1708 replies to this topic

[nancyd]

Does resveratrol have particular side effects for women because of its effect on estrogen?

Edited by nancyd, 20 April 2009 - 09:37 PM.

[2tender]

I dont think it would be harmful to overall hormonal profile, unless you were pregnant or attemping to become pregnant. If I was female I wouldnt take it within 6 mos to a year of being pregnant. To be clear: dont take it if you are pregnant or plan to be pregnant soon.Consult a real Physician if you have concerns If you are pregnant now I would stop taking it. I think there is a warning on the label or the site on the banner above regarding pregnancy. If you take it, and start having irregular menses, it could be a concern. Im sure others more experienced here will chime in.

[maxwatt]

I dont think it would be harmful to overall hormonal profile, unless you were pregnant or attemping to become pregnant. If I was female I wouldnt take it within 6 mos to a year of being pregnant. To be clear: dont take it if you are pregnant or plan to be pregnant soon.Consult a real Physician if you have concerns If you are pregnant now I would stop taking it. I think there is a warning on the label or the site on the banner above regarding pregnancy. If you take it, and start having irregular menses, it could be a concern. Im sure others more experienced here will chime in.

Good advice. Resveratrol is a very weak estrogen mimetic, and has both agonizing and antagonizing effects depending on the tissue type. But the efffects have AFAIK only been shown in vitro. Probably the dose available from oral administration will not have noticeable effects of this type. As always with xenobiotics, one should start with a low dose, and gradually ramp up the dose noting any untoward effects until the desired dose is reached, or titrate the dose based on one's reaction.

Pregnancy is another matter, I found but one paper dealing with it in mice. The doses were very high, administered by injection; oral administration is likely to have far less effect than those noted in the mice's offspring. The major effect on offspring seemed to be earlier onset of puberty. Though I cannot say for sure this is not positive (earlier puberty onset can be a sign of good health or of good nutrition, as well as hormonal disturbance) I can say for sure I shall never take resveratrol while I am pregnant.

Reprod Toxicol. 2004 Aug-Sep;18(6):803-11. Links
Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring.

Nikaido Y, Yoshizawa K, Danbara N, Tsujita-Kyutoku M, Yuri T, Uehara N, Tsubura A.
Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.

The objective of this study was to examine the effects of maternal exposure to xenoestrogen, at levels comparable to or greater than human exposure, on development of the reproductive tract and mammary glands in female CD-1 mouse offspring. Effects of genistein (GEN), resveratrol (RES), zearalenone (ZEA), bisphenol A (BPA) and diethylstilbestrol (DES) were examined. Beginning on gestational day 15, pregnant CD-1 mice were administered four daily subcutaneous injections with 0.5 or 10 mg/kg/day of GEN, RES, ZEA or BPA, 0.5 or 10 microg/kg/day of DES dissolved in dimethylsulfoxide (DMSO), or DMSO vehicle (n = 6). Vaginal opening was monitored, 6 animals per group were autopsied at 4, 8, 12 and 16 weeks of age and estrous cyclicity was monitored from 9 to 11 weeks of age. Maternal exposure to xenoestrogen accelerated puberty onset (vaginal opening) and increased the length of the estrous cycle; mice treated with GEN, RES, BPA or DES spent more time in diestrus, and ZEA-treated mice spent more time in estrus. Lack of corpora lutea and vaginal cornification were observed at 4 weeks of age in the high-dose GEN (33%) and RES (17%) groups, and in the high- and low-dose BPA groups (33 and 50%, respectively) and DES groups (83 and 100%, respectively). Lack of corpora lutea and vaginal cornification was observed in the high-dose ZEA group at 4, 8, 12 and 16 weeks of age (83, 100, 83 and 33%, respectively). Mammary gland differentiation was accelerated in ZEA- and BPA-treated mice with corpora lutea at 4 weeks of age. ZEA-treated mice without corpora lutea showed mammary growth arrest at 8, 12 and 16 weeks of age; their mammary glands consisted only of a dilatated duct filled with secreted fluid. Mammary gland growth was similar with xenoestrogens other than ZEA or BPA to that of the controls at all time points. High-dose GEN and RES and high- and low-dose BPA and DES exerted transient effects on the reproductive tract and mammary glands, whereas ZEA exerted prolonged effects.

PMID: 15279878

[Shay]

I can only recall a couple anecdotes from this forum where women were using resv and was a bit nervous about getting my wife on a daily regimen, but felt that more likely than not there was no real risk.

This whole issue is terribly confusing though. My wife was showing early symptoms of metabolic syndrome which was curtailed with dietary changes. There's been evidence of some help by resveratrol in this regard so it sounds like a good idea, right? Well what about the fact that if I recall correctly, metabolic syndrome often initially manifest as PCOS (poly cystic ovarian syndrom) in women, which is at least partially if not fully caused by elevated estrogen? The elevated estrogen appears due to the body's own fat stores and exogenous sources like soy and milk. Oh, and resveratrol.

I dont think it would be harmful to overall hormonal profile, unless you were pregnant or attemping to become pregnant. If I was female I wouldnt take it within 6 mos to a year of being pregnant. To be clear: dont take it if you are pregnant or plan to be pregnant soon.Consult a real Physician if you have concerns If you are pregnant now I would stop taking it. I think there is a warning on the label or the site on the banner above regarding pregnancy. If you take it, and start having irregular menses, it could be a concern. Im sure others more experienced here will chime in.

Good advice. Resveratrol is a very weak estrogen mimetic, and has both agonizing and antagonizing effects depending on the tissue type. But the efffects have AFAIK only been shown in vitro. Probably the dose available from oral administration will not have noticeable effects of this type. As always with xenobiotics, one should start with a low dose, and gradually ramp up the dose noting any untoward effects until the desired dose is reached, or titrate the dose based on one's reaction.

Pregnancy is another matter, I found but one paper dealing with it in mice. The doses were very high, administered by injection; oral administration is likely to have far less effect than those noted in the mice's offspring. The major effect on offspring seemed to be earlier onset of puberty. Though I cannot say for sure this is not positive (earlier puberty onset can be a sign of good health or of good nutrition, as well as hormonal disturbance) I can say for sure I shall never take resveratrol while I am pregnant.

Reprod Toxicol. 2004 Aug-Sep;18(6):803-11. Links
Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring.

Nikaido Y, Yoshizawa K, Danbara N, Tsujita-Kyutoku M, Yuri T, Uehara N, Tsubura A.
Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.

The objective of this study was to examine the effects of maternal exposure to xenoestrogen, at levels comparable to or greater than human exposure, on development of the reproductive tract and mammary glands in female CD-1 mouse offspring. Effects of genistein (GEN), resveratrol (RES), zearalenone (ZEA), bisphenol A (BPA) and diethylstilbestrol (DES) were examined. Beginning on gestational day 15, pregnant CD-1 mice were administered four daily subcutaneous injections with 0.5 or 10 mg/kg/day of GEN, RES, ZEA or BPA, 0.5 or 10 microg/kg/day of DES dissolved in dimethylsulfoxide (DMSO), or DMSO vehicle (n = 6). Vaginal opening was monitored, 6 animals per group were autopsied at 4, 8, 12 and 16 weeks of age and estrous cyclicity was monitored from 9 to 11 weeks of age. Maternal exposure to xenoestrogen accelerated puberty onset (vaginal opening) and increased the length of the estrous cycle; mice treated with GEN, RES, BPA or DES spent more time in diestrus, and ZEA-treated mice spent more time in estrus. Lack of corpora lutea and vaginal cornification were observed at 4 weeks of age in the high-dose GEN (33%) and RES (17%) groups, and in the high- and low-dose BPA groups (33 and 50%, respectively) and DES groups (83 and 100%, respectively). Lack of corpora lutea and vaginal cornification was observed in the high-dose ZEA group at 4, 8, 12 and 16 weeks of age (83, 100, 83 and 33%, respectively). Mammary gland differentiation was accelerated in ZEA- and BPA-treated mice with corpora lutea at 4 weeks of age. ZEA-treated mice without corpora lutea showed mammary growth arrest at 8, 12 and 16 weeks of age; their mammary glands consisted only of a dilatated duct filled with secreted fluid. Mammary gland growth was similar with xenoestrogens other than ZEA or BPA to that of the controls at all time points. High-dose GEN and RES and high- and low-dose BPA and DES exerted transient effects on the reproductive tract and mammary glands, whereas ZEA exerted prolonged effects.

PMID: 15279878

[maxwatt]

I can only recall a couple anecdotes from this forum where women were using resv and was a bit nervous about getting my wife on a daily regimen, but felt that more likely than not there was no real risk.

This whole issue is terribly confusing though. My wife was showing early symptoms of metabolic syndrome which was curtailed with dietary changes. There's been evidence of some help by resveratrol in this regard so it sounds like a good idea, right? Well what about the fact that if I recall correctly, metabolic syndrome often initially manifest as PCOS (poly cystic ovarian syndrom) in women, which is at least partially if not fully caused by elevated estrogen? The elevated estrogen appears due to the body's own fat stores and exogenous sources like soy and milk. Oh, and resveratrol.

It is not, alas, that simple. Resveratrol does bind to estrogen receptors, somewhat weakly compared to some other polyphenols. However, it blocks some types of receptors and may activate other. Probably the benefits outweigh the risks if she is showing symptoms of metabolic syndrome. There is a book on PCOS that recommends resveratrol supplements as treatment, but the authors are naturopaths, not MD's or biologists as far as I can tell. I've fond no science, not studies on this specific issue.

[unglued]

Maybe there's little empirical science about resveratrol and fertility, but doesn't the theory say that sirtuins evolved as a way to extend the individual's lifespan (and therefore future reproductive potential) by diverting resources away from the reproductive system during times of famine? And that might apply more to females than males, since by definition a female body devotes more resources to reproduction, particularly in mammals. So if resveratrol does some good, and it doesn't come for free, the cost is more likely to come out of fertility than anything else.

[maxwatt]

Maybe there's little empirical science about resveratrol and fertility, but doesn't the theory say that sirtuins evolved as a way to extend the individual's lifespan (and therefore future reproductive potential) by diverting resources away from the reproductive system during times of famine? And that might apply more to females than males, since by definition a female body devotes more resources to reproduction, particularly in mammals. So if resveratrol does some good, and it doesn't come for free, the cost is more likely to come out of fertility than anything else.

Possibly.

BEDEVERE:
And what do you burn apart from witches?
VILLAGER #2:
Wood!
BEDEVERE:
So, why do witches burn?
[pause]
VILLAGER #3:
B--... 'cause they're made of... wood?
BEDEVERE:
Exactly! So, how do we tell whether she is made of wood?
VILLAGER #1:
Build a bridge out of her.
BEDEVERE:
Ah, but can you not also make bridges out of stone?
VILLAGER #1:
Oh, yeah.
BEDEVERE:
Does wood sink in water?
VILLAGER #2:
No, it floats! It floats!
VILLAGER #1:
Throw her into the pond!
BEDEVERE:
What also floats in water?
VILLAGER #1:
Uh, very small rocks?
ARTHUR:
A duck! So, logically...
VILLAGER #1:
If... she... weighs... the same as a duck,... she's made of wood.
BEDEVERE:
And therefore?
VILLAGER #2:
A witch!

[Anthony_Loera]

Maybe there's little empirical science about resveratrol and fertility, but doesn't the theory say that sirtuins evolved as a way to extend the individual's lifespan (and therefore future reproductive potential) by diverting resources away from the reproductive system during times of famine? And that might apply more to females than males, since by definition a female body devotes more resources to reproduction, particularly in mammals. So if resveratrol does some good, and it doesn't come for free, the cost is more likely to come out of fertility than anything else.

Sorry, but I really don't believe it comes out of fertility.

My new daughter Samantha, born 04/09 is definite proof in my mind that res may have only helped my 42yo wife, considering the specialists we saw about 5 years ago said it would be a miracle baby, because they said her egg quality was horrible.

Well... we overcame that, first with my son now with my daughter... we have two miracle babies...

Sorry, I personally do not believe that the "good" comes at the cost of fertility.

Cheers
A

Attached Files

•  Samantha_04092009.jpg   48.69KB   33 downloads

Edited by Anthony_Loera, 24 April 2009 - 05:08 PM.

[kenj]

Hey Anthony, that's amazing, congratz. Two cheers.

[saxiephon]

My congratulations also on these awesome births!

SAX

[maxwatt]

Did your wife take resveratrol during her pregnancy? Or only prior to conception?

[Anthony_Loera]

Did your wife take resveratrol during her pregnancy? Or only prior to conception?

Hi Max,

For our daughter, my wife was on res only prior to conception: 500mg of the regular res and she took it most of the time for health (not every day), she was about 120lbs.
But she stopped as soon as we realized she was pregnant.

A

[tunt01]

what was the newborn's weight?

[maxwatt]

what was the newborn's weight?

A little over half a stone, I bet.

[JLL]

Is that more or less than a duck?

[maxwatt]

Is that more or less than a duck?

It that the same as a henway? (One stone = 14 pounds, which would be an equally obscure unit of measure by now if it weren't for Ronald Reagan.)

[Anthony_Loera]

Hmm... definitely not 14 lbs

She was 5lb 12oz, Cesarean... her due date was around the 26th, we had her scheduled for the 17th for a c-section at south miami hospital, but she started tap dancing early on the 9th and wouldn't let up until she broke out...

We were concerned a bit, but it turns out she was fine, no issues, and we took her home two days later. The mommy was feeling more beat-up than the baby,

Cheers
A

Edited by Anthony_Loera, 25 April 2009 - 03:30 PM.

[nancyd]

How much should I take of the Tween 80 supplement and how often should I take it? I'm 5'5", 115 lbs. How long should I wait to eat after taking it? I would just be taking it for prevention. I don't have any physical health problems-that I'm aware of anyway. Is this a good time to start or is it better to wait until there is a condition you could benefit from?

Edited by nancyd, 27 April 2009 - 03:19 AM.

[2tender]

How much should I take of the Tween 80 supplement and how often should I take it? I'm 5'5", 115 lbs. How long should I wait to eat after taking it? I would just be taking it for prevention. I don't have any physical health problems-that I'm aware of anyway. Is this a good time to start or is it better to wait until there is a condition you could benefit from?

This is only my opinion; I would take 1 daily, within 3 hours of arising, on an empty stomach, or with breakfast. I experienced minor stomach upset initially, but that and some minor joint pain subsided within 2-3 weeks. I wouldnt wait. What is the measure of your chronology?

[Mind]

This thread has been going on over two years now. What is the general feeling about the effectiveness of resveratrol in promoting better health? How many of you have test data to show improvement in aging bio-markers, or are we mainly talking anecdotal evidence at this point?

[2tender]

This thread has been going on over two years now. What is the general feeling about the effectiveness of resveratrol in promoting better health? How many of you have test data to show improvement in aging bio-markers, or are we mainly talking anecdotal evidence at this point?

While my general health is probably not bad, I feel that Resveratrol has been a welcome addition to my regimen, actually Ive decreased my other supplements over the years, and am using Res. on a daily basis with seemingly good results in areas of energy, feelings of well being, stamina, and fat loss. I dont have any bloodwork though some similarly my subjective feelings about Res. are purely anecdotal and even perhaps, placebo. Who knows, maybe this is just another "vitamin fad" and Ill stop taking it eventually. However, based on all that I have read, and that includes experiences of weightlifting, bodybuilders that cycle Androgens: I think there really is something to Resveratrol that promotes health, has few long term side effects and may be taken for extended periods of time, provided one finds the product type that is compatible with their system.

[nancyd]

How much should I take of the Tween 80 supplement and how often should I take it? I'm 5'5", 115 lbs. How long should I wait to eat after taking it? I would just be taking it for prevention. I don't have any physical health problems-that I'm aware of anyway. Is this a good time to start or is it better to wait until there is a condition you could benefit from?

This is only my opinion; I would take 1 daily, within 3 hours of arising, on an empty stomach, or with breakfast. I experienced minor stomach upset initially, but that and some minor joint pain subsided within 2-3 weeks. I wouldnt wait. What is the measure of your chronology?

I'm 36.

[2tender]

How much should I take of the Tween 80 supplement and how often should I take it? I'm 5'5", 115 lbs. How long should I wait to eat after taking it? I would just be taking it for prevention. I don't have any physical health problems-that I'm aware of anyway. Is this a good time to start or is it better to wait until there is a condition you could benefit from?

This is only my opinion; I would take 1 daily, within 3 hours of arising, on an empty stomach, or with breakfast. I experienced minor stomach upset initially, but that and some minor joint pain subsided within 2-3 weeks. I wouldnt wait. What is the measure of your chronology?

I'm 36.

Probably a good age to start, I would review the precautions, avoid excessive alchohol intake and see how I feel after 10 days, if I got any side effects, I would quit for a day, then resume. JMO

[maxwatt]

This thread has been going on over two years now. What is the general feeling about the effectiveness of resveratrol in promoting better health? How many of you have test data to show improvement in aging bio-markers, or are we mainly talking anecdotal evidence at this point?

After one year of use: increase in HDL by 30%, decrease in total cholesterol of 10%. About a 10% drop in fasting glucose.

This is an improvement, but I still consider my numbers marginal for life extension purposes, though my doctor is quite happy with them.

I will have another set of lab work done in the next few months and see what the two year figure is.

Arthritis is much improved, though ther eis no proof it is due to resveratrol; remissions do occur naturally.

[davidd]

I think there is a general concensus by some of us that we have more/better mitochondria as a result of taking resveratrol. If that means fewer free radicals, then that could improve lifespan/health.


I was very close to being able to determine (indirectly) the effect on my mitochondria (via VO2Max before/after), but something started confounding my tests. Does anyone know if lack of vitamin D has a negative effect on mitochondria?

David

[bluemoon]

After 18 months, I can run faster than a rolling "o", am stronger than a silent "e" and can jump over a capital "T" in a single bound. These used to be powers that only Letterman possesed, but I think in my case resveratrol has made a difference -- oh, and with smoother skin.

[tintinet]

Golly gee! I think it's just as good as "Ever So Much More So!" And easier to get!

[gregandbeaker]

After 18 months, I can run faster than a rolling "o", am stronger than a silent "e" and can jump over a capital "T" in a single bound. These used to be powers that only Letterman possesed, but I think in my case resveratrol has made a difference -- oh, and with smoother skin.

Great one! I haven't thought about Letterman in 20 years!

[AcaiBerry]

Resveratrol can boost your energy levels and give you the vigor and flexibility of youth.I Love resveratrol and these products are very effective for health. Your blog sounds good. Keep posting more information about resveratrol .

Edited by maxwatt, 13 May 2009 - 03:15 PM.

[timziums88]

Amazing. I just posted in another thread about resveratrol benefits.

The other thing I forgot to mention (figured I would put it here instead) is that many of the supplements can affect your body more than you know. Just be careful with supplement levels, etc!