having a high VO2 max level keeps you from being feeble. I'm 63, and my VO2 max score is 55, putting me in the "superior" category for my age (or the "excellent" category for the 20-29 yr old range). I do this, btw, with super minimal time doing cardio work. I do one all-out max effort sprint on a spin cycle three days a week, just one all out 12 second workout three times a week. And with zero warm-up. My total time on the spin bike is under one minute per session, or under three mins per week, and I'm getting a far far better cardiorespiratory benefit that people who spend 90 minutes on a treadmill jogging their little hearts out.

Additionally, having ample skeleton muscle is also super important to maximizing your longevity. Again, it comes down to: don't become feeble, unless dying soon is your goal.

 

Thank you. I am now concerned about my uric acid (average 6.3 mg/dl, sigma of 0.6, my lab ref. range is 3.7-7.6) as measured over 30 years. What can I try to lower it w/o pharmaceuticals if possible? Do you have a reference for the low value you claim as optimal? Tks.