1084 replies to this topic

[stephen_b]

I'm imagining the taste of Resv mixed with pure Cocoa powder...(gags)

I think I can handle it...I'll try it in a shot glass mixed with water tonight

Tastes good actually. I've mixed cocoa and resveratrol in fish oil before.

Stephen

[sUper GeNius]

Got an email from Longevinex today. Same old spiel that large doses are not necessary. I have pasted it below:


-----------------------------------------------------------------------------------------------------------------------------------------------------
See Longevinex® featured on the electronic billboard, Reuters Building, Times Square, New York, Tuesday April 1
Growing body of evidence shows matrix of polyphenols, as provided in Longevinex®, exert greater benefit than resveratrol alone. 150-year lifespan not far off?

Longevinex® found to be superior to green tea molecule in independent human study.

San Dimas, CA – While molecular biologists and news reporters present jaw-dropping evidence that a red wine molecule called resveratrol may usher in the advent of anti-aging pills, other researchers report that a matrix of small natural molecules, such as those in Longevinex®, exert far greater effects than resveratrol alone. For example, a recently reported human study found the Longevinex dietary supplement is superior to green tea.

And while Barbara Walters (ABC News) interviews senior Americans who are living vibrantly active lives beyond the age of 100, she also interviews experts who now say small molecules that can influence the genetic machinery within living cells, concentrated in pill form, may make it possible for Americans to live 150 healthy years on a regular basis.

An optimal matrix for nutraceuticals would provide molecules found in grapes, sesame seeds, onions and apple peels which appear to work additively (1) and synergistically (2), even exerting a greater effect upon the human genome than plain resveratrol. (3)

While many of the beneficial effects of these natural molecules appear to be dose dependent, requiring doses that exceed those found in foods, there may be diminishing returns when supra-high doses of these molecules are employed.

For example, one study shows that extreme doses resveratrol may impair the uptake of folic acid (vitamin B9) by intestinal cells. (4) Folic acid is an essential nutrient required for repair of DNA gene strands and is utilized by the body to limit the amount of an undesirable blood protein called homocysteine.

Optimal health benefits appear to be achieved when consuming an array of polyphenolic molecules in the range of (100-200 milligrams), as provided in 2-3 glasses of aged red wine, or in well-designed nutraceuticals like Longevinex®, which contain no alcohol. Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Late in 2007 Steven R McAnulty, Ph.D., Associate Professor in the Health, Leisure, and Exercise Science department at Appalachian State University, in the first successful human study of a resveratrol supplement, reported that Longevinex®, but not the primary active molecule (catechin) in green tea, significantly reduces markers of oxidation and inflammation among endurance athletes at modest doses. The results of that study were eventually reported at the Annual Meeting of the American College of Sports Medicine, Southeast Chapter in February, 2008.

For more information about Longevinex, please visit: www.longevinex.com or call 1 866 405-4000. ####

1. Food Chemistry Toxicology 2008 Apr;46(4):1320-6.

The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage.

Kaindl U, Eyberg I, Rohr-Udilova N, Heinzle C, Marian B.

Department of Medicine 1, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

In the colorectal epithelium oxidative stress is observed endogenously in premalignant adenoma cells or induced by nutritional factors like fatty acid hydroperoxides (LOOH). Bioactive phenols like resveratrol and quercetin can quench reactive oxygen species and protect from pro-oxidative damage. Our study used colorectal adenoma and carcinoma cell lines to assess antioxidant protective effects of resveratrol and quercetin. It demonstrated that both compounds efficiently protect from oxidative stress induced by LOOH. Effective concentrations (10muM resveratrol and 1muM quercetin) can easily be reached in the intestinal lumen after consumption of plant foods or food supplements. Both compounds prevent LOOH-induced formation of intracellular H(2)O(2), stimulation of cyclooxygenase-2 and vascular endothelial growth factor. For reduction of endogenous H(2)O(2) levels in colorectal tumor cells higher antioxidant-concentrations are needed in all cell lines. Que! rcetin (10muM) alone even increased H(2)O(2) in LT97 adenoma cells and stimulated VEGF production. Resveratrol and quercetin also induced 10-30% and 40-60% cell loss respectively by apoptosis. In summary, this indicates that resveratrol and quercetin have little protective capacity in absence of exogenous stress. They are however highly efficient in protecting against nutrition induced oxidative stress damage suggesting that this constitutes the major part of their tumor protective activity.

1. Pharmazie. 2002 Aug;57(8):556-8.

Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.

Melzig MF, Escher F.

Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany. matthias.f.melzig@rz.hu-berlin.de

Quercetin and resveratrol are weak inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) activity of the neuroblastoma cell line SK-N-SH. The long term incubation of the cells for 4 days with quercetin, resveratrol and a combination of both substances in concentrations lower than necessary for inhibition of NEP and ACE activity induced the cellular enzyme activity of NEP and ACE associated with an inhibition of cellular proliferation. The long term treatment of neuroblastoma cells with quercetin and resveratrol enhanced the differentiation state of the cells. Taking into account the significance of NEP and ACE for the degradation of amyloid beta peptides, the effect of quercetin and resveratrol as constituents of red wine for a neuroprotective activity is discussed.

1. Molecular Nutrition Food Research 2006 Nov; 50(11):1072-9.

Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity.

Hsu CL, Yen GC

Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan. Fax: +886-4-2285-4378.

Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre-adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3-L1 pre-adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORAC(ROO) value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time- and dose-dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not! necrotic cells. Quercetin treatment of cells caused a significant time- and dose-dependent increase in the caspase-3 activity. Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3-L1 pre-adipocytes.

2. Biochemical Pharmacology. 2000 Nov 15; 60(10):1539-48.

Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway.

Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D.

Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA. marionc@astro.temple.edu

In atherosclerosis and tumor initiation, inducible nitric oxide synthase (iNOS) has been implicated in the damage of vascular walls and DNA, respectively. Moderate consumption of red wine has been ascribed as a preventive for coronary heart disease; however, there has been much debate over whether the beneficial effect is from grape polyphenolic components or ethanol. We studied the interaction of grape compounds on nitric oxide (NO) production by macrophages, mediators of blood vessel damage in atherosclerosis. For the murine macrophage cell line RAW 264.7, stimulation with lipopolysaccharide and interferon-gamma led to expression of the iNOS gene and production of NO. The polyphenols quercetin and resveratrol at a micromolar range suppressed iNOS gene expression and NO production, as determined by reverse transcription-polymerase chain reaction and nitrite assay. The polyphenols were also found to be scavengers of NO in an acellular system using sodium! nitroprusside under physiological conditions. Ethanol, at a moderate level, did not produce any appreciable level of reduction of iNOS or NO activity. However, its presence at 0.1 to 0.75% enhanced the effect of grape polyphenols concentration-dependently. Thus, the interaction between these components plays a significant role in the health effects of red wine, especially with respect to their effect on the NO pathway.

3. Proceedings Nutrition Society 2008 Feb; 67(1):42-7.

Effects of dietary polyphenols on gene expression in human vascular endothelial cells.

Nicholson SK, Tucker GA, Brameld JM.

Division of Nutritional Sciences, University of Nottingham, School of Biosciences, Loughborough LE12 5RD, UK. sbxskn@nottingham.ac.uk

Previous studies have shown that consumption of fruit and vegetables plays a role in preventing the onset of CVD. These beneficial effects have been linked to the presence of polyphenolic compounds in plant-derived foods and their antioxidant capacity. It has been hypothesised that polyphenols may also have a direct effect on vascular endothelial cell growth and the expression of genes involved in angiogenesis and other roles of the endothelium. Previous studies in this area have tended to use concentrations of polyphenols that are supraphysiological (1-100 microm). The effects of more physiological concentrations (0.1 microm) of various individual polyphenols on gene expression were therefore investigated in cultured human umbilical vein endothelial cells (HUVEC) using both microarray and quantitative RT-PCR methodologies. Treatment of HUVEC with ferulic acid, quercetin or resveratrol (0.1 microm) resulted in changes to gene expression that for the thre! e treatments amounted to significant (>2-fold) down-regulation of the expression of 363 genes and significant (>2-fold) up-regulation of 233 genes of the 10 000 genes present on the microarray. The majority of these genes were affected by resveratrol. Quantitative RT-PCR studies indicated that resveratrol (0.1 microm) significantly increased the expression of the gene encoding endothelial NO synthase (eNOS), which synthesises the vasodilator molecule NO, and both resveratrol and quercetin decreased expression of the potent vasoconstrictor, endothelin-1 (ET-1), while ferulic acid had no effect. The effects of resveratrol (0.1 microm) were also investigated when HUVEC were under oxidative stress following treatment with H2O2 (0-50 microm), which dose-dependently increased expression of eNOS and ET-1. Resveratrol stimulated eNOS mRNA in the absence of H2O2 and still allowed the increase with H2O2, but the effects were not additive. In contrast, resver! atrol blocked the stimulatory effect of H2O2 on ET-1 exp ression. Hence, resveratrol has potent effects at a physiological concentration (0.1 microm) that would be expected to result in vasodilation and therefore help reduce blood pressure and the risk of CVD.

4. European Journal Nutrition 2007 Sep;46(6):329-36.

Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds.

Lemos C, Peters GJ, Jansen G, Martel F, Calhau C.

Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal. clara006@med.up.pt

Folate is a water-soluble B vitamin with a crucial role in the synthesis and methylation of DNA and in the metabolism of several amino acids. In the present study we investigated whether beverages like wine, beer and tea, or some of their specific constituents, affect the intestinal uptake of (3)H-folic acid or (3)H-methotrexate (an antifolate). All tested beverages significantly inhibited the uptake of (3)H-folic acid by Caco-2 cells. Most of these beverages, with the exception of wines (not tested), also inhibited (3)H-methotrexate uptake in these cells. Additionally, ethanol, when tested separately, inhibited the uptake of both compounds. Some of the tested phenolic compounds, namely myricetin, epigallocatechin gallate (EGCG) and isoxanthohumol, markedly inhibited (3)H-folic acid uptake. Myricetin and EGCG also had a concentration-dependent inhibitory effect upon the uptake of (3)H-methotrexate by Caco-2 cells. Resveratrol, quercetin and kaempferol we! re able to inhibit the transport of both compounds, but only in the concentration of 100 microM. In conclusion, dietary constituents may impact on intestinal folate uptake, as here shown for phenolic compounds.



Longevinex
457 W. Allen Ave. Suite 117
San Dimas, CA 91773
http://www.longevinex.com
(866) 405-4000

If you wish to be removed from our mailing list, please click here.

[niner]

To paraphrase Ronald Reagan, "there he goes again"...

Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Sounds like someone's been reading ImmInst. Widely?

[sUper GeNius]

To paraphrase Ronald Reagan, "there he goes again"...

Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Sounds like someone's been reading ImmInst. Widely?

yeah, it's a frigging epidemic.

I take 4 to 5 grams per day, have no tendon problems whatsoever. Now if he mentioned projectile defecation as a side effect, then I would have to agree.

[missminni]

To paraphrase Ronald Reagan, "there he goes again"...

Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Sounds like someone's been reading ImmInst. Widely?

yeah, it's a frigging epidemic.

I take 4 to 5 grams per day, have no tendon problems whatsoever. Now if he mentioned projectile defecation as a side effect, then I would have to agree.

There was only one person who mentioned the achilles heel issue, and it had nothing to do with Res, and he writes a paper as if this is a common side effect. Isn't that unethical?
As for the the other side effect, I will vouch for that. The cramps are ridiculous when I go over a gram. How do you deal with 4 to 5 grams? I know my dad does that much with no problem and my dogs, they do more than that and have no issue with it either. I'm the only one who can't handle it.
It's doing wonders for my dogs, and my Dad still gets benefit from it, although he still has to take vicodin to be pain free...he has spinal stenosis. He just got diagnosed. But he says the Res still helps and he never slept better in his life. There has to be something that mitigates the laxative effect or
is it possible that its your body's way of saying that's all you should take? I envy my dogs. They get healthier every day and I get Montezuma's revenge.

[sUper GeNius]

To paraphrase Ronald Reagan, "there he goes again"...

Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Sounds like someone's been reading ImmInst. Widely?

yeah, it's a frigging epidemic.

I take 4 to 5 grams per day, have no tendon problems whatsoever. Now if he mentioned projectile defecation as a side effect, then I would have to agree.

There was only one person who mentioned the achilles heel issue, and it had nothing to do with Res, and he writes a paper as if this is a common side effect. Isn't that unethical?
As for the the other side effect, I will vouch for that. The cramps are ridiculous when I go over a gram. How do you deal with 4 to 5 grams? I know my dad does that much with no problem and my dogs, they do more than that and have no issue with it either. I'm the only one who can't handle it.
It's doing wonders for my dogs, and my Dad still gets benefit from it, although he still has to take vicodin to be pain free...he has spinal stenosis. He just got diagnosed. But he says the Res still helps and he never slept better in his life. There has to be something that mitigates the laxative effect or
is it possible that its your body's way of saying that's all you should take? I envy my dogs. They get healthier every day and I get Montezuma's revenge.

I generally do not get diarrhea from the t-res. What I get is one or two massive urges to go a day, an unstoppable urge. If I'm not near a toilet then I will get some cramps off and on until I do go. But generally my stools are soft, but not diarrhea. Hope no one is eating breakfast as they read this.

[missminni]

I generally do not get diarrhea from the t-res. What I get is one or two massive urges to go a day, an unstoppable urge. If I'm not near a toilet then I will get some cramps off and on until I do go. But generally my stools are soft, but not diarrhea. Hope no one is eating breakfast as they read this.

Lucky you. Wow. Maybe it's just my body chemistry.

[malbecman]

Yes, you have to love that "widely reported" part. I've taken up to 4 grams per day and never had a tendonitis problem (altho' my usual dose is ~1 gram).

To paraphrase Ronald Reagan, "there he goes again"...

Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Sounds like someone's been reading ImmInst. Widely?

[inawe]

To paraphrase Ronald Reagan, "there he goes again"...

Supra-high dose resveratrol pills (500 mg or more) have recently been introduced, which may be counterproductive. For example, Achilles heel tendonitis is now widely reported when using supra-high dose resveratrol pills.

Sounds like someone's been reading ImmInst. Widely?

Seems the consensus is for lower doses. Here on Imminst the dosage went from 20 post a day to just a couple.

[stephen_b]

I took 8 grams this morning on an empty stomach in an effort to knock out the remaining traces of my bronchitis, being inspired by missminni's dog. Nothing to report in terms of side effects four hours later.

Stephen

[kenj]

I'm one of those poor souls who reported about tendon pain. Follow-up: no tendon problems, - after a break, I continue to take a gram, or more.

[missminni]

I took 8 grams this morning on an empty stomach in an effort to knock out the remaining traces of my bronchitis, being inspired by missminni's dog. Nothing to report in terms of side effects four hours later.

Stephen

How's the bronchitis?

[Anthony_Loera]

Bill does take at least 300mg, according to his website.

I guess he has made the decision not to take 500mg or more, and that is fine.
But to say that it has been reported that it causes issues, etc, etc... when I have not experienced any, nor have yet to see any study that talks about these issues, might be a bit premature. You know Sirtris would have talked about it after their mega gram studies regarding safety...

As far as mega grams, I can only point back to Dr. Sinclair's November paper where I believe it states that toxicity has been shown at 1 gram per kilogram of body weight in animals.

I suppose that would make it 70grams for a 70KG person... Of course you can divide this by ten and get 7grams to be on the safe side...

A

[stephen_b]

I took 8 grams this morning on an empty stomach in an effort to knock out the remaining traces of my bronchitis, being inspired by missminni's dog. Nothing to report in terms of side effects four hours later.

Stephen

How's the bronchitis?

Well, I've had it for over three weeks now. It worsened and showed itself to be bacterial when I got a little run down on a family vacation, I went on antibiotics 5 days ago, and today I took the big dose of resveratrol in the hopes of knocking it back further. I'll know more after a good night's sleep. Thanks for asking.

Stephen

Edited by stephen_b, 01 April 2008 - 09:06 PM.

[Anthony_Loera]

I just saw a bit of the Barbara Walters and Dr. Sinclair interview tonight...

Barbara:
"How much wine, do I have to drink to get the <resveratrol longevity effects>?"

Dr. Sinclair...
"You would need to drink 1000 bottles <of wine>..."

For the average red wine, that sounds like 2-7 grams, maybe a bit more.
A

[sUper GeNius]

I just saw a bit of the Barbara Walters and Dr. Sinclair interview tonight...

Barbara:
"How much wine, do I have to drink to get the <resveratrol longevity effects>?"

Dr. Sinclair...
"You would need to drink 1000 bottles <of wine>..."

For the average red wine, that sounds like 2-7 grams, maybe a bit more.
A

"wesweratrol wongevity effects."

[scorpe]

I generally do not get diarrhea from the t-res. What I get is one or two massive urges to go a day, an unstoppable urge. If I'm not near a toilet then I will get some cramps off and on until I do go. But generally my stools are soft, but not diarrhea. Hope no one is eating breakfast as they read this.

Lucky you. Wow. Maybe it's just my body chemistry.

May be it is woman related. I gave my wife resv. since she had a severe cold and I also gave here some other pills but she is not interested what she takes as long as it helps. Yesterday she mentioned that she had a bit diarrhea and she never has problems like that so I told here it could be the resv. Are more women using resv. and do they have more problems with resv. then men?

[katzenjammer]

Has anyone here ever tried Dermacrine from primordial performance? They claim to have developed a topical formula that, among other compounds, includes resveratrol. Just thought someone here might have looked into it.

[exotiq]

Has anyone here ever tried Dermacrine from primordial performance? They claim to have developed a topical formula that, among other compounds, includes resveratrol. Just thought someone here might have looked into it.

It's a joke. There is a negligible amount of resv in their sustain product. Use Jacob's DMSO gel if you're intent on transdermal delivery.

[katzenjammer]

Has anyone here ever tried Dermacrine from primordial performance? They claim to have developed a topical formula that, among other compounds, includes resveratrol. Just thought someone here might have looked into it.

It's a joke. There is a negligible amount of resv in their sustain product. Use Jacob's DMSO gel if you're intent on transdermal delivery.

Yeah, I was wondering about that - there doesn't seem to be any information about the amount of each compound, including Resv. I'm sure they would claim that their "special" delivery technology means less resv is needed in the first place.

[theukraine]

On rsv/whey protein shakes: Are people still using this method? It seems very convenient to me. However, I was under the impression that casein binds to EGCG--rendering it useless. Does this mean that I can't take green tea at the same time? Is it possible similar things happen with the rsv?

[maxwatt]

On rsv/whey protein shakes: Are people still using this method? It seems very convenient to me. However, I was under the impression that casein binds to EGCG--rendering it useless. Does this mean that I can't take green tea at the same time? Is it possible similar things happen with the rsv?

Not a problem, gallates are bound to casein more strongly than resveratrol; some green tea extract purveyors claim recent studies show the binding to EGCG only delays absorbtion, rather than preventing it. A couple of us havused whey protein or milk consistently, and found it did not diminish the positive effects we got from resveratrol.

Currently I'm using HPMC as a dispersant, to suspend resveratrol in water. Works too.

For those I offered to get some HPMC 50 at cost, I should have it early next week.

[tintinet]

On rsv/whey protein shakes: Are people still using this method? It seems very convenient to me. However, I was under the impression that casein binds to EGCG--rendering it useless. Does this mean that I can't take green tea at the same time? Is it possible similar things happen with the rsv?

Ain't no casein in whey, qua whey, BTW, so non-issue for pure whey (concentrates and isolates).

[theukraine]

Thanks for the info, I was adding some whole milk to my protein shakes--hence the casein--to improve the taste. I guess I will forego the milk when I take EGCG at the same time. I figure this way I can still take all my supplements in the morning, hopefully improve rsv bioavailability, and not have to worry about whether casein affects EGCG or not.

[exotiq]

I started the dark chocolate experiment this week with Revgenetics X500 caps and Ghirardelli's 60% cocoa baking chocolate. I take one square (will check measurement) of the choc and nuke it for 35 seconds with a tsp of water. The water keeps the chocolate from buring in the micro. I pour-off the excess H20 and add one X500 cap and stir with a teaspoon and down the hatch.

My daughter suffers from PWS and loves her small daily chocolate fix.

[maxwatt]

I started the dark chocolate experiment this week with Revgenetics X500 caps and Ghirardelli's 60% cocoa baking chocolate. I take one square (will check measurement) of the choc and nuke it for 35 seconds with a tsp of water. The water keeps the chocolate from buring in the micro. I pour-off the excess H20 and add one X500 cap and stir with a teaspoon and down the hatch.

My daughter suffers from PWS and loves her small daily chocolate fix.

Keep water away from chocolate, it ruins it.

Actually on further thought, you might find it easier to mix the res into chocolate milk. I prefer Fox's U-bet syrup to Hershey's. You will have to use 98 or 99% resveratrol rather than a 50% extract.

Edited by maxwatt, 17 April 2008 - 12:11 PM.

[exotiq]

I started the dark chocolate experiment this week with Revgenetics X500 caps and Ghirardelli's 60% cocoa baking chocolate. I take one square (will check measurement) of the choc and nuke it for 35 seconds with a tsp of water. The water keeps the chocolate from buring in the micro. I pour-off the excess H20 and add one X500 cap and stir with a teaspoon and down the hatch.

My daughter suffers from PWS and loves her small daily chocolate fix.

Keep water away from chocolate, it ruins it.

Actually on further thought, you might find it easier to mix the res into chocolate milk. I prefer Fox's U-bet syrup to Hershey's. You will have to use 98 or 99% resveratrol rather than a 50% extract.

Thanks for the PM MW. I was only using the water to keep the choc from burning. It wasn't bitter at all. I'll try syrup. What about the concerns related to milk?

[maxwatt]

I started the dark chocolate experiment this week with Revgenetics X500 caps and Ghirardelli's 60% cocoa baking chocolate. I take one square (will check measurement) of the choc and nuke it for 35 seconds with a tsp of water. The water keeps the chocolate from buring in the micro. I pour-off the excess H20 and add one X500 cap and stir with a teaspoon and down the hatch.

My daughter suffers from PWS and loves her small daily chocolate fix.

Keep water away from chocolate, it ruins it.

Actually on further thought, you might find it easier to mix the res into chocolate milk. I prefer Fox's U-bet syrup to Hershey's. You will have to use 98 or 99% resveratrol rather than a 50% extract.

Thanks for the PM MW. I was only using the water to keep the choc from burning. It wasn't bitter at all. I'll try syrup. What about the concerns related to milk?

Concerns with milk are unfounded; milk proteins do bind tea polyphenols, which lead people to assume it would inactivate all polyphenols. This is not the case. Only gallates appear to be affected as to serum levels, and even these are affected primarily as tot he speed of absorption rather than the absolute level. Several members, including myself, have taken resveratrol with milk or whey proteins, and find the effects are not diminished vis a vis joint pain.

Milk proteins do bind to resveratrol, similar to a detergent action, but release it in the gut.

[Smithy]

Nano Dispersion Gel

The combination of A1-E, 4-AD-EC, and 1-Diol-EC, in Nano-Dispersion Gel, is almost beyond description. In fact, the Nano-Dispersion Gel complex is right out of science fiction, except it's real. The best way to describe this stuff is to say, if you don't want it in you, don't touch it!

Reservatrol in Nano Dispersion Gel - REZ-V

What do you guys think? In the link to the thread, those body builders are saying positive things about transdermal resv.

[theukraine]

There are threads here as well as on LEF about the antagonistic effects of niacinamide on resveratrol effectiveness. It seems that Ortho-Core is essentially the only multi that does not include it. Do any of you worry about this/actively attempt to reduce niacinamide consumption? Any clue on how much niacinamide would be enough to cause problems?