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TAC is a TERT activator compound that delays aging through two pathways: by extending telomeres and regulating gene expression.
Hong Seok Shim et al., TERT activation targets DNA methylation and multiple aging hallmarks.
Cell Doi: https://doi.org/10.1...ell.2024.05.048
In preclinical experiments, researchers treated elderly mice (equivalent to humans over 75 years old) with TAC for 6 months. The results showed that these older mice exhibited many "youthful" characteristics, such as enhanced cognitive abilities, the generation of new neurons in the hippocampus of the brain, and an increase in certain genes related to learning, memory, and synaptic biology. Additionally, neuromuscular control was strengthened, muscle strength and coordination improved, and the common issue of sarcopenia in older animals was reversed.
Tests on samples like blood and brain tissue also revealed that the elderly mice treated with TAC significantly reduced inflammatory responses, with a decrease in various disease-related inflammatory cytokines. They also eliminated accumulated senescent cells by inhibiting the key aging factor, the p16 gene.
At the same time, safety tests indicated no significant toxicity, including cancer risk.
Edited by longevitydiary, Today, 08:12 AM.
