According to reports in Nature Aging , scientists have developed a revolutionary "single-cell immune aging clock" that uses gene expression data to measure the biological age of individual immune cells, offering unprecedented insights into how the immune system ages and responds to infections and vaccinations.
HIV-infected H9 T cell
BSIP
·
gettyimages.com
Single-Cell Clock Reveals Immune Aging
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dailyed
17 hours ago
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According to reports in Nature Aging , scientists have developed a revolutionary "single-cell immune aging clock" that uses gene expression data to measure the biological age of individual immune cells, offering unprecedented insights into how the immune system ages and responds to infections and vaccinations.
Single-cell immune aging clock
Developed by researchers at the Center for Individualized Infectious Medicine (CiiM), this innovative tool uses machine learning to analyze transcriptomic data from millions of immune cells in individuals aged 18 to 97 years . By identifying specific genes associated with aging and inflammatory processes, the clock serves as a marker for immune cell aging, allowing precise tracking of changes in immune function over time . This revolutionary technology reveals significant heterogeneity in immune aging between individuals, influenced by factors such as inflammation and pathological conditions, offering new insights into personalized medicine and the potential for targeted interventions to mitigate age-related immune decline .
HIV-infected H9 T cell
BSIP
·
gettyimages.com
Single-Cell Clock Reveals Immune Aging
User avatar
dailyed
17 hours ago
5,864
151
According to reports in Nature Aging , scientists have developed a revolutionary "single-cell immune aging clock" that uses gene expression data to measure the biological age of individual immune cells, offering unprecedented insights into how the immune system ages and responds to infections and vaccinations.
Single-cell immune aging clock
Developed by researchers at the Center for Individualized Infectious Medicine (CiiM), this innovative tool uses machine learning to analyze transcriptomic data from millions of immune cells in individuals aged 18 to 97 years . By identifying specific genes associated with aging and inflammatory processes, the clock serves as a marker for immune cell aging, allowing precise tracking of changes in immune function over time . This revolutionary technology reveals significant heterogeneity in immune aging between individuals, influenced by factors such as inflammation and pathological conditions, offering new insights into personalized medicine and the potential for targeted interventions to mitigate age-related immune decline .
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IMMClock and Immune Aging
IMMClock, a novel immune aging clock developed by researchers, provides accurate age estimates for CD8⁺ T cells, CD4⁺ T cells, and NK cells using gene expression data . This innovative tool offers unique insights into immune aging processes and their implications for health and disease:
IMMClock demonstrates that intrinsic cellular aging processes are more significantly altered during immune aging compared to differentiation processes .
The clock confirms strong associations between immune aging and established processes such as cellular senescence, exhaustion, and telomere length at the single-cell level .
Immune aging is accelerated in several pathological conditions, including type 2 diabetes, heart disease, and cancer .
IMMClock reveals that the post-disruption immune age of individual T cells is strongly correlated with their pre-disruption immune age .
The immune age of resting T cells is highly predictive of their post-stimulation activation state .
Application of IMMClock to cancer patient data shows a strong correlation between CD8⁺ T cell exhaustion levels and immune age, with notably elevated immune age in the tumor microenvironment compared to blood .
These findings highlight the potential of IMMClock to advance our understanding of immune aging and identify interventions that can simultaneously rejuvenate and activate immune cells, potentially strengthening efforts to counter age-related immune decline .
HIV-infected H9 T cell
BSIP
·
gettyimages.com
Single-Cell Clock Reveals Immune Aging
User avatar
dailyed
17 hours ago
5,864
151
According to reports in Nature Aging , scientists have developed a revolutionary "single-cell immune aging clock" that uses gene expression data to measure the biological age of individual immune cells, offering unprecedented insights into how the immune system ages and responds to infections and vaccinations.
Single-cell immune aging clock
Developed by researchers at the Center for Individualized Infectious Medicine (CiiM), this innovative tool uses machine learning to analyze transcriptomic data from millions of immune cells in individuals aged 18 to 97 years . By identifying specific genes associated with aging and inflammatory processes, the clock serves as a marker for immune cell aging, allowing precise tracking of changes in immune function over time . This revolutionary technology reveals significant heterogeneity in immune aging between individuals, influenced by factors such as inflammation and pathological conditions, offering new insights into personalized medicine and the potential for targeted interventions to mitigate age-related immune decline .
technologynetworks.com favicon
semanticscholar.org favicon
5 sources found
IMMClock and Immune Aging
IMMClock, a novel immune aging clock developed by researchers, provides accurate age estimates for CD8⁺ T cells, CD4⁺ T cells, and NK cells using gene expression data . This innovative tool offers unique insights into immune aging processes and their implications for health and disease:
IMMClock demonstrates that intrinsic cellular aging processes are more significantly altered during immune aging compared to differentiation processes .
The clock confirms strong associations between immune aging and established processes such as cellular senescence, exhaustion, and telomere length at the single-cell level .
Immune aging is accelerated in several pathological conditions, including type 2 diabetes, heart disease, and cancer .
IMMClock reveals that the post-disruption immune age of individual T cells is strongly correlated with their pre-disruption immune age .
The immune age of resting T cells is highly predictive of their post-stimulation activation state .
Application of IMMClock to cancer patient data shows a strong correlation between CD8⁺ T cell exhaustion levels and immune age, with notably elevated immune age in the tumor microenvironment compared to blood .
These findings highlight the potential of IMMClock to advance our understanding of immune aging and identify interventions that can simultaneously rejuvenate and activate immune cells, potentially strengthening efforts to counter age-related immune decline .
semanticscholar.org favicon
semanticscholar.org favicon
2 sources found
Applications in infections and vaccinations
taking sinovac covid-19 vaccination injection
Mufid Majnun
·
unsplash.com
The Single Cell Immune Aging Clock has revealed fascinating insights into how infections and vaccinations interact with immune aging. During COVID-19 infections, researchers observed a notable age acceleration in monocytes, which decreased as patients recovered . This suggests that severe infections can temporarily accelerate immune aging, which could explain why older individuals are more vulnerable to complications.
Vaccine responses have also shown intriguing patterns of immune aging. After BCG vaccination, individuals with elevated interferon response genes at baseline showed age rejuvenation in their CD8+ T cells . This highlights the potential of some vaccines not only to protect against specific pathogens but also to rejuvenate certain aspects of the immune system. These findings open exciting prospects for developing targeted vaccination strategies that could simultaneously enhance immunity and counteract age-related immune decline, particularly in older populations .
HIV-infected H9 T cell
BSIP
·
gettyimages.com
Single-Cell Clock Reveals Immune Aging
User avatar
dailyed
17 hours ago
5,864
151
According to reports in Nature Aging , scientists have developed a revolutionary "single-cell immune aging clock" that uses gene expression data to measure the biological age of individual immune cells, offering unprecedented insights into how the immune system ages and responds to infections and vaccinations.
Single-cell immune aging clock
Developed by researchers at the Center for Individualized Infectious Medicine (CiiM), this innovative tool uses machine learning to analyze transcriptomic data from millions of immune cells in individuals aged 18 to 97 years . By identifying specific genes associated with aging and inflammatory processes, the clock serves as a marker for immune cell aging, allowing precise tracking of changes in immune function over time . This revolutionary technology reveals significant heterogeneity in immune aging between individuals, influenced by factors such as inflammation and pathological conditions, offering new insights into personalized medicine and the potential for targeted interventions to mitigate age-related immune decline .
technologynetworks.com favicon
semanticscholar.org favicon
5 sources found
IMMClock and Immune Aging
IMMClock, a novel immune aging clock developed by researchers, provides accurate age estimates for CD8⁺ T cells, CD4⁺ T cells, and NK cells using gene expression data . This innovative tool offers unique insights into immune aging processes and their implications for health and disease:
IMMClock demonstrates that intrinsic cellular aging processes are more significantly altered during immune aging compared to differentiation processes .
The clock confirms strong associations between immune aging and established processes such as cellular senescence, exhaustion, and telomere length at the single-cell level .
Immune aging is accelerated in several pathological conditions, including type 2 diabetes, heart disease, and cancer .
IMMClock reveals that the post-disruption immune age of individual T cells is strongly correlated with their pre-disruption immune age .
The immune age of resting T cells is highly predictive of their post-stimulation activation state .
Application of IMMClock to cancer patient data shows a strong correlation between CD8⁺ T cell exhaustion levels and immune age, with notably elevated immune age in the tumor microenvironment compared to blood .
These findings highlight the potential of IMMClock to advance our understanding of immune aging and identify interventions that can simultaneously rejuvenate and activate immune cells, potentially strengthening efforts to counter age-related immune decline .
semanticscholar.org favicon
semanticscholar.org favicon
2 sources found
Applications in infections and vaccinations
taking sinovac covid-19 vaccination injection
Mufid Majnun
·
unsplash.com
The Single Cell Immune Aging Clock has revealed fascinating insights into how infections and vaccinations interact with immune aging. During COVID-19 infections, researchers observed a notable age acceleration in monocytes, which decreased as patients recovered . This suggests that severe infections can temporarily accelerate immune aging, which could explain why older individuals are more vulnerable to complications.
Vaccine responses have also shown intriguing patterns of immune aging. After BCG vaccination, individuals with elevated interferon response genes at baseline showed age rejuvenation in their CD8+ T cells . This highlights the potential of some vaccines not only to protect against specific pathogens but also to rejuvenate certain aspects of the immune system. These findings open exciting prospects for developing targeted vaccination strategies that could simultaneously enhance immunity and counteract age-related immune decline, particularly in older populations .
pubmed.ncbi.nlm.nih.gov favicon
semanticscholar.org favicon
2 sources found
Clinical Implications of Immune Clocks
Elevated immune aging, as measured by these novel clocks, is strongly correlated with chronic diseases such as cancer and cardiovascular disease. In cancer patients, higher immune age in CD8+ T cells is linked to exhaustion and poor clinical outcomes . These tools offer exciting possibilities for predictive health monitoring, potentially predicting an individual's susceptibility to infections, vaccine efficacy, and risk of age-related diseases . By accounting for inter-individual variability, immune clocks could guide tailored treatments for chronic diseases and inform the development of personalized preventive strategies. Moreover, insights gained from these clocks could pave the way for innovative therapeutic interventions aimed at rejuvenating the immune system or mitigating age-related inflammation
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