38 replies to this topic

[longevitydiary]

To explore longer-lasting health and vitality, the "Longevity Diary Comprehensive Anti-aging Solution" is an innovative product that combines the latest technology and research findings, aimed at helping to delay aging and maintain health and vitality. This solution is based on advanced genetic and cellular technology, comprehensively combating aging through various physiological mechanisms. It is effective not only in outward appearance but also fundamentally improves cellular function, promoting overall health.

 

Animal Experiment Progress

In small-scale animal experiments (n=5), our comprehensive solution achieved an 80% life extension effect, fully demonstrating the remarkable efficacy of our approach. However, due to issues like dose control, non-specific targeting, and side effects, we have not yet reached our initial goal of >150% life extension. We are actively making adjustments and optimizations to further enhance the overall efficacy of the solution.

 

Key Features and Benefits

Genetic Optimization: By regulating gene expression, the transcription and translation efficiency of longevity genes are enhanced, fundamentally combating cellular aging.

Enhanced Cellular Metabolism: Promotes energy generation and waste elimination, boosting cellular vitality.

Immune Enhancement: Enhances the ability of cells to cope with reactive oxygen species (ROS), improving overall immune function.

Cell Membrane Protection: Increases the integrity and function of cell membranes, providing a more stable environment for cells.

[longevitydiary]

Title: Can Longevity Valley's CS008 Achieve Immortality? Rejuvenation or Age-Freezing?
Summary:
CS008 is the only research project by Longevity Diary aimed at rejuvenation. It is focusing on genetic stabilizers.
Background
As age increases, the risk of many health problems due to the deterioration and failure of organ function also increases. These degenerative mechanisms are likely the result of the cellular aging process. Identifying the focal points of aging and applying molecular therapy to edit these focal points can fully restore cellular vitality and reverse the structure and function of organs. DNA represents a "Book of Life" that determines the phenotype of an organism. The aging process alters the structure and function of various molecules in the body. DNA changes, genomic instability, and epigenetic modifications are linked to age-related epigenetic changes, which are potential causes of DNA damage in aging cells.

Overall methylation and associated genomic stability decrease as cells age. DNA damage accelerates aging markers. While low DNA methylation leads to DNA instability through various mechanisms, young DNA sequences are highly methylated. Therefore, low DNA methylation and young DNA genomic instability mechanisms are interrelated. DNA damage in aging cells triggers a persistent DNA damage response (DDR), resulting in cellular aging. Thus, a key mechanism of the aging process might involve DNA changes that reduce DNA integrity. This reduction leads to DNA fragility and the accumulation of endogenous DNA damage. Therefore, epigenetic drift may represent the aging process at the molecular level.

Mechanism
We recently discovered that CS008 can enhance DNA integrity, reduce DNA damage and DDR, and revitalize the structure and function of organs to a youthful state by mitigating torsional stress caused by transcription or replication during DNA strand separation. When cells begin to age, low methylation might become the result. SIRT1, a protein that prevents aging, inhibits histone deacetylation, preventing terminal DNA methylation. This is also determined by AGO4, an effector protein of RNA-directed DNA methylation, which enhances overall low methylation.

One scenario involves the loss of methylated DNA-AGO4. Another scenario involves the accumulation of DNA damage, promoting DNA demethylation during DNA repair. Increased DNA torsion results in DNA damage, thereby increasing the DDR. Persistent DDR promotes cellular aging, and the accumulation of aging cells leads to the deterioration of bodily structure and function. CS008 restores aging cells to a youthful state.

Conclusion
By using CS008, DNA durability is increased, DNA damage is limited, and aging cells are revitalized, improving the structural and functional degradation caused by aging. CS008 targets the primary molecular pathological mechanisms of a degenerative disease. It represents a new therapeutic strategy that inhibits the upstream molecular aging process, potentially revolutionizing the treatment of DNA damage or age-related diseases and conditions.

[longevitydiary]

The issue of drug resistance refers to the body's gradual adaptation to a drug, resulting in decreased sensitivity to it and a subsequent reduction in its efficacy. This is a global challenge. longevity diary addresses the problem of drug resistance by increasing the number of transport proteins through the following strategies:

1. Promoter and Enhancer Optimization: By optimizing the sequences of promoters and enhancers, longevity diary enhances the transcription efficiency of transport protein genes. They employ stronger promoters and combine promoters with enhancers to boost transcriptional activity.

2. Inhibition of Protein Degradation Pathways: By inhibiting protein degradation pathways such as the ubiquitin-proteasome system, longevity diary reduces the degradation of transport proteins, thereby increasing their steady-state levels within the cell.

3. Guided Protein Folding and Transport: Using chemical chaperones, longevity dairy promotes the proper folding and transport of transport proteins to the cell membrane, thereby increasing the number of functional transport proteins.

By leveraging these technologies and strategies, longevity diary primarily tackles drug resistance by increasing the quantity of transport proteins. This method involves regulating transcription and translation processes to enhance cellular function and mitigate drug resistance. longevity diary will continue to optimize these comprehensive anti-aging solutions with the goal of achieving immortality. Currently, combining ancient dietary practices, a healthy lifestyle, modern medical care, and longevity diary's elixir of immortality may potentially lead to achieving the goal of immortality.

[longevitydiary]

As longevity and health become increasingly prominent focuses for people today, longevity diary responds to this demand by continually improving its anti-aging products, striving to meet users' expectations with top-quality offerings. In addition, longevity diary is meticulously conducting product side effect tests.

Let's delve into longevity diary's unique "5+1+1" anti-aging method and preliminary test results.

[Exploring the "5+1+1" Anti-aging Method]

longevity diary's anti-aging approach employs a multi-layered comprehensive strategy known as the "5+1+1" plan:

1. Five Days a Week: Daily consumption of a different anti-aging component from the longevity diary CS series. This may include various core anti-aging substances like telomerase activation, long gene transcription, gene stability, senescent cell clearance, etc., aimed at providing comprehensive bodily support.
2. Once a Week: Application of CS007, a specially designed topical product, targeting deep skin care to combat aging.
3. One Day Rest: Abstaining from any supplements to give the body a chance to recover naturally, avoiding dependency on supplements, and ensuring more noticeable long-term effects.

[User Feedback: Noteworthy Preliminary Results]

During a small-scale test over the past 1-6 months (n=10), user feedback has revealed encouraging results:

1. Cognitive and Physical Enhancement: One user reported clearer thinking and increased physical strength, indicating potential benefits in enhancing cognitive function and physical capacity.
2. Lightness in the Body: Another user expressed feeling lighter and having noticeably lighter steps when climbing stairs, suggesting the product may positively affect energy metabolism and nervous function.
3. Menopause Symptom Improvement: A menopausal user shared that her sleep problems significantly improved, going from insomnia to sleeping through the night.
4. Cellular Anti-aging: A user observed a 13% increase in telomere length, a highly significant result indicating the product's potential in delaying cellular aging.
5. Biological Age Reversal: Using multiple sets of biological aging clocks, a user saw a reduction in biological age by 3 years, further verifying the product's potential in slowing the overall biological aging process.
6. Skin Improvement: A user noted that her skin became as smooth as a baby's, highlighting the product's potential in improving skin condition.

[Future Plans]

Based on the positive feedback, longevity diary plans to further optimize key components such as Telomerase Activation Component (TAC) and continue improving comprehensive anti-aging solutions. Through scientific methods and testing, longevity diary strives to continually enhance product quality and effectiveness to meet users' high expectations.

[Contact Information]

WeChat: alphachn

[Conclusion]

longevity diary's comprehensive anti-aging solution exhibits significant promise. Preliminary user feedback indicates positive effects in various areas, such as cognitive function, physical capacity, sleep quality, and cellular health. With continuous optimization and enhancement, longevity diary is poised to become an effective and popular anti-aging product. 

[longevitydiary]

CS011: The Terminator of Cardiovascular Diseases

Since the development of the anti-aging solution (food-grade) by Longevity Diary, the company has received a series of positive feedbacks, including wrinkle elimination, improved respiration, enhanced energy, and sharper reactions (with use of over three years). These results have been achieved even without the intervention of the more effective CS008 anti-aging solution (pharmaceutical-grade). To further enhance anti-aging effects, Longevity Diary has conducted in-depth studies on cardiovascular diseases, which plague humanity, and developed the CS011 solution. This is expected to further enhance anti-aging outcomes.

In recent years, scientists have made significant advances in the treatment of cardiovascular diseases. However, Longevity Diary's research reveals that the multi-component formulation of CS011 has the potential to reverse atherosclerosis. This could represent a revolutionary step in the treatment of these fatal diseases.

[Reversal of Atherosclerosis]
Atherosclerosis is a disease caused by the buildup of plaques on arterial walls, leading to heart attacks and strokes. Experimental results in mouse models of atherosclerosis have shown that CS011 can significantly reduce plaque formation. This makes CS011 a highly promising solution for the treatment of atherosclerosis.

[Components of CS011]
The multi-component formula of CS011 includes:

• Longevity Diary's proprietary formula
• Quercetin
• Nattokinase
• Serrapeptase
• Vitamin E
• Pomegranate extract

These components work synergistically, displaying exceptional therapeutic effects in various aspects.

[Cardiovascular Health]
Experiments demonstrate that supplementation with CS011 leads to a sustained reduction in blood pressure, indicating partial disappearance of arterial plaques and a reversal of cardiovascular system damage.

[Future Prospects]
Despite the enormous potential of CS011, a large number of clinical trials and comprehensive studies are needed to translate these laboratory and animal model results into clinical applications. Nonetheless, these preliminary research results already instill great hope for the future application of CS011 in ending cardiovascular diseases. With further research and development, CS011 might become a milestone in modern medicine, taking a decisive step in combating cardiovascular diseases. We hope that one day, this breakthrough solution can provide humanity with a healthier and longer life.

[longevitydiary]

CS013 Anti-Cancer Solution: A Comprehensive Strategy to Tackle Cancer

Cancer, the "persistent malady" of the 21st century, continues to be one of the leading causes of death worldwide despite rapid advancements in science and technology. Longevity Diary's exploration of cancer solutions is not only critical to the quality of life for countless patients but also represents a significant challenge in the medical field. This article will introduce CS013's comprehensive strategy to tackle cancer.

[Longevity Diary's CS013 Broad-Spectrum Anti-Cancer Solution]

Macrophages are a crucial component of the immune system with the ability to recognize and engulf cancer cells. Activating macrophages can enhance the immune system's aggressiveness against cancer cells, playing a vital role in cancer treatment. Longevity Diary's therapeutic approach is based on activating macrophages. CS013 small molecules can promote the differentiation of macrophages into the M1 type, precisely regulate gene expression, induce the transformation of macrophages into the M1 type, activate macrophages within the tumor microenvironment, and enhance their anti-cancer effects.

There have already been multiple anti-cancer cases. Some cancer patients, who had metastases and were not candidates for surgery, experienced significant tumor shrinkage after using the cancer solution CS013, thereby becoming eligible for surgery. These cases demonstrate the potential of CS013 in treating complex and advanced cancers, bringing new hope to patients.

[Conclusion]

The path to cancer prevention and treatment is long and arduous, but the development of modern medicine provides us with increasingly effective methods. From early screening and prevention to the optimization of traditional treatments, the introduction of innovative therapies, and the application of comprehensive treatment strategies, every step marks firm progress toward the goal of conquering cancer. In the future, with continuous advancements in science and technology, cancer solutions will become more diversified and precise, offering patients more hope and a better quality of life.

[longevitydiary]

CS008plus: A Revolutionary Invasive Treatment Method for Human Immortality

With continuous advancements in science and technology, significant breakthroughs have been made in combating aging and extending human lifespan. Recently, Longevity Diary researchers have invented a revolutionary invasive treatment method that can maintain genomic stability and might enable humans to achieve immortality.

[Causes of Human Aging]

Longevity Diary believes that the cause of human aging lies not in genes or cellular aging but in errors in gene transcription and translation. Gene transcription is the process of converting DNA sequence information into RNA, and translation is the process of converting RNA information into proteins. When errors occur in these two processes, it leads to the production of abnormal or damaged proteins. These erroneous proteins can accumulate within cells, impair cellular function, and trigger the aging process.

Additionally, as people age, the mechanisms in the body that repair these errors gradually weaken, further exacerbating the accumulation of erroneous proteins and the decline of cellular function. In response to this, Longevity Diary has invented the small molecule CS008 to maintain the stability of transcription and translation.

Recently, the Longevity Diary team has invented a new invasive treatment method called CS008plus, which addresses issues of gene transcription and translation. After thorough evaluation, the team has deemed this method to be highly risky and extremely complex, with each step being critical—any mistake could nullify the entire effort, comparable to a transplantation surgery.

[Principle of the Revolutionary Invasive Treatment Method]

This invasive treatment method employs a series of advanced technologies to directly affect gene transcription and translation within the cell nucleus. The main steps include injecting specific proteins, enzymes, and histones to enhance the stability of gene translation and transcription, promoting DNA repair and chromosome protection, and restoring the function of tissues and organs.

[Future Prospects]

Although this invasive treatment method is still in the experimental stage, its demonstrated potential is highly promising. The invention of an invasive treatment method that maintains the stability of gene transcription and translation marks a significant step forward in humanity's quest for immortality. With this achievement, Longevity Diary has completed its comprehensive therapeutic solutions: the Youth Fountain Therapy (Small Cup), the CS008 Therapy (Medium Cup), and the CS008plus Therapy (Large Cup). The next focus will be on applying anti-aging therapies to combat cardiovascular diseases, cancer, Alzheimer's disease, and other age-related conditions.

[longevitydiary]

Due to the extremely high cost, the experiment had only one case: an 83-year-old man at the end stage of life. Because of the complexity of the synthesis, only one dose was used. Over the course of a year, there were noticeable improvements in his appearance and physical fitness, making him look and feel several years younger. Currently, in his 90s, he shows no obvious signs of aging.

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Edited by longevitydiary, 30 October 2024 - 07:27 AM.

[longevitydiary]

Longevity Diary Product CS002 Reverses Aging

An exciting new study published on BioRxiv reports that the small molecule compound TGF-β inhibitor Repsox can reverse several aspects of human cellular aging and extend the lifespan of worms.

Previous research utilized a combination of seven drugs, which might produce significant side effects if used in humans or animals. This new study indicates that using only TGF-β inhibitors yields similar results to the seven-drug mixture.

The drug used in the study is Repsox, a TGF-β inhibitor. However, Repsox has not been tested for human safety and presents considerable side effects in humans. In response to these side effects,Longevity Diary conducted in-depth research and invented the formula CS002. This formula comprises a selective reversible LSD1 inhibitor, TGF-β inhibitor, and Longevity Diary's proprietary ingredients.

[Brief Summary of Results:]

Longevity Diary researchers treated human fibroblasts with CS002 and observed significant improvements in several key biomarkers associated with youth and vitality.

DNA Damage (measured by γH2AX levels):

• The 7-chemical mixture reduced γH2AX levels by approximately 70%
• CS002 reduced γH2AX levels by about 86%

Heterochromatin Marks:

• The 7-chemical mixture increased H3K9me3 by approximately 2-fold, H3K27me3 by about 3-fold
• CS002 increased H3K9me3 by approximately 2-fold, H3K27me3 by about 5-fold

Cellular Senescence:

• CS002 decreased senescence-associated β-galactosidase levels by approximately 70% in stress-induced senescent cells and by about 55% in replication-senescent cells. Additionally, CS002 reduced the expression levels of senescence-associated genes p21, p53, and IL6.

Oxidative Stress:

• Imbalance between the production of free radicals and antioxidant defenses can damage macromolecules. Indeed, CS002 reduced oxidative stress levels, indicating an improvement in metabolic homeostasis. In the CS002 formula, AKG exerts some of its anti-aging effects via DNA/histone demethylation. AKG is also a compound used by longevity researchers in another chemical cellular reprogramming formula, CS003.

γH2AX is a phosphorylated form of the H2A histone variant H2AX. It is a crucial marker of DNA damage.

A reduction in γH2AX signals suggests that the chemical mixture can improve this aging-related marker and enhance genomic integrity. Reducing DNA damage is considered an important mechanism through which reprogramming interventions may extend lifespan.

H3K9me3 and H3K27me3 are histone marks associated with heterochromatin and gene silencing. The levels of these repressive marks tend to decline with age. Thus, the increased levels of H3K9me3 and H3K27me3 observed through chemical treatments in this study indicate a regenerative effect on the epigenome.

The decline of H3K9me3 and H3K27me3 is considered a hallmark of aging for several reasons:

1. Loss of these marks leads to heterochromatin defects and re-expression of normally silenced regions, resulting in genomic instability.
2. Removal of the marks occurs in an age-dependent manner due to altered histone modification activities.
3. Declining levels are associated with premature aging disorders and diseases related to aging.
4. Experimental interventions that maintain or increase H3K9me3 and H3K27me3 levels can extend lifespan and health span.

Senescence-associated β-galactosidase (SA-β-Gal) is an enzymatic marker indicative of the burden of senescent cells. The percentage of cells showing SA-β-Gal activity in cultures or tissues correlates directly with the level of senescence. During aging, senescent cells accumulate in tissues, leading to a significant increase in measured SA-β-Gal activity. The dose of CS002 is 350 milligrams per day. Due to its high cost, LongevityDiary is seeking solutions to make it more affordable.

[longevitydiary]

Topical longevity diary Product CS007 Reduces Skin Aging and Aging Biomarkers in Humans

The search for youthfulness typically turns to lotions, supplements, serums, and diet, but soon there will be a new option joining the competition. longevity diary's product CS007 is one such option. According to research, CS007 can slow skin aging in humans. longevity diary researchers have previously used the core drug in CS007 to slow aging in mice, flies, and worms, but this current study is the first to show its effects on human tissue, particularly skin, where signs of aging were reduced. When applied topically to humans, changes included reduced wrinkles, less sagging, and a more even skin tone.

As researchers continue to seek the elusive "fountain of youth" and methods to extend lifespan, we see the growing potential for the use of this drug. So, we say, let's try it out on the skin. The skin is a complex organ composed of immune cells, nerve cells, and stem cells — you can learn a lot about the biology of the drug and the aging process just by observing the skin. To this end, the CS007 formula comprises longevity diary's proprietary drug, carnosine, L-Fucose, and magnesium.

[Experiment]

In the current longevity diary study, 13 participants aged over 40 applied CS007 cream on one hand every 1-2 days and a placebo on the other hand for eight months. Researchers examined the subjects at 2, 4, 6, and 8 months, including blood tests and biopsies at 6 or 8 months.

After eight months, the majority of hands treated with CS007 showed increased collagen levels, while p16 protein levels significantly decreased. The p16 protein is a key marker of cellular aging in the skin. Lower levels of p16 indicate fewer aging skin cells, which is associated with the reduction of skin wrinkles. Besides cosmetic benefits, high levels of p16 lead to skin atrophy, a common condition in elderly individuals linked to fragile, tear-prone skin, slow healing after cuts, and increased risk of infections or complications following injury.

[Mechanism]

How does CS007 work? CS007 blocks a protein that acts as a mediator in human cell metabolism, growth, and aging. When examining the p16 protein more closely, CS007's ability to improve human health becomes more evident. The p16 protein is a stress response in human cells when damaged but also acts as a cancer-prevention mechanism. When cells undergo mutations that would typically result in tumors, this response helps prevent tumors by slowing down the cell cycle process. It does not produce tumors but leads to the aging process instead.

"When cells age, they become harmful and produce inflammation," said a longevity diary researcher. "This is part of aging. These stressed cells are now releasing inflammatory markers. If you taper down the pathway, you get a smaller phenotype; by slowing growth, you seem to extend lifespan and help the body self-repair — at least in mice. This is similar to what is observed in calorie restriction."

Currently, longevity diary researchers are applying for patents on CS007. Meanwhile, they are experimenting with the absorption rates of various drugs, including DMSO, Transcutol, and Excipial Hydrocrème.

[Self-Experimenters]

Using laser tomography among self-experimenters showed a reduction in wrinkles by 42% to 46% to 62% to 68% within three months. The elasticity of the skin on the back of the self-experimenters' hands improved significantly, with rebound time reducing from around 4 minutes to just a few seconds. One hand treated with CS007 for 4 months appeared about 7 years younger. Self-experimenters rated the improvement as highly significant compared to Retinoic acid and Fluorouracil.

Another self-experimenter said, "CS007 works best before wrinkle formation. Once wrinkles form, the improvement process is present but very slow. The face showed no fine lines or wrinkles with CS007 application; the skin was completely smooth, without crow's feet, smile lines, or forehead lines. Some fine lines that I had before starting with CS007 have gradually reduced — the skin looks smoother and healthier. I have been using it for about 36 months."

[longevitydiary]

CS001 Solves Gene Transcription Issues

 

[Principle]

The principle behind this protocol is that if you improve how cells work, then you improve how the body works. Cells function by producing energy and proteins. If cells cannot produce all the necessary proteins, they will not function properly. The theory supporting this protocol is that there are issues in transcribing genes and producing mRNA, but also in translating mRNA into proteins. Cells need to handle varying amounts of nutrients and energy supply. The main cellular energy currency (ATP) is primarily produced by mitochondria.

However, when mitochondria take up glucose and push it through the Krebs/Citrate/TCA cycle (citrate and tricarboxylic acid are the same thing), they produce ATP. Mitochondria also export citrate/tricarboxylates to the cytoplasm through the citrate carrier protein (SLC25A1). This is then used by the cytoplasm (and nucleus) for various purposes. An interesting role of TCA in the cytoplasm is to indicate the cell's energy status. TCA is converted into acetyl-CoA by the ACLY enzyme. The levels of acetyl-CoA in the cytoplasm and nucleus control the transcription process of genes.

When genes are transcribed into mRNA, an enzyme complex known as RNA polymerase II reads the gene and produces mRNA (using RNA as a substrate). One of the steps involves opening the gene by acetylating the histones that preserve the gene. This is done by a hat that requires acetyl-CoA to do its work. Approximately every 142 base pairs need one acetylation. Without acetylation, RNA Pol II cannot complete its work. Later, histone deacetylases (HDAC) come and remove the acetyl groups from the histones. Thus, the availability of acetyl-CoA controls the production of mRNA.

It requires a significant amount of ATP to translate mRNA into proteins, so acetyl-CoA limits mRNA production when energy is insufficient, preventing an excess of mRNA waiting for protein production. Transcription also requires ATP, but acetyl-CoA is the primary limiting factor. As organisms bear the burden of aging cells (among other reasons), SLC25A1 (citrate carrier) expression decreases, trapping citrate in the mitochondria. My protocol focuses more broadly on both translation and transcription.

[Improving Transcription Methods]

The main issue is the lack of acetyl-CoA. However, the interaction between acetylation and deacetylation also presents problems. We do not want HDAC to deacetylate a histone while a stalled RNA Pol II remains stuck to it. I haven't found any information about this on PubMed, but it is evident that gene transcription improves when HDAC is inhibited (there are many different HDACs). Therefore, I believe we can identify several pathways to improve transcription.

[longevitydiary]

CS005 Product: For the current group of individuals seeking mild anti-aging benefits, longevity diary has invented a small molecule.

A small RhoGTPase regulates various functions in eukaryotic cells. Its activity is significantly elevated in several tissues of aged mice, and increased activity in mouse models exhibits premature aging-like phenotypes and shortened lifespan. These data indicate a causal relationship between elevated activity, aging, and reduced lifespan. Here, we demonstrate that systemic treatment of aged mice for seven consecutive days with an activity-specific inhibitor significantly extends both average and maximum lifespan. Furthermore, based on DNA methylation levels in blood cells, the levels of aging-associated cytokines IL-1β, IL-1α, and INFγ in the serum of treated older animals are comparable to those in younger animals, with a notably younger epigenetic clock.

Overall, our data suggest that systemic treatment aimed at reducing activity in aged mice can extend lifespan. Biological (epigenetic) age is significantly reversed by 30%. Here, we demonstrate that after short-term systemic treatment with a specific inhibitor, transplanting elderly hematopoietic stem cells (HSC) from treated mice into elderly mice with impaired immune function is sufficient to extend their healthy lifespan and overall lifespan without the need for additional treatment. Specifically, we show that systemic treatment increases the myogenic regeneration potential of elderly skeletal muscle stem cells, thereby enhancing the strength and endurance of aged mice.

[longevitydiary]

Light Anti-Aging Product CS006 Features:

 

1. Muscle Growth:

   • Can increase muscle mass by 7 to 10 pounds in the first week. You can use this product to quickly build muscles.

2. Muscle Maintenance:

   • CS006 can maintain muscles when you cannot go to your favorite gym during the pandemic. Some bodybuilders reported that they stopped working out for months but were able to maintain muscle mass just by taking CS006.

3. Healing:

   • Rapid healing of strains and sprains. CS006 enhances the body's self-healing capabilities.

4. Increase Bone Density:

   • In human studies, it was found that bones became healthier and less brittle. This is not only good news for elderly people who worry about breaking a hip while bathing, but it also reduces the risk of injury during exercise.

5. Cognitive Enhancer:

   • It is a powerful nootropic. It provides you with a significant amount of energy and motivation.

6. Boost Metabolism and Burn Fat:

   • Can speed up metabolism. If you do a lot of exercise, you can expect to lose a significant amount of fat as needed.

7. Promote Sleep:

   • Helps improve sleep quality.

Although CS006 has only extended the lifespan of mice by 15% in studies, this result was obtained by feeding CS006 to aged mice.

[longevitydiary]

The Anti-Aging Memory Enhancer CS010

The goal of  Longevitydiary is not only to combat aging but also to maintain, train, and enhance people's survival abilities, which are entirely dependent on our memory. Therefore,Longevity diary believes that CS010 may prove to be a valuable product in the future. CS010 is a breakthrough product developed by Longevitydiary neuroscientist

[Enhanced Effects]

Its memory-enhancing effect is attributed to the improvement of the neurotransmitter acetylcholine function. Placebo-controlled human studies on dyslexic and non-dyslexic individuals using a double-blind crossover method showed that the verbal learning ability of dyslexic individuals improved significantly by 15.0%.

[Mitochondrial Function Improvement]

Optimizing mitochondria is the ultimate performance boost, as mitochondria are the basic energy-producing mechanisms of all other elements. In previous studies, we demonstrated that CS010 enhances ATP production, mitochondrial membrane potential, and neurite growth in cellular and animal models of aging and Alzheimer's disease.

[Verbal Fluency]

One of the most apparent effects on enhancing language cognition is verbal fluency—your speech becomes more fluent, and you may find yourself getting into and out of tricky situations more easily. You will ultimately have very little left to say as your vocabulary improves, and you will not fear speaking in social situations or in front of others.

[Anti-Aging]

Elderly patients can benefit significantly from CS010 in managing cognitive impairment and senile dementia. It has a measurable anti-aging effect on the brains of aged rats and inhibits brain damage caused by alcoholism and hypoxia.

[Alzheimer’s Disease]

Long-term high-dose CS010 may slow the cognitive decline in Alzheimer's patients. The study supports that the primary mechanism of CS010 is:

• Increasing blood flow and oxygen consumption in parts of the brain.
• Enhancing glucose consumption in the brain.
• Maintaining mitochondrial membrane potential.

Aside from enhancing the activity of the corpus callosum (which helps with communication between the left and right hemispheres of the brain), it also improves interhemispheric communication. How does this feel? It feels like pleasant concentration and, at the same time, an optimistic attitude towards work and challenges. CS010 has achieved good results in productivity and focus.

[Depression]

CS010 has positive effects on depression, anxiety, epilepsy, dyslexia, post-stroke aphasia, schizophrenia, dementia, myoclonus, and cognitive decline after heart and brain surgery. It is actually better at treating depression compared to enhancing memory and is effective in treating cognitive impairment of cerebrovascular and traumatic origins. However, its overall effect on reducing depression and anxiety surpasses its memory-enhancing benefits.

A self-experimenter said, “I did notice that CS010 has a mood-stabilizing effect. Even under stress, I remained unusually optimistic. Negative emotions still occur, but prolonged adverse moods were uncommon. Increasing the dosage led to headaches, brain fog, or quickly reaching a tolerance point. It has significant and almost immediate effects on productivity, focus, and memory.” Significant transformative gains from using CS010 over a period include:

• Verbal intelligence
• Long-term memory
• Working memory
• Mood and mental health
• Energy and motivation

CS010 can increase productivity in the short term and improve memory in the long term. Researchers have repeatedly used and ceased using CS010 over the years, confidently confirming that, even without CS010, its usage has improved the baseline memory in every aspect.

[Addictive or Dependence?]

Over the past year, the author has used and stopped CS010 four times, finding it one of the least addictive substances. The author feels very focused. CS010 contains Alpha GPC, ensuring higher bioavailability and blood-brain barrier absorption. Sometimes it makes the author overly tense or even anxious. Additionally, it increases blood and oxygen flow to the brain, meaning that if you consume alcohol while taking CS010, you will get intoxicated faster.

The formula of CS010 includes choline, AlphaGPC, L-carnitine, Rhodiola, and several other safe ingredients.

[Side Effects]

Research on CS010 consistently indicates excellent tolerability and no adverse side effects. The toxicity is so low that rats filled their stomachs with it and did not die. The most common side effects are headaches, and when combined with alcohol, it is easy to get drunk.

[longevitydiary]

Longevity diary Synthesis of Telomerase TERT Activator TAC

Longevity recently published two articles on small molecule TAC as TERT activators targeting various aging traits, presenting some very intriguing results about aging and its reversal. The summary is as follows:

"Insufficient telomerase activity, due to low transcription of the TERT (telomerase reverse transcriptase) gene, leads to telomere dysfunction and aging pathology. Beyond its conventional role in telomere synthesis, TERT serves as a transcriptional co-regulatory factor for key genes in aging and age-related diseases. Here, Longevity diary reports the identification of a TERT activator compound (TAC) that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aging mice, TAC-induced TERT elevation promotes telomere synthesis, blunts tissue aging traits by reducing cellular senescence and inflammatory cytokines, and silences p16INK4a expression via promoter hypermethylation mediated by DNMT3B. In the brain, TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and maintains cognitive functions without apparent toxicity, including cancer risk. In summary, these findings highlight the crucial role of TERT in the aging process and provide preclinical proof of concept for physiological TERT activation as a strategy to mitigate various aging traits and associated pathologies."

Currently, the international issue lies in the identity of the activator molecule TAC, as no one knows its specific molecular structure. Recently, a Longevity diary researcher identified its molecular formula and successfully synthesized it, resulting in 100 milligrams of TAC with 90% purity.

[longevitydiary]

A Self-Experimenter's Story: The Effects of CS009 on Chronic Diseases

After taking approximately 5 grams of CS009 daily for a few months, my intermittent symptoms of Peripheral Arterial Disease (PAD) completely ceased.

[longevitydiary]

Introduction to the Longevity Diary Team

The longevity diary team comprises a group of bio-geeks passionate about anti-aging. The team not only tracks the latest anti-aging advancements worldwide but also  develop proprietary products. Thanks to its pioneering efforts in the anti-aging field,Longevity diary has achieved excellent experimental results with its self-developed products. Below are some of the products currently under research by longevity diary:

1. CS001: Addresses long gene transcription issues primarily by adjusting the body's acetyl-CoA levels. It has shown very promising outcomes so far.

2. CS002: Current epigenetic regulators have noticeable anti-aging effects but significant side effects, limiting their widespread use. Longevity diary has developed a low-side-effect alternative, successfully resolving the issue of severe side effects.

3. CS003: Reprogramming is a hot topic in anti-aging, but genetic manipulation carries high risks. Longevity diary focuses on chemical reprogramming and has currently developed several small molecules that achieve reprogramming effects.

4. CS004: Longevity diary believes that the increase in entropy hampers the development of the anti-aging industry. The team discovered that the distance between genes gradually increases with age. Longevity diary has identified a small molecule that can reduce this distance, with excellent experimental results.

5. CS005: For those seeking mild anti-aging effects, Longevity diary has invented a small molecule to clear waste produced by senescent cells in the body. The experimental results are very positive.

6. CS006-CS010: These products are aimed at different levels of anti-aging needs and include nootropics, skincare products, gene stabilizers, chronic disease alleviators, and rapid body recovery agents.

7. To ensure you can easily get in touch with the Longevity team for more information and support, you can contact them via WeChat:

8. WeChat ID: alphachn

   Please specify your needs or questions when sending a friend request so that the team can assist you promptly.

[pamojja]

Why no Internet presence? Something to hide?

[alphachn]

Why no Internet presence? Something to hide?

Longevity Diary is a company that serves high-end members. Previously, its main business was in China, but it is now attempting to expand internationally. In China, it focuses more on direct, focused, and personalized user engagement rather than extensive online marketing. Longevity Diary has written over 4,000 articles on anti-aging, with more than 1,800 of these being original articles. Most information about longevity diary is available on the WeChat network. The main theory of Longevity Diary Company is that aging is caused by genetic transcription failure leading to protein deficiencies. For example, hair growing in places without hair in old age such as a beard, SGO2 deficiency in elderly women leading to infertility, ADAR1 deficiency leading to decreased immunity, STAT3 deficiency resulting in unhealthy articular cartilage, and TERT gene failure causing a reduction in telomeres. These protein deficiencies cause older people to eat less yet gain weight more easily.

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Edited by alphachn, 31 October 2024 - 12:45 PM.

[pamojja]

Thanks for your honest response. Just be aware that in the West, almost all scams have little other sources than messenger services. Personally, I suspected such by your only CS011 formula posted too:

 

 

The multi-component formula of CS011 includes:

• Longevity Diary's proprietary formula
• Quercetin
• Nattokinase
• Serrapeptase
• Vitamin E
• Pomegranate extract

 

Pretty commonly known supplements. I take all of them since many years, beside 200 others. And attained remissions from 3 irreversible chronic diseases (PAD, COPD, ME/CFS).

 

However, I'm very wary of proprietary formulas. The total weight of all ingredients never add to the larger amounts I for example need from above listed ingredients. Taken as a proprietary blend, I would never know the effective dose of them individually. Therefore, too many disadvantages. Then taken individually with knowledge of the quality control of the original sources and individual effective doses..
 

 

Longevity Diary has written over 4,000 articles on anti-aging, with more than 1,800 of these being original articles.

 

Do you have any links other than chats?
 

 

 

[alphachn]

Thanks for your honest response. Just be aware that in the West, almost all scams have little other sources than messenger services. Personally, I suspected such by your only CS011 formula posted too:

 

 

Pretty commonly known supplements. I take all of them since many years, beside 200 others. And attained remissions from 3 irreversible chronic diseases (PAD, COPD, ME/CFS).

 

However, I'm very wary of proprietary formulas. The total weight of all ingredients never add to the larger amounts I for example need from above listed ingredients. Taken as a proprietary blend, I would never know the effective dose of them individually. Therefore, too many disadvantages. Then taken individually with knowledge of the quality control of the original sources and individual effective doses..
 

 

 

Do you have any links other than chats?
 

Thank you for your feedback. If you have any questions or concerns about the information we provide, please feel free to bring them up. We will do our best to answer them and ensure that the information provided is accurate and reliable.

1.Our team was established in 2013, and we are well-versed in all anti-aging technologies from 2013 to the present. All our team members are Chinese, including many traditional Chinese medicine doctors, so our English proficiency is quite poor. The articles we write are in Chinese and can be found in the WeChat community. This is our first time communicating with international experts. In the LongeCity community, there are many professionals, and if we were engaging in fraud, there would be no chance for us to be here. In fact, very few anti-aging products from Western countries appear here. Our presence here and the fact that we are open to questioning already speaks volumes. Not all Chinese products are of low quality; we only produce high-quality products.

2.The core of the CS011 formula is Longevity Diary's proprietary formula, which is the most important part. The other common ingredients（Pretty commonly known supplements） you mentioned are only used as auxiliary components. Longevity Diary's proprietary formula is a small molecule invented by our team and has not been disclosed.In fact, many formulas have the same ingredients, but the extraction methods differ greatly, leading to significant differences in quality.

3.200 supplements is an enormous number. According to the Pareto principle, 20% of the supplements can provide 80% of the benefits. Too many supplements can cause gradual damage to the liver and kidneys.Please refer to this article on the effects of six common supplements on the liver. Our team only uses around six self-invented small molecules.

https://jamanetwork....utm_term=080524

4.Most of our articles are interpretations of papers published in Nature. The attachment includes the only examples we have.

5.by the way.The tools for posting information on LongeCity are very smooth and easy to use, just like WeChat in China. Perhaps our team can start publishing English information here.

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[alphachn]

Pretty commonly known supplements. I take all of them since many years, beside 200 others. And attained remissions from 3 irreversible chronic diseases (PAD, COPD, ME/CFS).

 

Longevity Diary's proprietary formula of CS011 is a CD47 inhibitor that does not attack red blood cells which is not a known supplements.

[pamojja]

Thanks again. Trough communication things become clearer. I mentioned nobody engaging in this thread, therefore suspected the same doubt in other here.

 

All our team members are Chinese, including many traditional Chinese medicine doctors, so our English proficiency is quite poor. The articles we write are in Chinese and can be found in the WeChat community. This is our first time communicating with international experts. In the LongeCity community, there are many professionals, and if we were engaging in fraud, there would be no chance for us to be here. In fact, very few anti-aging products from Western countries appear here. Our presence here and the fact that we are open to questioning already speaks volumes. Not all Chinese products are of low quality; we only produce high-quality products.

 

That's why I asked for links. Even if only on WeChat, with KI now there is enough translation possible to understand the gist, and our experts could verify the articles for all too obvious errors. I use Chinese herbals extracts too, but only from companies who take care assuring proper cultivation and no artificial unnecessary and potentially harmful additions.
 

2.The core of the CS011 formula is Longevity Diary's proprietary formula, which is the most important part. The other common ingredients（Pretty commonly known supplements） you mentioned are only used as auxiliary components. Longevity Diary's proprietary formula is a small molecule invented by our team and has not been disclosed.In fact, many formulas have the same ingredients, but the extraction methods differ greatly, leading to significant differences in quality.

 

You see, there is the biggest problem for me with proprietary formulas. No control over what one is actually ingesting. In most proprietary formulas, cheaper, too little other ingredients are used. With individually bought supplements, the consumer is somewhat empowered to know the extraction method, and therefore the quality too.

 

3.200 supplements is an enormous number. According to the Pareto principle, 20% of the supplements can provide 80% of the benefits. Too many supplements can cause gradual damage to the liver and kidneys.Please refer to this article on the effects of six common supplements on the liver. Our team only uses around six self-invented small molecules.

https://jamanetwork....utm_term=080524

 

If you have interest in my remissions, see here. With dietary intervention (of which natural supplements are part of), and all body systems out of whack (as in my case), diversity at least does assure a much more diverse and healthy microbiome. When tested at the time of my main remission, it showed more microbial diversity than 94% of all ubiome tests done until then.

In short, with 200 distinct natural ingredients of supplements, my NAFLD with non-circulated nodules, and a CKD stage 1 all reversed within of 16 years of use too. Of course, while monitoring all blood markers, which thereby especially of the liver and kidney gradually improved.
 

4.Most of our articles are interpretations of papers published in Nature. The attachment includes the only examples we have.

 

Thanks. Could you post just the text instead of the picture? So it could be easier read, and sources directly linked?

Edited by pamojja, Yesterday, 10:42 AM.

[pamojja]

double post

 

 

 

 

 

Edited by pamojja, Yesterday, 10:41 AM.

[alphachn]

Thanks again. Trough communication things become clearer. I mentioned nobody engaging in this thread, therefore suspected the same doubt in other here.

 

 

That's why I asked for links. Even if only on WeChat, with KI now there is enough translation possible to understand the gist, and our experts could verify the articles for all too obvious errors. I use Chinese herbals extracts too, but only from companies who take care assuring proper cultivation and no artificial unnecessary and potentially harmful additions.
 

 

You see, there is the biggest problem for me with proprietary formulas. No control over what one is actually ingesting. In most proprietary formulas, cheaper, too little other ingredients are used. With individually bought supplements, the consumer is somewhat empowered to know the extraction method, and therefore the quality too.

 

 

If you have interest in my remissions, see here. With dietary intervention (of which natural supplements are part of), and all body systems out of whack (as in my case), diversity at least does assure a much more diverse and healthy microbiome. When tested at the time of my main remission, it showed more microbial diversity than 94% of all ubiome tests done until then.

In short, with 200 distinct natural ingredients of supplements, my NAFLD with non-circulated nodules, and a CKD stage 1 all reversed within of 16 years of use too. Of course, while monitoring all blood markers, which thereby especially of the liver and kidney gradually improved.
 

 

Thanks. Could you post just the text instead of the picture? So it could be easier read, and sources directly linked?

1. The real reason for the international stagnation in anti-aging measures is the ongoing search for specific cellular mechanisms, which may be inherently unsolvable. Cellular reprogramming methods reveal that the exposure time to OSKM/OSK varies for different cell types. Similarly, the process of clearing senescent cells shows that aging characteristics differ for each cell type, making it impossible to target all cells uniformly. Biological aging clock algorithms reveal varying degrees of aging across different organs. This is the current state of international anti-aging, leading to its lack of enthusiasm.

At  longevity diary, we believe that perhaps we have overcomplicated the real cause of aging. Faced with international stagnation, we have to explore on our own, and it feels like we are on the verge of uncovering the path to immortality.

2.I've carefully read through your approach, and indeed, you are taking a lot of supplements. However, there is a concern: elevating all levels might mean that none are truly elevated. How old are you? Perhaps your body has the ability to heal itself? Our viewpoint is that identifying and supplementing the one or two deficiencies to maintain balance might be better than elevating everything.

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Edited by alphachn, Yesterday, 11:41 AM.

[pamojja]

2.I've carefully read through your approach, and indeed, you are taking a lot of supplements. However, there is a concern: elevating all levels might mean that none are truly elevated. How old are you? Perhaps your body has the ability to heal itself?

 

Now I'm 57, The body has the ability to heal itself most when young. As my experiences with bad diet and numerous tropical infection show. But only to a certain degree. With the onslaught of infections' organs always remain somewhat damaged. And with aging, the restorative healing power declines. For me, it started around age 40 with a walking-disability from PAD. Where I obviously needed all the various life-style interventions to attain remissions again. Along bodies weaker ability to heal itself. The NAFDL healed before supplementation naturally, the non-circulated nodules in the liver disappeared only with supplementation, and enzymes gradually improved further.

 

Some nutrients despite moderate dosing, like vitamin K or CoQ10, reached astronomical blood levels. Others are still deficient despite megadosing, for example Mg, Zinc or vitamin C. Nutrients too high in blood, like copper, wasn't possible to really bring down through abstention. So it wasn't possible to elevate all levels equally,, and therefore wouldn't apply.

[longevitydiary]

We don't know your detailed situation, but how about your BMI? And your waist circumference? Perhaps you could start with reducing abdominal fat.

[pamojja]

Our viewpoint is that identifying and supplementing the one or two deficiencies to maintain balance might be better than elevating everything.

 

Exactly my experience. Nutrients levels rise or fall differently in different persons with different biochemical individuality, despite the exact same supplement dose. Short of clairvoyance, a user has to test each supplement ingredient individually by starting with low dose, increase gradually, while regularly monitoring lab-test for any slight change to the better or worse. And individually adjust doses.

 

Something obviously completely impossible with prefabricated proprietary formulas. Therefore by offering proprietary formulas, don't you act completely contrary to your views?

 

 

 

 

 

[longevitydiary]

Exactly my experience. Nutrients levels rise or fall differently in different persons with different biochemical individuality, despite the exact same supplement dose. Short of clairvoyance, a user has to test each supplement ingredient individually by starting with low dose, increase gradually, while regularly monitoring lab-test for any slight change to the better or worse. And individually adjust doses.

Something obviously completely impossible with prefabricated proprietary formulas. Therefore by offering proprietary formulas, don't you act completely contrary to your views?

Our proprietary formula consists of only one self-invented ingredient, and there are only two choices: yes or no. We currently do not have a product for PAD.

[longevitydiary]

Exactly my experience. Nutrients levels rise or fall differently in different persons with different biochemical individuality, despite the exact same supplement dose. Short of clairvoyance, a user has to test each supplement ingredient individually by starting with low dose, increase gradually, while regularly monitoring lab-test for any slight change to the better or worse. And individually adjust doses.

Something obviously completely impossible with prefabricated proprietary formulas. Therefore by offering proprietary formulas, don't you act completely contrary to your views?

We will customize proprietary formulas based on the user's situation. Each proprietary formula consists of only one ingredient, and users have only two choices: to choose our product or not to choose our product.