[anti-aging firewalls] Disease free aging and quantum phenomena

by Vince Giuliano

By Vince Giuliano

Those who know me are possibly familiar with my recent series of writings relating to quantum reality-creating phenomena in the Being and Creation blog. There is a scientific link between this line of inquiry and my concern about long lives and disease- free aging. The link is that:

There is a powerful underlying process in old age of quantum intercellular communications that postpones the onset of age-related diseases, and this process is interfered with by the presence of chronic inflammation.

I have already written extensively about how chronic inflammation accelerates the aging process. And on how preventing or limiting chronic inflammation has likely been the central factor keeping me going until now. My 95^th birthday is in a few weeks now, and I expect to keep going actively at least until I am 100. The process of rapid decline in very old age that I have discussed previously is progressive DNA methylation in cellular histones, rendering them unable to do their jobs of activating health-maintaining genes.

This current blog entry suggest a different earlier- proposed mechanism involving intercellular communications via quantum tunneling processes. In both cases, chronic inflammation aids and abets the process of decline. Preventing or seriously slowing chronic inflammation can lead to much longer healthy lives.

I will start here with the 2019 publication Cellular parabiosis and the latency of age-related diseases. “ ‘All things are difficult before they are easy’ (Thomas Fuller, 1608–1661) and all things appear complicated before they become simple. This and the accompanying paper [1] propose simple concepts that can account for the aetiology of ageing and age-related diseases (ARD). Apparent complexity of ageing and diseases (actually, of their consequences) reflects the complexity of healthy organisms but reveals little to nothing about the root cause(s) of age-related morbidity and mortality. Identifying the causes and early cellular stages of ARD will be instrumental in eventual mitigation of degenerative diseases, including cancer.” — “The incidence of death and diverse ARD increases with about the fifth power of time, suggesting a common biological clock (with species-specific speed) and perhaps a shared common cause. A common cause would mean that it might be simpler to mitigate all ARD collectively than any particular one—reminiscent of the long-lasting simultaneous resistance of super-centenarians to all ARD.” (VG – I quite agree)”

‘“ Cellular parabiosis is the traffic of metabolites and functional and informational molecules between neighbouring cells preventing the expression of recessive phenotypes” According to this article cellular parabiosis involves a constant exchange of information among neighboring cells. This exchange postpones the onset of ARDs for long periods, and it is breakdown of this exchange that leads to ARDs and mortality.” — “The one-dimensional nature of these fundamental building blocks, then, opens up the way for a mathematical formulation of the chain as a completely integrable field theory model, characterized by an infinite-number of conservation laws. The latter are associated with global excitation modes, completely delocalized in the chain space-time. This integrability structure proves sufficient in providing a satisfactory solution to memory coding and capacity [5]. (ref)” I comment that as quantum field theory model, entanglement among cells may be more than local, and the strange effects may apply such as retro causation.

According to the author, the cellular parabiosis takes place through several primary mechanisms: one of which is quantum tunneling between microtubules. This is clearly laid out in several of the authors illustrations in that article. “Many names, often redundant, were given to diverse extracellular structures shown, or presumed, to be the vectors of intercellular molecular traffic [22–25]. Most familiar are gap junctions, desmosomes and neuronal synapses that allow for the trafficking of metabolites and electrolytes. Since the majority of cellular catalytic activities are involved in the biosynthesis of metabolites and their intermediates (at least 120 000 kinds in humans), gap junctional traffic may phenotypically suppress the majority of random genome alterations. However, tunnelling nanotubes (TnT) [22,25], extracellular vesicles [23] and/or exosomes [24] were shown to transfer diverse RNAs, proteins (including prions) and even entire organelles (mitochondria, lysosomes, Golgi apparatus) and viruses—all functionally expressed in recipient cells [22,23]. One study showed unequivocally that dozens of protein species pass directly between the cells through TnTs [28]. The most efficient means for molecular exchange between cells packed in tissues may be still undiscovered (e.g. imaginable recurrent partial cell fusions). The presence of diffusible effectors of cellular parabiosis in conditioned media would not be surprising [29].

Here are some of the key points of that paper:

There is a very long period of latency in very old age before serious susceptibility to ARDs of a cell begins, perhaps measured in years.
During this period, the non-susceptibility of individual cells to the end of this latency is because of a steady stream of supportive communication and possibly exchange of organelles with neighboring cells. The author calls this process cellular parabiosis.
This communication and exchange of organelles may take place through various mechanisms, and there is strong evidence that quantum tunneling between tubulin is involved. Microtubules are structural and organnel-transportation filaments in cells.
The quantum tunneling can also be used to characterize age-related increase in ARD susceptibility to cancers.
This cellular parabiosis communication and exchange of organelles can be stopped by the presence of age-related chronic inflammation.
Reduction of chronic inflammation can result in the resumption of the communication and exchange of organelles continuing the period of latency before susceptibility to ARDs sets in

“Inhibiting inflammation and SASP turns the arrow in opposite direction by the re-establishment of parabiosis and phenotypic suppression (i.e. healing by phenotypic reversion).” I believe this is what I have personally done.

Microtubules and quantum tunneling and entanglement

A number of published papers support the quantum effects hypothesis for microtubules. Some of these go back 20 years or more. Others are very recent

From On Quantum Mechanical Aspects of Microtubules (1997) “MicroTubules (MT) appear to be one of the most fundamental structures of the interior of living cells [1]. These are paracrystalline cytoskeletal structures which seem to play a fundamental role for the cell mitosis. It is also believed that they play an important role for the transfer of electric signals and, more general, of energy in the cell.” They serve as miniature railways for the transportation of proteins and organelles within cells. Motor proteins can carry such substances from one end of the cell to the other by riding on microtubules as rails. The distance can be relatively long. Some nerve cells for example extend from the brain to remote parts of the body. Further, microtubules are subject to quantum entanglement across neighboring cells – and possibly across remote cells as well. Here are some key points and citations:

Quantum Basis for Consciousness: Research by Mike Wiest and his team at Wellesley College suggests that anesthesia’s effectiveness via microtubule interaction supports a quantum theory of consciousness. They found that drugs affecting microtubules within neurons delay the onset of unconsciousness caused by anesthetic gases1.
Photon Entanglement in Myelin Sheath: A research group in China has shown that many entangled photons can be generated inside the myelin sheath that covers nerve fibers. This could explain the rapid communication between neurons, which is essential for consciousness2.
Neuronal Cytoskeleton and Consciousness: Stuart Hameroff proposed that consciousness and cognition could be explained by quantum and classical processes in microtubules inside neurons. He suggests that these processes are critical to consciousness and cognition3. Numerous papers support this hypothesis.

Here are the related citations for further reading:

Other relevant publications include:

Where does this leave me with respect to practical longevity?

I have now propounded in these blogs on two putative mechanisms that lead the body to stop defending against ARDs, typically starting in one’s 80s.

The mechanisms described above, where cellular parabiosis no longer works due to the presence of age-related chronic inflammation.
A mechanism I have characterized in blog entries where lifelong double and triple methylation, particularly at histone position HK3me has reached the point where that histone can turn on multiple necessary.

These two mechanisms are not necessarily mutually exclusive.

In both cases, taking personal initiatives to reduce chronic inflammation appears to be an effective strategy for postponing the operation of these mechanisms and the massive onset of ARDs. This is what I have done, employing classical anti-inflammatory herbs as the basis for reduction of the chronic inflammation, I expect to continue this approach at least until I reach 100, continuing to research and write blogs about both Intentional Reality Creation and longevity science.

View the full article at Anti-Aging Firewalls

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