I'm a member of the 2500/98% club myself.
When you get a chance could you comment on any observations at that dosage?
Sure. First, these dosage levels are experimental in humans. This seems obvious, but I thought I should make that clear for anyone wandering by. Source and purity are both important considerations. Even as the body of research on resveratrol convinces me that high doses are a good thing, I don't want to be concentrating contaminants along with it. I personally use a natural extract of P. cuspidatum purified to 98%+ trans-resveratrol, assayed, from a trusted supplier.
Aside from occasional difficulty sleeping, which is helped by nightly melatonin, I find no ill effects so far (about 6 weeks in). The most noticeable positive effect is increased stamina, measured mostly as mental stamina, since I spend most of my time at this keyboard, and do not engage in much structured exercise. When I do exert, there is a clear benefit physically as well. I rarely feel tired now. I regularly work 12 to 16 hour days without exhaustion. This is new, although I also experienced a stamina increase after starting apple polyphenols. Some nights, I'm not even tired. I've also noticed some positive sexual effects.
I feel more relaxed, and my blood pressure has dropped a few points, from normal to just about perfect (118/70 last check). My pulse has slowed a few beats. I feel very good. Stress is reduced, but that could be from my vacation
I also take high dose antioxidants (150,000+ ORAC units/day from various polyphenols), CoQ10, chlorella, turmeric, apple, grape seed extract, NADH, royal jelly (yum), EVOO, lots of coffee, and I eat very well, organic when feasible. I'm 50 years old.
Our small experimental group, using either 50% or 98% extracts, reports the following effects:
Katrina: 50% and 98% blend, appx 2 g. daily. Katrina has congenital (borderline) hypertension. She reports drops of 10-15 in both systolic and diastolic readings, placing her in the normal range for the first time since her youth, with a concomitant decrease in pulse rate from 85 to about 75. She also reports increased stamina and well-being, and very occasional insomnia. Katrina also takes 2-4 g of apple polyphenols, CoQ10, a multivitamin, melatonin, progesterone, b-12 and other nutrients. However, no change in BP was observed prior to resveratrol.
Rick: 50% extract, 4 g. daily. Rick has seen dramatic increase in physical stamina measured on treadmill exercise. In 2 months, he has doubled his distance at increased speed and is still not tired when he completes the workout. Also apple polyphenols 2 g. daily, grape seed extract 1 g. daily. No insomnia reported.
Suzanne: 50% 1 g. daily. Suzanne reports 8 lbs of weight loss in 14 days, a desired effect for her. She also reports increased energy.
Sleeplessness seems to be a side effect of high doses for some. Have you found this to be true? I just view this as time to get more done, but it's bothersome to others. It's certainly a tradeoff I'm willing to make for the reported benefits (in animals) of increased catalytic enzyme activity (all 3!), increased mitochodrial efficiency and proliferation, reversal of atherosclerosis, inhibition of neuropathies, blocking of prostate cancer, treating multiple myeloma, and on and on.
Of course, specific crossover effects from animals to humans have yet to be exhaustively studied- as can be said of many things. I don't have time to wait for multigenerational studies of longevity effects of resveratrol and other phytochemicals in humans. I've reviewed the research, made my best guess on optimal dosage, and searched the globe for pure extracts from a natural plant source, clean enough to take in these amounts. I'm excited that this new generation of superantioxidants is available. I wish I'd had them in the toolkit when my parents were alive- they might be still. And, I'm always open to new and better information.
And you?
