1708 replies to this topic

[cell]

Se this- soon Coke Diet with resveratrol.
http://calorielab.co...-resveritol.jpg

[tintinet]

I don't like injection of anything, either, let alone some plant extract! Akkk!

I can just imagine trying to explain an injection site reaction or infection due to doing that! LOL!

[proteomist]

I can tell you you don't want to try snorting it. [wis]

Hi, I asked this before, but got no respnses.

Is anyone taking Resveratrol in another method besides orally? One of my suppliers mentioned the 98% resveratrol was being taken by injection in her country in some instances.

I personally dont like needles, and wondered if anyone here knew of someone who was doing this.

Anthony

[bixbyte]

Se this- soon Coke Diet with resveratrol.
http://calorielab.co...-resveritol.jpg

Try some 98% RSV mixed with guacamole on a dorito chip

Hits the spot [tung]

Alex

[macanizer]

I just finished a 25g bottle of 50% resveratrol that I bought from BAC. I doubt I'll be ordering any more, it was way too bitter for my taste. Anyone tried some other 50% resveratrol with somewhat less noticeable taste? or do I need to upgrade to 98% for that?

[tintinet]

If ya really want a clean taste, IME, the 99%+ purity synthetic is the way to go, but, of course, at a price.

I've had some 98%+ purity extract that's fairly close, with just a touch of detectable taste also, as well as some 98% extract that tasted fairly awful! :{

Recently, someone reported a producer of 98% extract was adding charcoal filtering as a final processing step to ensure a clean taste, but I don't know if that particular product is available, yet....

[Anthony_Loera]

You took it in powder form I presume? Trying to mix it with water, juice, chocolate milk?

If it still tatstes bad, encapsulate it, and you will be fine. You will also not pay the extra price for purity, just to receive for the same effects as the 50% powder.

Try it out... capsules work for me, and I started with powder myself as well.

Anthony

[maxwatt]

If ya really want a clean taste, IME, the 99%+ purity synthetic is the way to go, but, of course, at a price.

I've had some 98%+ purity extract that's fairly close, with just a touch of detectable taste also, as well as some 98% extract that tasted fairly awful! :{

Recently, someone reported a producer of 98% extract was adding charcoal filtering as a final processing step to ensure a clean taste, but I don't know if that particular product is available, yet....

I think much of the "taste" -- it's really more of a burning sensation-- comes from residual acetic acid that's used as a slovent -- along with ethanol -- in the HPLC extraction process. It can be removed by washing, or evaporation, which is what eventually seems to happen with the extracts I've sampled. It does prevent the conversion of trans-resveratrol to the cis isomer.

[macanizer]

Anthony: yes, it was powder form. I remember you said on another thread you were going to also carry the 25g bottles, similar to BACs, at a competitive price. Any update on this?

maxwatt: besides washing or evaporating, is there something else that can be done? even if it's just to reduce some of that bitter flavor. I guess I could try some of that miracle fruit Maestro is talking about [thumb]

[maxwatt]

Anthony: yes, it was powder form.  I remember you said on another thread you were going to also carry the 25g bottles, similar to BACs, at a competitive price. Any update on this? 

maxwatt: besides washing or evaporating, is there something else that can be done?  even if it's just to reduce some of that bitter flavor.  I guess I could try some of that miracle fruit Maestro is talking about  [thumb]

I would try encapsulating what you do have. http://capsuleconnec...ntpage&Itemid=1
Their capsule machine is $14.95, they also sell capsules. You probably want the "0" size rather than "00".

Trying to wash and dry the powder without a home chemistry lab would be a recipe for frustration. I have had a sample of 50% resveratrol with very little taste. I've had 98% that tasted, or rather induced, a burning sensation until exposed to air for a while. Another 98% sample was almost tasteless, though one individual felt it left a bitter aftertaste.

[bixbyte]

Anthony: yes, it was powder form.  I remember you said on another thread you were going to also carry the 25g bottles, similar to BACs, at a competitive price. Any update on this? 

maxwatt: besides washing or evaporating, is there something else that can be done?  even if it's just to reduce some of that bitter flavor.  I guess I could try some of that miracle fruit Maestro is talking about  [thumb]

I would try encapsulating what you do have. http://capsuleconnec...ntpage&Itemid=1
Their capsule machine is $14.95, they also sell capsules. You probably want the "0" size rather than "00".

Trying to wash and dry the powder without a home chemistry lab would be a recipe for frustration. I have had a sample of 50% resveratrol with very little taste. I've had 98% that tasted, or rather induced, a burning sensation until exposed to air for a while. Another 98% sample was almost tasteless, though one individual felt it left a bitter aftertaste.

Max et all,

Make sure you buy some surgical masks when you cap your RSV.
I capped some and breathed in a lot of powder.
Experienced a RSV after taste for around 3 days.
Nothing could disguise the rank taste in my mouth and throat.
The next time I wore a mask.
Really helped.

Alex

[proteomist]

That's a really good idea since it makes such a fine powder. I've also found that it takes a static charge very easily and can become really hard to work with, sticking to things or jumping around when you try to move it.

I swallowed a couple of hand-packed 98% capsules the other day that I had not tamped down hard, so there was appreciable air inside them. Five minutes later I belched and exhaled what looked like a cloud of smoke and tasted like resveratrol. Startled the hell out of me.

Anthony: yes, it was powder form.  I remember you said on another thread you were going to also carry the 25g bottles, similar to BACs, at a competitive price. Any update on this? 

maxwatt: besides washing or evaporating, is there something else that can be done?  even if it's just to reduce some of that bitter flavor.  I guess I could try some of that miracle fruit Maestro is talking about  [thumb]

I would try encapsulating what you do have. http://capsuleconnec...ntpage&Itemid=1
Their capsule machine is $14.95, they also sell capsules. You probably want the "0" size rather than "00".

Trying to wash and dry the powder without a home chemistry lab would be a recipe for frustration. I have had a sample of 50% resveratrol with very little taste. I've had 98% that tasted, or rather induced, a burning sensation until exposed to air for a while. Another 98% sample was almost tasteless, though one individual felt it left a bitter aftertaste.

Max et all,

Make sure you buy some surgical masks when you cap your RSV.
I capped some and breathed in a lot of powder.
Experienced a RSV after taste for around 3 days.
Nothing could disguise the rank taste in my mouth and throat.
The next time I wore a mask.
Really helped.

Alex

[Anthony_Loera]

Anthony: yes, it was powder form.  I remember you said on another thread you were going to also carry the 25g bottles, similar to BACs, at a competitive price. Any update on this? 

maxwatt: besides washing or evaporating, is there something else that can be done?  even if it's just to reduce some of that bitter flavor.  I guess I could try some of that miracle fruit Maestro is talking about  [thumb]

Yes, actually I have been waiting on a website update that the guys over at helldesign are working on before introducing more products.

If you are interested, email me and we will ship it out to you.

Thanks
Anthony Loera

[health_nutty]

Thank you Mind. I will email Anthony directly with my question.

Edited by health_nutty, 25 April 2007 - 10:51 PM.

[Mind]

Ok, I know you guys are all on the straight and narrow here, but try to keep the posts from straying too much toward one business or product. If you have specific questions for Anthony that do not directly relate to the topic ("500mg official log"), please use PMs or email.

[Anthony_Loera]

No problem Mind,

So I will try to post something more relevant to the group here...

Has anyone else noticed the disappearance of (ejem...) athlete's foot? I haven't had it since I started taking the 2 grams of resveratrol. I think it may be related, as resveratral is an anitfugal as well... but this didn't really hit me until I started cleaning out my bathroom drawers the other day and saw a spray for it, that I used to use without much success...

Any others notice this?

Anthony

[bixbyte]

Very vivid colorful dreams taking RSV plus nightly colostrum.
I take one Source Natural Colostrum that costs under $9 for 60 caps.
One cap taken before bed.
Colorful tropical fish swimming around plus plus plus...
Colostrum supposedly enhances my immune system.

Anyone else testing out adding Colostrum for immunity?

Alex

[alterego]

Has anyone else noticed the  disappearance of (ejem...) athlete's foot? I

Yes.

[PWAIN]

BixByte,

I take a few scoops of colostrum every day. I use the BAC product - 200Grams of 30% powder for $16.50. Tastes a bit like milk powder. I find giving some to the whole family keeps illness down. Subjective but I think it helps.

BOT: I have found greatly reduced incidence of headaches and when I do get one, it goes pretty quickly. I think this is due to the Resveratrol 700mg/day but I have also added a lot of other things so can't be certain.

Also have greatly reduced (almost eliminated) indigestion/heartburn. My eczema does not seem to have been helped in any way. Weight seems unaffected too.

[bixbyte]

BixByte,

I take a few scoops of colostrum every day. I use the BAC product - 200Grams of 30% powder for $16.50. Tastes a bit like milk powder. I find giving some to the whole family keeps illness down. Subjective but I think it helps.

BOT: I have found greatly reduced incidence of headaches and when I do get one, it goes pretty quickly. I think this is due to the Resveratrol 700mg/day but I have also added a lot of other things so can't be certain.

Also have greatly reduced (almost eliminated) indigestion/heartburn. My eczema does not seem to have been helped in any way. Weight seems unaffected too.

________________________________________________________

My wife and I dose 750 to 850+ mg day RSV
Try taking the Colustrum only when you go to sleep for a couple days.
Let me know if you experience vivid dreams?
Just curious....

Thanx

Alex Kalman

_______________________________________________________________

[tintinet]

hm, 2000mg/day? I'd have to guess your weight but reading some on your webpage i kinda guess someone is either not applying some scaling factor to calculate human dosage or someone is trying to emulate the massive dose used in that french experiment with the superathlete mice :-). I mean, even one 500mg cap for me would be close to 9mg/kg/d!

There does seem to be a linear dose/response ratio for many of the things they have tested for. I would think increased doses are in some ways beneficial, up to the point where negative effects are seen. In toxicology tests with rats, 300/mg/kg had no downside, but 1000 mg/kg produced increased incidence of nephrological problems, lesions and tumors, if I recall. The Auwerx paper cited increased number and vitality of mitochondria at 400 mg/kg, so we can assume for rats the maximal dose is between 400 mg/kg and 1000 mg/kg. In humans with the appropriate scaling factor for weight and body volume, this would mean that up to 7 gm/day for a 70 kg man would likely have no deleterious effect. This is assuming a lot, and caution would dictate no more than half that, even if you like to live dangerously. Or humans may be able to metabolize higher amounts than the rat/equivalent; certainly we have better cancer repair mechanisms, and might not have the same problems. Chinese herbal literature mentions overdoses of Fo-ti, an herb that at various times has been confounded with Polygonum cuspidatum, our main source of resveratrol. (I cannot translate the amount, 14 grams of root processed to remove the laxative principle, into dosage recommendations in a meaningful way, but the overdose amount in the old herbals is equivalent to 14 grams a day. Today Fo-ti is considered to be a different species of Polygonum.) The symptoms, though, just might be what a resveratrol overdose in humans would look like: peripheral neuropathy, or tingling and numbness of fingers and toes. This was reversed when patients stopped taking the herb. This is from the "New Chinese Pharmacopia", which is 400 years old.

Is anyone taking high doses of resveratrol experiencing tingling in their fingers or toes?

The main obstacle to taking high doses of resveratrol, besides prudence and expense, is the emodin content. Even low-emodin extracts, at 50% resveratrol, contain enough emodin that most people would be uncomfortable taking more than the equivalent of 500 or 600 gm of resveratrol a day. Synthetic resveratrol, or high purity herbal extracts, would forestall that.

Of course we are assuming that Sinclair is correct in his thesis that SIRT activation by resveratrol mimics calorie restriction. Some researchers claim otherwise. In that case all we have is a performance enhancing drug that makes old people feel young and young people feel like atheletes.

Yep. Tingling, most fingers, at first intermittent, and lately more constant. Just started a coupla days ago- and damned annoying! Going on quick t-resv. taper starting yesterday.

Updates pending.....

[maxwatt]

s.  Chinese herbal literature mentions overdoses of Fo-ti, an herb that at various times has been confounded with Polygonum cuspidatum,...The symptoms, though, just might be what a resveratrol overdose in humans would look like:  peripheral neuropathy, or tingling and numbness of fingers and toes.  This was reversed when patients stopped taking the herb.  This is from the "New Chinese Pharmacopia", which is 400 years old.

Is anyone taking high doses of resveratrol experiencing tingling in their fingers or toes?

Yep. Tingling, most fingers, at first intermittent, and lately more constant. Just started a coupla days ago- and damned annoying! Going on quick t-resv. taper starting yesterday.

Updates pending.....

What was you dose p to when you experienced peripheral neuropathy, and how much do you weigh? Also, what else do you take? (Quercetin, bioperine, black pepper?)

[bixbyte]

hm, 2000mg/day? I'd have to guess your weight but reading some on your webpage i kinda guess someone is either not applying some scaling factor to calculate human dosage or someone is trying to emulate the massive dose used in that french experiment with the superathlete mice :-). I mean, even one 500mg cap for me would be close to 9mg/kg/d!

There does seem to be a linear dose/response ratio for many of the things they have tested for. I would think increased doses are in some ways beneficial, up to the point where negative effects are seen. In toxicology tests with rats, 300/mg/kg had no downside, but 1000 mg/kg produced increased incidence of nephrological problems, lesions and tumors, if I recall. The Auwerx paper cited increased number and vitality of mitochondria at 400 mg/kg, so we can assume for rats the maximal dose is between 400 mg/kg and 1000 mg/kg. In humans with the appropriate scaling factor for weight and body volume, this would mean that up to 7 gm/day for a 70 kg man would likely have no deleterious effect. This is assuming a lot, and caution would dictate no more than half that, even if you like to live dangerously. Or humans may be able to metabolize higher amounts than the rat/equivalent; certainly we have better cancer repair mechanisms, and might not have the same problems. Chinese herbal literature mentions overdoses of Fo-ti, an herb that at various times has been confounded with Polygonum cuspidatum, our main source of resveratrol. (I cannot translate the amount, 14 grams of root processed to remove the laxative principle, into dosage recommendations in a meaningful way, but the overdose amount in the old herbals is equivalent to 14 grams a day. Today Fo-ti is considered to be a different species of Polygonum.) The symptoms, though, just might be what a resveratrol overdose in humans would look like: peripheral neuropathy, or tingling and numbness of fingers and toes. This was reversed when patients stopped taking the herb. This is from the "New Chinese Pharmacopia", which is 400 years old.

Is anyone taking high doses of resveratrol experiencing tingling in their fingers or toes?

The main obstacle to taking high doses of resveratrol, besides prudence and expense, is the emodin content. Even low-emodin extracts, at 50% resveratrol, contain enough emodin that most people would be uncomfortable taking more than the equivalent of 500 or 600 gm of resveratrol a day. Synthetic resveratrol, or high purity herbal extracts, would forestall that.

Of course we are assuming that Sinclair is correct in his thesis that SIRT activation by resveratrol mimics calorie restriction. Some researchers claim otherwise. In that case all we have is a performance enhancing drug that makes old people feel young and young people feel like atheletes.

Yep. Tingling, most fingers, at first intermittent, and lately more constant. Just started a coupla days ago- and damned annoying! Going on quick t-resv. taper starting yesterday.

Updates pending.....

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++

By any chance did you perform any physical activity that might have caused your tingling sensations?
Sudden loss of neurological in your extremities. Peripheral Neuropathy.
Your fingers tingle but not your toes?
Think about neurology, your toes are the furtherest away from the nerve roots.

Maybe you did something like banged yourself and forgot?


Alex

[tintinet]

I suppose differential diagnosis includes a wide range of ailments, at this point.

The tingling is fairly symmetrical, with right hand usually more prominently involved than left, and, at times, toes, also (although quite mildly.).

Dose was a bit over 1 gram/day, avg.

Weight: 127 lbs.

[alterego]

After taking 200mg a day for about 4 weeks of T-Res, no significant changes in my rheumatoid arthritis related blood-markers have occurred. I'm starting to cycle out the T-Res supplementation completely until further research on humans will be available.

Btw., my athlete foot did re-appear (yuck) so that must have been entirely non-related to the T-Res.

[bixbyte]

I suppose differential diagnosis includes a wide range of ailments, at this point.

The tingling is fairly symmetrical, with right hand usually more prominently involved than left, and, at times, toes, also (although quite mildly.).

Dose was a bit over 1 gram/day, avg.

Weight: 127 lbs.

Ask you medical care provider to have a full blood urine analysis.

[kenj]

Yep. Tingling, most fingers, at first intermittent, and lately more constant. Just started a coupla days ago- and damned annoying! Going on quick t-resv. taper starting yesterday.

RE: tingling, perhaps consider the B6 vitamer(s) also, -- along w/resv.
A while ago I developed a minor rash below my lower lip and some numbness in my fingers one evening -- lasted for a few hours.
I was surprised to look up various examples of accumulating B6 toxicity-ish experiences, from the 50-100mg range!, IIRC, when taken for several months.
Prior to the brief numb feeling, I was taking the LEF mix powder (2 scoops, yielding some 50mg pyridoxine, IIRC) along with extra pyridoxine (10-20mg), P-5-P (50mg) and pyridoxamine (2-300mg). Also resveratrol 300mg and various other things.
Dropping all B6 vitamers, including the LEF mix (but not resveratrol) cleared the rash.

[tintinet]

Ya. I first considered B6 toxicity, as that is apparently the most notorious, and easily inducible sensory peripheral neuropathy via supplementation. But, AFAIK, I'm not taking very high B6 doses (maybe a total of 50 mg/day, max.)

Nevertheless, I'm tapering several supplements to see if I can eliminate it.

[tintinet]

Hello everyone,

A couple other resveratrol users and I have come across a company advertising 98% and 99% trans-resveratrol extract powder:
Changsha Organic Herb, Incorporated, based in Hunan, China. Website: http://www.organic-herb.com.

As it stands, the current (as of 4/30/07) quoted cost of 98% and 99% trans-resveratrol is $680 and $800 U.S. Dollars respectively, per kilogram- extremely inexpensive (68 and 80 cents per gram). Orders for quantities below one kilogram are also allowed, but the price is slightly higher. This eliminates the need for a bulk purchase.

The purpose of this post is to enlist other users who would be interested in purchasing this product individually, but would prefer to have it independently tested and assayed beforehand. Due to the considerable cost of such testing, we propose splitting the analysis expenses. At the moment, three of us are interested in having this product tested and are planning to test the advertised 99% trans-resveratrol.

The cost of the complete testing, which includes HPLC analysis for trans-resveratrol, cis-resveratrol, and emodin along with testing for the heavy metals mercury, lead, arsenic, and cadmium, and a plate count, is $600 U.S. dollars. Two of us have recently ordered from this company and have found that the product seems to be of very high quality and the company seems to be professional.

If you are interested in possibly purchasing this product and prior to this would like to have it independently tested and analyzed by American Analytical Chemistry Laboratories Corp. (http://www.aaclabs.com), please let me know. The $600 dollar cost would be split among all of us (however many sign on to share the analysis expenses), potentially making testing much more affordable.


Thanks.

[xanadu]

It seems that problems associated with rsv overdoses are starting to appear. Now it's tingling and numbness in the peripherals. I noticed over stimulation, difficulty sleeping and over aggressiveness myself. It only took me around 70mg per day to notice those effects. Some people may need a lot more before running into problems. Be careful with this stuff. More is not always better.

Since I use small amounts there would be no reason to order huge quantities of 98 or 99%. Emodin has beneficial effects and I only get a little on the 50% stuff. I've quit taking it altogether since about 4 days ago. I like the way I'm tapering off. I miss the "up" feeling but it's a relief and I'm catching up on sleep. I will get back to it probably end of the week.