6 replies to this topic

[Galaxyshock]

A lesser-known cannabinoid possibly effective for treating anxiety while enhancing memory.

 

Summary:A new study shows that Cannabigerol (CBG) significantly reduces anxiety without the intoxicating effects of THC. The clinical trial found that 20 mg of CBG reduced anxiety and stress in participants, with memory enhancement as an unexpected benefit. The study highlights CBG’s potential as an alternative anxiety treatment. Further research is needed to confirm these findings and explore additional benefits.

Key Facts:

• CBG significantly reduced anxiety and stress in a clinical trial.
• CBG did not produce the intoxication or cognitive impairments associated with THC.
• The study found CBG may enhance memory recall.

Source: Washington State University

→ source (external link)

 

Pharmacological properties:

 

Cannabigerolhas affinity and activity at CB1 and CB2 cannabinoid receptors in vitro.[3][9] It appears to be unique among cannabinoid compounds by also having high affinity and activity at α2 adrenergic receptors and moderate activity at serotonin 5-HT1A receptors.[3][11]

→ source (external link)

 

I'm interested in cannabinoidergic anxiolytics. Anyone know where to get this stuff?

[adamh]

Science.bio I have bought from them before

[zorba990]

Interesting. I wonder how it compares to Palmitoylethanolamide

[Galaxyshock]

Interesting. I wonder how it compares to Palmitoylethanolamide

 

Do you take Palmitoylethanolamide? I imagine these cannabinoidergics that aren't really psychoactive like THC have somewhat similar effect to them. Cannabidiol is also nice but very expensive here. FAAH-inhibitors are promising too for anxiety and other things.

 

 

Science.bio I have bought from them before

 

 

Ok, but it seems they don't ship to EU unfortunately. I'll have to find some other vendor for Cannabigerol.

[Daniel Cooper]

Interesting. I wonder how it compares to Palmitoylethanolamide

 

I want palmitoylethanolamide to work so bad because on paper it looks like it should be just the ticket for several issues that I deal with and have minimal side effects.

 

I've tried it numerous times for extended periods escalating up to pretty high doses - and I've never felt any effect from it whatsoever. Maybe I got a little placebo early on, but long term I might as well have been taking water. Every few years I'll read a study on it and talk myself into trying it again, but in the end .... nothing.

 

I think I'm finally done with it. The only positive I can say is that it never caused any adverse reactions. Because from my point of view it did nothing at all.

[gamesguru]

CBD seems to have similar properties.

 

Wouldn't rush to call it a world-class cognitive enhancer or productivity aid, but it certainly has some subtle benefits (even perhaps in healthy controls).

 

Are CB1 receptor antagonists nootropic or cognitive impairing agents? - Varvel - 2009 - Drug Development Research - Wiley Online Library

https://analyticalsc....1002/ddr.20334

 

Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice - ScienceDirect

https://www.scienced...166432822000808

 

Cannabidiol (CBD) improves cognition and decreases anxiety in the SAMP8 mouse model of Alzheimer’s - Farr - 2021 - Alzheimer's & Dementia - Wiley Online Library

https://alz-journals...1002/alz.054428

 

Use of cannabidiol (CBD) for the treatment of cognitive impairment in psychiatric and neurological illness: A narrative review.

https://psycnet.apa..../2023-67738-001

 

[fall]

Cannabinoids are excellent for many reasons but there are a lot of obstacles with it today when it comes to using cannabinoids individually. Spending most of my time in California and been involved with sales of these products, so sourcing of CBG in itself is not an issue, however, issue lies in finding it in isolated form and trusting the product is clean and without trace amounts of THC, this goes for dispensaries as well and other individual cannabinoids such as CBD tablets and oil. In California for example, it can be difficult to find a CBD product with guarantee of no THC traces. Most labels will indicate a small trace amount of THC, some even lack info and simply cannot be trusted. Not just because of presence of THC which is actually quite benign compared to many contaminants found in legal weed products these days. The industry also suffer from dubious and sometimes straight up faked testing practices (although this has improved somewhat lately). Point is CBG and other individual cannabinoids shows plenty of promise but is not very feasible today. I recommend smoking the Cannabis flower as it is or using full-spectrum oral/topical solution, it is a wonderful herb, but do take long breaks.