1708 replies to this topic

[vitaminboss]

Anthony, "placebo period"???? Are you joking?? Buddy this isn't bee pollen, spirulina, or grapeseed extract, this is a molecule thats found in tiny quantities in red wine and never used by itself alone in chinese medicine in such large doses as an isolated molecule. Relatively speaking, 500mg is an ENORMOUS DOSE for a compound that has such broad effects on various systems.

Take a look at Figure 3. Plasma resveratrol is dwarfed by its conjugates in healthy people. Interfere with conjugation and you could get a vastly enhanced response.

Some people use lecithin to increase absorption, but they have to exert a lot of effort to get it mixed before consumption.

vitaminboss,

I have seen normal folks that don't have issues go through this period. We do have many customers, and do not rely on what one person says.

As for 500mg, Kenj points out (by linking to the human escalation study), not much gets into the human system at all unless you increase dose, or absorption. Of course if you are the exception because you have a screwed up system due to CFS, Chemo damage, or some other unknown issue (because you refuse to see doctors anymore). Then I ask you not to take resveratrol at all until you figure out what is happening.

As a matter of fact, I would ask you not to take anything until you see if your liver is working properly. How you are going to find this out, without a doctor... I have no idea. But that is my suggestion. It amazes me how you can feel things happening to you on a cellular level, while others sometimes do not realize when they have just passed gas. It leads me to think there is a mental element to this that hasn't been explored. Most folks on a long term regimen will feel "good" when first starting the regimen, then as time goes by this feeling usually dwindles which leads to older habits kicking in... then they may miss taking their vitamins one day, and start "skipping" them... until they fully stop taking them.

Resveratrol is not a stimulant, if you believe it will make you feel great from day one, and that is your purpose for taking it... then I will ask you to stop taking it. Most honest descriptions of benefits I have heard, come after 6 weeks. If that is too long a time period for you (or anyone reading this post) then it may that some personal habits need to be extended to encompass the longer regimen needed to see if Resveratrol will help provide you good health benefits.

A

Anthony, you are attempting to discredit my first hand experiences deliberately. The nonsense your pushing is hearsay, and is totally unsubstantiated. Your presenting your information from the position of a business person wanting to sell as much of this stuff as possible. POINT IS: RESVERATROL at these high concentrated doses isn't found anywhere in nature, and not even used in such doses in TCM. END OF STORY! If you don't believe my physical reactions to it, I ask that you advise some individuals with insulin resistance to try it and see what they tell you...

Edited by vitaminboss, 19 June 2008 - 05:14 PM.

[Anthony_Loera]

V,

I am trying to acknowledge that you have an issue that can be attributed to many things, specially if you make assumptions without visiting a doctor. This happens to be dangerous, and in my opinion a dumb decision that can endanger your life.

You made your point stating that resveratrol is not found in nature at such concentrations, but the simple fact is that neither are most herbal extracts.

My point is simple, if you are a normal person, most of the resveratrol you take get's flushed out of your system, and the resveratrol that is found in the plasma is much less than what was seen in the plasma of animals or in many other in-vitro experiment. See USC study , and the Boocock study.

Many people here know this, and are trying to find ways to increase absorption.

If you don't go see a doctor, and continue to say 500mg of resveratrol is the cause of your physical reactions, then... there is no reason to find you credible at this point, and I will have to stop acknowledging your posts.

A

Edited by Anthony_Loera, 19 June 2008 - 07:08 PM.

[Hedgehog]

The fact of the matter here is that you couldn't find a better lab rat example to test Resv than myself. CFS is known to be a sub-clinical metabolic disorder, primarily focused on mitochondrial dysfunction. Its a chicken & egg example. Mito's starve, leads to neurological/glandular, cardiovascular, immune and muscular impairment. Once the brain and glands starve of energy for a while, the hypothalamus goes haywire sending the entire system off homeostasis affecting system wide metabolism and ultimately gene expression... Step away from cancer, which then kicked in, followed by CHEMO which threw the cherry on the cake as far as DNA damage.. ANYWAY this isnt a CFS forum.

Are you talking about Chronic Fatigue Syndrome? If so there are a lot of other things that can cause this.

CFS is often associated with viral infection, although the presence of viruses has as yet not been consistently detected. (2) It is not clear whether anomalies of the HPA axis often observed in CFS, are cause or the consequences of the disorder. (3) Immune dysfunction as the cause of CFS is another hypothesis. (4) The psychiatric and psychosocial hypothesis denies the existence of CFS as a disease entity. Accordingly, the fatigue symptoms are assumed to be the consequence of other (somatic) diseases. Other possible causes of CFS are (5) oxidative stress and (6) genetic predisposition. ^{[2] [3]} Or it may be due to a combination of several of these factors. Whilst many hypotheses about CFS are made on the basis of specific findings others are proposed as a result of wider literature reveiw into the condition and the basic science.

What kind of chemo? It appears you are not fatigued on chemo but when you get off chemo you are. Must have been some good chemo or a chemo w/ very little side effects? maybe a Hh antagonist? I would think the chemo with CFS would make it worse? If you had a specific targeting chemo molecule maybe that can help you explain some of your side effects such as CFS going quiescent.

Edited by Hedgehog, 19 June 2008 - 07:34 PM.

[vitaminboss]

The fact of the matter here is that you couldn't find a better lab rat example to test Resv than myself. CFS is known to be a sub-clinical metabolic disorder, primarily focused on mitochondrial dysfunction. Its a chicken & egg example. Mito's starve, leads to neurological/glandular, cardiovascular, immune and muscular impairment. Once the brain and glands starve of energy for a while, the hypothalamus goes haywire sending the entire system off homeostasis affecting system wide metabolism and ultimately gene expression... Step away from cancer, which then kicked in, followed by CHEMO which threw the cherry on the cake as far as DNA damage.. ANYWAY this isnt a CFS forum.

Are you talking about Chronic Fatigue Syndrome? If so there are a lot of other things that can cause this.

CFS is often associated with viral infection, although the presence of viruses has as yet not been consistently detected. (2) It is not clear whether anomalies of the HPA axis often observed in CFS, are cause or the consequences of the disorder. (3) Immune dysfunction as the cause of CFS is another hypothesis. (4) The psychiatric and psychosocial hypothesis denies the existence of CFS as a disease entity. Accordingly, the fatigue symptoms are assumed to be the consequence of other (somatic) diseases. Other possible causes of CFS are (5) oxidative stress and (6) genetic predisposition. ^{[2] [3]} Or it may be due to a combination of several of these factors. Whilst many hypotheses about CFS are made on the basis of specific findings others are proposed as a result of wider literature reveiw into the condition and the basic science.

What kind of chemo? It appears you are not fatigued on chemo but when you get off chemo you are. Must have been some good chemo or a chemo w/ very little side effects? maybe a Hh antagonist? I would think the chemo with CFS would make it worse? If you had a specific targeting chemo molecule maybe that can help you explain some of your side effects such as CFS going quiescent.

Dude i'm done with chemo, since last year. My issues with Chronic Fatigue Syndrome have lingered for YEARS on and off. The last relapse happened 5 years ago 2 years before the cancer was diagnosed. This time the relapse was more of a complete adrenal crisis (similar to addisons). Massive loss of weight, constant nausea, sensitivity to cold etc. By the time i went to the doctors, nobody could diagnose anything. Just an fyi, my CFS can be traced back to infectious Mononucleosis i had when i was 18. After a few years of the infections coming back once in a while, thats when the nervous system issues began with fatigue, adrenal exhaustion and then ultimately collapse. Mind you, adrenal hormones are involved in glucose transport among other glucose involvement and energy metabolism in general. The reason any medically obvious adrenal abnormality cannot be identified is probably because the entie glandular system is dysfunctional due to the after effects of "glandular fever" the name for Mono in Europe..

The bottom line is, post chemo i'm back to square one. Although i did feel gradual improvement especially with the russian product, once I started RESV i felt reborn, little did i know it was utilizing all my reserves that I had built up to that point as fuel, furthering adrenal depletion by simply over-stimulating them. Basically like any other adaptogen/stimulant. PEOPLE, NOBODY HAS A RESVERATROL DEFICIENCY!! IT IS NOT, and i REPEAT, NOT A NECESSARY COMPONENT OF HUMAN METABOLISM, therefore IT INTERFERES, MANIPULATES, AND HIJACKS YOUR METABOLISM AND ENDOCRINE SYSTEM.. There is a reason studies call it an ENDOCRINE DISRUPTER...

Anthony, i have intelligent doctors overseas that I speak to. Why would I waist my time on dim-whits that can't help me and those who don't even know what Resveratrol is? Are you trying to make me sound insane just so you can actually sound intelligent? To be honest, I don't think your even FIT to run a nutriceutical business (I've been running a few for several years btw).. No offense of course :-)).

[Mind]

Anthony makes a good point here about concentrations. Almost every nutraceutical/supplement is concentrated x10, x100, x1,000 of what is found in nature. So far resv shows few side effects over a whole range of dosage.

There are many things a person can do to their body that changes their metabolism, endocrine function, and gene expression. Everything from over-eating, to drugs, to CR, to supplements. I am not sure why you are so upset about resveratrol in particular. It might have some long term negative side effects that come to light in a few years. Many people are willing to take that chance on resveratrol and many other supplements. They are experimenting with their bodies because they want to stay healthy longer and live longer. If people stuck with what they found in nature they would surely die, as did their ancestors. Supplements like resveratrol are just the tip of the iceberg when it comes to cellular and organ modification that will be needed to extend lives indefinitely. Much more radical treatments are in the pipeline.

[kenj]

Well, I didn't realize until Vitaminboss' recent posts that resveratrol is such a powerful ANTI-inflammatory compound. In Traditional Chinese Mecicine AFAIK a *blend* of nutrients is used for health and treating various disorders, - no super dose of one compound, so this is indeed a 1st for traditional medicine.
That said, I was out today this afternoon doing some High-Intensity Interval Training, and boy I was flying -- and I don't even feel any exertion or ache several hours later. I wonder how my nervous system is coping.

[Hedgehog]

Dude i'm done with chemo, since last year. My issues with Chronic Fatigue Syndrome have lingered for YEARS on and off. The last relapse happened 5 years ago 2 years before the cancer was diagnosed. This time the relapse was more of a complete adrenal crisis (similar to addisons). Massive loss of weight, constant nausea, sensitivity to cold etc. By the time i went to the doctors, nobody could diagnose anything. Just an fyi, my CFS can be traced back to infectious Mononucleosis i had when i was 18. After a few years of the infections coming back once in a while, thats when the nervous system issues began with fatigue, adrenal exhaustion and then ultimately collapse. Mind you, adrenal hormones are involved in glucose transport among other glucose involvement and energy metabolism in general. The reason any medically obvious adrenal abnormality cannot be identified is probably because the entie glandular system is dysfunctional due to the after effects of "glandular fever" the name for Mono in Europe..

The bottom line is, post chemo i'm back to square one. Although i did feel gradual improvement especially with the russian product, once I started RESV i felt reborn, little did i know it was utilizing all my reserves that I had built up to that point as fuel, furthering adrenal depletion by simply over-stimulating them. Basically like any other adaptogen/stimulant. PEOPLE, NOBODY HAS A RESVERATROL DEFICIENCY!! IT IS NOT, and i REPEAT, NOT A NECESSARY COMPONENT OF HUMAN METABOLISM, therefore IT INTERFERES, MANIPULATES, AND HIJACKS YOUR METABOLISM AND ENDOCRINE SYSTEM.. There is a reason studies call it an ENDOCRINE DISRUPTER...

Anthony, i have intelligent doctors overseas that I speak to. Why would I waist my time on dim-whits that can't help me and those who don't even know what Resveratrol is? Are you trying to make me sound insane just so you can actually sound intelligent? To be honest, I don't think your even FIT to run a nutriceutical business (I've been running a few for several years btw).. No offense of course :-)).

The bottom line is, post chemo i'm back to square one.

If your back to square one after chemo why don't you think the chemo had something to-do with it? Try to very the dosage. Until it stops hijacking your system or your endocrine system. A lot MD doctors don't care about nutriceuticasl there is little hard evidence that they work and they hardly go through a regulation process. Why would a MD doctor want to research something that is not FDA approved? maybe some docs are dim-wits but they don't want to waste their time on a non-approved treatment.

BTW: The way your write it doesn't appear you ARE FATIGUED at all.

[vitaminboss]

Dude i'm done with chemo, since last year. My issues with Chronic Fatigue Syndrome have lingered for YEARS on and off. The last relapse happened 5 years ago 2 years before the cancer was diagnosed. This time the relapse was more of a complete adrenal crisis (similar to addisons). Massive loss of weight, constant nausea, sensitivity to cold etc. By the time i went to the doctors, nobody could diagnose anything. Just an fyi, my CFS can be traced back to infectious Mononucleosis i had when i was 18. After a few years of the infections coming back once in a while, thats when the nervous system issues began with fatigue, adrenal exhaustion and then ultimately collapse. Mind you, adrenal hormones are involved in glucose transport among other glucose involvement and energy metabolism in general. The reason any medically obvious adrenal abnormality cannot be identified is probably because the entie glandular system is dysfunctional due to the after effects of "glandular fever" the name for Mono in Europe..

The bottom line is, post chemo i'm back to square one. Although i did feel gradual improvement especially with the russian product, once I started RESV i felt reborn, little did i know it was utilizing all my reserves that I had built up to that point as fuel, furthering adrenal depletion by simply over-stimulating them. Basically like any other adaptogen/stimulant. PEOPLE, NOBODY HAS A RESVERATROL DEFICIENCY!! IT IS NOT, and i REPEAT, NOT A NECESSARY COMPONENT OF HUMAN METABOLISM, therefore IT INTERFERES, MANIPULATES, AND HIJACKS YOUR METABOLISM AND ENDOCRINE SYSTEM.. There is a reason studies call it an ENDOCRINE DISRUPTER...

Anthony, i have intelligent doctors overseas that I speak to. Why would I waist my time on dim-whits that can't help me and those who don't even know what Resveratrol is? Are you trying to make me sound insane just so you can actually sound intelligent? To be honest, I don't think your even FIT to run a nutriceutical business (I've been running a few for several years btw).. No offense of course :-)).

The bottom line is, post chemo i'm back to square one.

If your back to square one after chemo why don't you think the chemo had something to-do with it? Try to very the dosage. Until it stops hijacking your system or your endocrine system. A lot MD doctors don't care about nutriceuticasl there is little hard evidence that they work and they hardly go through a regulation process. Why would a MD doctor want to research something that is not FDA approved? maybe some docs are dim-wits but they don't want to waste their time on a non-approved treatment.

BTW: The way your write it doesn't appear you ARE FATIGUED at all.

Chemo had EVERYTHING TO DO WITH IT!!! Cisplatin is one of the drugs that was used. Whats really interesting and very IRONIC is that Cisplatin damages the Neuro-Endocrine system.. Starting with the diencephalic brain structures, to the adrenals and periphery.. A real cherry on the sundae in my case.. Thank G-d i got treated at Leonardis Klinik in Germany, they gave me supportive IVs during and between treatments, like IV Piracetam 12 grams per day, IV Lipoic Acid, IV Glutathione, IV Ascorbic Acid, IV Ornithine L-Aspartate, and others. I went overseas for Chemo because I was so debilitated to handle American Chemo'n'go treatments, I was scared to death... ANYWAY, yea i'm not all that mentally fatigued because i'm taking a boatload of supplements and at the very least my cognitive function recovers the fastest (brain steals energy from the body). Keep in mind, the brain can be an energy HOG.. Besides, I'm doing a round of Cerebrolysin Injections (amazing peptidergic Nootrop) made in Austria. Been around for over 20 years I believe. Peptides extracted from pork brains which stimulate Neurotrophic factors and nerve regrowth. I think the USA is doing some phase III clinicals on this for Altzheimers... Its about time...

As far as doctors go, buddy we're on the same page, I don't think you understood me properly. That was exactly the point I made, although i do blame them for being dim-whits because today in the information age, they have NO EXCUSE not to be curious or read about nutriceuticals. Those that don;t, are either pure EVIL, or NAIVE.. FDA approved or not, the FDA is one of the rotten agencies aside from the AMA that keeps these white coat clowns misinformed and blinded from reality...

Edited by vitaminboss, 19 June 2008 - 10:56 PM.

[Hedgehog]

Sorry I must have grossly misread some of your posts. I have been in and out reading a few posts here and there...

Here is a study that supports the exercise idea. As for myself I'm not sure if resveratrol has really helped me or not. I cycle about 200+ miles every week. And while I;am getting stronger I'm not sure how much of it has to-do with resveratrol.


Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle.
Suwa M, Nakano H, Radak Z, Kumagai S. Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.

Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is considered to play a pivotal role in the exercise-induced metabolic adaptation of skeletal muscle. Although the oxidized form of nicotinamide adenine dinucloetide (NAD(+))-dependent histone deacetylase SIRT1 has been shown to mediate PGC-1alpha-induced metabolic adaptation, the effect of endurance exercise on the SIRT1 protein remains to be elucidated. The purposes of this study were (1) to investigate the distribution of SIRT1 and PGC-1alpha proteins in skeletal muscle and (2) to examine the effects of acute endurance exercise and low- or high-intensity exercise training on SIRT1 and PGC-1alpha protein expressions and on the metabolic components in rat skeletal muscle. Both the SIRT1 and PGC-1alpha proteins preferentially accumulate in red oxidative muscles. Acute endurance exercise on a motor-driven treadmill (20 m/min, 18.5% incline, 45 minutes) increases the PGC-1alpha protein expression at 18 hours after exercise and the SIRT1 protein expression at 2 hours after exercise in the soleus muscle. In the training experiment, the rats were divided into control, low-intensity (20 m/min, 18.5% incline, 90 min/d), and high-intensity (30 m/min, 18.5% incline, 60 min/d) training groups. After 14 days of training, the SIRT1 and PGC-1alpha proteins, hexokinase activity, mitochondrial proteins and enzyme activities, and glucose transporter 4 protein in the soleus muscle were increased by both trainings. In the plantaris muscle, SIRT1, hexokinase activity, mitochondrial proteins and enzyme activities, and glucose transporter 4 were increased by high-intensity training whereas the PGC-1alpha was not. These results suggest that endurance exercise increases the skeletal muscle SIRT1 protein content. In addition, the findings also raise the possibility that the SIRT1 protein expression may play a potentially important role in such adaptations, whereas an increase in the PGC-1alpha protein expression is not necessary for such adaptations

[Anthony_Loera]

To be honest, I don't think your even FIT to run a nutriceutical business (I've been running a few for several years btw).. No offense of course :-))

Hi V,

Maybe you are right regarding my fitness...
If you believe that I have to be at the peak of my game with 2% or less body fat, and exercising everyday... Well, I am definitely not that.

I don't exercise too much at all, I consider myself an 'office worker'. Trying to lift my son up and over into a bunch of pillows is getting harder and harder as he grows and get's heavier. (BTW: I consider that my 'aerobic' part of the day... hehe.) My wife thinks I should start to go to Bally's since it's on my route to the shipping office we have, although I think I prefer the LA Fitness that is closer to the facility where we encapsulate products. Either way, I agree... I am not as fit as I would like to be.

Now... we also don't run your typical "nutriceutical" business, and that's ok. All I can tell you is that "making sales" is not our ultimate goal, we simply have other goals that take precedence.

I am not sure if we have met, but by your post you appear to state that you have met me. May I ask your real name and the businesses you run? Most folks posting here who run businesses like myself, Relentless Improvement, and Biotivia usually post these things.

Cheers
A

[mikeinnaples]

To be honest, I don't think your even FIT to run a nutriceutical business (I've been running a few for several years btw).. No offense of course :-))

I feel the oppressive weight of irony crushing my soul.

[kenj]

Vitaminboss, it struck me perhaps get your cortisol up before taking resveratrol continuously.

Horm Res. 2005;64(6):280-6. Epub 2005 Nov 1.
Phytoestrogen resveratrol suppresses steroidogenesis by rat adrenocortical cells by inhibiting cytochrome P450 c21-hydroxylase.Supornsilchai V, Svechnikov K, Seidlova-Wuttke D, Wuttke W, Söder O.
Pediatric Endocrinology Unit, Q 2:08, Department of Woman and Child Health, Karolinska University Hospital, Stockholm, Sweden. Vichit.Supornsilchai@kbh.ki.se

BACKGROUND AND AIM: The phytoestrogen resveratrol is found in grapes, mulberries and peanuts, all of which are consumed regularly by humans. Resveratrol is also used in chemotherapy against cancer and aging and as a cardioprotectant. The aim of the present study was to characterize the effects of resveratrol on rat adrenal steroidogenesis and to study the underlying mechanism. METHODS: Adrenocortical cells were isolated from the adrenal glands of normal male rats (in vitro) and from male rats administered resveratrol in their diet for 12 weeks (ex vivo). Cells from resveratrol-treated and non-treated rats were tested ex vivo for responsiveness to ACTH and cells from normal rats were tested in vitro for responsiveness to ACTH in the presence and absence of resveratrol. Corticosterone and progesterone production were measured by RIA and expression of steroidogenic enzymes analyzed by PAGE/Western blotting. RESULTS: Corticosterone production was inhibited 47% by 50 microM resveratrol in vitro and 20% ex vivo, while progesterone production was elevated to 400% of the control value in in vitro experiments. Resveratrol treatment decreased adrenal cytochrome P450 c21-hydroxylase expression in vivo and cell culture conditions. No changes in cell viability or morphology were caused by exposure to resveratrol in both ex vivo and in vitro experiments. CONCLUSION: Resveratrol suppresses corticosterone production by primary rat adrenocortical cell cultures in vitro and ex vivo by inhibiting cytochrome P450 c21-hydroxylase. Copyright 2005 S. Karger AG, Basel

[robyn]

You can probably do much more than 500 mg. per day. I have been taking a blend of 400mg resveratrol and 100mg blend of quesrcetinand grapeseed extract, all in one capsule for almost 2 months now. Maintenance dose is two caps per day, but due to hypertension and cardiac issues, I take 4-5 caps per day. So I am taking at the minimum, 1600 mgs per day of the resveratrol. I had energy response at first, but have been pushing thruogh a longer detox stage due to all the meds I have been on for cardiac stuff. I expect to feel an upswing at about 3 months.

I know a doctor who had stage 4 lymphoma with large golf ball size tumor in his back who started taking this in Jan. He took usually 8 caps a day. It is now July and he no longer has the tumor and was declared to be in remission 2 months ago. My close friend underwent bladder cancer surgery in Nov. 2007. She had a completely clean scope checkup last week and the surgeon could not find where he cut on her to remove the cancer. completely smooth bladder wall. Her husband had skin cancer all over his face and ears. Five months of taking the resveratrol dose and it is gone. he was so excited about this that he asked me to feel the rims of his ears. it was a strange request, but I like him, so I agreed and both were smooth with no crustiness to them.

[maxwatt]

You can probably do much more than 500 mg. per day. I have been taking a blend of 400mg resveratrol and 100mg blend of quesrcetinand grapeseed extract, all in one capsule for almost 2 months now. Maintenance dose is two caps per day, but due to hypertension and cardiac issues, I take 4-5 caps per day. So I am taking at the minimum, 1600 mgs per day of the resveratrol. I had energy response at first, but have been pushing thruogh a longer detox stage due to all the meds I have been on for cardiac stuff. I expect to feel an upswing at about 3 months.

I know a doctor who had stage 4 lymphoma with large golf ball size tumor in his back who started taking this in Jan. He took usually 8 caps a day. It is now July and he no longer has the tumor and was declared to be in remission 2 months ago. My close friend underwent bladder cancer surgery in Nov. 2007. She had a completely clean scope checkup last week and the surgeon could not find where he cut on her to remove the cancer. completely smooth bladder wall. Her husband had skin cancer all over his face and ears. Five months of taking the resveratrol dose and it is gone. he was so excited about this that he asked me to feel the rims of his ears. it was a strange request, but I like him, so I agreed and both were smooth with no crustiness to them.

I'm glad you both were smooth with no crustiness .....

Sorry, couldn't resist.

I had what appeared to be a basal cell carcinoma. I mixed 98% resveratrol in skin cream (with CoQ10 as well) and applied it, holding it on with a water-proof bandate overnight for several days. By the time I got to my doctor to confirm what it was, it was gone, no trace.

[sUper GeNius]

You can probably do much more than 500 mg. per day. I have been taking a blend of 400mg resveratrol and 100mg blend of quesrcetinand grapeseed extract, all in one capsule for almost 2 months now. Maintenance dose is two caps per day, but due to hypertension and cardiac issues, I take 4-5 caps per day. So I am taking at the minimum, 1600 mgs per day of the resveratrol. I had energy response at first, but have been pushing thruogh a longer detox stage due to all the meds I have been on for cardiac stuff. I expect to feel an upswing at about 3 months.

I know a doctor who had stage 4 lymphoma with large golf ball size tumor in his back who started taking this in Jan. He took usually 8 caps a day. It is now July and he no longer has the tumor and was declared to be in remission 2 months ago. My close friend underwent bladder cancer surgery in Nov. 2007. She had a completely clean scope checkup last week and the surgeon could not find where he cut on her to remove the cancer. completely smooth bladder wall. Her husband had skin cancer all over his face and ears. Five months of taking the resveratrol dose and it is gone. he was so excited about this that he asked me to feel the rims of his ears. it was a strange request, but I like him, so I agreed and both were smooth with no crustiness to them.

I'm glad you both were smooth with no crustiness .....

Sorry, couldn't resist.

I had what appeared to be a basal cell carcinoma. I mixed 98% resveratrol in skin cream (with CoQ10 as well) and applied it, holding it on with a water-proof bandate overnight for several days. By the time I got to my doctor to confirm what it was, it was gone, no trace.

No shit, that's amazing. I wonder what the stuff would do to dysplastic moles. I've been afraid to experiment, thinking that it might actually promote a malignant change to the mole. I wonder whether t-res would be effective against melanoma?

[tintinet]

You can probably do much more than 500 mg. per day. I have been taking a blend of 400mg resveratrol and 100mg blend of quesrcetinand grapeseed extract, all in one capsule for almost 2 months now. Maintenance dose is two caps per day, but due to hypertension and cardiac issues, I take 4-5 caps per day. So I am taking at the minimum, 1600 mgs per day of the resveratrol. I had energy response at first, but have been pushing thruogh a longer detox stage due to all the meds I have been on for cardiac stuff. I expect to feel an upswing at about 3 months.

I know a doctor who had stage 4 lymphoma with large golf ball size tumor in his back who started taking this in Jan. He took usually 8 caps a day. It is now July and he no longer has the tumor and was declared to be in remission 2 months ago. My close friend underwent bladder cancer surgery in Nov. 2007. She had a completely clean scope checkup last week and the surgeon could not find where he cut on her to remove the cancer. completely smooth bladder wall. Her husband had skin cancer all over his face and ears. Five months of taking the resveratrol dose and it is gone. he was so excited about this that he asked me to feel the rims of his ears. it was a strange request, but I like him, so I agreed and both were smooth with no crustiness to them.

I'm glad you both were smooth with no crustiness .....

Sorry, couldn't resist.

I had what appeared to be a basal cell carcinoma. I mixed 98% resveratrol in skin cream (with CoQ10 as well) and applied it, holding it on with a water-proof bandate overnight for several days. By the time I got to my doctor to confirm what it was, it was gone, no trace.

No shit, that's amazing. I wonder what the stuff would do to dysplastic moles. I've been afraid to experiment, thinking that it might actually promote a malignant change to the mole. I wonder whether t-res would be effective against melanoma?

Ya. Dangerous to mess with small furry animals, especially dysplastic ones!

I would be nice to have a cure for melanoma, though.

[malbecman]

That's a nice finding, I've had several BCCs already (being an Anglo-Saxon in sunny CA) and will try that next time. Of course, I've not had any recently but maybe that is due to my supplementation.....

I had what appeared to be a basal cell carcinoma. I mixed 98% resveratrol in skin cream (with CoQ10 as well) and applied it, holding it on with a water-proof bandate overnight for several days. By the time I got to my doctor to confirm what it was, it was gone, no trace.

[fast turtle]

Resveratrol is not a stimulant, if you believe it will make you feel great from day one, and that is your purpose for taking it... then I will ask you to stop taking it. Most honest descriptions of benefits I have heard, come after 6 weeks. If that is too long a time period for you (or anyone reading this post) then it may that some personal habits need to be extended to encompass the longer regimen needed to see if Resveratrol will help provide you good health benefits.

Resveratrol is not a stimulant, but if you're getting the 50% product that consists largely of emodin as well, you are likely experiencing the effects of MAO-B inhibition from that compound (emodin is a very potent MAO-B inhibitor). MAO-B inhibition increases the amount of dopamine in the brain and may cause some stimulant-like effects. Unfortunately, emodin is also a known nephrotoxin, and the consumption of large amounts of emodin may damage the kidneys.

As for RES; I'm taking 500mg a day of the 99.7% batch sublingually daily and I've noticed since taking it that I start to feel hot and nauseous about 4-6 hours later, and this then persists for several hours. Anyone else have this sort of side effect? I've only been using this stuff about a week so far.

Edited by fast turtle, 22 July 2008 - 10:03 PM.

[craigb527]

I have noticed several people concerned over Resveratrol doses, etc. From what I read over the internet, it is non toxic even at large doses. I was taking about 10 grams a day for about two weeks in a row and did not suffer from any sickness. I quit taking it for a while, but I am going to start back. What it did was gave me much more endurance when it came to lifting weights, I could do far more reps. After I quit taking the large doses, the increased endurance went away.
I have been reading on the internet about how bad fluoride is for you, http://www.preferred...E_STUPIDITY.htm , and I am wondering if there is anything to counteract the negative effects of it (Iodine?) and also what the general consensus is on how bad it is actually for you. Also, I drink bottled water, but that too seems to contain fluoride. Is there a name brand water without fluoride? I apologize if this is the wrong spot to post fluoride stuff, I am just used to posting here.

[maxwatt]

I have noticed several people concerned over Resveratrol doses, etc. From what I read over the internet, it is non toxic even at large doses. I was taking about 10 grams a day for about two weeks in a row and did not suffer from any sickness. I quit taking it for a while, but I am going to start back. What it did was gave me much more endurance when it came to lifting weights, I could do far more reps. After I quit taking the large doses, the increased endurance went away.
I have been reading on the internet about how bad fluoride is for you, http://www.preferred...E_STUPIDITY.htm , and I am wondering if there is anything to counteract the negative effects of it (Iodine?) and also what the general consensus is on how bad it is actually for you. Also, I drink bottled water, but that too seems to contain fluoride. Is there a name brand water without fluoride? I apologize if this is the wrong spot to post fluoride stuff, I am just used to posting here.

There was a long thread on fluoride in the supplements section last year. The scientific consensus seemed to be that the amounts in drinking water aren't going to hurt you. The information on the website you gave is so ignorant and inaccurate it isn't even wrong. If you want to counter the negative effects of fluoride, I believe the energy from crystals can purify it.

[sUper GeNius]

I have noticed several people concerned over Resveratrol doses, etc. From what I read over the internet, it is non toxic even at large doses. I was taking about 10 grams a day for about two weeks in a row and did not suffer from any sickness. I quit taking it for a while, but I am going to start back. What it did was gave me much more endurance when it came to lifting weights, I could do far more reps. After I quit taking the large doses, the increased endurance went away.
I have been reading on the internet about how bad fluoride is for you, http://www.preferred...E_STUPIDITY.htm , and I am wondering if there is anything to counteract the negative effects of it (Iodine?) and also what the general consensus is on how bad it is actually for you. Also, I drink bottled water, but that too seems to contain fluoride. Is there a name brand water without fluoride? I apologize if this is the wrong spot to post fluoride stuff, I am just used to posting here.

There was a long thread on fluoride in the supplements section last year. The scientific consensus seemed to be that the amounts in drinking water aren't going to hurt you. The information on the website you gave is so ignorant and inaccurate it isn't even wrong. If you want to counter the negative effects of fluoride, I believe the energy from crystals can purify it.

What about a copper bracelet?

[craigb527]

There was a long thread on fluoride in the supplements section last year. The scientific consensus seemed to be that the amounts in drinking water aren't going to hurt you. The information on the website you gave is so ignorant and inaccurate it isn't even wrong. If you want to counter the negative effects of fluoride, I believe the energy from crystals can purify it.

Thanks. Hows it going Max. I agree the website seems to be skewed towards its own agenda. I listed it here because it was very negative towards fluoride and I wanted to ascertain what, if any, of it was true. From what I have seen on more realistic websites are the negatives of fluoride far outweigh the positives. That is assuming there are any positives at all. Most studies that I have read say there are not.
Anyway, I drink Deer Park bottled water which is said to contain natural flouride? , but is not supposed to have it specifically added to it.

Edited by craigb527, 25 July 2008 - 10:20 PM.

[maxwatt]

There was a long thread on fluoride in the supplements section last year. The scientific consensus seemed to be that the amounts in drinking water aren't going to hurt you. The information on the website you gave is so ignorant and inaccurate it isn't even wrong. If you want to counter the negative effects of fluoride, I believe the energy from crystals can purify it.

Thanks. Hows it going Max. I agree the website seems to be skewed towards its own agenda. I listed it here because it was very negative towards fluoride and I wanted to ascertain what, if any, of it was true. From what I have seen on more realistic websites are the negatives of fluoride far outweigh the positives. That is assuming there are any positives at all. Most studies that I have read say there are not.
Anyway, I drink Deer Park bottled water which is said to contain natural flouride? , but is not supposed to have it specifically added to it.

http://www.imminst.o...amp;hl=fluoride
\http://www.imminst.o...amp;hl=fluoride

"Natural" fluoride is enough to cause fluoridosis in some parts of Texas and other places. This is marketing gimmick on the part of Deer Park.

Fluoride Positive effect = improved dental health, which is obtainable by other means.
Mass fluoridation of water may be harmful for some portion of the population, but for most people it is not something to worry about.

[bixbyte]

You can probably do much more than 500 mg. per day. I have been taking a blend of 400mg resveratrol and 100mg blend of quesrcetinand grapeseed extract, all in one capsule for almost 2 months now. Maintenance dose is two caps per day, but due to hypertension and cardiac issues, I take 4-5 caps per day. So I am taking at the minimum, 1600 mgs per day of the resveratrol. I had energy response at first, but have been pushing thruogh a longer detox stage due to all the meds I have been on for cardiac stuff. I expect to feel an upswing at about 3 months.

I know a doctor who had stage 4 lymphoma with large golf ball size tumor in his back who started taking this in Jan. He took usually 8 caps a day. It is now July and he no longer has the tumor and was declared to be in remission 2 months ago. My close friend underwent bladder cancer surgery in Nov. 2007. She had a completely clean scope checkup last week and the surgeon could not find where he cut on her to remove the cancer. completely smooth bladder wall. Her husband had skin cancer all over his face and ears. Five months of taking the resveratrol dose and it is gone. he was so excited about this that he asked me to feel the rims of his ears. it was a strange request, but I like him, so I agreed and both were smooth with no crustiness to them.

I'm glad you both were smooth with no crustiness .....

Sorry, couldn't resist.

I had what appeared to be a basal cell carcinoma. I mixed 98% resveratrol in skin cream (with CoQ10 as well) and applied it, holding it on with a water-proof bandate overnight for several days. By the time I got to my doctor to confirm what it was, it was gone, no trace.

I had this spot on my right arm that looked like a possible suspicious cancer to me and made an appointment with a dermatologist after my family MD examined and referred me.

Unfortunately I should have taken a before and after photo.

I applied 98% DMSO mixxed with 98% Resveratrol directly to the site with a q-tip.
The Res powder "clung" to the site and when I would shower the white powder remained attached to the skin.
It was like applying make-up.
I continued to build up white layers for a couple days.
The site was itchy and pure white and looked like make-up or white paint directly on my skin.
After a couple weeks the "cancerous" like spot just fell off.
A few weeks later, I showed the site to a dermatologist and she said there was nothing there.
After explaining to her that I applied DMSO and RES to the skin.
She laughed and said if you have skin cancer, you have skin cancer and nothing takes it away.
The derm mentioned that people always apply various things.
Wish I had taken a before and after picture.

[tintinet]

Malarky. Skin cancer can be destroyed by any number of things, including those dermatologists may employ.

[jCole]

Day three of taking 99% RevGen P99.

500mg first thing in the morning, then another 500mg just before bed via Buccal delivery.

One thing I noticed, is I definitely get a very noticeable rush or buzz via this method, but if I mix it into a protein drink mixed with soy milk, I do not. Not sure if that's a indicator Buccal is far more effective for me or if there is some other mechanism at work happening here when absorbed via the mouth.

Dream recall and lucidity is amazingly better. I never remember my dreams, ever... but the last couple of nights have been pretty intense. One dream last night was visiting TFI after he beat his cancer.


Have not worked out yet, as I am on a week break, which I do every 7 weeks. Will see what happens on Monday.

[getmarkus]

Hello everyone,

Over the past 6 months I've been lurking on this forum taking in all the information exchanges members share. I figured it was time to introduce myself to the boards and thought the "500 club" was a great place to do it. To make a long story short I decided to take resveratrol after finding Sirtis via some financial stock research I was doing. This also happened to be at the same time in my life when I decided it was time to change some very bad health habits. After being extremely sedentary for over 10 years I decided to renew some old habits and start to workout and eat properly.

I am currently taking 1000mg micronized resveratrol on heavy workout days (M, W, F) and 500mg on off days (T, Th, S, Su). I've been taking resveratrol since May and have been on my current dosing routine for approximately 2-3 weeks. My gains in the gym and losses on the scale have been more then expected since starting my "new healthier lifestyle. I've lost 3 inches in the waist, 7% body fat (21.5 to 14.5), 10 lbs, and have increased muscle mass. My energy levels have been increased, my sleep pattern has remained unchanged but I feel more rested, and my cholesterol levels have remained in good ranges (this was a problem for me).

I can't attribute my positive changes solely to resveratrol. For all I know it is all just one big placebo effect. However, I do believe my results are from hard work, a better diet, and resveratrol combined. I find it hard to believe I could achieve what I have in such a short period of time without the resveratrol to help. Unfortunately, I am not sure I will ever know the truth behind that.

jCole, I read in your previous post you had a "buzz" or "rush" that you felt. I get this same feeling and it is intensified on 1000mg days. Even more so now that I am on the micronized version. I am interested to hear your results when you get back to working out. I also take a week off to "cleanse" my system, usually every 12 weeks.

That's all for now but I look forward to sharing more in the near future and learning more from you all.

Live Longer,

Markus

[davidd]

Hello,

Like getmarkus, I've been reading a lot of the information on here and I figured it was about time to give back by simply sharing my experiences with resveratrol. I started taking resveratrol after my dad mentioned seeing the Barbara Walter's special on living to 150. I googled around and ended up on this site, where I learned a lot about the chemical. However, it wasn't really the life extension aspects that caused me to start taking it. More below...

(Note: Very verbose post to follow, but maybe it will help someone else, which is why I'm taking the time to write this.)

My stats:

37 years old
6'1", 195 pounds
blood pressure historically has been 140/90 (may be lower now, not enough data yet)
cholesterol 155 total, 35 HDL (slightly below standard range of 40-110), 108 LDL, 12 VLDL, 62 triglycerides
very little exercise and desk job
I don't drink anything with caffeine in it (only caffeine would be from things like chocolate)


I started (after a very short ramp up period) with the following:

4 Country Life Resveratrol Plus capsules per day (400mg resveratrol total)
(http://www.country-l...412#Ingredients)
This is 100mg resveratrol per capsule from 200mg knotweed extract (so 50% pure), but also has other things like grape seed extract, grape skin extract and pine bark extract in it.
This was taken as 200mg with breakfast and 200mg with dinner.

6 Doctor's Best Quercetin Bromelain capsules per day (1500mg Quercetin total)
http://www.drbvitami...=43#Ingredients
This is 250mg Quercetin and 125mg Bromelain per capsule.
This was taken as 750mg with breakfast and 750mg with dinner.

2 multivitamins per day.
These are taken as 1 with breakfast and 1 with dinner.

I took the above for about 10 weeks.

Now, before the above, I took the following combination for several years, with the last few being pretty much what is below. Explanation to come.

2 multivitamins per day (1 with breakfast, 1 with dinner)
2 65mg iron supplements per day (1 with breakfast, 1 with dinner)

Currently, I am taking the following and have been for about 2 weeks:

6 Country Life Resveratrol Plus capsules per day (600 mg, 50% pure resveratrol 300mg with breakfast, 300mg with dinner)

2 multivitamins (1 with breakfast, 1 with dinner)


Why was I taking all the iron? I have a condition known as Gilbert's Syndrome (http://www.cnn.com/H...y/DS/00743.html), where I have elevated bilirubin in my blood (normal range is .2 to 1.3mg/dL, and I'm anywhere from 1.5 to 3.1 in the past 6 years). For me (and some others with the condition) this causes fatigue and lack of energy. I also have abdominal pain that may be attributed to it. Also some jaundice of the eyes and bodily fluids (semen).

I could speculate on how my condition might affect conjugation of resveratrol, but it's complex and mostly beyond my lay person understanding.

Someone recommended iron several years ago, so I tried it and it worked. And this wasn't just a coincidence. I would *know* when I had forgotten to take the iron due to tiredness later in the day. It also lowered the jaundice of the eyes a bit, but there was still some yellowing of bodily fluids.

The other thing that would *completely* remove the yellowing of eyes/fluids was if I drank the night before. I rarely drink, but when I have in the past, it was remarkable how easily I could wake up in the morning and the bright whiteness of my eyes.

My simplistic guesses on why the iron/alcohol had these effects? Bilirubin is a very powerful antioxidant (http://pediatrics.aa...full/113/6/1776). I'm actually lucky, in a way, because I'm rarely sick and I think the bilirubin has something to do with that. Iron and alcohol cause oxidative stress and increase free radical activity. By taking iron (or drinking), I believe I was reverse scavenging my scavengers. In other words, I think I was cancelling out some of the excess bilirubin, which was "used up" protecting my body from the free radicals.

So if I found the secret formula for my situation, why did I stop taking the iron? I was worried about the damage the excess iron may have been doing to my body. I had aches and pains, mostly in my joints. Excess iron has been shown to exacerbate arthritis. I had a hunch for a while that the iron was to blame, but I really didn't want to go back to being tired all the time. Then, when reading all about resveratrol, I started wondering... Seemed like resveratrol was generally good for cells (very simplistic) and I read that some people noticed increased energy levels. Of course, the added benefit of potential life extension wasn't lost on me either, nor were the potential anti-viral/anti-cancer benefits.

This was enough for me to try it. I read about the lack of bioavailability too, and although I know there is much debate on this topic, I decided to take it with quercetin in the hopes to increase bioavailability. I switched, overnight, from taking an extra 130 mg of iron daily (in addition to the 30 mg from the two multivitamins, so over 10 times the recommended daily allowance total) to just taking the 30 mg of iron from the multivitamins and the resveratrol and quercetin. I also started my wife on a lower amount of quercetin and resveratrol to see if would help with her migraine/cluster headaches and some fatigue she had as well. Quercetin and bromelain are supposed to be anti-inflammatory.

Results:

- I noticed an almost immediate energy boost. I'm speaking of within 1 day of taking the resveratrol/quercetin. I had to go with little sleep for a few days and was not nearly as tired as I would have been before. I wasn't sleepy after lunch either, which was typical for me. My wife was skeptical, but she became a believer after she started taking it too (she had low energy from what the doctors thought was endometriosis, but surgery revealed a very deformed/enlarged appendix that was removed). She can't even take the quercetin at night, or she can't sleep. I don't have that problem. I can't explain this immediate energy boost, I can only report it. I gave a bottle of resveratrol to a lady at work and she reported the same thing.

- I also didn't get a type of headache that I used to get with lack of sleep/food. It seems to help my wife with her migraines, but she does still get them. Maybe just not as severe or often. She isn't as regular with her supplement taking. It varies from day to day.

- I'm not sure when this started happening, but I noticed that if I exerted myself, using muscles that I normally don't use, I wouldn't be sore the next day. For example, I played catch with a football with some teenagers, where we were throwing the ball long distances (long for me). We did this for a couple hours. I would have normally been very stiff and sore the next day. I hardly noticed anything the next day. This would have been maybe about a month (guessing) after I started taking the quercetin/resveratrol.

- My jaundice of the eyes remained low. Oddly enough, bodily fluids were tinted very bright yellow. I attributed this to the quercetin, which is yellow in color and have since proved this by taking quercetin out of my diet and all yellow is gone.

- Over a period of weeks, the aches and pains were gone. I don't feel like an old man when I get up from a sitting position or get out of bed in the morning. I attribute this to reducing the iron, but it could also be that the quercetin/bromelain/resveratrol sped the healing process too. No pains now that I've only been on resveratrol for the past 2 weeks either.

- My cholesterol has always been low when I've had it tested, and since I don't have it tested often, I can't say whether there has been an effect.

- My blood pressure has *always* been 140/90 (what used to be considered borderline high blood pressure, but now that they changed the ranges, they consider it high). Even when I was running cross country in high school, competing at a high level, and was in the best shape of my life, it was still 140/90. It hasn't increased since then and until recently hadn't decreased. A while after I started taking the quercetin/resveratrol, I noticed that I'd sometimes get a 130something/80something on the blood pressure machines at the drug stores. This was rare for me. I recently bought a home machine and will be monitoring and recording my blood pressure over time to see whether there are any trends. The good news is that my high bilirubin may be keeping my arteries limber, and my cholesterol isn't high, and my heart is in good shape (more on that further down), so it doesn't seem to be a big health risk for me.

- I injured my lower back doing some lifting in my early 20's. Every so often, it will flair up and I'll get pain in my back and down my left leg (sciatica). I've only had a tinge of this since starting the supplements. Now, it could be that I'm more active in the summer than in winter and it does happen more when I'm less active, but I do think it is abnormal for me to go this long without having this flair up.

- Now here's a rather interesting situation that will make this long post even longer. About a month ago, I was in a hardware store. I needed to get a roll of rubber membrane off the floor, under a low shelf. These rolls weigh 60 pounds and are about a foot in diameter and about 6 feet long. In other words, it was an awkward thing to get out of a tiny space and I had to lift it over a couple vertical bars that they had in place to keep the things from rolling into the isle. I was doing all the lifting with my upper body, bent over at the waste, with my butt in the air. I say this, because my upper body was basically upside down, which is probably important for what happened.

I lifted the thing up and it tried to roll out of my arms, so I had to lunge and catch it. I then walked down the isle and put it in the cart. Within several seconds, I noticed a pain the center of my chest. Pain and tightness. I wasn't too worried, but after a couple minutes, it was not going away and was getting worse. A quick google on my phone for heart attack symptoms got me even more worried. I was sweating and had a pain in the center of my chest that wasn't going away. The information I read said that time is of the essence if you are having a heart attack and that you should really get in an ambulance ASAP.

So here I was, a typical guy who never goes to the doctor, never has anything wrong with me, and yet I've got all the signs of a heart attack. After 5 to 10 minutes without the pain going away, I went out and sat in my car for a minute or two and then decided I better call 911. "Better safe than sorry" and "I've got two kids" won out over male ego.

I'd say it was about 20 minutes until I was in the ambulance from when this thing started. They gave me some nitroglycerin and did an EKG. The pain went down. I think they gave me more nitro before we got to the ER too. The EKG in the ambulance looked fine.

In the ER, they ended up doing another EKG, chest x-rays, and blood tests. Everything checked out fine. The doctor said that EKGs are only about 50% of the story, so he scheduled me for a echo stress test (ultrasound of heart before and after a treadmill stress test) the following Thursday. All this happened on a Saturday and they don't do them on the weekends.

I did talk over possible causes with him and my best guess (I think he agreed) is that it was probably an esophageal spasm brought on by the weird angle I was lifting at and the grunting which maybe caused some acid to make its way too far north.

There was pain in my chest for about a week or so afterward, but it was mild. Just enough that I knew it was there.

Now the interesting part. I go to the stress test the following Thursday. I'm thinking I'm going to get tired pretty fast, because I get very little exercise. I'm on the treadmill walking and walking and walking as they raise the speed/incline. I'm thinking, geez, how long is this test?? And they said I'd know when I can't go any further, but I certainly wasn't feeling anywhere close to that. The woman conducting the test is saying I'm doing wonderfully. At 5 mph, I'm still walking and they are saying it is odd to have someone walk at that speed instead of run. The incline was at 18% at that time (it started at 1.7mph and 10% incline). I'm watching the meter and watching my heart rate continue to slowly increase, but I'm still feeling fine. She keeps telling me the EKG is fine. When they switched it from 5 mph to 5.5, my heart rate was at 190 and I started to jog. A minute into this level, my heart rate was 197 and I'm still wondering just how long I should keep going, because I wasn't ready to drop over (although I wasn't perfectly fresh either). I had been on the treadmill for 15 minutes by this time.

I didn't really go into it thinking about my endurance, except that I wondered if I'd be able to go long enough for them to see what they wanted to see. As I watched my heart rate, I thought maybe I'd just get off when it got to 200 beats per minute. But when it reached 200, I still felt pretty good, so I kept going several more seconds. I then remembered that I had to be able to get off the treadmill quickly to lie down on the bed so that they could do the "after" ultrasound (they have to do this while the heart is still beating fast and it slows down quickly, so time is of the essence). I was concerned if I went to total exhaustion, I'd have a hard time getting off and into place quickly. I figured I better get off then and I did feel pretty tired by that point. I do think I could have gone another minute or so if I really wanted to push it though.

I stopped at 16:14 into the test, at 5.5 mph and 20% grade. My heart rate was 200 beats per minute. My blood pressure was 180/80 at the end (started at 140/80, with the diastolic dipping down at first and then going back up to 80 at the end, which I was told is a good sign of not truly having hypertension).

After the ultrasound (which would be analyzed later by a doctor and checked out fine), she went over the test results with me. She was amazed at how much effort I was able to put in and I don't think she believed that I don't exercise. I said something about how that was probably just because it is mostly elderly people they get in there and she said that they actually get a lot of younger people too, because the test is used for a multitude of things these days. And of course, the goals are age adjusted.

She showed me that my age predicted heart rate was 183, so I achieved 109% of my predicted maximum. The thing that surprised her the most was a measure called METS (stands for metabolic equivalents). I did some research on this since then. 1 METS would be the measure of oxygen used while at rest. The more activity, the more oxygen you use and the higher your METS value would be. Here is a chart of approximate METS values for various activities (http://healthfullife...ves/METsTbl.htm). Another way that athletes usually measure this is as VO2 max (maximum volume of oxygen consumed during high exertion).

For my age, the predicted METS is 11.0. I achieved 17.4 (this is either estimated, based on tests where actual oxygen consumed is measured and comparing you to the people who were measured, or it is calculated (even more of an estimate) based on different formulas, taking into account either the product of heart rate and blood pressure or time to exhaustion, like this calculator (http://www.exrx.net/.../Treadmill.html)).

As you can see, I'm way above the METS predicted for my age. In fact, the chart she had in the office only went down to 20 years old and I was still above what was predicted for a 20 year old. If my memory serves correctly, a 20 year old was predicted as having a METS of 13.5 (correlates with the chart on this page http://www.washingto...5082201133.html). So I'm still above the typical 20 year old by a sizeable margin.

Now, if I hadn't stopped running 7 miles per day 19 years ago, I would have expected I'd be significantly above the norm, because the norm is all people, athletes or not. Without exercising, I'd still think I'd be a little above the norm, because I'm not grossly overweight. But it seems like I'm way the heck above the norm.

Converting METS to VO2 max, I'm at about 60 (measured as milliliters of oxygen consumed per kilogram of body weight per minute). I'm not sure how this can really be converted, since VO2 max includes your weight and METS doesn't. I'm guessing they just use average weights. The following page shows a chart of various VO2 max values for men and women, at various ages, both non-athletes and athletes (for a number of sports). It also has some good information about VO2 max and what may influence it. (http://www.sport-fit...com/VO2max.html) It also talks about the theory that mitochondrial quantity and size may have some impact on VO2 max. A quick glance shows that I'm at about the average VO2 max level for most athletes for most sports (sometimes on the bottom, sometimes on the top, often in the middle).

This discrepancy (high METS and little exercise) intrigued me, so I did some googling on the resveratrol and endurance and ended up right back at the Sinclair studies. I had read about the mice running nearly twice as far as the control group, but I forgot about that tidbit until I came across it again after trying to make sense of this stress test.

So, the question is, why did I score so high on the test? Is it because of the supplements that I was taking for 10 weeks prior? Is it because of my high bilirubin? Is it because I walked as long as I could in the test and didn't run until I had to, thus conserving energy? (that still wouldn't explain my max heart rate, but could possibly explain total time until exhaustion) Is it because I was in very good shape when I was young? Or is it simply a matter of genetics. And of course, it could be a complex mixture of the above items or something completely different in my environment.

Now I've read studies where they tested to see if athletes could improve their endurance by taking resveratrol. From what I remember, it didn't show any improvement (I have however, seen one study where cyclists performed 3% better by taking quercetin for a while before a race). However, these were *athletes*. Were the Sinclair mice in good shape before the tests? Or were they slugs like me? Is it possible that resveratrol is bringing me up to the level of an athlete (in some ways) without me having to exercise (more, better mitochondria cells)? And if you are an athlete, do you reach that point through exercise and there is just a limit you can reach either through exercise or supplements, so athletes don't benefit as much from taking resveratrol (for endurance that is)?

And, of course, my max oxygen consumption isn't really the same as my endurance. I did go for a comparatively long time on the graded treadmill, but my heart rate was still on the way up when I stopped. I've read that this is what is expected when people are out of shape. If you are in good shape, they'd expect your heart rate to level off for a while before you have to stop.

Anyway, I just thought people might find this interesting. I'm guessing a lot of people on this site are in pretty good shape, because of the benefits to life extension/health. Although I'm not an obese, bed ridden person, I'm certainly much less active than most athletes on a day to day basis. It seems contradictory that I should get the results I did and I can't help but wonder what role the supplements played in this.

I would be interested in any studies done on inactive people and/or elderly people to see if resveratrol (and/or quercetin) have any effect on VO2 max or endurance.


A few weeks ago, I ran out of my resveratrol, so I ordered more. For about a week, I was only taking quercetin/bromelain. When my resveratrol came, I decided to try a test by cutting out the quercetin/bromelain and I've only been taking resveratrol. As I mentioned above, I've upped the amount from 400 mg/day to 600 mg/day. I still take my 2 multivitamins each day too. I'm still feeling good from an energy perspective, haven't noticed too many aches or pains, and my jaundice isn't pronounced. The bright yellow has gone away from my bodily fluids as well. I attribute that to the lack of quercetin.

I'm considering ordering some 98% or 99% pure resveratrol powder. I like the capsules, because they are easy to take, but are more expensive (about 3 times more expensive, per gram of resveratrol). I haven't had any problems (that I'm aware of) with the emodin in the 50% pure resveratrol I'm taking. And, although I know people shy away from the 50% pure resveratrol due to loose stools from the emodin, emodin itself seems to be a good thing for the body. In particular, it looks promising for its anticancer properties:

prostate cancer - http://www3.intersci...l...=1&SRETRY=0
colon cancer - http://www.lieberton...9/cbr.2007.0425
breast cancer - http://pen.sagepub.c...stract/32/2/190
lung cancer (might be useful for The First Immortal??) - http://lib.bioinfo.pl/pmid:17935676

I may still keep some 50% resveratrol in my diet for the emodin.


On one hand, I'm thinking that I've found a good thing and I shouldn't rock the boat. But I'm much too curious. I'm thinking of trying to alter the variables and see what I get. I do have a programmable treadmill at home (that I don't use), so I'd probably be able to set up a Bruce protocol stress test. I just need to get a heart rate monitor.

I'm open to suggestions/requests for test ideas. Right now, I plan on making changes to supplementation and then watching for changes in blood pressure, energy, jaundice and endurance (if I can set up the treadmill test). I'm thinking I should stay on a given regimen for at least two or three months to give it time to do whatever its going to do and for the previous regimen to "wear off".

I've decided I should start exercising again. However, I'm going to delay this until I've done all the "testing" I can think of with low activity levels. I'll probably then re-do the same tests with higher activity levels and see what happens.

If anyone has any questions about what I posted, I'll do my best to answer them.

Thanks,
David

Edited by davidd, 22 August 2008 - 09:54 PM.

[jCole]

After a week of taking 500mg in the morning and 500mg in the evening I do not notice any good or bad effects from RSV as of yet. Except for a brief rushof sorts, when I take the RSV via buccal delivery.

My work outs are same as usual, as well as recovery time. Don't notice any more energy, all tho I'm in good shape anyways, so I'm sure that has something to do with it. No increase in mood, but I don't have problems with depression or poor mood either.

Asthma is still the same.

Overall, nothing so far.

But, from the various research I've had read, it seems RSV works well in people with various or certain conditions/ailments, or who may or may not be in peak physical condition already.


I will still continue to take RSV among my regular daily supplements for the possible life extending benefits and disease prevention. I'll report if I find/discover anything new from taking RSV.


Any comments?

Edited by jCole, 22 August 2008 - 11:11 PM.

[davidd]

After a week of taking 500mg in the morning and 500mg in the evening I do not notice any good or bad effects from RSV as of yet. Except for a brief rushof sorts, when I take the RSV via buccal delivery.

My work outs are same as usual, as well as recovery time. Don't notice any more energy, all tho I'm in good shape anyways, so I'm sure that has something to do with it. No increase in mood, but I don't have problems with depression or poor mood either.

Asthma is still the same.

Overall, nothing so far.

But, from the various research I've had read, it seems RSV works well in people with various or certain conditions/ailments, or who may or may not be in peak physical condition already.


I will still continue to take RSV among my regular daily supplements for the possible life extending benefits and disease prevention. I'll report if I find/discover anything new from taking RSV.


Any comments?

I'm trying to ascertain whether quercetin and bromelain pills, taken along with resveratrol, have any effect in endurance and/or recovery and/or soreness. Seems like you have a regular work-out routine. I'd be curious what would happen if you added these other items to your regimen for 3 months?

I'm curious. Is your 1 gram/day 50% pure or of a higher purity?