1708 replies to this topic

[malbecman]

unglued,

Thanks for keeping the thread alive and posting your results. After re-reading the Sinclair and Auwerx papers, as well as the various Sirtris releases, I'm pretty convinced that conventional blood work will not demonstrate anything from resveratrol dosing. Perhaps c-reactive protein would make a decent biomarker since it is a marker/predictor of inflammation but I'm just hazarding a guess at this point. However, since my c-reactive protein was already quite low before I started resveratrol dosing, likely due to my EPA/DHEA regime, I won't be able to report anything meaningful on that one when I do have my checkup........


-Malbec

I've already got the test results back.  My HMO has computerized their system, and what used to take weeks to report now takes less than 12 hours.  The blood is barely dry on the gauze.

To the extent that I'm looking for cholesterol improvements as a marker for resveratrol increasing my longevity, the results are disappointing.  They're back to almost exactly the levels they were in my last pre-resveratrol blood work a year before (August 2006):

Total Cholesterol:  129
Triglyceride:  130
HDL: 40
LDL calculated = 129 - 40 - 130/5 = 63
Glucose, fasting:  84

See previous results here.

My results are consistent with two theories:
1.  Although resveratrol may increase lifespan and even protect the cardiovascular system, it has no effect on cholesterol -- supported by two papers discussed before; see here and here.
2.  Or, Longevinex's claim is right, and their fancy nitrogen packaging preserves so much more resveratrol activity (or the synergistic effects with their other ingredients is so significant) that it's more cost-effective than the cheaper brands.  I used Longevinex during (northern) spring but then bought cheaper products (RevGenetics and Country Life and a little NSI) when I went to a higher dosage.  However, as I said above, I've seen modest improvements in weight, VO2 max, and blood pressure that seem to be sticking.

Looking forward to more data from the rest of you.

[methodice]

Proanthocyanidins as D2 agonists may explain some of the subjective effects of low purity extracts.

Pharmacol Biochem Behav. 2006 Oct;85(2):317-23.
Analysis of the antinociceptive effect of the proanthocyanidin-rich fraction obtained from Croton celtidifolius barks: evidence for a role of the dopaminergic system.
DalBó S, Jürgensen S, Horst H, Soethe DN, Santos AR, Pizzolatti MG, Ribeiro-do-Valle RM.
Departamento de Farmacologia, Centro de Ciências Biológicas, Bloco D, UFSC, Campus Universitário, Trindade, Florianópolis, SC, CEP 88040-900, Brazil.

    In a previous study, we demonstrated the antinociceptive effect of 63SF, a proanthocyanidin-rich fraction obtained from Croton celtidifolius barks, in chemical and thermal behavioural models of pain in mice. The current study now investigate the possible mechanisms underlying the antinociceptive activity of 63SF in the formalin test, by using drugs which interfere with systems that are implicated in descending control of nociception. The antinociceptive effect of 63SF (11 mg/kg, i.p., given 30 min prior to 2.5% formalin) was not altered by pre-treatment of animals 45-50 min beforehand with either prazosin (alpha(1)-adrenergic antagonist; 0.15 mg/kg, i.p.), yohimbine (alpha(2)-adrenergic antagonist; 0.15 mg/kg, i.p.), ketanserin (5-HT(2A)-receptor antagonist; 1.0 mg/kg, i.p.), or l-arginine (substrate for NO synthase, 600 mg/kg, i.p.). On the other hand, treatment with sulpiride, an antagonist of dopaminergic D(2)-receptors (1.0 mg/kg, i.p., 45 min of pre-treatment), reversed the antinociceptive activity of 63SF. Pre-treatment of animals with reserpine (5 mg/kg, i.p., 24 h beforehand) did not alter the antinociceptive effect of 63SF. The current results support the view that the 63SF exerts antinociceptive effects by enhancing the activity of descending control, possibly by direct stimulation of dopaminergic D(2) receptors.

PMID: 17030059

krillin what are the subjective effects you talk about?

[krillin]

krillin what are the subjective effects you talk about?

Some people reported getting high off of it.

[wydell]

My blood test results are below in part. I take res at about 500mg. I am not entirely consistent in taking it and I take so many other things, have a good diet, and exercise, so this post is probably meaningless in terms of trying to find relationship to res.

I have no pre-res blood results, but here is my blood work. I am 38, 6'2 and about 180lbs now


Chol 141
Trigl 40
HDL 70
LDL 63

I had a bunch of other tests done, but my results were not sent. I have to call to get them to send the results.

My HMO indicated over the phone that there was one test where I performed out of normal range in a negative way. I was slightly abnormal with creatinine at 1.5, but I went on creatine the week of test, was creatine loading, and was not drinking much water. I am cutting the creatinine.

When I get my other results, I will post. I am retesting on creatinine in a month.

[levkamensky]

OK... So is Biovita or Longevinex the way to go?

I am just starting. And from what I am hearing I'd be probably taking about 2000 milligrams. Simply because I couldn't afford any more. My disabilities income is quite small.

The study in 2003 showed that of all the Resveratrol vendors (14 others tested) only Longevinex's Resveratrol exhibited significant biological (Sirtuin 1) activity.

Does this still hold true today?

Is Biovita any good?

Their prices seem quite cheap but their 500 milligram capsules contain only 250 milligrams of trans-resveratrol. So to consume 2000 mg I'd need to spend $90 per month.

On the other hand for the same price I can afford only 300 mg at Longevinex. At least their pill now has 100 mg not 40 like before, but still! Why don't they stop being so damn greedy and give the people enough of that shit to work! If it really is the only potent shit from 15 brands. It's like a prick tease, "here this stuff will extend your life but we can only give you 5% of what will work". What sort of stupid sadistic game is this????? I bet even if they were selling human excriment they would charge $5 for every ounce, like they charge you $2 for every 5 cent teabag in a cafe.

I would prefer to achieve results closer to Auwerx's athlete mice.

I think Sinclair and American Docs in general are overcautious with respect to dosages in general. That's the trend I have observed. When you want to get a nail into a wall, just wack it, don't tease it it like a sissy... I remember on Biography one famous nuclear physicist who was dying of cancer, and the Docs couldn't save him, so he said to hell with you all, I'll manage my own treatment, and took 3 times the doses of chemotherapy they were giving him and cured himself. I lived in Malaysia, and the Docs there give you bigger shorter doses of antibiotics. So everyone gets well quick. Here in the states flues last for months, the infection keeps spreading from person to person. Which is why every week your kid gets infected at kindergarten every other week and you must spend more and more money on incompetent Docs. I think medicine in the States has become a semi-pseudoscience with all the overcaution and other virtual superstitions! Same thing with prices. They can market homelessness as an exotic time pass and and start selling space under a bridge to some dumb yappies at 1000 dollars a night. The so-called coffeeshops where if you are lucky they take a 5 cent tea bag put it in hot water and sell it to you for 4 bucks ($2 per refill) and call it tea (if you are not they will take some soap water and call it coffee). That's why Lincoln said "if this crap is tea give me coffee, if this crap is coffee give me tea" and that was long before the first Starbucks was built. In Russia lenen is considered the cheapest material that peasants wear! Here a lenen shirt costs 100 bucks! Cialis in malaysia is like $5 for 8 pills without prescription. How do they get to charge a dozen bucks a PILL for it here, only G-d knows. One word comes to mind when living here - bullshit. Bullshit that costs its weight in gold apparently.

I hope Longevinex is not a fad. Does anyone know what supplement Dr. Auwerx takes?

There was one journalist here proposing to do a new coparative study of supplements. We need to test this stuff and find out what really works rather than take these supplements blindfolded. Test te Sertuin 1 activity. If its not possible to conduct such studies in U.S. do it South Africa or wherever else that ppl are rational. Like me, I don;t know which supplement to take, and if I will be wasting my money completely or wisely investing it. Why do I have to play the guessing game? Why isn't this info available to consumers? Let's take this out of the realm of mystycism and superstetion (placebo effect as you call it) and get some concrete data people! Otherwise how are we different to a bunch of New Age nuts.

Edited by levkamensky, 28 September 2007 - 04:46 AM.

[levkamensky]

One the other hand, what's the point of taking higher doses to increase potency if you don't even know if the brand you are taking is potent AT ALL, or doesn't exhibit any biological activity?????

As the Chinese proverb says, NO POINT RUNNING FASTER IF YOU ARE ON THE WRONG ROAD GRASSHOPPER.

[Anthony_Loera]

levkamensky,

By the sound of your post it appears price is important. Sounds like maybe you want powder, as it is much cheaper than a capsule.

look at the price watch thread here:
http://www.imminst.o...&f=6&t=15059&s=

and see the prices for powder toward the end of the list.
Biotivia and Longevinex prices are also on this list, along with many others.

Thanks
Anthony Loera

[tintinet]

OK... So is Biovita or Longevinex the way to go?

...The study in 2003 showed that of all the Resveratrol vendors (14 others tested) only Longevinex's Resveratrol exhibited significant biological (Sirtuin 1) activity.

Does this still hold true today?

Is Biovita any good?....

1. Doubt seriously: Sinclair's Nature published rodent studies were done with non-encapsulated, synthetic powder trans-resveratrol added to the chow.

2. Biotiva: Who knows. The post COAs that state they have the real deal, at least.

And...ConsumerLabs.com was SUPPOSED TO HAVE posted their trans-resveratrol supplement review LAST SPRING, then...LATE SUMMER...

WHERE IS IT??????

[levkamensky]

tinitinet, anthony, thanks for your replies.

Anthony_Loera,

My understanding is that trans-resveratrol has to be properly encapsulated in order for it not to degenerate into the inactive cis resveratrol. If I buy powder doesn’t it defeat the purpose? Please enlighten me.

Its very important to have objective information about the effectiveness of these products/ Its not just about not wanting to waste money. We must avoid injury to plants, as I am an ethical fruitarian, (I don’t believe in theft from any life form – only a value for value voluntary symbiotic relations) taking extracts from leaves or anything other than “botanical fruit” is looting and violence, and would only be understandable (I don’t say justifiable) if there is a significant health benefit.

Longevinex are boasting that they are the only vendor of resveratrol who is able to encapsulate resveratrol well enough for it to remain potent. I suppose the other stuff they put in their pills (quercetin) also helps absorption. On the other hand the doses are much smaller than what Sinclair fed his mice (even if you factor in the differences in metabolism), not to mention the French dude’s super-athlete mice. Of course if money wasn’t an issue I’d say - buy 2000 mg of Longevinex’s tres. Unfortunately for me, like for some of you it is.

For around a 100 bucks (the amount I can spend per month on this thing) you can get 300 - 400 mg (x 1 month) of tres from Longevinex OR for approximately the same amount you can get 1500 mg (x 1 month) of tres from Biotivia (which seems to be the cheapest).

================================================
The bottom line of bottom lines than is – which of the two choices would be more potent (exhibit more biological activity), A. 400 mg from Longevinex or B. 1500 mg from Biotivia?
================================================
Moving forward, for now I already ordered one bottle from Biotivia and taking 500 mg trans a day (1000 mg). And what I felt so far, is being able to handle stress better, a bit more stabilized mood. Someone mentioned that trans-resveratrol is a serotonin reuptake inhibitor. Coincedentally I have those mood swings/depression/overreacting/inability to concentrate for a long period of time. (But that's not the main reason we are taking this thing!) Of course, it could be placebo effect from the enthusiasm that comes with trying something new. Who knows?! I guess there is no way to tell, but thought I’d contribute to the database of Club 500. The appetite does seem to be ever so slightly decreased and I am able to concentrate longer. In fact yesterday I spent the whole day reading this thread without the usual binging breaks. But I don’t feel any improvement with sex drive that someone reported (maybe it was just enthusiasm too?). The effects seem small.

---

tintinet,

I get the hit. Thanks for introducing me to ConsumerLab. I signed up and am going to make a search now, and tell you what I find.

[levkamensky]

And...ConsumerLabs.com was SUPPOSED TO HAVE posted their trans-resveratrol supplement review LAST SPRING, then...LATE SUMMER...

WHERE IS IT??????

Good question. The only thing I am able to find is a review that is like a general overview (it mentions that doses analogous to the ones used on mice are far more than the ones provided by most supplements, but also says t-rex shouldn't be given to pregnant mothers because it may inhibit growth, mild estrogen activity - so estrogen sensitive women should avoid... something related to cancer risk, thinning blood. Are we playing with matches?). They also say they will be testing products sold in US and Canafa and reporting what they find in 2007, which seems to be now... But I am unable to find any of those reports, no luck for me again!

[unglued]

levkamensky --

If you believe Longevinex's claim that oxygen destroys the potency of resveratrol, then powder is probably almost insert. If you believe Anthony's claim that dry resveratrol is perfectly stable, then the powder is a better value per dollar. If you believe what Sirtrus Pharmaceuticals tells stock analysis and investment firms, no over-the-counter resveratrol can have enough bioavailability to activate sirtuins. I don't think we know for sure who's right, although there have been animal studies cited in this topic which may provide clues. Big, carefully controlled studies in humans cost millions of dollars, and not coincidentally are typically funded by companies that hope to stand millions of dollars if the product works.

We must avoid injury to plants, as I am an ethical fruitarian, (I don’t believe in theft from any life form – only a value for value voluntary symbiotic relations) taking extracts from leaves or anything other than “botanical fruit” is looting and violence, and would only be understandable (I don’t say justifiable) if there is a significant health benefit.

Then you have a difficult choice to make: Buy resveratrol supplements made only from red wine powder and get a lower dosage per dollar, or buy a higher potency product made from Japanese knotweed which gives you more milligrams per dollar.

How low, as people, do we dare to stoop,
Making young broccoli bleed in the soup?
-- The Arrogant Worms,
"Carrot Juice Is Murder"

[maxwatt]

The need to encapsulate resveratrol is a myth promulgated by those marketing encapsulated products. If you read though the various resveratrol threads here, you'll find the issue was addressed in the seminal paper on resveratrol stability co-authored by Brent Trela. As a powder, pure trans-resveratrol is stable when not exposed to ultra-violet light, as from sunlight or laboratory fluorescent lights. In solution, trans-resveratrol is stable at pH under 11; above that level, it converts to cis-resveratrol. Acit solution actually converts cis-resveratrol into trans-resveratrol. At temperatures under 20 degrees Celsius, resveratrol is not particularly prone to oxidation. In short, when properly handled, stability is not an issue. Keep it cool, dry and in a dark place.

Bioavailbility is still an open issue, but less so if you have followed references noted in the Imminst threads on this topic. Though serum levels remain low in human subjects, there apparently exists an active transport mechanism via the red blood cells. There are rumors a paper is awaiting publication, showing resveratrol in humans is a COX-1 and COX-2 antagonist, via its effect on nf-Kappa P. This would imply bio-availability despite low serum levels. I personally find 98% resveratrol to be the most effective anti-inflammatory I've used for arthritis.

We must avoid injury to plants, as I am an ethical fruitarian, (I don’t believe in theft from any life form – only a value for value voluntary symbiotic relations) taking extracts from leaves or anything other than “botanical fruit” is looting and violence, and would only be understandable (I don’t say justifiable) if there is a significant health benefit.

The method of extracting resveratrol from Japanese knotweed: after the plant has bloomed and died back for the season, the roots are dug up. This process involves cutting with sharp tools, and leaves many bits of root in the soil which grow back the following year. (This is why it is so hard to eliminate the plant from a field once it is established.) The root is washed and fermented; the resulting alcohol is used to extract the resveratrol from the ground-up root. I think this may fit within your ethical framework. The plant is not killed in the process, though the roots are cut, the cutting propagates the plant.

[krillin]

  There are rumors a paper is awaiting publication, showing resveratrol in humans is a COX-1 and COX-2 antagonist, via its effect on nf-Kappa P.  This would imply bio-availability despite low serum levels.  I personally find 98% resveratrol to be the most effective anti-inflammatory I've used for arthritis.

I thought it inhibited COX directly in addition to its effects on NF-kB.

Bioorg Med Chem. 2004 Nov 1;12(21):5571-8.
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.
Murias M, Handler N, Erker T, Pleban K, Ecker G, Saiko P, Szekeres T, Jäger W.
Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is found in grapes and various medical plants. Among cytotoxic, antifungal, antibacterial cardioprotective activity resveratrol also demonstrates non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. In order to find more selective COX-2 inhibitors a series of methoxylated and hydroxylated resveratrol derivatives were synthesized and evaluated for their ability to inhibit both enzymes using in vitro inhibition assays for COX-1 and COX-2 by measuring PGE(2) production. Hydroxylated but not methoxylated resveratrol derivatives showed a high rate of inhibition. The most potent resveratrol compounds were 3,3',4',5-tetra-trans-hydroxystilbene (COX-1: IC(50)=4.713, COX-2: IC(50)=0.0113 microM, selectivity index=417.08) and 3,3',4,4',5,5'-hexa-hydroxy-trans-stilbene (COX-1: IC(50)=0.748, COX-2: IC(50)=0.00104 microM, selectivity index=719.23). Their selectivity index was in part higher than celecoxib, a selective COX-2 inhibitor already established on the market (COX-1: IC(50)=19.026, COX-2: IC(50)=0.03482 microM, selectivity index=546.41). Effect of structural parameters on COX-2 inhibition was evaluated by quantitative structure-activity relationship (QSAR) analysis and a high correlation was found with the topological surface area TPSA (r=0.93). Docking studies on both COX-1 and COX-2 protein structures also revealed that hydroxylated but not methoxylated resveratrol analogues are able to bind to the previously identified binding sites of the enzymes. Hydroxylated resveratrol analogues therefore represent a novel class of highly selective COX-2 inhibitors and promising candidates for in vivo studies.

PMID: 15465334

[maxwatt]

It seems to be at least partly the other way around.

Inflamm Allergy Drug Targets. 2007 Sep;6(3):168-73. Links
Anti-inflammatory responses of resveratrol.Das S, Das DK.
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut, USA. ddas@neuron.uchc.edu.

Resveratrol (trans-3,4',5-trihydroxystilbene), a natural polyphenolic, non-flavonoid antioxidant, is a phytoalexin found in many plants including grapes, nuts and berries. Recent studies have documented that resveratrol has various health benefits, such as cardiovascular and cancer preventive properties. However, the experimental basis for such health benefit is not fully understood. One of the possible mechanisms for its protective activities is by down regulation of the inflammatory responses. That includes the inhibition of synthesis and release of pro-inflammatory mediators, modifications of eicosanoid synthesis, inhibition of some activated immune cells, or inhibiting the enzymes, such as cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2), which are responsible for the synthesis of pro-inflammatory mediators through the inhibitory effect of resveratrol on transcription factors like nuclear factor kappaB (NFkappaB) or activator protein-1 (AP-1). Being a phenolic compound, resveratrol certainly possesses a low bioavailability and most importantly, a rapid clearance from the plasma. Recent growing interest in varying protective nature of resveratrol may clinically also hold a respectable position as a better alternative for anti-inflammatory drugs. The purpose of this review is to provide evidence that resveratrol exhibits potent anti-inflammatory activity and also to explain the underling mechanism for both resveratrol- induced cardioprotective and anti-inflammatory properties. While it is true that the cardioprotective properties of resveratrol are likely attributable, at least in part, to its anti-inflammatory properties, the mechanisms discussed address foremost mechanisms for the anti-inflammatory activity which, in turn, is responsible for cardioprotection.

PMID: 17897053

[tintinet]

Mon, 1 Oct 2007 09:38:56 -0400 (EDT)
Subject: RE: Trans-resveratrol supplement testing report status.
From: evelyn.delgado@consumerlab.com Add to Address BookAdd to Address Book Add Mobile Alert
To: Send an Instant Message to: Tintinet
<Tintinet@Tintinet.net>
Thank you for contacting us here at ConsumerLab.com. WE do apologize for the delay of the review it should be the next one coming out most likely in the next 2-3 weeks.



-----Original Message-----
From: Tintinet@Tintinet.net
Sent: Sat, September 29, 2007 11:10 pm
To: info@consumerlab.com
Subject: Trans-resveratrol supplement testing report status.

Greetings:

IIRC, you first stated your report on trans-resveratrol supplements would be available in Spring 2007. Spring came and went. Then you stated the report would be ready in late Summer. Gone as well.

Nonetheless, I've renewed my subscription for 2 more years ahead. Any updates?



Thanks!

[Anthony_Loera]

levkamensky, for powder and capsules
Check the prices available here, then check COAs

Price Watch:
http://www.imminst.o...&f=6&t=15059&s=

Biotivia, and Longevinex prices are on the list. If you do love Biotivia, tell them you want a price match using megaresveratrol or RevGenetics prices... as they are lower. However, Mega and RevGenetics also do price matching, so if you happen to find a better price anywhere else, I am sure they will match it.

RevGenetics uses Pfizer Vcaps that Biotivia claims to use, and the quality of the 99% powder has been documented (By a third party Lab) to be tested at 99.7% trans-resveratrol, which is better than what most people offer at this time.

I am sure Biotivia has a great product, but you should take a look at other quality brands that offer powder and capsules as well.

thanks
Anthony Loera

[tintinet]

BAC's new encapsulated 50% trans-reseveratrol PC extract to add? BAC Encapsulated 100 mg trans-resveratrol

[Anthony_Loera]

thanks tintinet... I just added it to the price watch.

[craigb527]

I have read quite a few posts, and have in the past week begun taking 400/mg day of longevinex. I notice I feel stronger and appetite has decreased. Gave some to my father, just telling him it was good for him take it (he is 76 yrs old). He stopped by a week later saying how strong he was feeling. He had no idea why, and didn't know the pills may have caused his increased well- being. Was wondering if anyone who has been taking res regularly for a while has noticed any changes (strength, condition, anti-aging, etc.) Wikipedia and othe sources make it seem like a wonder drug, is there truth to these claims? [lol]

[malbecman]

craigb527,

I think a good place to start reading people's anecdotal evidence is this thread. I know at 48(!) pages it is pretty long (thanks, health_nutty) but has a lot of posts by people taking daily resveratrol.

Welcome to the ImmInst Supplements forum.

-Malbec

I have read quite a few posts, and have in the past week begun taking 400/mg day of longevinex.  I notice I feel stronger and appetite has decreased.  Gave some to my father, just telling him it was good for him take it (he is 76 yrs old).  He stopped by a week later saying how strong he was feeling.  He had no idea why, and didn't know the pills may have caused his increased well- being.  Was wondering if anyone who has been taking res regularly for a while has noticed any changes (strength, condition, anti-aging, etc.)  Wikipedia and othe sources make it seem like a wonder drug,  is there truth to these claims? [lol]

[galtsgulch]

I previously tried taking some Vitamin Sh***e brand resveratrol and at 100 mg/day got ringing in my ears, probably from the high impurities. I switched to Relentless 300 mg and have been taking 900 mg/day for about a week without any problems. Unfortunately, I've drastically changed my supplement regime since my last blood tests, so I won't know whether that or another major change has had any particular effect.

Height 6' weight 152 lbs. I'm on the Rosedale diet (CarbCR) also

[craigb527]

OK. Thanks. Haven't really noticed people experiencing too many differences when they start taking resveratrol...

[tintinet]

Standard high dose 'induction' effects.....or due to emodin or whatnot...

[craigb527]

Was at Sam's Wholesale shopping and was surprised to see them selling Resvinatrol complete on the shelf. 32 oz. bottle.
Every one ounce serving contains 100/mg of resveratrol plus quercetin, ellagic acid and proanthocyanidins. Their website
claims it is packaged like longevinix with nitrogen packaging. Price was around $18.00. I bought it and have been drinking it. No noticeable
feelings from it. Any thoughts on if this is a good source of resveratrol or not? Seems better than longevinix because it contains proanthocyanidins, I don't
have to order through mail and is less expensive per serving

[maxwatt]

Was at Sam's Wholesale shopping and was surprised to see them selling Resvinatrol complete on the shelf.  32 oz. bottle.
Every one ounce serving contains 100/mg of resveratrol plus quercetin, ellagic acid and proanthocyanidins.  Their website
claims it is packaged like longevinix with nitrogen packaging.  Price was around $18.00.  I bought it and have been drinking it.  No noticeable
feelings from it.  Any thoughts on if this is a good source of resveratrol or not?  Seems better than longevinix because it contains proanthocyanidins, I don't
have to order through mail and is less expensive per serving

32 one ounce servings of 100 mg for $18; that's 3.2 grams for $18. The price per gram is about $5.62. Not the most expensive source of resveratrol out there, but close to it.

Comparitive Price Chart

[craigb527]

Any thoughts on the addition of proanthocyanidins Mr Watt?

[craigb527]

Thanks for link on price chart. Very helpful

[geo12the]

I have read quite a few posts, and have in the past week begun taking 400/mg day of longevinex.  I notice I feel stronger and appetite has decreased.  Gave some to my father, just telling him it was good for him take it (he is 76 yrs old).  He stopped by a week later saying how strong he was feeling.  He had no idea why, and didn't know the pills may have caused his increased well- being.  Was wondering if anyone who has been taking res regularly for a while has noticed any changes (strength, condition, anti-aging, etc.)  Wikipedia and othe sources make it seem like a wonder drug,  is there truth to these claims? [lol]

In terms of feelings produced I think the big problem can be placebo effect, which is very strong. Here is my experience: I never noticed any effects from resveratrol outside of mild laxative effects. In the past I occasionally have taken cranberry pills as prophylactics for urinary tract infections. When I took a cranberry pill with my normal morning dose of resveratrol I noticed a significant effect in terms of how I felt: more energetic, loss of appetite, more stamina on the treadmill that evening (It could be placebo effect but I don't think it is. Then again placebo effects can be strong). I was wondering if anyone else has noticed this? I was thinking it could be a synergistic effect between the resveratrol and polyphenols or other compounds in the cranberry pills. Any chance such a combination might increase the bioavaibilty of resveratrol?

[craigb527]

I take cranberry and have been for over a year. Continued taking cranberry when I started taking Resveratrol. My most noticeable changes are lack of appetite and I keep waking up during the night since I started taking resveratrol. I feel like I have more energy as well. Like you said, the energy might be placebo effect.

[geo12the]

I take cranberry and have been for over a year.  Continued taking cranberry when I started taking Resveratrol.  My most noticeable changes are lack of appetite and I keep waking up during the night since I started taking resveratrol.  I feel like  I have more energy as well.  Like you said, the energy might be placebo effect.

Very interesting that you were taking cranberry and noticed an effect after taking resveratrol and I was taking resveratrol and noticed an effect after taking cranberry. Who knows, maybe there really is a synergistic effect by taking them together.