1084 replies to this topic

[niner]

In this link the authors talk about sublingual delivery of **200mg** of Fentanyl, whcih is also lipid soluble. What also caught my eye is that the purpose was to create a "fast acting" method of the drug. Also discussed is how this delivery method avoids first pass liver metabolism. This all implies that sublingual delivery CAN in fact get into the blood stream quickly enough to avoid first pass liver conjugation, and that amounts of substance of at least 200mg can be done this way.

This wasn't 200mg. 200mg fentanyl would be enough to kill about 500 people. It had to be 200 ug. This is a very common mixup- milli = 1/1000, abbreviation is lowercase m. micro = 1/1,000,000. abbreviation is greek mu, which looks kind of like an ascii "u", so people here usually write it as "ug". Fentanyl is typical of the kinds of drugs that are used transdermally; very potent; used at very low dosages. When Russian security services gassed that theater and killed half the people in it, it was a volatile form of fentanyl that they used. Homebrew fentanyl is sometimes sold on the street as China White, which typically leaves a trail of dead junkies. So, the keyword here is "potent". You really can't deliver a lot of milligrams quickly across skin.

[maxhealthback]

To Anthony Loera, You are violating our trademark for Biotivia and Transmax by running Google adverts such as the one below as well as others in which you use the names Transmax and Biotivia. You are also implying in some of your ads that your product passed the consumer lab tests. It did not. This is a notification that you must cease and desist this false advertising immediately.

BIOTIVIA
Dr. Oz says Resveratrol
independently tested
www.RevGenetics.com

You are being sent this notice on this forum because it is known that you post and read messages on this forum. James Betz, Managing Director-Biotivia

[sUper GeNius]

Niner.

Yes, it was a typo on that webpage. Nevertheless, I have read of some substances in amounts as large as 100mg being used sublingually. Rember, we don't need a whole lot, as long as it gets across quickly.

[sUper GeNius]

To Anthony Loera, You are violating our trademark for Biotivia and Transmax by running Google adverts such as the one below as well as others in which you use the names Transmax and Biotivia. You are also implying in some of your ads that your product passed the consumer lab tests. It did not. This is a notification that you must cease and desist this false advertising immediately.

BIOTIVIA
Dr. Oz says Resveratrol
independently tested
www.RevGenetics.com

You are being sent this notice on this forum because it is known that you post and read messages on this forum. James Betz, Managing Director-Biotivia

Wow, that's pretty bush. I suspect that you are posting that here, not because Anthony reads these posts, but because we all do. I would NEVER buy any product from a person with that MO.

[Anthony_Loera]

To Anthony Loera, You are violating our trademark for Biotivia and Transmax by running Google adverts such as the one below as well as others in which you use the names Transmax and Biotivia. You are also implying in some of your ads that your product passed the consumer lab tests. It did not. This is a notification that you must cease and desist this false advertising immediately.

BIOTIVIA
Dr. Oz says Resveratrol
independently tested
www.RevGenetics.com

You are being sent this notice on this forum because it is known that you post and read messages on this forum. James Betz, Managing Director-Biotivia

Just to clear something up, we did not violate any trademarks, and we didn't participate in consumer labs testing. Implying we didn't pass CL testing is silly. We have our products independently tested by a US Lab with every batch. So far you have gotten tested independently... once this year? Is that correct?

Stop the spam James, it's beneath you.
Contact me by email from now on and leave the forums out of the issues you may have with RevGenetics and Google.

A

Edited by Anthony_Loera, 03 December 2007 - 03:56 PM.

[Brainbox]

To Anthony Loera, You are violating our trademark for Biotivia and Transmax by running Google adverts such as the one below as well as others in which you use the names Transmax and Biotivia. You are also implying in some of your ads that your product passed the consumer lab tests. It did not. This is a notification that you must cease and desist this false advertising immediately.

BIOTIVIA
Dr. Oz says Resveratrol
independently tested
www.RevGenetics.com

You are being sent this notice on this forum because it is known that you post and read messages on this forum. James Betz, Managing Director-Biotivia

To Anthony Loera, You are violating our trademark for Biotivia and Transmax by running Google adverts such as the one below as well as others in which you use the names Transmax and Biotivia. You are also implying in some of your ads that your product passed the consumer lab tests. It did not. This is a notification that you must cease and desist this false advertising immediately.

BIOTIVIA
Dr. Oz says Resveratrol
independently tested
www.RevGenetics.com

You are being sent this notice on this forum because it is known that you post and read messages on this forum. James Betz, Managing Director-Biotivia

Just to clear something up, we didn't participate in consumer labs testing. Implying we didn't pass CL testing is silly. We have our products independently tested by a US Lab with every batch. So far you have gotten tested independently... once this year? Is that correct?

Stop the spam James, it's beneath you.
Contact me by email from now on and leave the forums out of the issues you may have with RevGenetics and Google.

A

Analogous to the flame wars we had in the past, I will not moderate these contributions so that everyone is able to judge the level of marketing ethics that is implied by them.
However, if this develops into something really nasty, the imminst moderation team will not hesitate to edit or remove posts!

Edited by brainbox, 03 December 2007 - 12:38 PM.

[malbecman]

I would have to agree with missminni. While I only tried the DMSO/resveratrol cutaneous application once as mentioned in my post last week, I definitely noticed an improvement in my exercise routine that day as well as better sleeping. It does seem like the flux thru my skin was more than would be suggested by the calculations posted more recently. Still, only an n=1 and a 1 time experiment for me thus far. YMMV.....

good morning
While you were all theorizing
about the effectiveness, or lack of, of cutaneous application of Res/DMSO
I had the best night sleep I've had in a loooong time. I don't know if it's
coincidence or not, but the DMSO seems to be helping me sleep, and stay asleep.
Also, I will tell you that since using Res cutaneously, I notice marked improvement
in strength, endurance and mood. Much more than when I was just doing it orally.
I know most posters here have a science or math background and I respect that.
I don't think what I am going to say is in conflict with it, but some might think so.
Here goes.
I think one element that you seem to overlook is the one of belief. What one believes
can often be the most important factor. To my way of thinking, and I think this is backed up by science, our thoughts,
more than anything (except a bullet to the head), control our health. I believe that thoughts
influence our hormone production and hormones are basically what determine our
health, mental and physical. Simply put - mind over matter. (I guess you all might call that the placebo effect?)
That, to me, is the most important element of all. If I were a scientist,
that would be my field of interest. Faith is the most amazing medicine. Don't worry, I'm not
going to preach.

Now I hope some of you will try the cutaneous application and do blood work to find out
exactly what is getting through. If you find out that NONE is getting through, it will only
go to further support my belief, but something tells me you are going to be very pleasantly
surprised.

ETA~

ilanso: As per above, Niner's transdermal flux guess of 10 micrograms per square centimeter per hour translates to 1mg per hour for an area of 10 by 10 cm (forearm). One obvious way to improve on this is to increase the application surface area. Skin is our largest organ, at a bit less than 2 square meters (or 20,000 cm2) providing a 200-fold real estate reserve. Now I am not advocating keeping a jacuzzi full of DMSO+resv at the ready for twice a day quick skinny dippings (although, if you can afford it...). Instead, using a premixed adequate (just enough for saturation) amount in a bottle with a fine spray nozzle right after the morning shower (from neck to toes) may do the trick. Well, it may help to wait until most moisture is out of the skin (or dry off by using a hair dryer). Experimenting with quantities may then come down to choosing the treated proportion of the body. If deliberately done over minutes, this technique can provide an amount of staggering (much like CD laddering in a portfolio) sufficient to ensure a transient steady flow.

The only problem with this is that DMSO does cause bad breath and body odor. At the rate you are suggesting using it, you would not be able to
leave your house. That's why I'm trying to use as little as possible. I noticed the odor when I first used it liberally. Not pleasant. Perhaps the odor
could be mitigated with something. That I don't know.

PS
I see here that Dr. Jacobs has a product that addresses the issue of odor:
https://jacoblab.com...MSODusaSAL.html

DUSA SAL is DMSO gel enhanced with oil of wintergreen for reduced skin irritation and odor.

However, I must add that when I spoke with him on the phone, he did not recommend it. In fact he said the gel compounds were
not as effective in transport as was the liquid. I'm thinking maybe one could take a chlorophyll tablet to mitigate the odor.

[missminni]

I would have to agree with missminni. While I only tried the DMSO/resveratrol cutaneous application once as mentioned in my post last week, I definitely noticed an improvement in my exercise routine that day as well as better sleeping. It does seem like the flux thru my skin was more than would be suggested by the calculations posted more recently. Still, only an n=1 and a 1 time experiment for me thus far. YMMV.....

I'm happy to hear this. I'm doing it regularly and still having the same positive effects.
The better sleeping was an unexpected bonus.

[hormesis]

Sublingual administration of resveratrol may not be a good idea. Saliva strongly inactivates and binds a variety of polyphenols.

On a separate note, it looks like the solubility or pure resveratrol in a 75.5% alcohol everclear is somewhere between 70mg/ml and 100mg/ml when stored at room temperature. At 100mg/ml, some thin hair-like crystals began to form at the base of the bottle within 24hrs.

[asnufu]

I would have to agree with missminni. While I only tried the DMSO/resveratrol cutaneous application once as mentioned in my post last week, I definitely noticed an improvement in my exercise routine that day as well as better sleeping. It does seem like the flux thru my skin was more than would be suggested by the calculations posted more recently. Still, only an n=1 and a 1 time experiment for me thus far. YMMV.....

I'm happy to hear this. I'm doing it regularly and still having the same positive effects.
The better sleeping was an unexpected bonus.

So far, n=2 and effects are consistent and reproduceable. That's the closest so far to experimental evidence on this forum, insofar as I know. I've ordered my DMSO from the site mentioned by missminni and will be going this route myself. Who knows, maybe plasma levels are high enough to induce some of the Auwerx effects - just too bad we can't ask his mice if they slept well...

[ilanso]

hormesis: it looks like the solubility or pure resveratrol in a 75.5% alcohol everclear is somewhere between 70mg/ml and 100mg/ml when stored at room temperature. At 100mg/ml, some thin hair-like crystals began to form at the base of the bottle within 24hrs

malbecman: I did a quick and dirty solubility check with DMSO since it is a polar solvent like water. I was wondering how much t-resveratrol would go into it and whether it would make an effective carrier if one wanted to use the transdermal route of absorption. 200mgs of 99% pure t-resveratrol would almost, but not quite, go into 500ul (1/2 milliliter) of 99.9% DMSO

maxwatt: Either solubility is higher than the published 16 g/l, or something else is going on

If 75.5% ETOH can hold 75-100g/l resv., I would expect pure DMSO to largely beat that. So malbecman's 400g/l seems more plausible than maxwatt's 16 g/l, although still a little excessive. Did you notice any crystal deposits indicating oversaturation, malbecman? How dirty was your "quick and dirty" assay?

[malbecman]

Actually, the leftover resveratrol was more like a sludge that melted to the side of the glass vial. With some mixing or heating, more of it would have gone into solution, I'm sure.

I tried 100 mgs on my forearm after putting down ~0.5mls of DMSO first and it definitely mixed in as a paste first, then, just clear oily liquid like DMSO. Some white residue left over on the skin when all the DMSO evaporated but nowhere near 100mgs, more like 5-10mgs as a guesstimate.....

If 75.5% ETOH can hold 75-100g/l resv., I would expect pure DMSO to largely beat that. So malbecman's 400g/l seems more plausible than maxwatt's 16 g/l, although still a little excessive. Did you notice any crystal deposits indicating oversaturation, malbecman? How dirty was your "quick and dirty" assay?

[stephen_b]

Maybe we could test the ability of DMSO to dissolve resveratrol and compare notes. Can the more chemistry-minded among us give out some pointers?

Stephen

[missminni]

I recall somebody asking about applying DMSO w/Res directly on a hurting joint,
and Maxwatt said he was going to try it when he got his DMSO.
I just tried it about 20 minutes ago.
My middle toe was burning from the neuroma.
In the past I put plain DMSO on it and it relieved the pain long enough for me
to wear high heels and go out for the evening with no pain. But the pain would return
in a few hours.
Today I tried it with the Resveratrol mixed in.
Method - I sprayed the toe, put a bit of Res powder on it, rub it ( it dissolves right away)
and put a bit more powder on the oiliness remaining and rubbed it in again.
My toe stopped hurting almost immediately. It still has a bit of a numb feeling (part of the neuroma)
but no pain. Now, I will see how long that lasts and if
it reduces the amount of pain I have the next time it hurts.

[browser]

I would have to agree with missminni. While I only tried the DMSO/resveratrol cutaneous application once as mentioned in my post last week, I definitely noticed an improvement in my exercise routine that day as well as better sleeping. It does seem like the flux thru my skin was more than would be suggested by the calculations posted more recently. Still, only an n=1 and a 1 time experiment for me thus far. YMMV.....

I'm happy to hear this. I'm doing it regularly and still having the same positive effects.
The better sleeping was an unexpected bonus.

So far, n=2 and effects are consistent and reproduceable. That's the closest so far to experimental evidence on this forum, insofar as I know. I've ordered my DMSO from the site mentioned by missminni and will be going this route myself. Who knows, maybe plasma levels are high enough to induce some of the Auwerx effects - just too bad we can't ask his mice if they slept well...

The Wiki on the Internet says 16g/L.

[niner]

The Wiki on the Internet says 16g/L.

It be wrong, imho. There seems to be a lot of bad resveratrol solubility data out there. I speculate that some of it may have started out back when resveratrol was a compound of limited interest, and someone dissolved some amount of it in whatever solvent. They may have just been making up a standard solution, and were not conducting an actual solubility test. The number made it into a report without qualification, got onto a website, and before you know it people are googling it and treating it as a solubility number, when in fact it really just meant "at least this amount dissolved".

From my experience, the solubility of resveratrol in 95.5% ethanol (Everclear; not 75.5% btw) is in the range of 70-100 mg/ml. I haven't tried DMSO, but chemical intuition tells me that malbecman's value of 400mg/ml is not wildly wrong.

Anyone can edit a Wiki, right? Maybe we ought to fix it.

[maxwatt]

The Wiki on the Internet says 16g/L.

It be wrong, imho. There seems to be a lot of bad resveratrol solubility data out there. I speculate that some of it may have started out back when resveratrol was a compound of limited interest, and someone dissolved some amount of it in whatever solvent. They may have just been making up a standard solution, and were not conducting an actual solubility test. The number made it into a report without qualification, got onto a website, and before you know it people are googling it and treating it as a solubility number, when in fact it really just meant "at least this amount dissolved".

From my experience, the solubility of resveratrol in 95.5% ethanol (Everclear; not 75.5% btw) is in the range of 70-100 mg/ml. I haven't tried DMSO, but chemical intuition tells me that malbecman's value of 400mg/ml is not wildly wrong.

Anyone can edit a Wiki, right? Maybe we ought to fix it.

I think you are right. This is on the Sigma-Aldrich website, and they are more careful:

Resveratrol is soluble in EtOH at 50 mg/mL, in DMSO at least 16 mg/mL and is only very slightly soluble (warming
required) in water at 3 mg/100 mL.2

[niner]

I think you are right. This is on the Sigma-Aldrich website, and they are more careful:

Resveratrol is soluble in EtOH at 50 mg/mL, in DMSO at least 16 mg/mL and is only very slightly soluble (warming required) in water at 3 mg/100 mL.2

Yeah, that's probably the source of some of this. The "at least" got lost on the way to the Wiki, I suppose. They really ought to have an "at least" for the 50 in EtOH too, since it's 50-100% over that.

[missminni]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours.
Are there any studies about DMSO and sleep?
There should be.

[maxwatt]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours. :smile: :whis:
Are there any studies about DMSO and sleep?
There should be.

Here ya go!

Toxicology Letters
Volume 157, Issue 3, 4 July 2005, Pages 221-232
Abstract
Dimethyl sulfoxide (DMSO) is an efficient solvent for water-insoluble compounds, widely used in biological studies and as a vehicle for drug therapy, but few data on its neurotoxic or behavioural effects is available. The aim of this work is to explore DMSO's effects upon sleep/wake states. Twenty male rats were sterotaxically prepared for polysomnography. Four concentrations of DMSO (5%, 10%, 15%, and 20%, in saline) were examined. DMSO or saline were administered intraperitoneally at the beginning of the light period. Three hours of polygraphic recording were evaluated for stages of vigilance after treatment. Sleep/wake parameters and EEG power spectral analyses during sleep were investigated. Results show no significant effect after 5% or 10% DMSO treatment. DMSO 15% increased mean episode duration of light slow wave sleep (SWS), decreasing mean episode duration of deep SWS and of quiet wake (QW). DMSO 20% increased light SWS enhancing number of episodes, while decreased deep SWS mean episode duration. EEG power spectra of sigma and delta activity were also affected by DMSO. Therefore, DMSO at 15% and 20% affects sleep architecture in rats, increasing light SWS and reducing deep SWS. Being aware of DMSO behavioural effects seems important since experimental artefacts caused by DMSO can lead to the erroneous interpretation of results.

Glad you slept well! Is that why we havent' seen as many posts from you for the last few days? :smile:

[sUper GeNius]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours.
Are there any studies about DMSO and sleep?
There should be.

You are assuming that sleeping through the night is worse than waking up twice. I read recently that waking up a few times may actually indicate a "better" sleep than sleeping right through.

[missminni]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours. :smile: :whis:
Are there any studies about DMSO and sleep?
There should be.

Here ya go!

Toxicology Letters
Volume 157, Issue 3, 4 July 2005, Pages 221-232
Abstract
Dimethyl sulfoxide (DMSO) is an efficient solvent for water-insoluble compounds, widely used in biological studies and as a vehicle for drug therapy, but few data on its neurotoxic or behavioural effects is available. The aim of this work is to explore DMSO's effects upon sleep/wake states. Twenty male rats were sterotaxically prepared for polysomnography. Four concentrations of DMSO (5%, 10%, 15%, and 20%, in saline) were examined. DMSO or saline were administered intraperitoneally at the beginning of the light period. Three hours of polygraphic recording were evaluated for stages of vigilance after treatment. Sleep/wake parameters and EEG power spectral analyses during sleep were investigated. Results show no significant effect after 5% or 10% DMSO treatment. DMSO 15% increased mean episode duration of light slow wave sleep (SWS), decreasing mean episode duration of deep SWS and of quiet wake (QW). DMSO 20% increased light SWS enhancing number of episodes, while decreased deep SWS mean episode duration. EEG power spectra of sigma and delta activity were also affected by DMSO. Therefore, DMSO at 15% and 20% affects sleep architecture in rats, increasing light SWS and reducing deep SWS. Being aware of DMSO behavioural effects seems important since experimental artefacts caused by DMSO can lead to the erroneous interpretation of results.

Glad you slept well! Is that why we havent' seen as many posts from you for the last few days? :smile:

No, I've just been posting on the cocoa thread about the benefits of drinking cocoa tea made from Jamaican cocoa balls that have been in my freezer since 1992, along with my deceased canary Tulip.
Many of those posts were moved to the two new humor threads that the admin so tactfully formed to house them.

[missminni]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours.
Are there any studies about DMSO and sleep?
There should be.

You are assuming that sleeping through the night is worse than waking up twice. I read recently that waking up a few times may actually indicate a "better" sleep than sleeping right through.

Where did you read that? On the thread where that Fascist idiot wants to kill the population of China to avoid WWIII?
Let me tell you that sleeping through the night is only surpassed by one other activity that I am too much of a lady to mention.
It is heaven. Waking up every 3 hours is hell and you look like hell in the morning too.
No. Can't be better to wake up, unless you are having a dream that you are going to die.

[sUper GeNius]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours.
Are there any studies about DMSO and sleep?
There should be.

You are assuming that sleeping through the night is worse than waking up twice. I read recently that waking up a few times may actually indicate a "better" sleep than sleeping right through.

Where did you read that? On the thread where that Fascist idiot wants to kill the population of China to avoid WWIII?
Let me tell you that sleeping through the night is only surpassed by one other activity that I am too much of a lady to mention.
It is heaven. Waking up every 3 hours is hell and you look like hell in the morning too.
No. Can't be better to wake up, unless you are having a dream that you are going to die.

Hey minnimi, we allow the ladies play Bacci Ball where I am from. We are enlightened

Anyway, I'll find a link to what I read and get back to you. Zzzzzzzz.....

Edited by FuLL meMbeR, 04 December 2007 - 03:09 PM.

[missminni]

The DMSO/Res on toe is still effective as of this AM.
No pain, no numbness. Last applied at about 9pm last night.
That makes two applications so far.
I will see how it holds up when I go workout.
also, improved sleep from DMSO - just amazing.
I sleep through the night! I used to wake up every 3 or 4 hours.
Are there any studies about DMSO and sleep?
There should be.

You are assuming that sleeping through the night is worse than waking up twice. I read recently that waking up a few times may actually indicate a "better" sleep than sleeping right through.

Where did you read that? On the thread where that Fascist idiot wants to kill the population of China to avoid WWIII?
Let me tell you that sleeping through the night is only surpassed by one other activity that I am too much of a lady to mention.
It is heaven. Waking up every 3 hours is hell and you look like hell in the morning too.
No. Can't be better to wake up, unless you are having a dream that you are going to die.

Hey minnimi, we allow the ladies play Bacci Ball where I am from. We are enlightened

Anyway, I'll find a link to what I read and get back to you. Zzzzzzzz.....

check out what Maxwatt said on the cocoa thread. I have been vindicated. I'm not an idiot. I'm an idiot savant.

[bixbyte]

Sublingual administration of resveratrol may not be a good idea. Saliva strongly inactivates and binds a variety of polyphenols.

Maybe digestive wise saliva does have those properties.
But, I mix the Vodka and RSV on a spoon and pour mixture below my tongue.
Hold the "puddle" for 5 to 10 minutes without speech or closing my mouth.
Looked in a mirror and figured it out.

[missminni]

Sublingual administration of resveratrol may not be a good idea. Saliva strongly inactivates and binds a variety of polyphenols.

Maybe digestive wise saliva does have those properties.
But, I mix the Vodka and RSV on a spoon and pour mixture below my tongue.
Hold the "puddle" for 5 to 10 minutes without speech or closing my mouth.
Looked in a mirror and figured it out.

I tried that with whiskey (JD). I put the powder under
my tongue, took a little JD in my mouth and let it mix with the powder, which it did
pretty quickly, but then holding it in my mouth under my tongue for longer than a minute became
difficult due to the burning sensation. did you get that?

[thenaturalstep]

That made me wonder, what if you inject it directly to the blood stream, or sniff it? ... (newbi in the area)

[maxwatt]

Sublingual administration of resveratrol may not be a good idea. Saliva strongly inactivates and binds a variety of polyphenols.

Maybe digestive wise saliva does have those properties.
But, I mix the Vodka and RSV on a spoon and pour mixture below my tongue.
Hold the "puddle" for 5 to 10 minutes without speech or closing my mouth.
Looked in a mirror and figured it out.

I tried that with whiskey (JD). I put the powder under
my tongue, took a little JD in my mouth and let it mix with the powder, which it did
pretty quickly, but then holding it in my mouth under my tongue for longer than a minute became
difficult due to the burning sensation. did you get that?

Don't take your Jack D. neat, dilute 50-50 with water. Works just as well for this purpose, no better, there is no burning sensation.

[sUper GeNius]

We have all these new nifty ways of taking t-res now! I had a dream last night that I was Tony Montana with 20lbs of pure t-res on my desk...