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Boron (Boric Acid): Anti AGE, Gut Ribose production, etc?

boron age nad

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#1 Logic

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Posted 31 December 2024 - 03:38 PM


I'm way out of practice in this field of study so this is just some interesting points on Boron (and Boric Acids) that may be worth further research.

 
Boric acid: A simple molecule of physiologic, therapeutic and prebiotic significance
 
boric acid and borax supplementation on lipid peroxidation (LPO), antioxidant activity
and DNA damage in rats have been investigated. Boron supplementation (100 mg/kg) in diet was found to
decrease LPO, and enhance the antioxidant defense mechanism and vitamin status

A wide array of sugars, including ribose, can be formed from formaldehyde (formose reaction) under pos-
sible prebiotic conditions, however, ribose has no selectivity and is rather unstable [51] . Boric acid and borate
minerals have been suggested to play a crucial role in transforming the prebiotic organic molecules to give
ribose in a stable form
by acting as a complexing agent. It is well known that boric acid and borate complexes
with 1,2-diol and 2,3-diol compounds and the cyclic form of ribose presents two hydroxyl groups in a cis
configuration for complexation with boron. Benner and co-workers demonstrated that ribose formation from
formaldehyde and glycolaldehyde is stabilized in the presence of borate [52] . da Silva and co-workers showed
possible clues on the roles of borate ions, alkaline and earth alkaline ions in the synthesis and stabilization
of ribose during the pre-RNA period [53] .

https://www.research...ic_significance
 

Effects of boron-containing compounds on cardiovascular disease risk factors
 
BCCs may inhibit Maillard reactions, by forming stable borate esters with cis-diol on furanose rings, thus making possible the chemical evolution in aqueous media of sugar and aminoacids, simultaneously, at temperatures of 80–100 degrees C [127]. As a result, borate/borate ester anions in living systems may inhibit glycation.
 

BCCs (as borate) have been demonstrated to increase NAD+/NADH ratio in animals

https://www.scienced...946672X18301561
 


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