1084 replies to this topic

[Anthony_Loera]

theukraine,

can you post your question as a standalone post? I am not sure how it relates to maximizing resveratrol effectiveness. It doesn't appear to be a part of this thread.

A

[stephen_b]

Keep water away from chocolate, it ruins it.

How so? I've been mixing my chocolate powder into hot water. Does this degrade the chocolate?

Stephen

[tintinet]

Keep water away from chocolate, it ruins it.

How so? I've been mixing my chocolate powder into hot water. Does this degrade the chocolate?

Stephen

Likely yes, to some degree. Depends, also, upon what you started with (raw cocoa vs. roasted, processed, dutched, etc.)

[maxwatt]

Keep water away from chocolate, it ruins it.

How so? I've been mixing my chocolate powder into hot water. Does this degrade the chocolate?

Stephen

Chocolate powder for beverages is different.
Bar or Couverture chocolate, as used for molding or coating, takes on an unattractive appearance if water is present, and the taste and texture are unfavorably impacted.

[stephen_b]

Likely yes, to some degree. Depends, also, upon what you started with (raw cocoa vs. roasted, processed, dutched, etc.)

I've been using raw cocoa powder.

The other way I take it is to mix a heaping teaspoon into my tablespoon of cod liver oil. Tastes good too.

Stephen

[stephen_b]

Anyone try NOWs liquid lecithin? Wow is that ever hydrophobic. It seems to dissolve much better in milk.

Stephen

[mikeinnaples]

Anyone try NOWs liquid lecithin? Wow is that ever hydrophobic. It seems to dissolve much better in milk.

Stephen

No, I have been using lecithin granules from bulk foods and disolving enough for a few days at a time in water and refrigerating it. It taste so much better than most of the liquid lecithin i have used my resveratrol just disappears in it.

Dunno.

[stephen_b]

I've reversed my low opinion of liquid lecithin. Mixed in water, it's a disaster. Put in some whey powder first though and the lecithin dissolves very well. I just add a gram of 99% resveratrol, drink twice daily, and I'm done. I've cut out the vodka step entirely.

Stephen

[mikeinnaples]

I've reversed my low opinion of liquid lecithin. Mixed in water, it's a disaster. Put in some whey powder first though and the lecithin dissolves very well. I just add a gram of 99% resveratrol, drink twice daily, and I'm done. I've cut out the vodka step entirely.

Stephen

Have you tried lecithin granules at all? I have found consistency that seems to work quite well. I am mixing it up a few days worth at a time. If it gets too thick I can just add a little water and shake it up, it i add too much water I can just add a few more granules.

[stephen_b]

Have you tried lecithin granules at all?

Yes, it's all I've ever used up until now. If you mix it up on the spot, there is much more stirring with the granules. On the other hand, if the liquid lecithin mixes so well with whey and water, maybe the granules would too.

[maxwatt]

If you're using whey powder, you don't need the lecithin. The whey protein does a good job of dispersing resveratrol.

This message brought to you from the Department of Redundancy Department

[krillin]

If you're using whey powder, you don't need the lecithin. The whey protein does a good job of dispersing resveratrol.

Whey protein has trouble with Vital Prime. I still have a few resveratrol floaters after stirring 200 times. Whey is still much better than Miralax, which has no noticeable effect. Milk thistle is the exact opposite: whey does nothing, but Miralax is significantly (but not fully) effective.

[krillin]

You have to read the full text to find out that curcumin and turmeric induce UGT1A1 and UGT1A6 at concentrations lower than their inhibitory concentrations. (Trans-resveratrol is metabolized by the former but not the latter.)

Biol Pharm Bull. 2006 Jul;29(7):1476-9.
Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells.
Naganuma M, Saruwatari A, Okamura S, Tamura H.
Kyoritsu University of Pharmacy, Tokyo, Japan.

Turmeric, the powdered dry rhizome of the Curcuma longa plant, and curcumin, the major anti-oxidant constituent of turmeric, have been shown to possess chemopreventive activity. To elucidate the possible interaction of turmeric and curcumin with conjugation reactions, which in many cases are involved in the activation of procarcinogens, we measured their effects in the conjugation of 1-naphthol in Caco-2 cells, a human colon carcinoma cell line, within a 24 h period. Turmeric exhibits inhibitory activity toward both sulfo- and glucuronosyl conjugations of 1-naphthol at approximately the same levels (IC(50)=0.24 and 0.29 mg/ml, respectively). Curcumin inhibits sulfo-conjugation at lower concentrations (IC(50)=9.7 microg/ml), but only showed weak inhibition toward glucuronosyl conjugation of 1-naphthol in Caco-2 cells. In addition, turmeric was found to strongly inhibit in vitro phenol sulfotransferase (SULT) activity and demonstrate moderate inhibitory properties against UDP-glucuronosyl transferase (UGT) activity in Caco-2 cells (IC(50)=0.17 mg/ml and 0.62 mg/ml, respectively). Curcumin also strongly inhibits in vitro phenol sulfotransferase activity with an IC(50) of 2.4 microg/ml. Moreover, and in contrast to the moderate inhibition of UGT activity by turmeric and curcumin, both induce the expression of the UGT1A1 and UGT1A6 genes, revealed by real-time PCR analysis. These findings are indicative of a possible interaction of both turmeric and curcumin with conjugation reactions in the human intestinal tract and colon. This in turn may affect the bioavailability of therapeutic drugs and toxicity levels of environmental chemicals, particularly procarcinogens.

PMID: 16819192

[maxwatt]

If you're using whey powder, you don't need the lecithin. The whey protein does a good job of dispersing resveratrol.

Whey protein has trouble with Vital Prime. I still have a few resveratrol floaters after stirring 200 times. Whey is still much better than Miralax, which has no noticeable effect. Milk thistle is the exact opposite: whey does nothing, but Miralax is significantly (but not fully) effective.

You should try some HPMC.

[mikeinnaples]

Going to try HPMC eventually .......but for now the best results I get is as follows:

Potato Vodka + Vital Prime -> wait till dissolved + pre-dissolved Lecithin with a thick consistency -> stir till dissolved -> drink


For silymarin this has been working well:

Extra Virgin Olive oil + Silymarin -> mix and refrigerate for 10 minutes -> mix again -> add in pre-dissolved lecithin with a thick consistency -> stir -> drink


Not sure if the olive oil will have any negative effect on the milk thistle, but it has been working like a charm to get it dissolved and dispersed.

[krillin]

Maybe there is a drawback to green tea. It induces UGT1A8 and UGT1A10, the latter being able to glucuronidate resveratrol.

At least UGT1A1 is safe. Couldn't find anything on UGT1A9.

Drug Metab Dispos. 2007 Feb;35(2):228-33.
Effects of green tea compounds on irinotecan metabolism.
Mirkov S, Komoroski BJ, Ramírez J, Graber AY, Ratain MJ, Strom SC, Innocenti F.
Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

The effects of green tea compounds on the metabolism of irinotecan have never been investigated. We aimed to study whether catechins [(-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC), (-)-epicatechin] affect the inactivation metabolism of irinotecan into 7-ethyl-10-[4-N-(1-piperidino)-1-amino]carbonyloxycamptothecin (NPC) (by CYP3A4) and 7-ethyl-10-hydroxycamptothecin (SN-38) into 7-ethyl-10-hydroxycamptothecin glucuronide (SN-38G) (by UGT1A1). Human liver microsomes, hepatocytes and Hep G2 cells were incubated with catechins and treated with irinotecan and/or SN-38. NPC and SN-38G formation was measured by high-performance liquid chromatography. UGT1A1 mRNA levels were measured by real-time polymerase chain reaction. In human liver microsomes, a concentration-dependent decrease in the formation of NPC and SN-38G was observed. In human hepatocytes, a significant increase in SN-38G production was observed in 33% (EGCG), 44% (ECG), and 44% (EGC) of the hepatocyte preparations. Phenobarbital increased the formation of SN-38G in 100% of the same hepatocyte preparations. In Hep G2 cells, no increase in SN-38G formation was observed. With the exception of ECG in one liver, catechins did not increase UGT1A1 mRNA levels. NPC production was also significantly increased in 40% of the hepatocyte preparations for each catechin. However, the production of 6beta-hydroxytestosterone remained unaffected in other hepatocyte preparations. At pharmacologically relevant concentrations, catechins are unlikely to inhibit the formation of irinotecan inactive metabolites when administered concomitantly. The induction effect of catechins on UGT1A1 seems to be modest and highly variable. Catechins do not induce CYP3A4 activity. The effect of acute and prolonged use of green tea on the pharmacokinetics of irinotecan in patients remains to be evaluated.

PMID: 17108060

[krillin]

Forget it. It was intended as a joke. I saw the word vagina and couldn't control myself. I have to learn how to take vaginas more seriously.

They bite when offended.

I added this to my Netflix queue after reading Camille Paglia's favorable review.

Are you sure you want to watch that movie?
When Maxwatt wrote that they bite I thought it was just a figure of speech. May be he saw the movie, or better yet he produced it.

It's now available to watch instantly on Netflix, so you don't have to waste a rental slot. Not as violent as I expected, but I still approve.

[edward]

hydroxypropyl methylcellulose (HPMC) $31 a pound!

This site sells thickeners, emulsifiers etc. to chefs interested in molecular gastronomy, advanced pastry making etc.

scroll down to the bottom of the page for hydroxypropyl methylcellulose, the first items are only methylcellulose
http://www.willpowde...lcellulose.html

[maxwatt]

hydroxypropyl methylcellulose (HPMC) $31 a pound!

This site sells thickeners, emulsifiers etc. to chefs interested in molecular gastronomy, advanced pastry making etc.

scroll down to the bottom of the page for hydroxypropyl methylcellulose, the first items are only methylcellulose
http://www.willpowde...lcellulose.html

OMG, we can make a chocolate resveratrol mousse au gratin!

[malbecman]

Nice find, Edward! Thanks........

hydroxypropyl methylcellulose (HPMC) $31 a pound!

This site sells thickeners, emulsifiers etc. to chefs interested in molecular gastronomy, advanced pastry making etc.

scroll down to the bottom of the page for hydroxypropyl methylcellulose, the first items are only methylcellulose
http://www.willpowde...lcellulose.html

[lojzenov]

Ok, can someone please answer two questions. I've been reading this thread for an hour and i've come to 10th page, still pretty much no clue

In summary
With what should i mix trans-resveratrol (99%) ? (without ethanol/alcohol if possible)
Should i still be taking green tea(EGCG) or should i stop?

thanks

[missminni]

Ok, can someone please answer two questions. I've been reading this thread for an hour and i've come to 10th page, still pretty much no clue

In summary
With what should i mix trans-resveratrol (99%) ? (without ethanol/alcohol if possible)
Should i still be taking green tea(EGCG) or should i stop?

thanks

I mix it in milk. It dissolves quickly and is tasteless, and from what I understand, whey protein
enhances resveratrol.

[maxwatt]

Ok, can someone please answer two questions. I've been reading this thread for an hour and i've come to 10th page, still pretty much no clue

In summary
With what should i mix trans-resveratrol (99%) ? (without ethanol/alcohol if possible)
Should i still be taking green tea(EGCG) or should i stop?

thanks

Missminni's method of mixing resveratrol with milk is a good one. If you prefer not to use milk, you can mix a small amount of HPMC* in water, dissolve, then add the powdered resveratrol ad stir. If it is good quality, most of the resveratrol particles will be small, as will be the case with micronized resveratrol. Most of the 98 and 99% that Hedgehog looked at, though not micronized, most of the particles were smaller than 10 microns. Vital Prime had the most large particles.

Up to 30 or 40 ml of an alcoholic beverage is thought to be good for ones health. It is not necessary, but I believe it greatly enhances the bioavailability of non-mcronized resveratrol, and perhaps of micronized powder too. If you don't like alcohol, use milk.

I sometimes use this method: Put 30 ml (one shot) of 80 proof alcohol (e.g., Jack Daniels, Scotch, et al.) in a "rocks" glass. Add powdered resveratrol, stir. Works with two or three grams, haven't tried more. This greatly reduces the particle size, especially the larger particles (more surface area). Dissolve 30 mg of HPMC in 3 ounces (90cc) cold water. The higher the gelling temperature of the HPMC, the easier this will be. Pour the HPMC water into the Resveratrol & booze. Stir and imbibe. The alcohol is so dilute one might as well not be drinking. The resveratrol may form a sludge at the bottom if allowed to sit, but it is easily stirred up. Adding more water disperses it readily, indicating the HPMC is bound to it and dispersing it in water.

---

I do not think there is a reason to stop supplementing green tea. On the contrary, the effect may be more than additive. A recently published study found that resveratrol does not modulate IGF-1, though it shares most other gene-activation with caloric restriction. Green tea modulates IGF-1** so it should fill in the gap, more closely mimicking the effects of caloric restriction than resveratrol alone. I take a green tea extract, or drink copious amounts of green tea.

*Edward's post above gives a source for HPMC.

** 10: Adhami VM, Siddiqui IA, Ahmad N, Gupta S, Mukhtar H.
Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer.
Cancer Res. 2004 Dec 1;64(23):8715-22.
PMID: 15574782

Edited for speling and accuracy

Edited by maxwatt, 15 June 2008 - 12:01 PM.

[lojzenov]

Thanks, your answer was very helpfull
I'll probably try it with whey protein or alcohol
One more quick question. Is it really worthless taking resveratrol if you supplement with niacinamid ?

Edited by lojzenov, 15 June 2008 - 02:16 PM.

[maxwatt]

Thanks, your answer was very helpfull
I'll probably try it with whey protein or alcohol
One more quick question. Is it really worthless taking resveratrol if you supplement with niacinamid ?

Niacinamide was said to block the Sirt1 activation in flatworms and yeast. It did not extend the lifespan of wrms, and apparently blocked the life-extending effect of resveratrol.
Why are you supplementing with niacinamide?

[lojzenov]

It's an ingredient in my multivitamin(pretty much every multi has it, except few exceptions like ortho core and supernutrition perfect blend, which are quite expensive)

[krillin]

hydroxypropyl methylcellulose (HPMC) $31 a pound!

This site sells thickeners, emulsifiers etc. to chefs interested in molecular gastronomy, advanced pastry making etc.

scroll down to the bottom of the page for hydroxypropyl methylcellulose, the first items are only methylcellulose
http://www.willpowde...lcellulose.html

According to this site

E15 ~ 15 cps
E4M ~ 4000 cps
F50 ~ 50 cps

[stephen_b]

It's an ingredient in my multivitamin(pretty much every multi has it, except few exceptions like ortho core and supernutrition perfect blend, which are quite expensive)

Well, resveratrol itself is expensive too. You can ask yourself why buy expensive resveratrol and then hobble its effects with niacinamide.

[sUper GeNius]

It's an ingredient in my multivitamin(pretty much every multi has it, except few exceptions like ortho core and supernutrition perfect blend, which are quite expensive)

Well, resveratrol itself is expensive too. You can ask yourself why buy expensive resveratrol and then hobble its effects with niacinamide.

Is inositol nicotinate an okay form of B3?

[krillin]

It's an ingredient in my multivitamin(pretty much every multi has it, except few exceptions like ortho core and supernutrition perfect blend, which are quite expensive)

Well, resveratrol itself is expensive too. You can ask yourself why buy expensive resveratrol and then hobble its effects with niacinamide.

Is inositol nicotinate an okay form of B3?

That's what I use.