"Resveratrol interacts with β-LG to form 1:1 complexes." BLG is 18.4 KDa, while resveratrol is 228 Daltons, so for 1 gram of resveratrol you'll need 18,400/228 = 80 grams of the protein. For a 5 gram dose, you're looking at a bit less than a pound of the protein. That's a lot of milk... Might it be the case that resveratrol also binds to other milk proteins? At perhaps greater than 1:1? It should also be solubilized by milk fat, which is already in suspension.
Also, this makes me wonder if human serum albumin is not acting as a carrier protein for resveratrol in the blood. Might that be a mechanism for it to dodge secondary metabolism?
It dissolves well in chai (50% milk) - 12oz + 4g res seems to work fine. The pre made mixes (found in cartons) I've seen, list pepper as the most abundant ingredient besides black tea - perhaps this is helpful, but I am not willing to speculate.
Regarding albumin (in my limited understanding): Given the extreme abundance of albumin in plasma, I too have often wondered what it might be bound with (resveratrol, being one permutation). In many plasma profiling (peptides) studies it is removed using a depletion column since it will swamp all the other signals. Are you aware of work in this area? I've seen good methods for releasing small molecules from plasma proteins, but wasn't sure if anyone looked specifically at albumin. Since I'm mostly algorithm jockey, I'm less familiar with extraction protocols.
I've used lecithin as a carrier too, and a hand blender makes lecithin soluble in about 15 seconds (as a comment to a previous post by maxwatt). I've used chai the last few weeks though - because of convenience.
Without a quantitative measuring stick, I cannot speculate on what is a better carrier. The only option discussed on these boards that I have not attempted is DMSO.
Are there any legal/regulatory issues that prevent a group of people from contracting a lab to analyze a batch of samples? grassroots pharmacokinetics coop? has anyone previously looked at the cost structures for this? I see people extracting their own plasma all the time in the lab - it is much easier than having to muck with IRB approvals, if you just need any ol' blood sample. A 'trained phlebotomist' does not ensure a good stick - in fact I'm sure the labs I've seen aren't the only ones with a few phlebotomist jokes. Some thought would need to be put into the protocols, but I assume most of the important bits are already in the literature - sample collection specifics could be distributed e.g. via a youtube video. The key would be having enough people to make it worthwhile - both statistically, and economically. Set up and tear down of the instruments for different protocols seems to be where the technicians eat up the most labor cost, the auto sampler takes over after that - so setup should be a one time charge split among the number of samples. Solvent and column costs would also be split. Data analysis is simple, if we are only looking for the res peak - depending on the protocol, and availability of the raw data, there may be other peaks of interest that could be extracted too.
Free markets being what they are, I'm sure a suitable lab(s) could be found if there was sufficient interest. Like most people who have played with 99% res, I've invested $1K + thus far and I presume we all have a similar level of confidence in the commentary seen on the web discussing different carriers - and nothing beats knowing which data point you are in the spread when looking at a study
maxwatt, anthony, and others likely have a better handle on the total market for high purity res and thus whether there is a community large enough to support such a coop - dealers might collaborate on distributing study literature to new customers with their order since it would serve a common interest
