1708 replies to this topic

[missminni]

yes i do do a form of exercises where i can compare before and after endurance, in fact i was hoping to see some improvement in endurance with this particular exercise, inspired by this poster who said that he noticed significant improvements in endurance after ten grams. i take mine with grapefruit juice to maximize bioavailability. i take capsules, what do you take?

I take the powder 98%. I take it a few different ways. One is dissolved in milk ( about 400-500 mg) then cutaneously with DMSO maybe another 400 mg, and also, under the tongue with a little Jack Daniels to dissolve it, also about 400 mg. Sometimes I'll use a bit more wi†h the DMSO or take more orally. By the end of the day I've taken anywhere between 1 and 2 grams. The DMSO it the most effective
way as far as feeling a difference when you exercise. Maybe you should try it with the DMSO.this is what I use.
I know I'm all over the place with it, but i am covering all bases and I'm having good results.

[levkamensky]

yes i do do a form of exercises where i can compare before and after endurance, in fact i was hoping to see some improvement in endurance with this particular exercise, inspired by this poster who said that he noticed significant improvements in endurance after ten grams. i take mine with grapefruit juice to maximize bioavailability. i take capsules, what do you take?

I take the powder 98%. I take it a few different ways. One is dissolved in milk ( about 400-500 mg) then cutaneously with DMSO maybe another 400 mg, and also, under the tongue with a little Jack Daniels to dissolve it, also about 400 mg. Sometimes I'll use a bit more wi†h the DMSO or take more orally. By the end of the day I've taken anywhere between 1 and 2 grams. The DMSO it the most effective
way as far as feeling a difference when you exercise. Maybe you should try it with the DMSO.this is what I use.
I know I'm all over the place with it, but i am covering all bases and I'm having good results.

Thanks for your opinion.

[levkamensky]

I ordered Longevinex for my parents, we will see if it is more effective as they claim.

[stochastic]

we will see if it is more effective as they claim.

how?

[missminni]

figured it out.

Edited by missminni, 22 December 2007 - 10:07 PM.

[sUper GeNius]

I am taking over about a 1300 mg a day. I let my beard grow in for the first time in a few years. I am quite astonished to see that my mustache has lost all of the grey that it had. Back to the natural color. The rest of the beard still has the grey in it. Not sure whether the hair on my head has lost any grey. I never let the roots come in, always dye it.

An interesting aside. For years I have been taking about 1mg of finesteride for thinng hair. Worked great for me. However, one side effect, perhaps desirable, is that I have lost other bod hair. I was becoming pretty hairy on my chest and upper back. Hair on upper back disappeared. Hair on the chest is considerably less dense.

I understand that the hormone that finesteride inhibits, (name escapes me,) is responsible for hair loss on the scalp, but hair growth on other parts of the body.

[tintinet]

I am taking over about a 1300 mg a day. I let my beard grow in for the first time in a few years. I am quite astonished to see that my mustache has lost all of the grey that it had. Back to the natural color. The rest of the beard still has the grey in it. Not sure whether the hair on my head has lost any grey. I never let the roots come in, always dye it.

An interesting aside. For years I have been taking about 1mg of finesteride for thinng hair. Worked great for me. However, one side effect, perhaps desirable, is that I have lost other bod hair. I was becoming pretty hairy on my chest and upper back. Hair on upper back disappeared. Hair on the chest is considerably less dense.

I understand that the hormone that finesteride inhibits, (name escapes me,) is responsible for hair loss on the scalp, but hair growth on other parts of the body.

Finasteride acts by inhibiting type II 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT).

A la Wikipedia.

[rinkuhero]

Hi, I'd like to know if this type of Resveratrol is a good deal for one new to it who wants to start taking it:

http://cgi.ebay.com/...1QQcmdZViewItem

If not, what other type/brand would you recommend instead.

You guys seem to know what you're talking about so your advice would be greatly appreciated. Thanks in advance!

[Anthony_Loera]

I don't know.

But they are listed in the price watch list here so you can compare the regular prices.
http://www.imminst.o...tch-t15059.html


The dose is 2 capsules at 250mg each. So you are actually getting 30 servings per container at 500mg and not 60 servings.
here is the label:
http://resveratrol-i...l_500_Label.jpg

I don't know about the quality or if they test it for safety.

I hope this helps
A

[sUper GeNius]

Sardi's latest treatise here for what it's worth:

http://www.longevine...r...7 in review

[luminous]

Sardi's latest treatise here for what it's worth:

http://www.longevine...r...7 in review

Interesting article, Fm. I don't know enough to say whether the following quote from the article has merit. If it does, then wouldn't that mean that all our concern over resveratrol's bioavailability has been unnecessary? I wonder if the "demonstrated health benefits" in lab animals includes longer-than-average lifespans? If so, then the implication is that the resveratrol has typically been administered orally--no special delivery methods or companion substances (whey, buttermilk, everclear, eye drops, patches, belly-button DMSO, etc.).

Bioavailablity questioned for no good reason

Here again, University of Leicester researchers expressed hesitancy over the fact most resveratrol is metabolized once it reaches the liver (attached to sulfur and glucuronate detoxification molecules), which makes resveratrol non-biologically available. However, these researchers fail to note the strong demonstrated health benefits that emanate from oral doses given to animals, and the fact that an enzyme, glucuronidase, frees up resveratrol so it is bioavailable at sites of inflammation, infection and malignancy. Furthermore, liver metabolism offers an advantage – it prolongs the life of resveratrol for up to 9 hours in the blood circulation.22,23

Given these facts, one wonders if some researchers continue to bring up the contrived bioavailability issue to dissuade the public away from resveratrol pills? One wonders.

Edited by luminous, 30 December 2007 - 04:14 AM.

[niner]

Sardi's latest treatise here for what it's worth:

http://www.longevine...r...7 in review

Interesting article, Fm. I don't know enough to say whether the following quote from the article has merit. If it does, then wouldn't that mean that all our concern over resveratrol's bioavailability has been unnecessary? I wonder if the "demonstrated health benefits" in lab animals includes longer-than-average lifespans? If so, then the implication is that the resveratrol has typically been administered orally--no special delivery methods or companion substances (whey, buttermilk, everclear, eye drops, patches, belly-button DMSO, etc.).

Bioavailablity questioned for no good reason

Here again, University of Leicester researchers expressed hesitancy over the fact most resveratrol is metabolized once it reaches the liver (attached to sulfur and glucuronate detoxification molecules), which makes resveratrol non-biologically available. However, these researchers fail to note the strong demonstrated health benefits that emanate from oral doses given to animals, and the fact that an enzyme, glucuronidase, frees up resveratrol so it is bioavailable at sites of inflammation, infection and malignancy. Furthermore, liver metabolism offers an advantage – it prolongs the life of resveratrol for up to 9 hours in the blood circulation.22,23

Given these facts, one wonders if some researchers continue to bring up the contrived bioavailability issue to dissuade the public away from resveratrol pills? One wonders.

Plasma levels of resveratrol have been measured in both rodents and humans. For a given mg/kg dose, the rodents have a substantially higher plasma level. I suspect that humans are better at conjugative metabolism of polyphenols than rodents are, and a long list of drugs that worked in rodents but failed in humans exists. Given these facts, one wonders if some resveratrol vendors continue to dismiss the bioavailability issue to encourage the public to buy resveratrol pills? One wonders.

[Anthony_Loera]

Plasma levels of resveratrol have been measured in both rodents and humans. For a given mg/kg dose, the rodents have a substantially higher plasma level. I suspect that humans are better at conjugative metabolism of polyphenols than rodents are, and a long list of drugs that worked in rodents but failed in humans exists. Given these facts, one wonders if some resveratrol vendors continue to dismiss the bioavailability issue to encourage the public to buy resveratrol pills? One wonders.

nice one niner...

[health_nutty]

I took some cranberry extract with my resveratrol this morning. I don't feel any different.

I took my normal resveratrol dose (800mg of t-res) with 4 oz of trader joe's 100% cranberry juice (actually 100% cranberry juice, not a juice blend) while on vacation.

I felt a lot of extra energy and some appetite suppression the first time I tried this. I have felt resveratrol in the past the first time I upped my dosage and when I first added grapefruit juice, and when I first added luteolin. I didn't feel anything when I added grape seed extract, quercitin, silymarin, or aspriin. It could be placebo effect, but I don't always feel the placebo when I try something different. Also I wasn't expecting to feel anything from the cranberry because I had tried the extract before, it just so happened my aunt had that juice.

Anyone else want to give 4-8 oz of 100% cranberry juice a try? Maxwatt?

Edited by health_nutty, 09 January 2008 - 09:54 PM.

[maxwatt]

I took some cranberry extract with my resveratrol this morning. I don't feel any different.

I took my normal resveratrol dose (800mg of t-res) with 4 oz of trader joe's 100% cranberry juice (actually 100% cranberry juice, not a juice blend) while on vacation.

I felt a lot of extra energy and some appetite suppression the first time I tried this. I have felt resveratrol in the past the first time I upped my dosage and when I first added grapefruit juice, and when I first added luteolin. I didn't feel anything when I added grape seed extract, quercitin, silymarin, or aspriin. It could be placebo effect, but I don't always feel the placebo when I try something different. Also I wasn't expecting to feel anything from the cranberry because I had tried the extract before, it just so happened my aunt had that juice.

Anyone else want to give 4-8 oz of 100% cranberry juice a try? Maxwatt?

Been there, done that. No noticeable effect, and pure unsweetened cranberry juice is .... gross. Not as gross as 2 girls one cup, but pretty bad. I had to mix it with grape juice to finish the bottle.

[krillin]

Not as gross as 2 girls one cup, but pretty bad.

I wasn't grossed out at all, but I had read beforehand that it was the result of a peanut butter and chocolate enema.

[health_nutty]

Not as gross as 2 girls one cup, but pretty bad.

I wasn't grossed out at all, but I had read beforehand that it was the result of a peanut butter and chocolate enema.

I'm afraid to ask.

[malbecman]

Ok, to get the thread a little back on track......


I have to admit that after ~1 year of taking resveratrol, I finally caught a cold. Boo! I had previously reported in this thread several times having avoided all colds thrown my way. So I finally got one from my kids but compared to rest of my family, I definitely got the "lite" version. Whereas they were stuck with ~5 days of a deep cough, nasal congestion and tiredness, I only suffered ~2 days of tiredness and a shallow cough limited to my upper respiratory tract. Now I'm back...

Placebo effect? Maybe but just thought I'd make a note here.

[health_nutty]

Ok, to get the thread a little back on track......


I have to admit that after ~1 year of taking resveratrol, I finally caught a cold. Boo! I had previously reported in this thread several times having avoided all colds thrown my way. So I finally got one from my kids but compared to rest of my family, I definitely got the "lite" version. Whereas they were stuck with ~5 days of a deep cough, nasal congestion and tiredness, I only suffered ~2 days of tiredness and a shallow cough limited to my upper respiratory tract. Now I'm back...

Placebo effect? Maybe but just thought I'd make a note here.

I've noticed this with the colds I get too. I have a 2 and 4 year old; most of the time I'm able to avoid the colds they throw at me (being sneezed on, coughed at, etc). When I don't, the cold is like you described.

[zawy]

I finally caught a cold. Boo!

Try zicam. I get 70% relief for 4 hours after doing the gel and lozenges. Don't sniff the gel because there are reports of the burning causing permanent loss of smelling as is known to occur with zinc

Edited by zawy, 16 January 2008 - 12:37 AM.

[tintinet]

I finally caught a cold. Boo!

Try zicam. I get 70% relief for 4 hours after doing the gel and lozenges. Don't sniff the gel because there are reports of the burning causing permanent loss of smelling as is known to occur with zinc

Even know this, I've dared to use the nasal gel, but with great care:

1: Laryngoscope. 2006 Feb;116(2):217-20.Click here to read Links

Comment in:
Laryngoscope. 2006 Sep;116(9):1720-1; discussion 1722-3.
Laryngoscope. 2006 Sep;116(9):1721-2; discussion 1722-3.

Intranasal zinc and anosmia: the zinc-induced anosmia syndrome.
Alexander TH, Davidson TM.

Department of Surgery, Head and Neck Surgery and Continuing Medical Education, University of California, San Diego School of Medicine, VA San Diego Healthcare System, San Diego, CA 92103, USA.

OBJECTIVE: Commercial preparations of intranasal zinc gluconate gel are marketed as a remedy for the common cold. However, intranasal zinc has been reported as a cause of anosmia in humans and animals. Seventeen patients presenting with anosmia after the use of intranasal zinc gluconate are described. METHODS: The authors conducted a retrospective case series of patients presenting to a nasal dysfunction clinic and conducted complete history and physical examination on all patients, including nasal endoscopy. All patients underwent detailed odor threshold and identification testing. RESULTS: Threshold and identification testing revealed impaired olfaction in all patients. Inflammatory and traumatic causes of anosmia were excluded based on history, physical examination, and imaging. All patients diagnosed with zinc-induced anosmia or hyposmia reported sniffing deeply when applying the gel. This was followed by an immediate sensation of burning lasting minutes to hours. Loss of sense of smell was then perceived within 48 hours. Seven of 17 patients never developed symptoms of an upper respiratory infection. CONCLUSIONS: The zinc-induced anosmia syndrome, characterized by squirt, sniff, burn, and anosmia, occurs after the exposure of olfactory epithelium to zinc cation. It can be distinguished from postviral anosmia based on history.

PMID: 16467707 [PubMed - indexed for MEDLINE]

Haven't had a real cold in over a year (crossed fingers).

[niner]

I finally caught a cold. Boo!

Try zicam. I get 70% relief for 4 hours after doing the gel and lozenges. Don't sniff the gel because there are reports of the burning causing permanent loss of smelling as is known to occur with zinc

Even know this, I've dared to use the nasal gel, but with great care:

1: Laryngoscope. 2006 Feb;116(2):217-20.Click here to read Links

OK, that's pretty scary. You really don't want to lose your sense of smell. I guess they tell you not to sniff it, but still... I'd recommend using zinc lozenges instead. They work pretty well for me.

[TianZi]

Sardi's latest treatise here for what it's worth:

http://www.longevine...r...7 in review

Interesting article, Fm. I don't know enough to say whether the following quote from the article has merit. If it does, then wouldn't that mean that all our concern over resveratrol's bioavailability has been unnecessary? I wonder if the "demonstrated health benefits" in lab animals includes longer-than-average lifespans? If so, then the implication is that the resveratrol has typically been administered orally--no special delivery methods or companion substances (whey, buttermilk, everclear, eye drops, patches, belly-button DMSO, etc.).

Bioavailablity questioned for no good reason

Here again, University of Leicester researchers expressed hesitancy over the fact most resveratrol is metabolized once it reaches the liver (attached to sulfur and glucuronate detoxification molecules), which makes resveratrol non-biologically available. However, these researchers fail to note the strong demonstrated health benefits that emanate from oral doses given to animals, and the fact that an enzyme, glucuronidase, frees up resveratrol so it is bioavailable at sites of inflammation, infection and malignancy. Furthermore, liver metabolism offers an advantage – it prolongs the life of resveratrol for up to 9 hours in the blood circulation.22,23

Given these facts, one wonders if some researchers continue to bring up the contrived bioavailability issue to dissuade the public away from resveratrol pills? One wonders.

Plasma levels of resveratrol have been measured in both rodents and humans. For a given mg/kg dose, the rodents have a substantially higher plasma level. I suspect that humans are better at conjugative metabolism of polyphenols than rodents are, and a long list of drugs that worked in rodents but failed in humans exists. Given these facts, one wonders if some resveratrol vendors continue to dismiss the bioavailability issue to encourage the public to buy resveratrol pills? One wonders.

Niner, you frequently point out that "a long list of drugs that worked in rodents but failed in humans exists", but how long, exactly, is that list? Precisely how often do treatments that worked in mice fail in humans, and how does that percentage change depending on the type of intervention being tested? Is the failure rate across the board 10%? 50%? 90%?

If the failure rate is 10%, the list failures would be very long, but the list of successes much, much longer. The value of the studies in mice isn't that it proves anything definitively, but that it demonstrates an increased probability that an intervention will or will not work generally in humans. It would be interesting to review a meta-level study of the success / failure rate of medical studies over the past few decades with mice, with break-downs for particular areas of research. Have one handy?

Edited by TianZi, 17 January 2008 - 03:32 PM.

[niner]

Sardi's latest treatise here for what it's worth:

http://www.longevine...r...7 in review

Interesting article, Fm. I don't know enough to say whether the following quote from the article has merit. If it does, then wouldn't that mean that all our concern over resveratrol's bioavailability has been unnecessary? I wonder if the "demonstrated health benefits" in lab animals includes longer-than-average lifespans? If so, then the implication is that the resveratrol has typically been administered orally--no special delivery methods or companion substances (whey, buttermilk, everclear, eye drops, patches, belly-button DMSO, etc.).

Bioavailablity questioned for no good reason

Here again, University of Leicester researchers expressed hesitancy over the fact most resveratrol is metabolized once it reaches the liver (attached to sulfur and glucuronate detoxification molecules), which makes resveratrol non-biologically available. However, these researchers fail to note the strong demonstrated health benefits that emanate from oral doses given to animals, and the fact that an enzyme, glucuronidase, frees up resveratrol so it is bioavailable at sites of inflammation, infection and malignancy. Furthermore, liver metabolism offers an advantage – it prolongs the life of resveratrol for up to 9 hours in the blood circulation.22,23

Given these facts, one wonders if some researchers continue to bring up the contrived bioavailability issue to dissuade the public away from resveratrol pills? One wonders.

Plasma levels of resveratrol have been measured in both rodents and humans. For a given mg/kg dose, the rodents have a substantially higher plasma level. I suspect that humans are better at conjugative metabolism of polyphenols than rodents are, and a long list of drugs that worked in rodents but failed in humans exists. Given these facts, one wonders if some resveratrol vendors continue to dismiss the bioavailability issue to encourage the public to buy resveratrol pills? One wonders.

Niner, you frequently point out that "a long list of drugs that worked in rodents but failed in humans exists", but how long, exactly, is that list? Precisely how often do treatments that worked in mice fail in humans, and how does that percentage change depending on the type of intervention being tested? Is the failure rate across the board 10%? 50%? 90%?

If the failure rate is 10%, the list failures would be very long, but the list of successes much, much longer. The value of the studies in mice isn't that it proves anything definitively, but that it demonstrates an increased probability that an intervention will or will not work generally in humans. It would be interesting to review a meta-level study of the success / failure rate of medical studies over the past few decades with mice, with break-downs for particular areas of research. Have one handy?

The data's out there, if you're interested in writing a paper. I don't know of an actual "list" off the top of my head, (that statement was a rhetorical device that roughly translates to "shitloads") but I'd venture that the failure percentage is a lot higher than 10%.

[bentl]

The need to encapsulate resveratrol is a myth promulgated by those marketing encapsulated products. If you read though the various resveratrol threads here, you'll find the issue was addressed in the seminal paper on resveratrol stability co-authored by Brent Trela. As a powder, pure trans-resveratrol is stable when not exposed to ultra-violet light, as from sunlight or laboratory fluorescent lights. In solution, trans-resveratrol is stable at pH under 11; above that level, it converts to cis-resveratrol. Acit solution actually converts cis-resveratrol into trans-resveratrol. At temperatures under 20 degrees Celsius, resveratrol is not particularly prone to oxidation. In short, when properly handled, stability is not an issue. Keep it cool, dry and in a dark place.

and over in "Maximizing Resveratrol Effectiveness"

Naringin is as much an inhibitor of sufonation as quercetin, It's the component that makes grapefruit taste bitter. Piperine (black pepper) inhibits glucoronidation, I drink a little grapefruit juice with my resveratrol, which I've been mixing with lecithinated water, sometimes mixing resveratrol into a suspension in alcohol (it does not dissolve completely in only 30 ml, which is the most I'd want to drink.)

Please forgive my ignorance of biochemistry. Does this imply that you can mix resv with grapefruit juice (ph ~3) and not have to worry about cis vs. trans anymore once it sits long enough for any cis to convert to trans... or would this be a suspension and not a solution and so not apply, or not work for some other reason?

[maxwatt]

The need to encapsulate resveratrol is a myth promulgated by those marketing encapsulated products. If you read though the various resveratrol threads here, you'll find the issue was addressed in the seminal paper on resveratrol stability co-authored by Brent Trela. As a powder, pure trans-resveratrol is stable when not exposed to ultra-violet light, as from sunlight or laboratory fluorescent lights. In solution, trans-resveratrol is stable at pH under 11; above that level, it converts to cis-resveratrol. Acit solution actually converts cis-resveratrol into trans-resveratrol. At temperatures under 20 degrees Celsius, resveratrol is not particularly prone to oxidation. In short, when properly handled, stability is not an issue. Keep it cool, dry and in a dark place.

and over in "Maximizing Resveratrol Effectiveness"

Naringin is as much an inhibitor of sufonation as quercetin, It's the component that makes grapefruit taste bitter. Piperine (black pepper) inhibits glucoronidation, I drink a little grapefruit juice with my resveratrol, which I've been mixing with lecithinated water, sometimes mixing resveratrol into a suspension in alcohol (it does not dissolve completely in only 30 ml, which is the most I'd want to drink.)

Please forgive my ignorance of biochemistry. Does this imply that you can mix resv with grapefruit juice (ph ~3) and not have to worry about cis vs. trans anymore once it sits long enough for any cis to convert to trans... or would this be a suspension and not a solution and so not apply, or not work for some other reason?

My father takes his resveratrol in orange juice, and it seems to work for him. Tre rate of conversion is not all that quick, but if one has a fairly pure soruce of trans-resveratrol, the only way to get it to convert to cis would be to leave it sit in direct sun, fluorescent or halogen light. It takes a source of ultraviolet to convert. The equilibrium between the cis and trans forms is driven toward cis only at pH greater than 11. Not a problem unless one habitually drinks ammonia and lye.

I've stopped going out of my way to take grapefruit juice with my resveratrol. There's enough in a normal diet, and one can overwhelm the body's glucoronidation and sulfonation mechanisms by taking a bigger dose of resveratrol. This seem to happen at dosages between 500 and 800 mg.

[Hedgehog]

My father takes his resveratrol in orange juice, and it seems to work for him. Tre rate of conversion is not all that quick, but if one has a fairly pure soruce of trans-resveratrol, the only way to get it to convert to cis would be to leave it sit in direct sun, fluorescent or halogen light. It takes a source of ultraviolet to convert. The equilibrium between the cis and trans forms is driven toward cis only at pH greater than 11.

I have left a clear glass flask out in the lab for the past week and I have have gotten a little conversion to CIS. At most it is about 6%. I'm assuming it was 99% resveratrol when I started the stability study.

Maxwatt do you know of any data for resveratrol in warm/hot water or other solvent. I assume it as at least stable up to 37C?

[Anthony_Loera]

My father takes his resveratrol in orange juice, and it seems to work for him. Tre rate of conversion is not all that quick, but if one has a fairly pure soruce of trans-resveratrol, the only way to get it to convert to cis would be to leave it sit in direct sun, fluorescent or halogen light. It takes a source of ultraviolet to convert. The equilibrium between the cis and trans forms is driven toward cis only at pH greater than 11.

I have left a clear glass flask out in the lab for the past week and I have have gotten a little conversion to CIS. At most it is about 6%. I'm assuming it was 99% resveratrol when I started the stability study.

Maxwatt do you know of any data for resveratrol in warm/hot water or other solvent. I assume it as at least stable up to 37C?

Does the lab has Fluorescent lighting and open windows without uv filters I presume?

A

[Dmann]

Resveratrol is a crappy drug. It is sulfated and glucuronidated like crazy, so you have to take a ton of it to do much good. It has some negative side effects, like the GI upsets that occur in some people, even when taking high purity extracts or synthetics. Recently we've seen evidence that it is immunosuppressive. It's not even that powerful of a SIRT1 activator. I think that when Sinclair says "real", he means "good". The 1000 times he refers to is related to the potency of the drug as a SIRT1 activator; one of the NCEs is active at nanomolar concentrations, while resveratrol requires micromolar concentrations for similar effect. The NCE sounds like a very good drug, or very "real", if you will. I'm not surprised that the stock popped. I'm also not surprised that I was enough of a pinhead not to own any, but it always looks obvious in retrospect. BTW, don't take what I say here as a big anti-resveratrol screed. I'm still taking it. I think it gave me a tummy ache last night so maybe I'm a little grumpy. (Or maybe it was the jalapenos...)

Taking 2 or 3 grams does not seem like a ton to me. And if an upset tummy is the worst side effect, I'd say that is pretty damn
good compared to the side effects of most "real or good drugs".
I recall the post about the evidence of it being immunosuppressive however I don't recall that evidence being conclusive.
Was it?
It will be interesting to see what the side effects of his new "real good drug" will be.
I don't discount that it might be more effective in activating SIRT1 but I just don't believe in throwing out the baby with the bathwater.
I'm sorry if I am coming across as super critical of Dr. Sinclair and his publicity push for Sirtris, but it was a bit too obvious for me to ignore.

What are your thoughts of the Holstein Pharmaceutical: www.redwinepatch.com This seems to be an easier way than using DMSO to transport the t-res into the bloodstream.

[maxwatt]

Resveratrol is a crappy drug. It is sulfated and glucuronidated like crazy, so you have to take a ton of it to do much good. It has some negative side effects, like the GI upsets that occur in some people, even when taking high purity extracts or synthetics. Recently we've seen evidence that it is immunosuppressive. It's not even that powerful of a SIRT1 activator. I think that when Sinclair says "real", he means "good". The 1000 times he refers to is related to the potency of the drug as a SIRT1 activator; one of the NCEs is active at nanomolar concentrations, while resveratrol requires micromolar concentrations for similar effect. The NCE sounds like a very good drug, or very "real", if you will. I'm not surprised that the stock popped. I'm also not surprised that I was enough of a pinhead not to own any, but it always looks obvious in retrospect. BTW, don't take what I say here as a big anti-resveratrol screed. I'm still taking it. I think it gave me a tummy ache last night so maybe I'm a little grumpy. (Or maybe it was the jalapenos...)

Taking 2 or 3 grams does not seem like a ton to me. And if an upset tummy is the worst side effect, I'd say that is pretty damn
good compared to the side effects of most "real or good drugs".
I recall the post about the evidence of it being immunosuppressive however I don't recall that evidence being conclusive.
Was it?
It will be interesting to see what the side effects of his new "real good drug" will be.
I don't discount that it might be more effective in activating SIRT1 but I just don't believe in throwing out the baby with the bathwater.
I'm sorry if I am coming across as super critical of Dr. Sinclair and his publicity push for Sirtris, but it was a bit too obvious for me to ignore.

What are your thoughts of the Holstein Pharmaceutical: www.redwinepatch.com This seems to be an easier way than using DMSO to transport the t-res into the bloodstream.

Transdermal administration does not result in blood serum levels anywhere nears as high as those that can be obtained by oral administration. This has been covered in this forum at length.