WOW! True life extension starts with benaGene?
#91
Posted 06 April 2007 - 04:58 AM
#92
Posted 07 April 2007 - 05:17 PM
The info on benagene.org looks good however I agree with a what a few others have said about waiting for third party information and the replication of the mice experiments. If others get the same kind of results then I will definitely consider taking it. If it does prove effective by other researchers I would love to see a rat/mouse study where one group was supplemented with resveratrol, one group supplement benagene and one group supplemented with benagene AND resveratrol, along with a control group of course. Perhaps different dosage levels also... Maybe I should order some lab rats and do it myself...
#93
Posted 08 May 2007 - 06:51 PM
I looked at the Benagene site and it looks as if though the C57BL/6 male mice you were using had roughly 50% survivorship of 21 (control, basically AL) and 26 (Benagene) months, and maximum lifespan of 27 (control, basically AL) and 31 (Benagene) months. However, if you look at CR studies done on the same species, these numbers appear to be generally MUCH higher, for example here
http://www.fasebj.or...nt/02-0533fjev1
the 50% survivorships are 26.3 (AL) and 32.6 (40% CR) months, and maximum lifespans are 34.3 (AL) and 42.7 (40% CR). These too were C57BL/6 male mice.
Based on this, it looks to me as if you did a real crappy job of taking care of your mice and Benagene barely normalized their lifespan, getting about the same lifespan as AL mice (sic!) of the same species usually tend to get. That hardly seems like a proof of CR effect though.
Am I missing something here?
#94
Posted 08 May 2007 - 09:19 PM
Thoust pulls no punches.
Yes, in some studies, the C57BL/6 male mice live longer, in some they live shorter. This is why it is critical to have a control group under the same conditions, and not "assume" a lifespan, even though C57BL/6 has been studied extensively. My lab conditions are not the same as other lab conditions, so we try to compare "apples" to "apples".
Currently, the Jackson Laboratory is performing long-term studies on various breeds, including several types of C57BL/6. It appears we are within tolerance levels of their work, but their work is not yet complete. You may want to check it out at
http://phenome.jax.o...s&sym=Jaxshock1
Another "popular" study you may want to look at is at Life Extension's website where they did a lifespan study on melatonin (not that I am advocating melatonin use).
http://www.lef.org/m...g95/95dec2d.htm
You will note that the average lifespan of the control group is 23 months, similar to my results. The literature shows a wide range.
The good news is that the National Institute of Health is now working on repeating the research on benaGene with better facilities and many more mice. The bad news is that it will take several years. The good news is that they will publish their findings.
Regards,
Alan
#95
Posted 14 May 2007 - 09:18 PM
Terra Biological, who developed "benaGene" is considering various advertising strategies to "get the word out". One thing our marketing department has requested is testimonials. If you have used the product and would like to make a testimonial, please e-mail it to me directly at acash(at)benaGene.org. Please replace the (at) with a @ (I do this so I don't increase my spam load).
I thank you for the help.
Sincerely,
Alan Cash
#96
Posted 28 May 2007 - 10:41 PM
Anyone else tried it specifically for lower blood glucose? Or just noted that effect via testing?
#97
Posted 29 May 2007 - 03:37 AM
I'm glad you are going to monitor your fasting blood glucose levels. You may want to start doing that now, so that you can see your baseline, and the "swings" in your baseline. It will take benaGene about 3 weeks to work. At that time, you will see a decrease in fasting glucose and also the size of the fluctuations (or swings) in your fasting glucose level.
We recommend taking benaGene with an evening meal. If you take it on an empty stomach, about 50% of the people feel light headed due to the glucose lowering effect. We don't see this strong an effect when taken with food.
#98
Posted 29 May 2007 - 05:39 AM
Edited by frankbuzin, 29 May 2007 - 05:59 AM.
#99
Posted 29 May 2007 - 07:52 AM
#100
Posted 29 May 2007 - 02:39 PM
The evening meal advice actually came from talking with our customers.
Regards,
Alan
#101
Posted 01 June 2007 - 01:38 AM
What differences have people taking Benagene noted WRT timing the dose?
#102
Posted 01 June 2007 - 12:48 PM
Some of our customers brought this to our attention. They noted after taking benaGene, it had a calming effect. It may be due to the lowering of glucose levels. benaGene has an immediate effect on blood sugar levels, and then the secondary effect, after 2.5 to 3 weeks to lower overall (fasting glucose) levels. We believe the second effect is due to changes in the genomic response, and it is probably the more important effect. We can measure both the immediate effects and the change at 2.5 to 3 weeks with a simple glucose meter.
Since in some customers it has a calming effect, it make sense to take it at night. We now recommend with an evening meal because the initial effect can make some people light-headed if they take it on an empty stomach. We do not have a double blind study on the calming effect-- just customer reports.
Regards,
Alan
#103
Posted 01 June 2007 - 05:43 PM
Some of our customers brought this to our attention. They noted after taking benaGene, it had a calming effect. It may be due to the lowering of glucose levels
FWIW, I noted similar effect from R-Lipoic Acid first times I took it (w/o being "light-headed").
#104
Posted 11 June 2007 - 08:17 PM
I'm going to a use my HbA1c test and get it mailed off before starting.
#105
Posted 23 July 2007 - 02:47 AM
~5/5: Started benaGene 1 pill/day
5/25 draw: Fasting glucose 86
7/17 draw: Fasting glucose 94, HbA1c 4.7% (ref 4.8-5.9)
8/7 draw: Fasting glucose 91
Continuing benaGene at least until my supply runs out. All tests by LabCorp. Far from a controlled experiment, all sorts of things changed in that time.
Edited by trevyn, 13 August 2007 - 12:35 AM.
#106
Posted 27 July 2007 - 05:01 AM
You may want to measure daily glucose levels with a glucose meter. If you compare "before" and "after" benaGene, you should also see a marked drop in your glucose "swing"-- the levels will stabilize and remain more stable.
Your HbAlc (which measures glucose interaction with hemoglobin over a 120 day span) is a little bit lower than would be expected with readings of 86 and 94, but is still in the normal range (at the low end). Keeping the glycosylated hemogloben down is good, indicating great glucose control, and is a good long-term strategy.
Keep us posted on any test updates.
Regards,
Alan
#107
Posted 29 July 2007 - 08:03 PM
I dropped the 300mg (75% gymnemic acid) Gymnema Sylestre extract which was taken 15-20min before meals, and the 920mg Cinnamon (cassia) & 1.2g Fenugreek Seed that were each taken with meals. I still take Na-ALA with meals. I also cut out all of my high caffeine sources (coffee, low carb energy drinks, etc) at the same time. Major headaches the first week.
Within the 4 weeks since I dropped them, my fasting avg has rose slightly from 94 to 98. A bigger difference would likely be seen post-meal testing, but because of limited supply of strips I haven't been doing that. Another 200 strips should be here Monday and I will resume more frequent testing.
The first week of beneGene hasn't affected my fasting numbers in any obvious way, but we will see how they look in 4 weeks. And when the strips get here (hopefully tomorrow as I'm now out as of today), I will be noting the pre and post meal numbers. With the +/- 20% afforded BG meters, the composition of meals, timing of meals, exercise, supplements, etc. I'm not so concerned about small changes in day to day testing, but more of the efects over time.
My HbAlc came back last week: 5.0% (ref range 3.8 - 5.9). Using the commonly used formula:
AvgBGL = (HbA1c * 33.3) - 86
My avg BG would be 81. Even taking into account the Dawn effect, with such a higher fasting number I must be going hypo a good bit for that to avg out. I will test a few times in the 2-4am range to see how it looks then and will test more frequent through the day (would be nice to have a CBGM at this point) to note any hypoglycemia.
#108
Posted 21 October 2007 - 10:24 AM
NIA begins Aging "Intervention" testing with benaGene
http://www.nia.nih.g...tingProgram.htm
Is that the one Spindler is doing? If so i would like to think that it helped someone *cough* suggested testing Benagene
Let's see what comes from it.
#109
Posted 21 October 2007 - 04:31 PM
#110
Posted 21 October 2007 - 06:27 PM
#111
Posted 21 October 2007 - 08:03 PM
Is it the vitamin C that provides the stability? For how long?
#112
Posted 21 October 2007 - 09:50 PM
#113
Posted 21 October 2007 - 11:12 PM
I have no idea if it truly makes all the difference or not. I guess the data and feedback will tell that story in time.
#114
Posted 22 October 2007 - 07:02 PM
#115
Posted 24 October 2007 - 03:13 PM
#116
Posted 26 October 2007 - 07:59 AM
#117
Posted 26 October 2007 - 03:42 PM
#118
Posted 13 February 2008 - 09:43 PM
#119
Posted 06 July 2008 - 09:34 AM
#120
Posted 06 July 2008 - 11:46 AM
The latest update I found on this is here
http://www.mfoundati...hread.php?t=715
I'm still taking it. Still no noticeable effects, etc.
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