1084 replies to this topic

[missminni]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

I tried the DMSO, I think the spray bottle is the way to go. I just had a small bottle of it and tried to drip it onto my arm. Very messy way to go and its feels oily (DMSO is a high boiling point solvent). I sprinkled ~100mgs on it, it covered approx. 1/2 my inside forearm by the time I spread it all around. I had to drip a little more DMSO on as all the t-res did not go into solution right away and made more of a paste. Again, I think its just the messiness of my method of application. 10-15 minutes later, its all gone. Some small white powder marks at the edges of the original DMSO smear which I take to be t-resveratrol that did not get into solution but the rest of my inner forearm is clean and no signs of dermatitis (skin irritation).

The spray is the only way to go. That's why I got the spray bottle.
It also happened to be the one that was 30% aloe, so that appealed to me.
If you spray in the crook of your inner arm and let it puddle up a bit and
put the powder in there, it will melt in. 50-100 mgs is a very small amount of powder.
If it doesn't all absorb, just spray a little more dmso on it.

[stephen_b]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

[stephen_b]

I had the impression that 99% DMSO would give someone a rash, and the dermatologist we worked with had issues mixing it into a cream. I guess I have to try it our for myself.

Maybe the dermatologist was fixated on the cream and wouldn't consider a DMSO solution (marketing reasons)? Just speculating...

Stephen

[missminni]

To Sum Up:

99.9% DMSO in a small spray bottle
50-100mg 99% t-resveratrol powder


I had the impression that 99% DMSO would give someone a rash, and the dermatologist we worked with had issues mixing it into a cream. I guess I have to try it our for myself.

thanks
Anthony Loera

That's 99.9% DMSO in a Solution of 70%. The DMSO needs to be diluted to 70% strengh either with water, or aloe, something and then applied. You can buy it that way in a spary bottle from
http://www.herbalrem...dmso-spray.html
The reason it doesn't work in cream is because the cream blocks the absorption. It only works in liquid state. The gel doesn't work
well either. This is information I got when i spoke with Dr Jacobs. He recommended the liquide at 70%

[stephen_b]

Interesting. Anyone have a source of pure DMSO in glass bottles?

Looks like LEF is carrying their entire line.

Stephen

[mikeinnaples]

I wonder ....could you open the DMSO spray bottle and disolve/pre-mix your Resv, then a couple of times a day just give yourself a couple of spray on the crook of your arm. Wonder how long that would last pre-mixed. I suppose you couldn't refrigerate because the DMSO would go solid (but would it laden with RESV?).

Hmm interesting stuff.

Also ....are you concerned that the Aloe Vera mixed with the DMSO could affect the RESV since it is something other than pure DMSO ? I think I would prefer the water mixed instead of the aloe.

Edited by mikeinnaples, 30 November 2007 - 07:54 PM.

[malbecman]

I don't want to recommend a particular doseage, 50-100 mgs was just a range that I picked that should give a high serum level. Everyone should scale their doseage accordingly to what they feel comfortable with, just like with the oral dosing.

To Sum Up:

99.9% DMSO in a small spray bottle
50-100mg 99% t-resveratrol powder


I had the impression that 99% DMSO would give someone a rash, and the dermatologist we worked with had issues mixing it into a cream. I guess I have to try it our for myself.

thanks
Anthony Loera

[missminni]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

[sUper GeNius]

Anthony_Loera

Do you have enough confidence in the purity of your 99% t-res now that you know that many of us will be taking it with DMSO directly into the bloodstream? I kind of worry about what that other 1% is going into me now. Anyone have thoughts here? Is 99% pure pure enough for DMSO delivery?

[missminni]

I wonder ....could you open the DMSO spray bottle and disolve/pre-mix your Resv, then a couple of times a day just give yourself a couple of spray on the crook of your arm. Wonder how long that would last pre-mixed. I suppose you couldn't refrigerate because the DMSO would go solid (but would it laden with RESV?).

Hmm interesting stuff.

Also ....are you concerned that the Aloe Vera mixed with the DMSO could affect the RESV since it is something other than pure DMSO ? I think I would prefer the water mixed instead of the aloe.

I don't know about pre-mixing. My instinct says no, that the fresher the
combination, the better it would be, but I really have no clue.
As to the Aloe Vera -
I love Aloe. I have been eating/drinking fresh aloe gel for years (from the living plant, not the bottle).
I can't imagine it doing anything but good stuff. I hope it doesn't adversely affect Res, but I don't know.
I do know that when I apply the mixture to my arm, I feel the effects very soon after...5 to 10 minutes. The first time
I did it, I really felt it. Now, I don't notice as much, but I did feel the difference when I went to work out today, so I guess
the aloe isn't interfering.

[missminni]

Anthony_Loera

Do you have enough confidence in the purity of your 99% t-res now that you know that many of us will be taking it with DMSO directly into the bloodstream? I kind of worry about what that other 1% is going into me now. Anyone have thoughts here? Is 99% pure pure enough for DMSO delivery?

I thought about it too. I'm taking 98% pure so that leave 2% of ass't metals and emodin.
Does anyone know if that is anything to be concerned about?

[Anthony_Loera]

Anthony_Loera

Do you have enough confidence in the purity of your 99% t-res now that you know that many of us will be taking it with DMSO directly into the bloodstream? I kind of worry about what that other 1% is going into me now. Anyone have thoughts here? Is 99% pure pure enough for DMSO delivery?

Hi, the last test here:

Resveratrol 99% COA

has it at 99.8%...

I am confident enough to try it myself using DMSO, and we doing some work with it for another RevGenetics project I mentioned previously here regarding injectables. I don't recommend injectables at this point, as we are working on solubility for rsv with a company in Pompano Beach.

Having said that, the DMSO might be something one of my customers in Canada may seriously consider with his t-rsv powder.

A

[missminni]

Anthony_Loera

Do you have enough confidence in the purity of your 99% t-res now that you know that many of us will be taking it with DMSO directly into the bloodstream? I kind of worry about what that other 1% is going into me now. Anyone have thoughts here? Is 99% pure pure enough for DMSO delivery?

Hi, the last test here:

Resveratrol 99% COA

has it at 99.8%...

I am confident enough to try it myself using DMSO, and we doing some work with it for another RevGenetics project I mentioned previously here regarding injectables. I don't recommend injectables at this point, as we are working on solubility for rsv with a company in Pompano Beach.

Having said that, the DMSO might be something one of my customers in Canada may seriously consider with his t-rsv powder.

A

Do you mean may seriously consider taking or seriously consider making, i.e. as a commercial product.

[Anthony_Loera]

Anthony_Loera

Do you have enough confidence in the purity of your 99% t-res now that you know that many of us will be taking it with DMSO directly into the bloodstream? I kind of worry about what that other 1% is going into me now. Anyone have thoughts here? Is 99% pure pure enough for DMSO delivery?

Hi, the last test here:

Resveratrol 99% COA

has it at 99.8%...

I am confident enough to try it myself using DMSO, and we doing some work with it for another RevGenetics project I mentioned previously here regarding injectables. I don't recommend injectables at this point, as we are working on solubility for rsv with a company in Pompano Beach.

Having said that, the DMSO might be something one of my customers in Canada may seriously consider with his t-rsv powder.

A

Do you mean may seriously consider taking or seriously consider making, i.e. as a commercial product.

I just ordered this spray bottle:
http://www.herbalrem...st-sprayer.html

So, I will seriously try DMSO using RevGenetics powder for my personal use. If the product itches, presents a rash, or makes my wife run for the hills because of my breath, I will probably not consider it as a possible product for RevGenetics.


thanks
A

Edited by Anthony_Loera, 30 November 2007 - 09:40 PM.

[malbecman]

missmini,

2.4 micromolar is a concentration measurement of the resveratrol in the blood. It is 0.0000024 moles of resveratrol per liter of blood, a pretty small concentration-but then most substances in your body are at low concentrations. A mole is a unit that is independent of the mass or density of a molecule and represents a finite amount of it. In this case, a mole is 6.023 E23 atoms in scientific notation or written out, its 602,300,000,000,000,000,000,000 atoms.

you're correct, I assumed 100% absorption in my dermal absorption calculation but it is likely lower, more like 50-80%. Also, since resveratrol is lipophillic (literally, fat loving, dissolves in fat and not water), a lot of it does likely get hung up in the dermal cell membranes (which have a lot of lipid/fat). Still, it should be better than taking it orally....

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

[browser]

I'm looking forward to what comes out of this, especially since I suggested using DMSO as a transport agent. If it works, I'm in.

[ilanso]

Well, actually, Chip has suggested it first over 2 years ago (13-Mar 2005, 08:54 PM):

http://www.imminst.o...o...ost&p=52989

He also discussed DMSO in various other posts

[missminni]

Well, actually, Chip has suggested it first over 2 years ago (13-Mar 2005, 08:54 PM):

http://www.imminst.o...o...ost&p=52989

He also discussed DMSO in various other posts

I read the previous discussions about DMSO being used as a transport and they were mostly
about how and why it wouldn't work. How come nobody actually tried it?
I'm not taking anything away from anybody, but talk is cheap.
You gotta walk the walk.

[niner]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

Malbecman has already done a good job of explaining as well as qualifying his original upper limit calculation, but I'd like to throw in another thing. Not only is the ~88uM plasma concentration a theoretical upper limit assuming ALL of the resveratrol makes it through the skin, but it is also assuming that it gets through the skin instantly, just like an IV injection. It isn't going to get through the skin instantly, however. It will take many minutes before most of it is absorbed, so as Maxwatt mentioned, the liver will constantly be taking the resveratrol away, converting it to the various conjugates. So in reality, you are not going to get 88uM at any time. You will probably be lucky to get a couple micromolar. Not that that's bad, mind you- orally, it would take a 5 gram dose to reach a couple micromolar. So this would seem to be more cost effective, if nothing else. Without some research lab somewhere doing a blood level, we can only speculate as to what's really happening, but it does seem like a reasonable thing.

Also note that by washing the drug in with DMSO, you are bypassing many of the systems that nature has evolved to protect you from foreign substances. Just like shooting up, really. We do indeed walk the walk around here, but it would seem to be on the exercise wheel in our human guinea pig cage...

[sUper GeNius]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

It isn't going to get through the skin instantly, however. It will take many minutes before most of it is absorbed, so as Maxwatt mentioned, the liver will constantly be taking the resveratrol away, converting it to the various conjugates.

You are making assumptions. I agree that 88 may be simply be an upper limit, but are you basing your assumption of the "many minutes" absorption time on anything in fact? Wher eis the rest of the tres as the first bit is being absorbed into teh blood stream? I make a counter supposition. The tres will go entirely into circulation within a minute, just as one can taste the DMSO in ones mouth almost immediately. Any evidence to the contrary? Why not 40uM? 50? 60?

[missminni]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

Malbecman has already done a good job of explaining as well as qualifying his original upper limit calculation, but I'd like to throw in another thing. Not only is the ~88uM plasma concentration a theoretical upper limit assuming ALL of the resveratrol makes it through the skin, but it is also assuming that it gets through the skin instantly, just like an IV injection. It isn't going to get through the skin instantly, however. It will take many minutes before most of it is absorbed, so as Maxwatt mentioned, the liver will constantly be taking the resveratrol away, converting it to the various conjugates. So in reality, you are not going to get 88uM at any time. You will probably be lucky to get a couple micromolar. Not that that's bad, mind you- orally, it would take a 5 gram dose to reach a couple micromolar. So this would seem to be more cost effective, if nothing else. Without some research lab somewhere doing a blood level, we can only speculate as to what's really happening, but it does seem like a reasonable thing.

Also note that by washing the drug in with DMSO, you are bypassing many of the systems that nature has evolved to protect you from foreign substances. Just like shooting up, really. We do indeed walk the walk around here, but it would seem to be on the exercise wheel in our human guinea pig cage...

LOL
Often, ignorance is bliss. In my case it allows me to take chances I might not if I knew better.
But knowing that restreverol is not harmful, even in large doses, and that DMSO shares the same reputation, I didn't
see it as a risk at all. The only thing I worried about was that it wouldn't be effective. But it was. Very much so.
I hope I didn't offend anyone by what I said. It's just that when I get an idea, I have to act on it to find out if it works or not.
Theorizing only goes so far.

[missminni]

You are making assumptions. I agree that 88 may be simply be an upper limit, but are you basing your assumption of the "many minutes" absorption time on anything in fact? Wher eis the rest of the tres as the first bit is being absorbed into teh blood stream? I make a counter supposition. The tres will go entirely into circulation within a minute, just as one can taste the DMSO in ones mouth almost immediately. Any evidence to the contrary? Why not 40uM? 50? 60?

I read that DMSO enters the bloodstream in 5 minutes, and that is about the time I've noticed it.
The first time I took Res like that I actually felt it, almost like a rush, but not euphoric. Now I don't feel that, but I do
feel the difference when I work out. Maybe there is enough left in my system so that my body is used to it, and it
no longer has that initial effect. I don't even get the garlic taste in my mouth, or maybe I don't notice.
I am looking forward to hearing how it affects others.

[niner]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

It isn't going to get through the skin instantly, however. It will take many minutes before most of it is absorbed, so as Maxwatt mentioned, the liver will constantly be taking the resveratrol away, converting it to the various conjugates.

You are making assumptions. I agree that 88 may be simply be an upper limit, but are you basing your assumption of the "many minutes" absorption time on anything in fact? Wher eis the rest of the tres as the first bit is being absorbed into teh blood stream? I make a counter supposition. The tres will go entirely into circulation within a minute, just as one can taste the DMSO in ones mouth almost immediately. Any evidence to the contrary? Why not 40uM? 50? 60?

Assumptions? Moi? OK, you're right. The "many minutes" (for most of the resveratrol, mind you) was based on nothing more than my meager knowledge of chemistry, pharmacology, and biophysics. How much DMSO does it take for you to be able to taste it? One micromolar? One nanomolar?

[sUper GeNius]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

It isn't going to get through the skin instantly, however. It will take many minutes before most of it is absorbed, so as Maxwatt mentioned, the liver will constantly be taking the resveratrol away, converting it to the various conjugates.

You are making assumptions. I agree that 88 may be simply be an upper limit, but are you basing your assumption of the "many minutes" absorption time on anything in fact? Wher eis the rest of the tres as the first bit is being absorbed into teh blood stream? I make a counter supposition. The tres will go entirely into circulation within a minute, just as one can taste the DMSO in ones mouth almost immediately. Any evidence to the contrary? Why not 40uM? 50? 60?

Assumptions? Moi? OK, you're right. The "many minutes" (for most of the resveratrol, mind you) was based on nothing more than my meager knowledge of chemistry, pharmacology, and biophysics. How much DMSO does it take for you to be able to taste it? One micromolar? One nanomolar?

Can you be more specific? For instance, what specific knowledge do you have regarding the delivery of substances dissolves in DMSO? Again, why closer to the lower limit, (2uM,) rather than closer to the upper limit, 88uM? I have very little knowledge of chemistry, pharmacology, and biophysics. But at least I do know that. I can imagine that the answer depends on the rate of absorption vs the rate of conjugation by the liver. Can you provide ANY hard data?

[niner]

LOL
Often, ignorance is bliss. In my case it allows me to take chances I might not if I knew better.
But knowing that restreverol is not harmful, even in large doses, and that DMSO shares the same reputation, I didn't
see it as a risk at all. The only thing I worried about was that it wouldn't be effective. But it was. Very much so.
I hope I didn't offend anyone by what I said. It's just that when I get an idea, I have to act on it to find out if it works or not.
Theorizing only goes so far.

I'm not offended. Really, I'm glad that you're looking at this and sharing it with us. I might even try it myself, if y'all turn into Auwerx rats. I was not concerned about the toxicity of resveratrol or DMSO, but rather the other stuff that's going along for the ride. And I really think that a realistic expectation for peak plasma concentration of free resveratrol from a topical application of 100mg is probably single digit uM at best.

Edit: fixed weird software-induced glitch...

Edited by niner, 01 December 2007 - 04:59 AM.

[missminni]

LOL
Often, ignorance is bliss. In my case it allows me to take chances I might not if I knew better.
But knowing that restreverol is not harmful, even in large doses, and that DMSO shares the same reputation, I didn't
see it as a risk at all. The only thing I worried about was that it wouldn't be effective. But it was. Very much so.
I hope I didn't offend anyone by what I said. It's just that when I get an idea, I have to act on it to find out if it works or not.
Theorizing only goes so far.

I'm not offended. Really, I'm glad that you're looking at this and sharing it with us. I might even try it myself, if y'all turn into Auwerx rats. I was not concerned about the toxicity of resveratrol or DMSO, but rather the other stuff that's going along for the ride. And I really think that a realistic expectation for peak plasma concentration of free resveratrol from a topical application of 100mg is probably single digit uM at best.

I've been using more like 200 to 300 mg and am planning on upping that.
I was concerned about the "other stuff" too, but the res i am taking is 98.7% pure and 1.3% that remains
is harmless from what I've been told. The thing to watch our for when using DMSO is that you don't have any bug repellant
or other chemical products on your skin.
What number uM is necessary to get optimal activity and how much res would be
needed to achieve it?

[niner]

Good question on what would be the proper doseage. If a 5 gram oral dose gave a measured blood level of ~2.4 uM from the paper Maxwatt referenced and a 100 mg dermal dose that I calculated gave a ~88uM dose, then you should need to really scale down your doseage. 50-100 mgs should be plenty for everyone.

That would suggest that 2.7 mg would be needed, right? A pretty small amount.

Stephen

OMG?
I've been doing 100 to 200 mg cutaneously thinking that was a small amount, and
that at least 80% of it would enter the bloodstream, as opposed to the 10% that gets in
orally.
I don't understand...what ~2.4uM or ~88uM represent.
I'm lost here. Somebody please explain. Thanks

It isn't going to get through the skin instantly, however. It will take many minutes before most of it is absorbed, so as Maxwatt mentioned, the liver will constantly be taking the resveratrol away, converting it to the various conjugates.

You are making assumptions. I agree that 88 may be simply be an upper limit, but are you basing your assumption of the "many minutes" absorption time on anything in fact? Wher eis the rest of the tres as the first bit is being absorbed into teh blood stream? I make a counter supposition. The tres will go entirely into circulation within a minute, just as one can taste the DMSO in ones mouth almost immediately. Any evidence to the contrary? Why not 40uM? 50? 60?

Assumptions? Moi? OK, you're right. The "many minutes" (for most of the resveratrol, mind you) was based on nothing more than my meager knowledge of chemistry, pharmacology, and biophysics. How much DMSO does it take for you to be able to taste it? One micromolar? One nanomolar?

Can you be more specific? For instance, what specific knowledge do you have regarding the delivery of substances dissolves in DMSO? Again, why closer to the lower limit, (2uM,) rather than closer to the upper limit, 88uM? I have very little knowledge of chemistry, pharmacology, and biophysics. But at least I do know that. I can imagine that the answer depends on the rate of absorption vs the rate of conjugation by the liver. Can you provide ANY hard data?

My estimate is lower than the theoretical maximum because skin is tough to get through. There is no active transport, only passive diffusion. That will be aided by DMSO, to be sure, but it's still limited by the speed of diffusion, which is not instantaneous. Resveratrol is somewhat lipophilic (logP is around 3, IIRC) as Malbecman mentioned, so it is going to tend to partition into the subcutaneous fat. That is going to slow down its entry into plasma. Meanwhile, the conjugative enzymes in the liver are chewing the resveratrol up about as fast as it's getting in. Sulfation of resveratrol in the liver is very efficient. As the resveratrol diffuses into systemic circulation, there's only a couple of minutes before it's going to see the liver, and at that point it's mostly going to be conjugated. So anyway, as you state above, it's down to the rate of absorption vs the rate of conjugation. The rate of conjugation is fast. That's pretty well established from published pharmacokinetic studies. The rate of dermal absorption is a bigger question. Percutaneous flux is typically measured in micrograms x cm(-2) x Hr(-1). A typical value for a drug with a permeation enhancer might be 0.1 to 100. 10 is reasonable for a guesstimate, so if the area was 100 cm**2, the flux would be 1mg per hour. Even if this is off by a factor of a hundred, it still doesn't look too promising. Transdermal delivery is usually used for things that are very potent and for which you want to maintain a continuous low plasma concentration. Fentanyl would be a great example.

[sUper GeNius]

Are you saying that we are looking at 100mg/hr tops? If so, that is far worse than ingesting it, as far as peak blood levels, no? What would happen if one ingested the DMSO?? 1gm dissolved in say, 5ml, down the hatch.

[niner]

Are you saying that we are looking at 100mg/hr tops? If so, that is far worse than ingesting it, as far as peak blood levels, no? What would happen if one ingested the DMSO?? 1gm dissolved in say, 5ml, down the hatch.

Yeah. If I were off by another order of magnitude, it would be a gram an hour. That wouldn't be too bad. Still, that's now a thousand times as much as what I think is a reasonable guess. The guess could easily be off by a factor of ten, but I think a thousand is probably pushing it.

If you ingested a solution in DMSO, I think most of it would come out of solution as soon as it hit the stomach. It should act about the same as ethanol. The way some of us are taking resveratrol is to dissolve it in ethanol, then pour it with stirring into an aqueous solution of Miralax. (polyethylene glycol) The resveratrol comes out of solution, but forms very small particles, stabilized by the PEG. This method was developed by lucid, and is sort of a poor man's SRT501. Anyway, you'd get a cloud of resveratrol particles in your stomach. Without a stabilizing agent, I don't know if you'd maintain as fine a particle size, but it doesn't sound like a bad way to take it, if you want to drink the DMSO anyway. Wouldn't DMSO taste kind of bad though?

[sUper GeNius]

So what do you think a reasonable number would be then? You said 2 uM is what you would get from 5 grams orally. Now is that 5 g ordinary powedered t-res? You think 200mg in dmso through the skin is likely yo get you to 2uM?