1708 replies to this topic

[craigb527]

I am still curious if this holds any weight --->>

http://www.longevine...tory=Imitations

I would like to see someone take 6,000 mg of Longevinex's resveratol, and see if they experience effects similar to Auwerx's mice. Unfortunately it's beyond my means.

I wouldn't get too enamored with longevinix. As long as you are purchasing 99% res and thats what you are getting, you are better off than what longevinix gives you. They can't give you anything better than 99% pure no matter what it comes in. It is just a sales pitch to scare the masses into buyng their product.

[levkamensky]

What's your current dose by the way?

I am not enamored with them. The watermelon salesman can tell you a watermelon is ripe. But there is only one way to know if a water melon is ripe - take it home and cut it open. You know what I mean? A watermelon isn't such a big investment, but when you are talking about investing a lot of money, not to mention time that is unrefundable then how much more you need the certainty of hard evidence!

The only way to be sure if there is truth to their claims is to have one guy take seven grams of resveratol from Anthony for example, and another the same dose from Longevinex, and then compare the effects. If there is no difference in effects well then we know for sure that it's just an underhanded marketing strategy. Which is good, because facts are always good, unlike assumptions. What makes you so sure that it is?

By the way, who is taking Longevinex here, and are the effects you are feeling any different?

[craigb527]

Up until two days ago I was taking 15 grams/day all at once, I started taking 5 grams/day all at once and moved up one or so a day til I hit 15 grams, did that for a few days, now I am taking 2 grams/day maintenance dose to see if I keep the increased endurance.

Edited by craigb527, 25 October 2007 - 01:45 AM.

[levkamensky]

How did you feel at 2 grams before you upped the dose to 15?

[craigb527]

nothing really. Didn't feel a big difference til around 10 to 12. Then it was undeniable.

[wydell]

I have taken some very large doses over the past couple weeks  with no negative noticeable side effects.  I got bloodwork done before I started taking res, will get it done again in a couple of weeks.  What should I look for?

I would be very interested to see your before and after results. I think the only thing you can do is compare it to the baseline you already established at this point.

It would be interesting to know before and after heart rate, blood pressure, and body temp as well.

[craigb527]

I have taken some very large doses over the past couple weeks  with no negative noticeable side effects.  I got bloodwork done before I started taking res, will get it done again in a couple of weeks.  What should I look for?

I would be very interested to see your before and after results. I think the only thing you can do is compare it to the baseline you already established at this point.

It would be interesting to know before and after heart rate, blood pressure, and body temp as well.

No changes in heart rate or blood pressure. I check it every other day... subtle changes up or down.. nothing to constitute change 125 to 135/ 80 to 90 . heart rate 65 to 70 bpm. No clue on body temp, never thought to check it.

[levkamensky]

So why don't you stay at 10 to 12?

[craigb527]

So why don't you stay at 10 to 12?

Read this article and became concerned over statment I highlighted in red. Decided to cut back and see how I felt.

Is Resveratrol an Exercise Pill?
Double Your Pleasure, Double Your Fun, and Double How Far You Can Run
s we go to press, a paper has just been published showing that resveratrol greatly increases physical performance in normal young mice.1 This follows hard on the heels of the recent finding, by David Sinclair and colleagues, that resveratrol extends lifespan in obese middle-aged mice by providing the health and longevity benefits of caloric restriction—without caloric restriction (see the article on page 4)! All this suggests that resveratrol is a sort of “fountain of youth,” at least for mice, and probably for humans.

In the new study, by Johan Auwerx and colleagues, resveratrol-supplemented mice ran twice as far as those not receiving it. Resveratrol facilitated their muscles to produce more energy, more efficiently. The study confirmed a connection found previously between the principal biochemical pathway activated by resveratrol and an animal’s physiology. Since that same pathway exists in humans, it’s likely that human physiology will respond similarly.

Whatever your physical condition, any continuous exertion, such as running, will eventually result in exhaustion. But if the new study holds for humans, supplementing with resveratrol might double the distance you could run before exhaustion set in, and you would appear to be a trained athlete, with a reduced heart rate and more powerful muscles. According to Auwerx, “Resveratrol makes you look like a trained athlete without the training.”

Will Exercise Become Obsolete?

In an article we published last August (“Resveratrol—Star Molecule Against Disease and Aging”), we quoted from a 2006 paper by Joseph Baur and David Sinclair, who said, “In addition, resveratrol treatment increases mitochondrial biogenesis … and, at least under certain conditions, improves insulin sensitivity, which is consistent with observations in calorie-restricted animals.”4 [emphasis added] It is these benefits that the Auwerx study points to as the principal explanations for increased muscle power. Mitochondrial biogenesis means the production of more mitochondria, the organelles that produce energy within the cell.

Indeed, the mice fed resveratrol were found to have more mitochondria in their muscle cells. These mice burned more fat, did not gain weight (unlike the mice in the Sinclair study), and had improved insulin sensitivity. Especially interesting was the fact that their muscle fibers appeared to be more like the type developed by trained human athletes. Could resveratrol be an exercise nutrient that can provide the benefits of exercise without the need to exercise? Could resveratrol make exercise obsolete?

Unfortunately, the amount of resveratrol used in the Auwerx study was 400 mg per kilogram of body weight, per day, which is 18 times greater than the largest amount used in the Sinclair study (22.4 mg per kilogram of body weight, per day). Dr. Sinclair and his family and colleagues take 5 mg of resveratrol per kilogram of body weight, per day, or 22% of the 22.4-mg/kg amount he gave his obese mice. If we applied that 22% factor to the 400-mg/kg amount used in the Auwerx study, a would-be human athlete would need to take about 88 mg of resveratrol per kilogram of body weight, per day. For a 75-kg (165-lb) human, the total daily consumption would then be 6.7 g, a pharmacological amount that is not advisable, especially for men, based on studies showing that resveratrol can act as a powerful systemic aromatase inhibitor when very large amounts are taken.5

The enhanced metabolism seen in the Auwerx study was due primarily to the resveratrol-mediated activation of an enzyme called PGC-1á, which stimulates mitochondrial biogenesis.

Next month, in our ongoing series on Durk Pearson & Sandy Shaw’s 21st Century Weight Loss Program (see Part 2 of their Glycemic Control Strategy on page 16), we will learn that there are other ways to enhance PGC-1á activity. Durk & Sandy will offer a formulation to do just that—one that will also, by the way, contain a large amount of resveratrol (about half of what Sinclair is taking). These ingredients and others will be used in combination in the second major product division of the weight loss program.

Also, we will cover the Auwerx study (along with any other important developments) next month, so stay tuned. These are extremely exciting times for life extenders and life enhancers.

"the total daily consumption would then be 6.7 g, a pharmacological amount that is not advisable, especially for men, based on studies showing that resveratrol can act as a powerful systemic aromatase inhibitor when very large amounts are taken."

Can someone explain the above statement and ramifications please?

[maxwatt]

"the total daily consumption would then be 6.7 g, a pharmacological amount that is not advisable, especially for men, based on studies showing that resveratrol can act as a <span style='color:red'>powerful systemic aromatase inhibitor </span>when very large amounts are taken."
Can someone explain the above statement and ramifications please?

I searched Pub Med with the terms "resveratrol aromatase"

Toxicol Sci. 2006 Jul;92(1):71-7. Epub 2006 Apr 11. Links
The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.Wang Y, Lee KW, Chan FL, Chen S, Leung LK.
PMID: 16611627

The administration of 10 nmol/l testosterone-a substrate of aromatase-produced a 50% increase in the MCF-7aro cell number. This cell proliferation specifically induced by testosterone was significantly reduced by 10 microM resveratrol. In addition, 50 microM resveratrol significantly reduced the CYP19-encoding mRNA abundance in SK-BR-3 cells.

Not long ago it was debated here whether serum levels anywhere near this high could be obtained.

ChemMedChem. 2007 Oct 1; [Epub ahead of print] Links
Combining Computational and Biochemical Studies for a Rationale on the Anti-Aromatase Activity of Natural Polyphenols.Neves MA, Dinis TC, Colombo G, Sá E Melo ML.
PMID: 17910019

Aromatase, an enzyme of the cytochrome P450 family, is a very important pharmacological target, particularly for the treatment of breast cancer. The anti-aromatase activity of a set of natural polyphenolic compounds was evaluated in vitro. Strong aromatase inhibitors including flavones, flavanones, resveratrol, and oleuropein, with activities comparable to that of the reference anti-aromatase drug aminoglutethimide, were identified. Through the application of molecular modeling techniques based on grid-independent descriptors and molecular interaction fields, the major physicochemical features associated with inhibitory activity were disclosed, and a putative virtual active site of aromatase was proposed. Docking of the inhibitors into a 3D homology model structure of the enzyme defined a common binding mode for the small molecules under investigation. The good correlation between computational and biological results provides the first rationalization of the anti-aromatase activity of polyphenolic compounds. Moreover, the information generated in this approach should be further exploited for the design of new aromatase inhibitors.

PMID: 17910019

One would expect mild aromatase inhibition over time to cause increased testosterone production.
Resveratrol was once thought to be estrogenic because of its structure, and does show some such effects in vitro. The situation is complicated, and warrants further study. I don't think anyone can draw definite conclusions yet based on the data available.

I've taken as much as 5g daily, single dose, and the endurance increase was definite. Currently at 2.5 g, still have improved endurance. Even at around 1 g/day there I noted a 5% increase in maximum sustainable power on a cycling ergonometer last spring. I've not used the device since then, but believe subjectively I have more power than I normally would given my level of training. Velopismo has reported similar effects with cycling on similar doses, and other riders in his club have noted his improved performance.

Edited by maxwatt, 25 October 2007 - 07:44 PM.

[Anthony_Loera]

I am still curious if this holds any weight --->>

http://www.longevine...tory=Imitations

I would like to see someone take 6,000 mg of Longevinex's resveratol, and see if they experience effects similar to Auwerx's mice. Unfortunately it's beyond my means.

I wouldn't get too enamored with longevinix. As long as you are purchasing 99% res and thats what you are getting, you are better off than what longevinix gives you. They can't give you anything better than 99% pure no matter what it comes in. It is just a sales pitch to scare the masses into buyng their product.

FYI:
- Longevinix does not use 99% t-res, they encapsulate 50% t-res using Pfizer patented capsule and machine.
- I believe Bill Sardi has stated 99% is too expensive, so they use 50%.
- Pfizer has mentioned that their patented capsules could only hold a little over 200mg of 99% t-res. (maybe 250mg)

Longevinex knows they are limited by the technology they have chosen. For them to back peddle so that they could increase dosage in a capsule to match Sirtris would have them look pretty bad. I personally don't think this will happen.

If you want to compete against Longevinex, call capsugel and have them bottle your rsv, then price it under Longevinex, and market the heck out of it.
We don't do this as we know the molecule is much more stable than Longevinex portrays it to be. We have tested it.

A

[maxwatt]

[....

If you want to compete against Longevinex, call capsugel and have them bottle your rsv, then price it under Longevinex, and market the heck out of it.
We don't do this as we know the molecule is much more stable than Longevinex portrays it to be. We have tested it.

A

Competing against Longevinex would be like competing in the Special Olympics -- even if you win, you're still "special". I have a very low opinion of the product and the promoter: unfounded hype, based on unsubstantiated inferences from inadequate research, promulgating myths that have long been proven false. For example, in correspondence, when confronted with studies that contradict his claims as to stability, he changes the subject, then repeats his old assertions.

Edited by maxwatt, 25 October 2007 - 07:45 PM.

[resveratrol]

I have a very low opinion f the product and the promoter: unfounded hype, based on unsubstantiated inferences from inadequate research, promulgating myths that have long been proven false.

Max, does your skepticism extend to their unified theory of aging? I find it interesting and I haven't been able to make up my mind yet as to its validity.

[maxwatt]

I have a very low opinion f the product and the promoter: unfounded hype, based on unsubstantiated inferences from inadequate research, promulgating myths that have long been proven false.

Max, does your skepticism extend to their unified theory of aging? I find it interesting and I haven't been able to make up my mind yet as to its validity.

Pseudoscience. But like a broken clock tells the right time twice a day, he is unlikely to be wrong all the time.

[health_nutty]

"the total daily consumption would then be 6.7 g, a pharmacological amount that is not advisable, especially for men, based on studies showing that resveratrol can act as a <span style='color:red'>powerful systemic aromatase inhibitor </span>when very large amounts are taken."
Can someone explain the above statement and ramifications please?

I searched Pub Med with the terms "resveratrol aromatase"

Toxicol Sci. 2006 Jul;92(1):71-7. Epub 2006 Apr 11. Links
The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.Wang Y, Lee KW, Chan FL, Chen S, Leung LK.
PMID: 16611627



Not long ago it was debated here whether serum levels anywhere near this high could be obtained.

ChemMedChem. 2007 Oct 1; [Epub ahead of print] Links
Combining Computational and Biochemical Studies for a Rationale on the Anti-Aromatase Activity of Natural Polyphenols.Neves MA, Dinis TC, Colombo G, Sá E Melo ML.
PMID: 17910019

Aromatase, an enzyme of the cytochrome P450 family, is a very important pharmacological target, particularly for the treatment of breast cancer. The anti-aromatase activity of a set of natural polyphenolic compounds was evaluated in vitro. Strong aromatase inhibitors including flavones, flavanones, resveratrol, and oleuropein, with activities comparable to that of the reference anti-aromatase drug aminoglutethimide, were identified. Through the application of molecular modeling techniques based on grid-independent descriptors and molecular interaction fields, the major physicochemical features associated with inhibitory activity were disclosed, and a putative virtual active site of aromatase was proposed. Docking of the inhibitors into a 3D homology model structure of the enzyme defined a common binding mode for the small molecules under investigation. The good correlation between computational and biological results provides the first rationalization of the anti-aromatase activity of polyphenolic compounds. Moreover, the information generated in this approach should be further exploited for the design of new aromatase inhibitors.

PMID: 17910019

One would expect mild aromatase inhibition over time to cause increased testosterone production.
Resveratrol was once thought to be estrogenic because of its structure, and does show some such effects in vitro. The situation is complicated, and warrants further study. I don't think anyone can draw definite conclusions yet based on the data available.

I've taken as much as 5mg daily, single dose, and the endurance increase was definite. Currently at 2.5 mg, still have improved endurance. Even at around 1 mg/day there I noted a 5% increase in maximum sustainable power on a cycling ergonometer last spring. I've not used the device since then, but believe subjectively I have more power than I normally would given my level of training. Velopismo has reported similar effects with cycling on similar doses, and other riders in his club have noted his improved performance.

I suppose you mean grams and not mg?

[craigb527]

Not sure about "powerful systemic aromatase inhibitor", but I do know that I had a definite increase in testicle size with larger doses, which would seem to me to be a greater production of testosterone. Seems to contradict the estrogen theory. Also at higher doses, it kinda felt like I was breathing fresh air all the time. A couple deep breaths after working out and I was fine. No glass of water to quench my thirst necessary. Longer workout times and way more reps. Whereas, before resveratrol there would be heavy breathing for a few minutes after a lesser workout, plop down on the chair and drink water to recover. I bet the long distance cyclists have been taking it for years with no one testing for it.

Edited by craigb527, 25 October 2007 - 05:58 PM.

[stephen_b]

If you want to compete against Longevinex, call capsugel and have them bottle your rsv, then price it under Longevinex, and market the heck out of it.
We don't do this as we know the molecule is much more stable than Longevinex portrays it to be. We have tested it.

A

Maybe a better reason to encapsulate it is to put it in a lecithin solution.

Stephen

[stephen_b]

Max, does your skepticism extend to their unified theory of aging?  I find it interesting and I haven't been able to make up my mind yet as to its validity.

Pseudoscience. But like a broken clock tells the right time twice a day, he is unlikely to be wrong all the time.

I'm quite interested in the hypothesis that most men have too much iron, and that the reason for fewer cases of heart disease and perhaps even increased longevity seen by women is iron loss via menstruation.

There was also a Finnish study that showed:

in a multivariate model adjusted for the main coronary risk factors, the blood donors' risk of acute myocardial infarction was 86% less than that of the non-donors. [...] However, voluntary blood donors seem to be generally more health conscious and more healthy than those who do not donate blood, and this may have caused self selection bias. In our study the association between donating blood and reduced risk for myocardial infarction was weakened but remained significant after adjustment for the main coronary risk factors.

Stephen

Edit: other news story citing a 30% decrease in risk.

"What this means for men is - if you donate blood, in a sense you can become a virtual woman and protect yourself from heart disease," said Meyers.

Yep, always wanted to be a 'virtual woman'. [lol]

[craigb527]

I'm quite interested in the hypothesis that most men have too much iron, and that the reason for fewer cases of heart disease and perhaps even increased longevity seen by women is iron loss via menstruation

While iron is a necessary nutrient, it is needed only in small amounts. When too much iron is absorbed from the diet, it can cause a wide variety of health problems. High levels of iron are associated with an increased risk for cancer, heart disease, and other illnesses such as endocrine problems, arthritis, diabetes, and liver disease.1

Men absorb iron from the food that they eat, and once this iron is in the body it has essentially no way to get out. Women also absorb iron, however they are generally-though not completely- protected from excess iron accumulation through regular iron loss by way of menstrual blood (they lose this benefit after menopause).2 Because of the health risks associated with high levels of body iron, all men should consider having their iron levels tested.3 If the test results indicate that iron levels are too high, specific treatments and lifestyle modifications may be used to lower body iron stores to more healthy levels.

Excess Iron and Cancer  [:o]
Iron acts as a cancer-promoting agent by two separate yet synergistic mechanisms: 1) by producing "free radicals," and 2) by feeding cancer cells. Iron increases the production of free radicals, and-in fact-the production of free radicals is largely proportionate to the level of iron.4 This means that the more iron there is in the body, the more free radicals will be produced and thus the greater the risk of disease, in this case, cancer. Free radicals are oxygen-containing molecules which damage (oxidize) the DNA of cells. Since DNA controls the activities of the cell, once the DNA is damaged, the cell becomes "out of control." Essentially, all cancer cells are out of control. These cancer cells then replicate and grow rapidly and eventually infiltrate and damage the body's organs. Additionally, cancer cells consume many nutrients and thereby starve the host. One of the nutrients cancer cells need most is iron. In fact, researchers now think that iron may be a "rate-limiting" nutrient for cancer cell growth.5 This means that the more iron that is available, the more the cancer cells will divide and flourish, and the better chance they have of killing the host. Recent research has shown that people with high levels of iron have an increased risk for cancer.5, 6

Excess Iron and Heart Attacks    [huh]

The free radicals which are produced by iron can promote the development of heart disease. Free radicals can damage (oxidize) cholesterol in the blood. When cholesterol has been oxidized, it is much more likely to "get stuck" in the arteries and blood vessels in the body and especially in the arteries that deliver nutrients and oxygen to the heart. When too much of this cholesterol becomes stuck in the arteries, it makes the inside of the artery smaller, and less blood can get to the heart muscle. Eventually, the blood flow may become so reduced that the heart cannot receive enough oxygen and nutrients, and some of the "starved" heart tissue may die-this is called a heart attack. Heart attacks are one of the leading killers of people in this country and are a very common cause of death in men. Men who have high levels of iron are at an increased risk for heart attack.7

link
http://menweb.org/alexiron.htm

I am convinced Stephen B, what is the solution (easiest)? Is the best solution to give blood because I do not think they will take my blood with all the supplements I take (Saw Palmetto being one). But wait, I just found out this about saw palmetto

Tannin content of herb may limit iron absorption 7

So, the very reason I can't give blood to reduce my iron levels may in fact be reducing my iron levels. [thumb] link http://www.med.umich...ha/umherb01.htm

Edited by craigb527, 25 October 2007 - 07:11 PM.

[stephen_b]

Hi craigb527. I'm avoiding taking vitamin C when I have any source of vegetable iron, since it increases absorption. I've also got some apolactoferrin, which will latch on to iron in the gut. Green tea impedes iron absorption too.

One thing I've cut out is bioperine. Its manufacturer claims it enhances iron absorption. I had been taking turmeric extract with bioperine (NSI brand), and turmeric is supposed be high in iron. However, turmeric is supposed to fight against iron-induced damage in the cardiovascular system (here in a rodent model) and may help prevent Alzheimer's (and here too).

So for me, I'm donating blood, taking apolactoferrin (it's in LEF's whey product), eliminating bioperine but taking LEF's bioperine-free curcumin, and drinking green tea when I eat veggie sources of iron whenever possible. No black pepper on the spinach salad.

Stephen

[craigb527]

OK. It seems there would be a pill to reduce iron in your blood. I take green tea supplement, but also Tumeric. Which I will cut out. Would antioxidants like acai, blueberry, pomegranate, etc. do anything to eliminate iron?

Edited by craigb527, 25 October 2007 - 09:25 PM.

[craigb527]

One thing I was thinking about, is that Auwerx's mice, or any animal taking high volume resveratrol supplementation, would actually use less oxygen during the course of the day. I know when I work out, heavy breathing has been all but eliminated, so in theory I would have to be using less oxygen. I am not sure about oxygen consumption at rest, but I think it is reduced as well. Short breaths seem to be fine. Has actual oxygen consumption been tested on mice on resveratrol? [mellow]

[geo12the]

nothing really.  Didn't feel a big difference til around 10 to 12.  Then it was undeniable.

Craig,

10 to 15 grams per day seems like an unnecessarily large dose to me. Be careful. Resveratrol is strong stuff. There can be too much of a good thing, and you want to be careful to not inadvertently do yourself harm. What effects did you feel at these large doses?

[maxwatt]

One thing I was thinking about, is that Auwerx's mice, or any animal taking high volume resveratrol supplementation, would actually use less oxygen during the course of the day.  I know when I work out, heavy breathing has been all but eliminated, so in theory I would have to be using less oxygen.  I am not sure about oxygen consumption at rest, but I think it is reduced as well.  Short breaths seem to be fine.  Has actual oxygen consumption been tested on mice on resveratrol? [mellow]

I do not think resveratrol will repeal the laws of thermodynamics. However, having more mitochondria in your muscles will make them stronger, with more endurance. I believe it would increase the contractile force a muscle could produce. But a given amount of work will still require the same amount of oxygen.

[craigb527]

nothing really.  Didn't feel a big difference til around 10 to 12.  Then it was undeniable.

Craig,

10 to 15 grams per day seems like an unnecessarily large dose to me. Be careful. Resveratrol is strong stuff. There can be too much of a good thing, and you want to be careful to not inadvertently do yourself harm. What effects did you feel at these large doses?

The red grape constituent resveratrol possesses cancer chemopreventive properties in rodents. The hypothesis was tested that, in healthy humans, p.o. administration of resveratrol is safe and results in measurable plasma levels of resveratrol. A phase I study of oral resveratrol (single doses of 0.5, 1, 2.5, or 5 g) was conducted in 10 healthy volunteers per dose level. Resveratrol and its metabolites were identified in plasma and urine by high-performance liquid chromatography-tandem mass spectrometry and quantitated by high-performance liquid chromatography-UV. Consumption of resveratrol did not cause serious adverse events. Resveratrol and six metabolites were recovered from plasma and urine. Peak plasma levels of resveratrol at the highest dose were 539 ± 384 ng/mL (2.4 µmol/L, mean ± SD; n = 10), which occurred 1.5 h post-dose. Peak levels of two monoglucuronides and resveratrol-3-sulfate were 3- to 8-fold higher. The area under the plasma concentration curve (AUC) values for resveratrol-3-sulfate and resveratrol monoglucuronides were up to 23 times greater than those of resveratrol. Urinary excretion of resveratrol and its metabolites was rapid, with 77% of all urinary agent-derived species excreted within 4 h after the lowest dose. Cancer chemopreventive effects of resveratrol in cells in vitro require levels of at least 5 µmol/L. The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy. However, the high systemic levels of resveratrol conjugate metabolites suggest that their cancer chemopreventive properties warrant investigation. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1246–52

If 5 grams allowed subjects to reach 2.4 µmol/L, and cancer chemopreventive effects of resveratrol in cells in vitro require levels of at least 5 µmol/L, I decided to up my resveratrol to 15 grams, an amount that I thought would put my blood levels above the 5 µmol/L to take advantage of its chemopreventive benefits. Necessary, no. But I made an educated guess at what I felt was a minimal risk worth taking. I don't have cancer, as far as I know, but who is to say I am not nipping something in the bud.

[craigb527]

One thing I was thinking about, is that Auwerx's mice, or any animal taking high volume resveratrol supplementation, would actually use less oxygen during the course of the day.  I know when I work out, heavy breathing has been all but eliminated, so in theory I would have to be using less oxygen.  I am not sure about oxygen consumption at rest, but I think it is reduced as well.  Short breaths seem to be fine.  Has actual oxygen consumption been tested on mice on resveratrol? [mellow]

I do not think resveratrol will repeal the laws of thermodynamics. However, having more mitochondria in your muscles will make them stronger, with more endurance. I believe it would increase the contractile force a muscle could produce. But a given amount of work will still require the same amount of oxygen.

OK. I thought resveratrol allowed muscles to use oxygen more efficiently. Thereby allowing use of less oxygen to exert the same amount of force. But it was just a thought, not caught up on my thermodynamics.

[geo12the]

I definitely can say I feel more endurance on the treadmill although for me I thought it started after taking cranberry at the same time as Resveratrol, but maybe that’s just when I started paying attention. Who knows. Whatever the case, I have significantly more endurance having done nothing different except take Resveratrol (2 Revgenetics R500 pills each morning) and perhaps there is a synergistic effect with cranberry. I’ll be on the treadmill, going at level 6.5 or 7 (level 6 is roughly a 10 minute mile), which is a fairly fast speed. Before I started taking resveratrol I usually would do level 6 on the weekends and level 5 during the week. Anyway this sounds too good to be true, but I will be running at level 6.5 or 7 and I honestly will feel like I am just walking. I’ll look down at my feet running and think “this feels weird”. Placebo effect? Perhaps, but I don’t think so.

[craigb527]

Craig,

10 to 15 grams per day seems like an unnecessarily large dose to me. Be careful. Resveratrol is strong stuff. There can be too much of a good thing, and you want to be careful to not inadvertently do yourself harm. What effects did you feel at these large doses

Here are two previous posts explaining how I felt with heavier doses. No ill feelings, queasiness etc. Worked up gradually to the larger doses. Also, no pains in any of my joints. I have had bad knees for years, they don't bother me now. In fact I feel no pain or soreness anywhere.

I experienced increased enduarance, less muscle fatigue, etc. I was taking large doses in order to experience this. When I started taking resveratrol I could do about 15 pushups before tiring. A week after taking heavy doses, I could do 50. When I began I was lifting two 35 pound dumbells over my head 30 to 35 times before tiring, after a week I could do it 100 times. Also, my muscles did not get sore at all during workouts or the next day. When I put at the end of my
statement it could be a placebo effect, I was being facetious. If it was a placebo effect, then the placebo effect made me stronger. But, I don't want to say, "Yes, run out and do heavy doses, you'll get stronger!" because I don't want to be responsible for health problems other individuals may incur from heavier doses. Also, I would recover very quickly after a workout, no heavy breathing like usual and the next day my muscles wold not be sore. One thing I noticed though, is that while my endurance was improved, I felt unmotivated to get things done. A kind of laziness while not exerting energy. Also, I am not sure if I became stronger or if it is more endurance, I have not attempted to see if I can actually lift more or just do more reps

Not sure about "powerful systemic aromatase inhibitor", but I do know that I had a definite increase in testicle size with larger doses, which would seem to me to be a greater production of testosterone. Seems to contradict the estrogen theory. Also at higher doses, it kinda felt like I was breathing fresh air all the time. A couple deep breaths after working out and I was fine. No glass of water to quench my thirst necessary. Longer workout times and way more reps. Whereas, before resveratrol there would be heavy breathing for a few minutes after a lesser workout, plop down on the chair and drink water to recover.

[maxwatt]

craigb527, I nominate you as an honorary Auwerx rat.

[craigb527]

craigb527, I nominate you as an honorary Auwerx rat.

Awesome! [lol]