1708 replies to this topic

[SearchHorizon]

Any comments?

I work out at least 5 days a week. Lifting + cardio.

I am super sensitive to all the changes in my body.

As soon as I receive my 99% resv, I will begin to track its effects on my muscle mass and leanness.

Current stat: 190 lb. Probably around 10 % bf. I can get leaner, but the problem is that I lose strength and muscle mass once I start cutting further. Perhaps resveratrol will help me get stronger and leaner without sacrificing muscle mass. I would love to gain some mass while getting leaner.

[jCole]

After a week of taking 500mg in the morning and 500mg in the evening I do not notice any good or bad effects from RSV as of yet. Except for a brief rushof sorts, when I take the RSV via buccal delivery.

My work outs are same as usual, as well as recovery time. Don't notice any more energy, all tho I'm in good shape anyways, so I'm sure that has something to do with it. No increase in mood, but I don't have problems with depression or poor mood either.

Asthma is still the same.

Overall, nothing so far.

But, from the various research I've had read, it seems RSV works well in people with various or certain conditions/ailments, or who may or may not be in peak physical condition already.


I will still continue to take RSV among my regular daily supplements for the possible life extending benefits and disease prevention. I'll report if I find/discover anything new from taking RSV.


Any comments?

I'm trying to ascertain whether quercetin and bromelain pills, taken along with resveratrol, have any effect in endurance and/or recovery and/or soreness. Seems like you have a regular work-out routine. I'd be curious what would happen if you added these other items to your regimen for 3 months?

I'm curious. Is your 1 gram/day 50% pure or of a higher purity?

99% pure from RevGen.

I may add other things in time to my RSV cocktail, but for now, I'll remain just taking RSV and observe my physical & mental state, then add something new after a month or two. Want to get some solid observations on just RSV for now and it's effect on me.

I'm also only 26 years old. My age may have something to do with the lack of noticeable effects thus far.

Edited by jCole, 25 August 2008 - 04:21 AM.

[jCole]

Any comments?

I work out at least 5 days a week. Lifting + cardio.

I am super sensitive to all the changes in my body.

As soon as I receive my 99% resv, I will begin to track its effects on my muscle mass and leanness.

Current stat: 190 lb. Probably around 10 % bf. I can get leaner, but the problem is that I lose strength and muscle mass once I start cutting further. Perhaps resveratrol will help me get stronger and leaner without sacrificing muscle mass. I would love to gain some mass while getting leaner.

I'm hyper sensitive myself to new supplements introduced into my system.

I'm currently on a low carb cut regimen myself after getting off a bulking phase, so I'm pretty weak as it is right now. So far no noticble increase in strength on RSV.

All tho I'm not sure what sort of interactions ketones vs. glucose have in regards to RSV metabolism in my system.

Edited by jCole, 25 August 2008 - 04:20 AM.

[Anthony_Loera]

Just a quick FYI because I think this information is lost:

=================================================
Sinclair's study on humans:
=================================================
The only human study that Sirtris and Sinclair has performed was using SRT501 in quantities of 2.5 grams and 5 grams.
See slide 23 below:

http://revgenetics.com/sirtris.htm
=================================================



Cheers
A

[davidd]

Just a quick FYI because I think this information is lost:

=================================================
Sinclair's study on humans:
=================================================
The only human study that Sirtris and Sinclair has performed was using SRT501 in quantities of 2.5 grams and 5 grams.
See slide 23 below:

http://revgenetics.com/sirtris.htm
=================================================



Cheers
A

Question: So when/if SRT501 is approved, do people think it will only be available with a prescription? I mean, if it doesn't harm you, then couldn't it be OTC? Unless there is some serious drug interaction issues?

It would be funny if we'd have to get a doctor's prescription for it to treat our disease of aging.

David

[Anthony_Loera]

If SRT501 is approved, it will be approved for diabetes or melas (sp?)
Doctors will then be able to "prescribe it" for off label use. The FDA can't do any enforcement regarding off label use, so it will be interesting.

However, if it's OTC... like aspirin, Tylenol, etc... then their is no doubt people will flock to it as well. But the bottle, can only state it is for treatment of diabetes, it can't say aging or the like, as the FDA doesn't recognize this as a disease.

A

[Crepulance]

Hello Hello, okay, I have a question. What is Pharmaceutical Grade Resveratrol, and how does it compare to your top of the line res available online, in every which way. Also, is there a ratio to work out how much more top grade online res you'd have to take to compensate for any insufficiencies? And thirdly, how do we get Pharma Grade Res?? Is there a black market hookup anyone knows about? What are the criteria for getting it? You have to be associated with a lab? Please let me know. I have a hunch out of all of you, someone out there has a sneaky answer and a sneaky hookup for the goods. Message me if you wanna keep it fairly incognito. Ta Ta all!!


Crep

[tintinet]

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

[Crepulance]

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?


Crep

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

[niner]

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

[Crepulance]

More to the point, what's the best way to take a gram of res? the whole gram at once? 500mg twice a day?


Crep

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

[tintinet]

More to the point, what's the best way to take a gram of res? the whole gram at once? 500mg twice a day?


Crep

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

Some, at least, aver a larger dose once is better than smaller doses distributed over the day.

[davidd]

More to the point, what's the best way to take a gram of res? the whole gram at once? 500mg twice a day?


Crep

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

Some, at least, aver a larger dose once is better than smaller doses distributed over the day.

I am curious. Is this done in the hope that the dose is high enough to create substrate inhibition in the phase 2 enzymes (http://dmd.aspetjour...stract/36/2/322) or is it done simply because the more there is added to the blood at the same time, the more passes it will take for the enzymes to process it, even if they are not inhibited, thus leading to a longer life for unchanged resveratrol in the blood? Or is there some other reasoning behind this?

[niner]

More to the point, what's the best way to take a gram of res? the whole gram at once? 500mg twice a day?

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

Some, at least, aver a larger dose once is better than smaller doses distributed over the day.

I am curious. Is this done in the hope that the dose is high enough to create substrate inhibition in the phase 2 enzymes (http://dmd.aspetjour...stract/36/2/322) or is it done simply because the more there is added to the blood at the same time, the more passes it will take for the enzymes to process it, even if they are not inhibited, thus leading to a longer life for unchanged resveratrol in the blood? Or is there some other reasoning behind this?

In this post, I presented an analysis of Boocock's data which suggests that the largest AUC (Area Under the plasma concentration/time Curve) per gram of resveratrol will occur with doses in the vicinity of 1 - 1.5 gram. The more resveratrol you take at a time, the higher your plasma concentrations will be, but if you are interested in the most efficient use, and you are taking very large doses, you might want to go with multiple doses. This would not be the case if you were taking a total dose of less than about a gram and a half. In that case, I would just take it all at once. Sirtris has experimented with both one and two per day dosing schedules.

In the linked post, I speculate about some possible mechanisms for this effect, but there could be others. The data seems to favor just popping a gram all at once, and that's easier anyway.

[maxwatt]

More to the point, what's the best way to take a gram of res? the whole gram at once? 500mg twice a day?

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

Some, at least, aver a larger dose once is better than smaller doses distributed over the day.

I am curious. Is this done in the hope that the dose is high enough to create substrate inhibition in the phase 2 enzymes (http://dmd.aspetjour...stract/36/2/322) or is it done simply because the more there is added to the blood at the same time, the more passes it will take for the enzymes to process it, even if they are not inhibited, thus leading to a longer life for unchanged resveratrol in the blood? Or is there some other reasoning behind this?

In this post, I presented an analysis of Boocock's data which suggests that the largest AUC (Area Under the plasma concentration/time Curve) per gram of resveratrol will occur with doses in the vicinity of 1 - 1.5 gram. The more resveratrol you take at a time, the higher your plasma concentrations will be, but if you are interested in the most efficient use, and you are taking very large doses, you might want to go with multiple doses. This would not be the case if you were taking a total dose of less than about a gram and a half. In that case, I would just take it all at once. Sirtris has experimented with both one and two per day dosing schedules.

In the linked post, I speculate about some possible mechanisms for this effect, but there could be others. The data seems to favor just popping a gram all at once, and that's easier anyway.

I have been experimenting with different doses, and dosing schedules. I have found that once per day at two grams or under is not sufficient to completely control arthritic symptoms; I would still have pain in my left big toe, though it was no longer stiff, and the ring finger on my right hand would "snap" when bent then straightened. 2.25 grams is enought to control these symptoms.

I have not found that twice-a-day dosing brings more improvement than a similar dose once-per-day. I've tried as much as 3 grams twice a day, and five grams once a day.

Arthritis symptoms may not be the only measure of effectiveness; perhaps the effects on cancer cells would be better with multiple doses per day, to maintain a constant high serum level. But arthritis is affected by nf-KappaB, which is in turn regulated by Sirt1. My experience suggests that the effect on these is maintained by a single high spike in serum level of resveratrol once a day, and they remain activated even if serum levels do not remain high 24x7.

[JLL]

Is there any reason not to take resveratrol while on CR or IF?

Edited by JLL, 18 September 2008 - 06:23 PM.

[davidd]

More to the point, what's the best way to take a gram of res? the whole gram at once? 500mg twice a day?

Well, I guess I've obtained "pharmaceutical grade" RSV in the past, but I fail to understand why anyone would currently seek it, unless they're interested in intravenous or intramuscular injection. IMO, the high purity RSV extracts available at a far lesser cost than PG are just as good for oral intake.

If I were to take a gram of Pharma Grade RSV do you know what it's equivalent in 98% pure would be?

You'd need to add 20mg, which is probably within the error limits of whatever you are using to dispense the powder, considering the variations in dryness which affect weight. I agree with tintinet; there's not much point in seeking out a highly purified synthetic resveratrol when there are so many reasonably priced 98 or 99% extracts.

Some, at least, aver a larger dose once is better than smaller doses distributed over the day.

I am curious. Is this done in the hope that the dose is high enough to create substrate inhibition in the phase 2 enzymes (http://dmd.aspetjour...stract/36/2/322) or is it done simply because the more there is added to the blood at the same time, the more passes it will take for the enzymes to process it, even if they are not inhibited, thus leading to a longer life for unchanged resveratrol in the blood? Or is there some other reasoning behind this?

In this post, I presented an analysis of Boocock's data which suggests that the largest AUC (Area Under the plasma concentration/time Curve) per gram of resveratrol will occur with doses in the vicinity of 1 - 1.5 gram. The more resveratrol you take at a time, the higher your plasma concentrations will be, but if you are interested in the most efficient use, and you are taking very large doses, you might want to go with multiple doses. This would not be the case if you were taking a total dose of less than about a gram and a half. In that case, I would just take it all at once. Sirtris has experimented with both one and two per day dosing schedules.

In the linked post, I speculate about some possible mechanisms for this effect, but there could be others. The data seems to favor just popping a gram all at once, and that's easier anyway.

Niner: Thanks for the explanation of the reasoning behind this type of dosing and thanks for the cross-link to the other thread. Lots of information in that one!

I believe the swamping that you refer to jives with the substrate inhibition ("swamping") in the study I linked to.

I am wondering what this means for ultra-mega-dosing, ala TheFirstImmortal? Would the theoretical best dosing schedule for taking 15 grams daily, be something like 4 g @ 8 am, 4 g @ 1 pm, 4 g @ 6 pm, 3 g @ 11 pm? I'm assuming that interrupting sleep to take a dose would be counterproductive, so only including waking hours. The 5 hour gaps were obtained by looking at the graph provided in the discussion you linked to, where it looks like the concentration decreases more rapidly after 5 hours.

I have been experimenting with different doses, and dosing schedules. I have found that once per day at two grams or under is not sufficient to completely control arthritic symptoms; I would still have pain in my left big toe, though it was no longer stiff, and the ring finger on my right hand would "snap" when bent then straightened. 2.25 grams is enought to control these symptoms.

I have not found that twice-a-day dosing brings more improvement than a similar dose once-per-day. I've tried as much as 3 grams twice a day, and five grams once a day.

Maxwatt: Does that mean it provides the same improvement, or does it mean it provides less improvement? Specifically, if you take 1.125 g, twice a day, for a total of 2.25 grams/day, does that work better or worse or the same as taking 2.25 grams all at once?

Also, did you try taking the single dose in the evening vs the morning to see if that had any effect?

Arthritis symptoms may not be the only measure of effectiveness; perhaps the effects on cancer cells would be better with multiple doses per day, to maintain a constant high serum level. But arthritis is affected by nf-KappaB, which is in turn regulated by Sirt1. My experience suggests that the effect on these is maintained by a single high spike in serum level of resveratrol once a day, and they remain activated even if serum levels do not remain high 24x7.

This is really what we care about from a longevity standpoint -- SIRT1 activation and the resulting things that follow. I am wondering if there are other things we could observe indirectly to see if the results jive with what you are theorizing about nf-KappaB and your toe? It would also be encouraging to see if we have good reproducibility with a higher number of people.

The other thing we believe is happening is mitochondria biogenesis. This takes too long to happen, however, and isn't so easy to test (although I'm still planning on using VO2 max to give a rough idea of mitochondrial activity).

What other things do we know that SIRT1 triggers that would be relatively easy to observe?

And how many days do you need to stay on a certain dosing schedule before you can feel the effects on your toe? Is it as quick as just one day?

David

[maxwatt]

QUOTE
I have been experimenting with different doses, and dosing schedules. I have found that once per day at two grams or under is not sufficient to completely control arthritic symptoms; I would still have pain in my left big toe, though it was no longer stiff, and the ring finger on my right hand would "snap" when bent then straightened. 2.25 grams is enought to control these symptoms.

I have not found that twice-a-day dosing brings more improvement than a similar dose once-per-day. I've tried as much as 3 grams twice a day, and five grams once a day.

Maxwatt: Does that mean it provides the same improvement, or does it mean it provides less improvement? Specifically, if you take 1.125 g, twice a day, for a total of 2.25 grams/day, does that work better or worse or the same as taking 2.25 grams all at once?

Also, did you try taking the single dose in the evening vs the morning to see if that had any effect?

QUOTE
Arthritis symptoms may not be the only measure of effectiveness; perhaps the effects on cancer cells would be better with multiple doses per day, to maintain a constant high serum level. But arthritis is affected by nf-KappaB, which is in turn regulated by Sirt1. My experience suggests that the effect on these is maintained by a single high spike in serum level of resveratrol once a day, and they remain activated even if serum levels do not remain high 24x7.

This is really what we care about from a longevity standpoint -- SIRT1 activation and the resulting things that follow. I am wondering if there are other things we could observe indirectly to see if the results jive with what you are theorizing about nf-KappaB and your toe? It would also be encouraging to see if we have good reproducibility with a higher number of people.

The other thing we believe is happening is mitochondria biogenesis. This takes too long to happen, however, and isn't so easy to test (although I'm still planning on using VO2 max to give a rough idea of mitochondrial activity).

What other things do we know that SIRT1 triggers that would be relatively easy to observe?

And how many days do you need to stay on a certain dosing schedule before you can feel the effects on your toe? Is it as quick as just one day?

David

Same improvement twice a day dosing vs. once a day dosing; 2.5 gm twice a day about the same effect as 2.5 to 3 gm once a day. I find once-a-day more cost effective. No difference between morning and evening administration, except less likelihood of digestive upset. A sugar-water solution -- two tsp sugar to one cup water, optional 1/4 tsp salt to replace electrolytes -- taken withe resveratrol, or on an empty stomacy -- fixes the intestinal problems that sometimes occur.

Velopismo and I have both noted improvements in cycling performance consistent with mitochondrial biogenesis. I use a Computrainer bicycle ergonometer in the winter. I found about a 10% improvement in wattage, and increased endurance at a given wattage. It took around a month for this to kick in. I do not think the training effect confounded this, I was comparing to performance in previous years.

My "tolio" improves within two to three days of increasing the dose. It takes a little longer, around 5 days, for it to deteriorate if I lower the dose too much, or take something that blocks Sirt1 activation, like quercetin or luteolin in amounts over 50 mg.

My dog's arthritic hips improve over the same time frame: 350 mg for 30 pound dog.

Another effect I've noted using a resveratrol containing skin cream: it greatly improves one's complexion, and is the best treatment I've found for acne rosacea.
A bonus: when rubbed on one's genitalia, it enhances male sexual function. It take several days for these effects to be manifest.

[malbecman]

Well, that reason right there is enough to use this stuff, folks!!!!! Maybe I need to come out with a skin cream line......

A bonus: when rubbed on one's genitalia, it enhances male sexual function. It take several days for these effects to be manifest.

[kenj]

Just a small update, - on the resveratrol+metformin combo and glucose control following a dinner (900+ calories spread over 2 hours; vegetables, falafel, pomegranate juice, a glass of wine, a cup of cocoa, glutenfree bread with cheese, a fruit bar, nuts, oil), - I took my BG an hour or so after the last bite: 61 mmol/L, - and absolutely not a trace of hypoglycemic feeling, which I find interesting.

[tintinet]

Just a small update, - on the resveratrol+metformin combo and glucose control following a dinner (900+ calories spread over 2 hours; vegetables, falafel, pomegranate juice, a glass of wine, a cup of cocoa, glutenfree bread with cheese, a fruit bar, nuts, oil), - I took my BG an hour or so after the last bite: 61 mmol/L, - and absolutely not a trace of hypoglycemic feeling, which I find interesting.

I've had my BG measured, randomly, at 50 mmol/L at time when I was feeling perfectly well. I got a panicked call from a health care provider regarding the value, but, to me, it was just another day....

[neuromancer]

Hey all, just wanted to introduce myself. Long time lurker, first time poster. Been reading imminst forums and taking action in my personal life, and meaning to post an introduction. Thought I'd do it here since I've been taking Resveratrol for a few months, and scaled up to about 3g/daily 99% Revgenetics Resveratrol for about a week now.

Thanks to imminst and all of this information, I'm taking 3 grams 99% Resveratrol daily, along with 24 x 2 G Piracetam (scaled it up over a week or two to find the right dosage) , melatonin, Ortho Core and Ortho Mind, DHEA (six weeks on, two off, haven't nailed down the dosage) and just started deprenyl (Jumex) 2.5 mg 4x / weekly. I can vouch for the "peanut butter" method of taking Res, but currently I'm mixing it with about 2 cups of plain Greek yogurt every day. Seems to be fine, the yogurt method seems to work better for me. Preceded by about a cup of mixed black/blue/raspberries for the quercetin, and sometimes mixed with a teaspoon or two of Manuka Honey.

(My understanding is that honey is known to not spoil. I understand thousand-year-old honey has been found to be still edible. It's been used for "first aid" in many cultures since the beginning of time. But Manuka honey is made from the New Zealand tea tree plant and carries additional benefits. It seems to help me a lot especially when sick.)

It's not that I want to live forever, but I'm plagued by severe diabetes. I'm 34, 250 lbs, and my A1C has been at 9.6 for about a year. For those who know what that means, it's an exreme case. I used to run two miles a day, but got diagnosed and everything went downhill. I started with an A1C of about 7.1 and it's been steadily getting worse for about five years. Haven't been able to reliably exercise - just no energy. My overtraining level is about the same as my regular training level - which means any exercise does almost as much harm as good. Haven't been able to reliably diet - my body constantly, constantly craves food, constantly feels starving even when I'm stuffed full to bursting with only protein and fat. My immune system was in the toilet, and I've been almost constantly sick for about two years, until now.

I've tried various supplements and medicine, and this year with Resveratrol (and choline, inositol, Piracetam, etc) I think I'm finally on the road to recovery. Doctors try to help, but, most of their cases are kids with a cold, and most of their prescriptions are to drink lots of fluids and take some asprin. It's hard to keep up on the edge of research, and hard get away from the shilling of pharmecutical companies. You just need to look out for yourself (but if anyone can recommend a good Phoenix doctor, it would be great) .

I want to live long enough to see grandkids and see the world, run again, and do the things that make life worth living.

I'm no scientist, or doctor, but smart, skeptical enough to accept the nearly-impossible, and able to find needles of useful information in the haystack of the internet. And for some time, felt like there was little to lose. You guys rock.

Just a long (short) story by way of introduction. Nice to meet everyone

- neuromancer WikipediaWictionaryChambers (UK)Google imagesGoogle defineThe Free DictionaryJoin exampleWordNetGoogleUrban DictionaryAnswers.comrhymezone.comMerriam-Webster<>0wvcidfjoguarm

[PWAIN]

Hey all, just wanted to introduce myself. Long time lurker, first time poster. Been reading imminst forums and taking action in my personal life, and meaning to post an introduction. Thought I'd do it here since I've been taking Resveratrol for a few months, and scaled up to about 3g/daily 99% Revgenetics Resveratrol for about a week now.

Thanks to imminst and all of this information, I'm taking 3 grams 99% Resveratrol daily, along with 24 x 2 G Piracetam (scaled it up over a week or two to find the right dosage) , melatonin, Ortho Core and Ortho Mind, DHEA (six weeks on, two off, haven't nailed down the dosage) and just started deprenyl (Jumex) 2.5 mg 4x / weekly. I can vouch for the "peanut butter" method of taking Res, but currently I'm mixing it with about 2 cups of plain Greek yogurt every day. Seems to be fine, the yogurt method seems to work better for me. Preceded by about a cup of mixed black/blue/raspberries for the quercetin, and sometimes mixed with a teaspoon or two of Manuka Honey.

(My understanding is that honey is known to not spoil. I understand thousand-year-old honey has been found to be still edible. It's been used for "first aid" in many cultures since the beginning of time. But Manuka honey is made from the New Zealand tea tree plant and carries additional benefits. It seems to help me a lot especially when sick.)

It's not that I want to live forever, but I'm plagued by severe diabetes. I'm 34, 250 lbs, and my A1C has been at 9.6 for about a year. For those who know what that means, it's an exreme case. I used to run two miles a day, but got diagnosed and everything went downhill. I started with an A1C of about 7.1 and it's been steadily getting worse for about five years. Haven't been able to reliably exercise - just no energy. My overtraining level is about the same as my regular training level - which means any exercise does almost as much harm as good. Haven't been able to reliably diet - my body constantly, constantly craves food, constantly feels starving even when I'm stuffed full to bursting with only protein and fat. My immune system was in the toilet, and I've been almost constantly sick for about two years, until now.

I've tried various supplements and medicine, and this year with Resveratrol (and choline, inositol, Piracetam, etc) I think I'm finally on the road to recovery. Doctors try to help, but, most of their cases are kids with a cold, and most of their prescriptions are to drink lots of fluids and take some asprin. It's hard to keep up on the edge of research, and hard get away from the shilling of pharmecutical companies. You just need to look out for yourself (but if anyone can recommend a good Phoenix doctor, it would be great) .

I want to live long enough to see grandkids and see the world, run again, and do the things that make life worth living.

I'm no scientist, or doctor, but smart, skeptical enough to accept the nearly-impossible, and able to find needles of useful information in the haystack of the internet. And for some time, felt like there was little to lose. You guys rock.

Just a long (short) story by way of introduction. Nice to meet everyone

- neuromancer WikipediaWictionaryChambers (UK)Google imagesGoogle defineThe Free DictionaryJoin exampleWordNetGoogleUrban DictionaryAnswers.comrhymezone.comMerriam-Webster<>0wvcidfjoguarm

I'd suggest you look at adding:

Benfotiamine
L-Carnosine
Pyridoxamine

These are supposed to help deal with AGEs. Also it may be worth looking up the product Viv*x which is the shaklee product that Sinclair is supposed to support. You may be able to make up your own remarkably similar product and shakelee claims it is 10x better at dealing with AGE's than plain Resveratrol. I think a good dose of various phenols wouldn't hurt either.

Finally cutting down hard on carbs and losing a bit of wieght will probably do more for you than anything else I could recommend. I am sure you have heard this a million times but I would be remis not to mention it.

[neuromancer]

Hey all, just wanted to introduce myself. Long time lurker, first time poster. Been reading ..snip...

I'd suggest you look at adding:

Benfotiamine
L-Carnosine
Pyridoxamine

These are supposed to help deal with AGEs. Also it may be worth looking up the product Viv*x which is the shaklee product that Sinclair is supposed to support. You may be able to make up your own remarkably similar product and shakelee claims it is 10x better at dealing with AGE's than plain Resveratrol. I think a good dose of various phenols wouldn't hurt either.

Finally cutting down hard on carbs and losing a bit of wieght will probably do more for you than anything else I could recommend. I am sure you have heard this a million times but I would be remis not to mention it.

Thanks for the tips I'll check that out. You're right too, cutting down the carbs and losing weight are tremendous factors. Unfortunately it's been a little too tough. Before the onslaught, I was actually dieting pretty well, even went totally vegan at one time. If you can do it right, you can be pretty healthy. It was really a lot of hard work trying to get healthy that just sort of went down the tubes. :(

With a tremendous amount of self-control, I held out on a high-protein low-carb diet for about ... I think ... two weeks. Up until then, it was the hardest thing I'd ever done. My sugar went down, but the cravings never went away, and there were some severe signs and symptoms of hypoglycemia. Shaking, sweats and chills, near-delerium, and constant fatigue. All this from having glucose drop to 150, from the usual level of 200+. Like having the flu, sort of. Lifestyle's also a factor, you have to be super committed at the expense of everything else.

I think good diet is more about good carbs rather than low carbs. mendoza.com provided a lot of good information, and I ordered "The G.I. Diet" from Canada before it was released in the states. Basically the less processed food is, the better it is for you. Cooking's not bad, but refining is. It's not hard to eat vegetables, but it's hard to get away from all the other crap. It takes maybe an hour to cook steel-cut oats, and washing up, and it's just a lot to maintain. Also, the "mediterranian diet" is particularly good, it's a little high in "good" fats, but it's basically healthful.

Mother nature set us up to handle certain foods in certain ways. We're pitting millions of years of evolutionary adaptation against maybe 50 - 100 years of experimentation with food that is manufactured rather than grown, chemical agents and all sorts of additives, not to mention fortification, which isn't the same as getting natural nutrients out of real food. Half of what we consume is just chemically manufactured, these days, anyway.

My half-assed theory is that diabetes is a combination of both nutrition problems (overload in calories and other things, and malnourishment in other ways) and immune system problems. This thought came after reading about a study done with mice and transplanted spleens - the researcher was able to cure type 1 diabetes by regenerating spleens. http://medgadget.com...n_cells_of.html I think the immune system was attacking the cells that produced insulin, and helping the immune system also reversed the diabetes. More related stuff here: http://www.scienceda...70527140321.htm These thoughts were cemented by research supporting the hypothesis that vaccinations correlated with a higher incidence of diabetes, although the arguments seem mixed on this issue. A doctor also once told me that he believed diabetes was related to viral infection, based on his experience (his son, and dad, were all DO's, along with some of their spouses, so they had a wealth of experience) . His sister had contracted diabetes after catching a virus at a young age.

My thought is that the body has an immune response to overly-high insulin or glucose or other factors related to diabetes. Diabetics have immune system complications and a rise in glucogen when one gets sick too... just a half-assed thought and I might have it all backwards anyway.

Thanks again for the tip, those nutrients are familiar too, I'll dig in. Hope this thread isn't totally hijacked ... I'll make it up by throwing in my own empirical data on my high-Resveratrol course.

~ neuromancer
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[davidd]

Velopismo and I have both noted improvements in cycling performance consistent with mitochondrial biogenesis. I use a Computrainer bicycle ergonometer in the winter. I found about a 10% improvement in wattage, and increased endurance at a given wattage. It took around a month for this to kick in. I do not think the training effect confounded this, I was comparing to performance in previous years.

Thanks for sharing that! Good information. I hadn't run across it on the site previously.

My "tolio" improves within two to three days of increasing the dose. It takes a little longer, around 5 days, for it to deteriorate if I lower the dose too much, or take something that blocks Sirt1 activation, like quercetin or luteolin in amounts over 50 mg.

Hmm...have you ever tried taking it for just one day to see if you get the benefit 2 to 3 days later for a duration of 1 day?

I have to admit, I'm really curious about the quercetin angle. I've read your posts before about how it somehow blocks your toe relief. My experiences with it seemed to be contradictory, as I was taking much less resveratrol (400mg daily...200mg morning and night), with a bunch of quercetin, yet still seemed to get the mitochondrial benefits. I guess after a lot of testing over a long period of time, I'll report back on whether I get even more benefit without the quercetin.

When you did take the quercetin with the resveratrol, was it 98% resveratrol? What type of quercetin? Did it have bromelain included with it?

My dog's arthritic hips improve over the same time frame: 350 mg for 30 pound dog.

Another effect I've noted using a resveratrol containing skin cream: it greatly improves one's complexion, and is the best treatment I've found for acne rosacea.

Is this a home brew skin cream, or something the rest of us can buy too? I have read other posts about people putting resveratrol on a variety of skin conditions with impressive results. I believe they used DMSO+resveratrol.

A bonus: when rubbed on one's genitalia, it enhances male sexual function. It take several days for these effects to be manifest.

Does it then take 5 days to wear off?!? *grins*

David

[maxwatt]

(cut POST 265311

Hmm...have you ever tried taking it for just one day to see if you get the benefit 2 to 3 days later for a duration of 1 day?

It takes several days for the pain to start up again, and several days for it to diminish again, on adding or ceasing quercetin co-administration.

When you did take the quercetin with the resveratrol, was it 98% resveratrol? What type of quercetin? Did it have bromelain included with it?

I take 98% resveratrol, the quercetin was something like 200 mg with bromelain. I also have tried luteolin, molecular structure very similar to quercetin. That was pure, and was as effective as quercetin in blocking pain-relief, and at a lower dose.

The "male enhancement" effect with topical application is noticeable after several days to a week, begins to wear off after 3 days. It's not constant, just more ready, willing and able, with more endurance. Not like those legendary Viagra 3-day woodies that cause gangrene and it falls off or something.

I have a home-brew, but it is of commercial quality. It's easy to make something similar, by adding resveratrol to your favorite skin cream. I think Revgenetic may come out with such a product. I've added a few other things to what I use. PM me if you are interested in details.

Edited by maxwatt, 24 September 2008 - 02:01 PM.

[tintinet]

WRT Diabetes: As noted, there are at least 2 forms. "Juvenile" onset (type I) and "Adult" onset (type II). They are a bit different WRT etiology and mechanism, so it might make more sense to separate the two types when speculating about causation, etc.

[Crepulance]

Ummm, in terms of a Resveratrol lotion having an erectile enhancement effect....ummm...did you ever think....that maybe....it's because you're rubbing LOTION on your penis? That teeeends to do it for me usually. Doesn't really matter if it's resveratrol lotion, pineapple lotion or fruity pebbles lotion, I'm usually good to go.


Crep

(cut POST 265311

Hmm...have you ever tried taking it for just one day to see if you get the benefit 2 to 3 days later for a duration of 1 day?

It takes several days for the pain to start up again, and several days for it to diminish again, on adding or ceasing quercetin co-administration.

When you did take the quercetin with the resveratrol, was it 98% resveratrol? What type of quercetin? Did it have bromelain included with it?

I take 98% resveratrol, the quercetin was something like 200 mg with bromelain. I also have tried luteolin, molecular structure very similar to quercetin. That was pure, and was as effective as quercetin in blocking pain-relief, and at a lower dose.

The "male enhancement" effect with topical application is noticeable after several days to a week, begins to wear off after 3 days. It's not constant, just more ready, willing and able, with more endurance. Not like those legendary Viagra 3-day woodies that cause gangrene and it falls off or something.

I have a home-brew, but it is of commercial quality. It's easy to make something similar, by adding resveratrol to your favorite skin cream. I think Revgenetic may come out with such a product. I've added a few other things to what I use. PM me if you are interested in details.

[elphaba]

This isn't a very precise report but wanted to write something since I'm so appreciative of others who take the time to share.

I started (approx) last November 2007 taking 1/4 tsp per day of the 50% resveratrol
Increased dosage to 1 gram per day taken in divided dosage.
Changed from 50% to 99% (thanks Anthony) at around middle of September 2008
Currently 1/4 tsp twice per day.

Several health problems:
Thyroid - hypothyroid - Armour 90 mg per day for at least 10 years
Peripheral neuropathy - have avoided any painkillers thus far (with very great effort)
Eczema and psoriasis - since about 1 1/2 years ago - went two rounds of steroids initially but have since managed to keep it from being overwhelming with lots of care using lotion and Benedryl (2 caps every night)
Benign relatively small cysts in my scalp - at least not so large that they are visible (unless the wind blows my hair a certain way, YUK)
(Taking hydergine to help with mental clarity, I am 62. Have taken hydergine for too many years to count.)

I am very much anticipating my thyroid results in January for my next checkup along with my A1C. I will report back.
I am a fish-a-terian. No meat except fish. I've never been one to drink cokes. Eat sweets maybe twice a week (and I realize I shouldn't then). Eat LOTS and LOTS of green vegetables. Main diet problem is that I'm addicted to grains and when I do eat, I eat WAY too much. Starting a new quasi low-carb diet today, i.e. no grains. (wish me luck.)

Summary:
Good news--

Since starting resveratrol, my cholesterol has dropped from 233 to 197. ( I also take a jillion vitamins including drinking Apple Cider vinegar in a.m. and p.m. which some say helps drop cholesterol)

My blood pressure has never been a problem (mainly because hypothyroid people tend to have low blood pressure). It has been 110 over 80 or 110 over 70 for many years. Since taking resveratrol, after last visit to my dentist and also to my endochrinologist, my blood pressure both times (separated by a week or so) was 106/59. Not sure if this is good news or bad news. I'm told this is not too low but wow -- seems a little low. We'll see what it is during my next checkups. We've had a hurricane here in Houston and we ate out when grocery stores were empty, electricity off in homes and restaurants open. I gained 10 pounds, YUK. So results may not be so good on next checkups.

Totally unexpected: A very large cyst on my scalp (larger than a small marble but smaller than a large marble) has shrunk to less than 1/4 its max size. (This cyst which the dermatologist said was benign started about 30 years ago and has grown little by little - I always hate to get my hair cut - it must be gross for the barber).
A second smaller cyst on my scalp which I have had (maybe) since 5 years ago has not shrunk at the same rate but IS shrinking.

Bad news--

Though I had eczema before taking resveratol, it seems to have gotten a lot worse since taking resveratol. Since before the eczema flareup I quit talking Alpha Lipoic Acid but plan to resume soon once my order is delivered. I'm hoping it may make a difference (don't ask me why).

Also, plantar fasciitis has reared its ugly head shortly after starting the 50% resveratrol. I was on a light walking program (which is saying a lot for me because of my neuropathy) but had to terminate because of the fasciitis. Switched to 99% but fasciitis still there and worse after light exercise such as going to grocery store. I'm not ruling out my obesity as the cause but thought it was interesting that the fasciitis coincided almost precisely with when I started the resveratrol.

Some background:

My doctor who is an endochrinologist isn't sure that I'm diabetic. I have never had an A1C higher than 5.8. (Maybe I eat fairly healthy?) But about three years ago, when trying to find out cause of my peripheral neuropathy, I demanded a glucose tolerance test and they gave it to me and I failed. My current doctor (endo), says that when people eat low carb, they have been known to get a "false positive" on a glucose tolerance test. Though the way I figure it, because of my obesity, if I'm not diabetic, I'm pre-diabetic.

I am 100 lbs overweight. Gained the weight starting from when peripheral neuropathy started 15 years ago (or so). Has gotten (very) progressively worse. It is clear weight gain is (mainly) because of the limitations the peripheral neuropathy placed on my activities. I am constantly trying to figure out how to keep from having to walk to reduce the pain. (I'm one of those fat people on the elevator who you wonder why she isn't walking up the stairs..)

Sorry if this report isn't that well organized but maybe it might be informative for someone.

I'll definitely post back in January when I get my latest A1C. If it is significantly down, I will have to credit that to the resveratrol (unless I lose weight by then also...than maybe the glory will be shared between the two.. crossing my fingers.)
And I'll also definitely post back if my fasciitis improves after starting back on the alpha lipoic regimen.
(And hopefully, my blood pressure doesn't go any lower.)

Ultimately, I'm really hoping that somehow even if it takes a while, my peripheral neuropathy symptoms will be reduced. At least I don't think they are progressing (but I haven't had a test in a while). Since resveratrol is being investigated for Diabetes, I'm hoping that there will be a report on it having a positive impact on neuropathy...crossing fingers.

[automita]

http://medicine.plos.../...040076&ct=1
i am 34 recently lost 55 pounds through calorie restriction and exercise i will start rev. next week. i am at 1400 calories on days i eat, 2 days of fasting a week. because of the workout regiment i have been putting on a lot of muscle and have added about 5 inches of vertical leaping ability without eating what i ate before i.e. protein shakes beef and chicken.