12 replies to this topic

[ahnenerbe]

I'm looking for the most comprehensive multi-antioxidant formula. There are many products that offer a combination of antioxidants. What do you guys think is the best?

Also what do you think about Berry Young Juice?
http://www.thereales...youngjuice.html

[Athanasios]

I know that this may not be exactly what you are thinking, but check out lipoic acid. You can do a search here to find a lot of info, including where people are getting theirs and what form they take.

Look into how it regenerates antioxidants in your blood, how it effects the mitochondria and lysosome, and what it does for insulin resistance, cardiovascular disease, brain preservation, liver antioxidant status, etc.

You may also want to look into how it is becoming more apparent that the proxidizing effects of some of these antioxidants may be creating the greatest benefits.

You can search some of this stuff at pubmed: http://www.ncbi.nlm.....fcgi?db=PubMed

I take my multivitamin, lipoic acid, some vit C, and drink plenty of green tea then call it day, I also eat well and exercise.

Hope you get more feedback for diversity of opinion.

[Shepard]

AOR's Network Synergy is pretty decent.

[ajnast4r]

http://www.jarrow.co....php?prodid=389

[ahnenerbe]

AOR's Network Synergy is pretty decent.

I think so too. But I take AOR's Ortho-Core already wouldn't it be too much on vitamins C and E?

I know that this may not be exactly what you are thinking, but check out lipoic acid. You can do a search here to find a lot of info, including where people are getting theirs and what form they take.

Look into how it regenerates antioxidants in your blood, how it effects the mitochondria and lysosome, and what it does for insulin resistance, cardiovascular disease, brain preservation, liver antioxidant status, etc.

You may also want to look into how it is becoming more apparent that the proxidizing effects of some of these antioxidants may be creating the greatest benefits.

Very interesting info here: http://www.benbest.c...eut/lipoic.html

So there is Lipoic Acid (LA), Alpha Lipoic Acid (ALA), DiHydroLipoic Acid (DHLA) and the R-enantiomer and the S-enantiomer LA forms. Which one is the most effective?

Both LA and DHLA can chelate heavy metals, but the R-form is more effective for chelation than alpha-lipoic acid [BIOCHEMICAL PHARMACOLOGY; Ou,P; 50(1):123-126 (1995)]. LA is most effective in chelating Cu2+, Zn2+ and Pb2+, but cannot chelate Fe3+. DHLA forms complexes with Cu2+, Zn2+, Pb2+, Hg2+ ( mercury) and Fe3+ that are poorly soluble in water. Although DHLA chelates Fe3+, it can also reduce Fe3+ to Fe2+ -- a pro-oxidant effect it shares with ascorbic acid. Insofar as most iron is tightly bound to ferritin protein, ascorbate reduction of Fe3+ rarely occurs, but DHLA may have the capacity to remove bound iron from ferritin.

[brutale]

I agree on Network Synergy, but you ought to add more ALA per cnorwood19's suggestion. Mito-Gold from AOR is good. You should also have a look at "herbal" antioxidants like tumeric, ginger, ginkgo, etc. The Vitamin Shoppe has some antioxidant cocktail formulas.

[zoolander]

here's a real good read

Trends Neurosci. 2006 Sep 23;

    Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses.

        * Mattson MP,
        * Cheng A.

    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.

    Diets rich in vegetables and fruits are associated with reduced risk of several major diseases, including neurodegenerative disorders. Although some beneficial phytochemicals might function solely as antioxidants, it is becoming clear that many of the beneficial chemicals in vegetables and fruits evolved as toxins (to dissuade insects and other predators) that, at subtoxic doses, activate adaptive cellular stress-response pathways in a variety of cells including neurons. Examples of such 'preconditioning' or 'neurohormesis' pathways include those involving cell-survival signaling kinases, the transcription factors NRF2 and CREB, and histone deacetylases of the sirtuin family. In these ways, neurohormetic phytochemicals such as resveratrol, sulforaphanes and curcumin might protect neurons against injury and disease by stimulating the production of antioxidant enzymes, neurotrophic factors, protein chaperones and other proteins that help cells to withstand stress. Thus, as we discuss in this review, highly conserved longevity and survival pathways in neurons are the targets of many phytochemicals.

    PMID: 17000014 [PubMed - as supplied by publisher]

For those of you who cannot get access to the full paper (join up) here are the main phytonutrients mentioned:

1. Resveratrol
2. Sulforaphane
3. Curcumin
4. Catechins
5. Allicin
6. Hypercin

[Athanasios]

So there is Lipoic Acid (LA), Alpha Lipoic Acid (ALA), DiHydroLipoic Acid (DHLA) and the R-enantiomer and the S-enantiomer LA forms. Which one is the most effective?

ALA is generally used for when lipoic has both R+ and S- forms. R(+)- is the most potent form of lipoic acid. Your body converts lipoic acid into DHLA in significant amounts, and the process in which it does this is one of the benefits of lipoic acid. Personally I would look for what has the most R(+). The cheaper cost of ALA may mean you might be able to get more R(+) per dollar that way. I take AORs R(+)-.

[ahnenerbe]

I don't understand all what is said here http://www.benbest.c...eut/lipoic.html . What is the relation between R-lioic acid and gluthatione? Does LA intake replaces completely gluthatione (SAMe) intake?

[Mind]

I take AOR's ortho-core.

[Athanasios]

I don't understand all what is said here http://www.benbest.c...eut/lipoic.html . What is the relation between R-lioic acid and gluthatione? Does LA intake replaces completely gluthatione (SAMe) intake?

That is weird. The relation between lipoic acid and glutathione is that lipoic acid boosts glutathione levels. The effect is more significant in older mice, because they have an age related decline of glutathione.

Ahnenerbe, check out this video on lipoic acid...it has some charts that show how well it works in the young and healthy, as well as the old. The speaker is Bruce Ames:

http://www.ucsd.tv/l...asp?showID=8343

Edit:

I see now why he wrote it that way "As with the thiol anti-oxidant glutathione," Lipoic acid is a thiol-containing compound.

Edited by cnorwood19, 03 October 2006 - 11:01 PM.

[zoolander]

This diagram should explain

[chipl]

GliSODin

http://www.plthomas.com/glisodin.htm