1084 replies to this topic

[tintinet]

So, is everyone using lecithin and/or Miralax and/or ETOH taking their t-resv. on an empty stomach or with food; in the AM, upon rising, or before bed?

Thanks!

[health_nutty]

I'm taking 50% resveratrol in wine and lecithin with food in the AM.

[oaklandj]

So, is everyone using lecithin and/or Miralax and/or ETOH taking their t-resv. on an empty stomach or with food; in the AM, upon rising, or before bed?

I'm personally taking on an empty stomach right now, because it's a bit easier (I take it before leaving for work, and eat breakfast at work), but I also read in another thread that taking with food might be better because there's a competitive reduction in glucuronidation. In the same thread (the 500-club one), someone suggested taking on an empty stomach maximizes absorption.

Not sure which is better - preventing metabolism, or optimizing absorption.

[malbecman]

I"m a believer in the optimizing absorption and hopefully getting max. peak blood levels. I take mine w/ lecithin in water on an empty stomach ~11am in the morning. I usually need coffee plus food first thing in the morning to get me going..... [tung]

[steelheader]

I've tried various morning combinations and sequences, all with the goal of having the best possible mid-morning workout. What seems to work best for me:

First thing in the morning: Alcar, r-lipoic, bacopa, rhodiola, and Omega-3 fish oil well mixed in water. (This is repeated in late afternoon with the addition of Pomegranate PomP40)

Followed by a cup of hot chocolate made with water and a couple tablespoons of raw cocoa powder

Next, usually about an hour after the alcar cocktail, one gram of 98% resveratrol in lecithin water.

Five or ten minutes later, the workout.

[riseboi]

I am toying with the idea of getting a 3 month supply of resv to do @ 2g/day. I would slowly ramp it to that amount. If I were to get blood tests before and after, what particular markers would I want to pay most attention to?

[maxwatt]

So, is everyone using lecithin and/or Miralax and/or ETOH taking their t-resv. on an empty stomach or with food; in the AM, upon rising, or before bed?

I'm personally taking on an empty stomach right now, because it's a bit easier (I take it before leaving for work, and eat breakfast at work), but I also read in another thread that taking with food might be better because there's a competitive reduction in glucuronidation. In the same thread (the 500-club one), someone suggested taking on an empty stomach maximizes absorption.

Not sure which is better - preventing metabolism, or optimizing absorption.

Sinclair and Auwerx's rodent studies obtained favorable effects mixing resveratrol with food.

FWIW, I've seen studies with CoQ10 - another non-water soluble, poorly absorbed supplement -- indicating that solubulized form achieved the highest concentrations, while lipid dispersed CoQ10 achieved almost as high a level. Plain CoQ10 powder achieved a much lower serum level. I expect a similar outcome for resveratrol.

I take resveratrol at breakfast, currentlly two grams, with Miralax water, or on alternate days, mixed into yogurt. I expect the fat aids absorbtion I plan to switch to Lcithin next week. I do not add quercetin; I believe eating a little fruit will reduce glucoridaton for better utilization.

Tonight I tried using a little Scotch to dissolve a gram of resveratrol, before adding Miralax and some water. The resulting murky and milky brown liquid tasted like Scotch, so it wasn't a complete waste.

Edited by maxwatt, 02 August 2007 - 09:33 PM.

[niner]

I take my entire daily dose at one time, on an empty stomach. The idea here is to maximize the peak blood level, as malbecman mentioned. I don't think it matters what time of day you take it, at least not with my present dose of 5 mg/kg synthetic rsv. I'm not getting any psych effects from it. At the moment I'm still dumping a spoonful of powder in my mouth, but am about to set up stock solutions of resveratrol in EtOH and Miralax in water, to be mixed just before drinking. My thinking in going with Miralax (PEG 3350) rather than lecithin is that lecithin is not very soluble in water, but PEG is. I want the emulsifier to be right there in solution (rather than dispersed like lecithin would be), when the rsv is coming out of solution in order to minimize particle size.

It would be interesting to play around with lecithin stabilized oil/water emulsions.

One problem with all of this is that short of drawing blood and analyzing for resveratrol, I have no idea how to determine which formulation is best. About the only thing we can do is look at conventional biomarkers, but we would need to be scrupulous about not changing other variables, and collecting decent data sets would take forever. I don't think we can really go by how great we feel under a given protocol, when you consider the impact of placebo effects and whatever else is going on in our lives at the moment.

[lucid]

My supply ran out for this week, so I am waiting on my new batch to arrive, but for the 2 weeks before this week: I have been mixing resv in ETOH then mixing that in a PEG+H20 mixture. Then I mix in a little pomegranate concentrate and add water until it tastes good. This practice doesn't take but a couple of minutes and saves me about 7 hours a day in life I also think I'm going to up my dose from 500mg to 1g since I am ordering a larger batch.

[whentnc]

Yeah, what health_nutty said.  I've never seen ALCAR come up in relation to resveratrol.  Quercetin may improve resveratrol bioavailability by inhibiting its glucuronidation and sulfation, but I'm not aware that ALCAR does anything for it. 

If your ethanol is dry, I've read it will hold 50 mg rsv per millilitre.  Water in the ethanol will suppress this.  I don't know the solubility of rsv in the two glycols, but I would speculate that it's less than ethanol, due to their higher ratio of hydroxyls to carbons.  RSV solubility in water is very low, 0.03 mg/ml.  These solubility numbers are from the not necessarily authoritative http://www.search.co...nce/Resveratrol.

For a sublingual (or transdermal) formulation, I was wondering if it would be a good idea to acidify the mixture a bit with a weak acid (white vinegar, ascorbic acid?) to make sure the resveratrol doesn't ionize.  Ionized substances tend not to be absorbed.  The pKa of the most acidic proton on resveratrol is 9.14 +/- 0.2 (http://ntp.niehs.nih...resveratrol.pdf) and the pH of saliva is normally around 7.4, I think, so the resveratrol should be 1.8% ionized.  (ionization calculator at http://www.manuelsweb.com/pka.htm)  If you use the low end of the pKa range and a pH of 7.5, it would be 3.5% ionized.  Thus acidification could help, but only a little.  You would not want to eat a Tums shortly before trying sublingual resveratrol though.

http://www.patentsto...escription.html

The results of these two tests provide evidence of a potent protective action afforded by the combination, which is particularly marked in the case of the combinations of acetyl L-carnitine and propionyl L-carnitine with resveratrol or with a grape extract containing resveratrol.

Description

The present invention relates to a new use of a combination composition of L-carnitine or an alkanoyl L-carnitine and a trihydroxy or tetrahydroxystilbene for the preventive or therapeutic treatment of cerebral disorders brought about by ageing and use of neurotoxic drugs.



The motility reduction percentages observed were 85.5% for endothelin alone and 69.6-65.5% and 60.3% for L-carnitine, acetyl L-carnitine and propionyl L-carnitine, respectively, which were administered intra-peritoneally to the animals at the dose of 300 mg/kg for the three days preceding the experiment and half an hour before the ET-1 injection.

Resveratrol alone (2.5 mg/kg) led to a 60.4% reduction and approximately the same reduction was achieved with a grape extract containing polyphenols and titred in resveratrol. However, the combination of resveratrol and carnitine restored the motility of the endothelin-treated animals almost to normal values. In the case of the combined administration of resveratrol and propionyl L-carnitine, the number of movements of the animals was practically identical to that of control animals, thus demonstrating an unexpected synergistic potentiation of the effects.

Significant synergistic activity was also detectable with the use of resveratrol or natural polyphenolic products containing resveratrol in combination with acetyl L-carnitine or, though to a lesser extent, with L-carnitine.

Edited by whentnc, 02 August 2007 - 07:13 PM.

[whentnc]

Yeah, what health_nutty said.   I've never seen ALCAR come up in relation to resveratrol.  Quercetin may improve resveratrol bioavailability by inhibiting its glucuronidation and sulfation, but I'm not aware that ALCAR does anything for it. 

If your ethanol is dry, I've read it will hold 50 mg rsv per millilitre.  Water in the ethanol will suppress this.  I don't know the solubility of rsv in the two glycols, but I would speculate that it's less than ethanol, due to their higher ratio of hydroxyls to carbons.  RSV solubility in water is very low, 0.03 mg/ml.  These solubility numbers are from the not necessarily authoritative http://www.search.co...nce/Resveratrol.

For a sublingual (or transdermal) formulation, I was wondering if it would be a good idea to acidify the mixture a bit with a weak acid (white vinegar, ascorbic acid?) to make sure the resveratrol doesn't ionize.   Ionized substances tend not to be absorbed.  The pKa of the most acidic proton on resveratrol is 9.14 +/- 0.2 (http://ntp.niehs.nih...resveratrol.pdf) and the pH of saliva is normally around 7.4, I think, so the resveratrol should be 1.8% ionized.  (ionization calculator at http://www.manuelsweb.com/pka.htm)  If you use the low end of the pKa range and a pH of 7.5, it would be 3.5% ionized.   Thus acidification could help, but only a little.   You would not want to eat a Tums shortly before trying sublingual resveratrol though.

Excellent - Great - -------- now here is more ---------

"HPBCD" " THPB-P -- hydroxypropyl BCD "

http://www.cyclodex....p?page_id=4&n=4

___--- so this would be MUCH better to use insted of ethanol or glycerol, all this stuff is on hit so lets figure this RSV, ALCAR, Quercitin, Ellegiac acid, in a THPB-P base - powerhouse delivery..


solubility (e.g., > 2000 fold) can be achieved by using low

concentration of BCD (1.5%) plus a small amount of additives (0.1%–

1%), such as carboxymethyl cellulose, sodium acetate and potassium

phosphate. This simple yet effective approach can also improve the

loading of t-RA up to 10 times over the previously published results

using CD derivatives including hydroxypropyl BCD (HPBCD).

Edited by whentnc, 02 August 2007 - 07:10 PM.

[health_nutty]

Very interesting. So are you just adding ALCAR to the mix?

[inawe]

http://www.patentsto...escription.html

The results of these two tests provide evidence of a potent protective action afforded by the combination, which is particularly marked in the case of the combinations of acetyl L-carnitine and propionyl L-carnitine with resveratrol or with a grape extract containing resveratrol.

I'm trying to figure this thing out. Whose advice should I follow?
I look very often at Pubmed. In many cases one paper contradicts
another. Some researchers have a solid reputation. Like David
Sinclair. To what extent was it spoiled when a vulture capitalist
convinced him to form a company (and then go public). What's the
primary goal now? Life extension or profit?
Then there are patents. If the Patent Office issues one it must mean
it has some merit, or not?
In the case discussed above, this guy Claudio Cavazza got a patent for
mixing a bit of resveratrol with all sorts of carnitines. I look a
little further and see that Cavazza has lots of patents about
carnitine for everything (hemorrhoids?). And I couldn't find any published paper by
this guy. Is it enough to pay a patent lawyer a couple of grands to
get one?
In Cavazza's company there are 3 things listed: 2 carnitines and
Procarbazine. This last one was FDA approved in 1969 so he must have
grabbed it free or very cheap.
Is it the game to set up a small "research" pharma and wait until some
vulture capitalist pours some money, or it gets bought by a bigger
outfit?

Correction: I meant to say "venture capitalist" and not "vulture
capitalist"

Edited by inawe, 02 August 2007 - 08:30 PM.

[whentnc]

http://www.patentsto...escription.html

The results of these two tests provide evidence of a potent protective action afforded by the combination, which is particularly marked in the case of the combinations of acetyl L-carnitine and propionyl L-carnitine with resveratrol or with a grape extract containing resveratrol.

I'm trying to figure this thing out. Whose advice should I follow?
I look very often at Pubmed. In many cases one paper contradicts
another. Some researchers have a solid reputation. Like David
Sinclair. To what extent was it spoiled when a vulture capitalist
convinced him to form a company (and then go public). What's the
primary goal now? Life extension or profit?
Then there are patents. If the Patent Office issues one it must mean
it has some merit, or not?
In the case discussed above, this guy Claudio Cavazza got a patent for
mixing a bit of resveratrol with all sorts of carnitines. I look a
little further and see that Cavazza has lots of patents about
carnitine for everything (hemorrhoids?). And I couldn't find any published paper by
this guy. Is it enough to pay a patent lawyer a couple of grands to
get one?
In Cavazza's company there are 3 things listed: 2 carnitines and
Procarbazine. This last one was FDA approved in 1969 so he must have
grabbed it free or very cheap.
Is it the game to set up a small "research" pharma and wait until some
vulture capitalist pours some money, or it gets bought by a bigger
outfit?

Correction: I meant to say "venture capitalist" and not "vulture
capitalist"

Good point -- I don't know. I do know that Acetyl L-Carnitine also has a very poor bioavailability and that I already take it along with my NA-RALA --- so either way I am going to put it into a sublingual -- so I figured, after reading that, that I might as well put them together -- and maybe add in the Quercetine too. Hopefully someone else will have a read

[niner]

Some researchers have a solid reputation. Like David
Sinclair. To what extent was it spoiled when a vulture capitalist
convinced him to form a company (and then go public). What's the
primary goal now? Life extension or profit?
Then there are patents. If the Patent Office issues one it must mean
it has some merit, or not?
In the case discussed above, this guy Claudio Cavazza got a patent for
mixing a bit of resveratrol with all sorts of carnitines. I look a
little further and see that Cavazza has lots of patents about
carnitine for everything (hemorrhoids?). And I couldn't find any published paper by
this guy.

Regarding LE vs. profit, in the free market, profit isn't everything, it's the only thing.

Patents... There has been a lot of abuse of the patent system of late. The USPTO seems to be horribly understaffed, as they have been granting patents for all sorts of nonsense for some while. My take is that a patent does not necessarily mean anything, though some certainly do.

Cavazza might be onto something with the ALCAR/RSV thing. Interesting results, but if they haven't been reproduced by anyone or published anywhere, well, let's just say it's a red flag. Maybe it's real, maybe it's not. I hope it's real, since I'm taking ALCAR and RSV. I feel pretty good, so who knows? I haven't fallen off any rotating platforms lately.

[niner]

"HPBCD" " THPB-P -- hydroxypropyl BCD "

http://www.cyclodex....p?page_id=4&n=4

___--- so this would be MUCH better to use insted of ethanol or glycerol, all this stuff is on hit so lets figure this RSV, ALCAR, Quercitin, Ellegiac acid, in a THPB-P base - powerhouse delivery..

There has been some use of Beta Cyclodextrin as a host for Resveratrol in the literature. In (J Pharmacol Exp Ther. 2002 Jul;302(1):369-73. Free Full Text. PMID: 12065739) they prepared an aqueous solution of 20% hydroxypropyl beta cyclodextrin that contained 6 mg/ml. That is a HUGE boost in solubility. Resveratrol in water alone is 0.03 mg/ml, so that's a 200-fold increase. They saw a peak plasma concentration of resveratrol aglycone (not yet glucuronidated) of 6.5 uM at an oral dose of 50 mg/kg. They did not look at resveratrol without CD complexation, but in a human study (Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1246-52. PMID: 17548692) Humans given a comparable dose of uncomplexed resveratrol had a peak plasma level of 2.4 uM from an oral dose of 5 grams. That would be 50 mg/kg if you weighed 100 kg. The rat peak occurred in the first few minutes, while the human peak occurred at 1.5 hours. Whether the time difference is due to complexation or species I don't know. Without looking at both complexed and uncomplexed RSV in the same species, I don't know how much we can take from this, but I'm struck by the apparent poor improvement in plasma levels from CD complexation, considering the effect that it has on solubility.

[malbecman]

Well, they did see a ~3X improvement in peak plasma levels, better than nothing, I guess. [wis]

50 mg/kg is a pretty large dose; you may be having other effects, too, in terms of metabolism since some low capacity metabolic pathways may be saturated at these higher dose levels (although glucuronidation and sulfation are usually considered pretty high capacity pathways......)

"HPBCD" " THPB-P -- hydroxypropyl BCD "

http://www.cyclodex....p?page_id=4&n=4

___--- so this would be MUCH better to use insted of ethanol or glycerol, all this stuff is on hit so lets figure this RSV, ALCAR, Quercitin, Ellegiac acid, in a THPB-P base - powerhouse delivery..

There has been some use of Beta Cyclodextrin as a host for Resveratrol in the literature. In (J Pharmacol Exp Ther. 2002 Jul;302(1):369-73. Free Full Text. PMID: 12065739) they prepared an aqueous solution of 20% hydroxypropyl beta cyclodextrin that contained 6 mg/ml. That is a HUGE boost in solubility. Resveratrol in water alone is 0.03 mg/ml, so that's a 200-fold increase. They saw a peak plasma concentration of resveratrol aglycone (not yet glucuronidated) of 6.5 uM at an oral dose of 50 mg/kg. They did not look at resveratrol without CD complexation, but in a human study (Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1246-52. PMID: 17548692) Humans given a comparable dose of uncomplexed resveratrol had a peak plasma level of 2.4 uM from an oral dose of 5 grams. That would be 50 mg/kg if you weighed 100 kg. The rat peak occurred in the first few minutes, while the human peak occurred at 1.5 hours. Whether the time difference is due to complexation or species I don't know. Without looking at both complexed and uncomplexed RSV in the same species, I don't know how much we can take from this, but I'm struck by the apparent poor improvement in plasma levels from CD complexation, considering the effect that it has on solubility.

[niner]

Well, they did see a ~3X improvement in peak plasma levels, better than nothing, I guess. 

50 mg/kg is a pretty large dose; you may be having other effects, too, in terms of metabolism since some low capacity metabolic pathways may be saturated at these higher dose levels (although glucuronidation and sulfation are usually considered pretty high capacity pathways......)

Yeah, a factor of ~3 isn't bad, although it might be due to species difference. But compared to the factor of 200 in solubility, it's disappointing. It just goes to show you that conjugation is the thing that kills resveratrol bioavailability rather than absorption. I think that you are right about metabolic pathways being saturated at high doses. My best guess is the glucuronidation and sulfation that occur in the gut. That's been shown to be saturable in a CACO2 model. The blood levels that have been seen in humans, comparing early PK studies where they looked at 25 mg doses and saw almost no free RSV vs. later studies with a 5 gm dose where they got 2.4 uM does suggest that something is getting saturated. In PMID: 17548692, the paper that looked at the 5 gm dose, they also looked at lower doses down to 0.5 gm. I'd like to see the relationship between dose and blood levels but don't have access to the full text. I wonder if the way that Tween 80 (or maybe PEG or CD) gets you higher levels is by whisking the resveratrol through the gut before it can get conjugated there, or maybe by increasing local concentration enough to swamp the gut enzymes?

[whentnc]

QUOTE
Niner,

I spoke with the main rep from cyclodex. He said that the derivatized group of cyclodextrin (THPB-) gives a molecule a 100 fold increase in bioavailability. Isn't that great news? Honestly, niner, I have very little chemistry background and am operating at capacity just stumbling through these particulars. I appreciate your help very much. All of the testing that has been done with resveratrol in the lab has been iIV - straight injection - all results are based upon getting 100% bioavailability. As you know, orally, you only absorb about 10 - 15%. Sublingually it is 100%. We HAVE to go the sublingual route in order to achieve maximum results. This will probably require dosing 5-10 times a day (I am not sure, but I think you can only do about 50mg at a time sublingual)

The rep at cyclodex said his team would give me the complete breakdown on how to put this together for 85EU$ an hour.
I am not looking at a major marketing operation -- I just want to put together a solid solution for me and my family -- and our pals @ImmInst. He said - to get me started to take 25g of THPB and put it into 100g of distilled water, then to add RSV until it gets cloudy - let it sit overnight -- and some other stuff -

My question to you: Do you have any idea how to figure out how much THPB and distilled water I would need to break down 100g of 98% RSV? The only thing I know is that the THPB to distilled water ratio is 1:4.

Thanks

Robert

ps whentnc stands for 'when tomorrow never comes'

Hi Robert,

There has been a lot of work done with oral dosing of resveratrol. Most of it, actually, has been dosed orally. There doesn't seem to be a huge problem with oral absorption; the real problem is that in the liver, and secondarily in the intestine are enzymes that modify the resveratrol by attaching a sugar (glucuronidation) or a sulfate (sulfation) to the molecule. The liver is highly efficient at this, so most of the resveratrol in your bloodstream is either glucuronidated or sulfated. We don't know what this does to resveratrol's effectiveness. Usually these modifications (generically referred to as "conjugation") result in an inactive molecule, but occasionally it is still active, and (rarely?) it might get de-conjugated inside a target cell, assuming it can get it. The only thing that I know for sure regarding deconjugation of resveratrol is that in rats, gut microbes will deconjugate it whereupon it is returned to the circulation as free resveratrol. It is a reasonable assumption that this happens in humans, but it doesn't have much bearing on the goal of obtaining high blood levels of pure resveratrol.

The main advantage of sublingual absorption is that the drug diffuses into the bloodstream in such a way that it does not immediately encounter the liver. Therefor it gets one pass through systemic circulation before it hits the liver and gets conjugated. The sublingual route does not offer as much surface area as the gut, so you still might not obtain a high peak plasma level that way. I don't have any data on that; that's just my guess about it.

Sirtris has a patented formulation (SRT501)of resveratrol that involves micronizing, i.e. getting it into a form where its particle size is in the range of 1-10 microns or so, then complexing it with an emulsifier/surfactant. They use polysorbate 80 for this. Guys at ImmInst speculate that we could use polyethylene glycol 3350 for this, which is sold over the counter as the laxative Miralax. Sirtris has shown that they get substantially higher blood levels of resveratrol using the SRT501 approach. I'm not sure how the formulation helps them avoid conjugation, but they at least claim higher levels. If that works, then cyclodextrin complexation might also work. I would imagine that Sirtris looked at CD, since that is a common approach, but maybe Sirtris went the route they did with 501 because it's cheaper in bulk. Anyway, I can only speculate, but it might work. The problem is how do you know it's working? I guess if your biomarkers start looking better and you get stronger, that's a good sign.

That paper I mentioned said that they got 6 mg RSV/ml of CD water solution. If you use that as the loading, then 100 gm resveratrol will need 16667 ml of solution, or 16.7 litres. In the paper I got this loading from, they used a 20% solution of CD, so that would be 200 gm per litre. Thus you'd be looking at 16.7 * 200 = 3.33 kg of CD. Ouch. That sounds like a lot of money. 6 mg/ml is about 200 times the water solubility of resveratrol as far as I know. If you could get a higher loading, then you wouldn't need as much CD, obviously, but I don't know how much more solubility you can get. It would probably be a lot more cost effective to use ethanol/Miralax like lucid described on ImmInst. That's what I'm doing.

You know, the 3 kg of CD for 100 gm resveratrol is bothering me. If it forms a 1:1 complex (I think that's what it does), it seems like you should not need a 30-fold excess of the CD. I wonder if 6 mg/ml is grossly undersaturated?

*the THPB (CD) is now 1.50 a gram

anyone have any other ideas?

[asnufu]

Thought I'd mention this find (using hot, non-boiling milk to deliver a phytochemical)

http://journals.camb...line&aid=928124

I'm expecting my first batch of 98% pure soon, and will try an ETHO+resv mix to solubilize, then add to hot milk to emulsify and enhance a la what's done above.
Thoughts appreciated ??

Edited by asnufu, 06 September 2007 - 02:51 PM.

[dannov]

I know this might seem out there, but how about an injectable solution?

[maxwatt]

I don't consider any of the available plant extracts or synthetics sufficiently pure to put directly in one's veins.

[health_nutty]

Thought I'd mention this find (using hot, non-boiling milk to deliver a phytochemical)

http://journals.camb...line&aid=928124

I'm expecting my first batch of 98% pure soon, and will try an ETHO+resv mix to solubilize, then add to hot milk to emulsify and enhance a la what's done above.
Thoughts appreciated ??

Interesting. Hot milk eliminates the effectiveness of tea. Sometimes it helps and sometimes it hurts. This stuff is not predictable!

[Anthony_Loera]

hmmm...

I know this might seem out there, but how about an injectable solution?

I think it will be an issue with solubility even if maxwatt was comfortable with a synthetic or pure source. As usually the IV liquid that is used when adding something to an IV is isotonic saline or 5% dextrose solution in water, and we all know how soluble resveratrol is in water...

A

[dannov]

True true, just wanted to put it out there. :D Thanks for the replies.

[geo12the]

Seems like there has been a lot of talk regarding bioavailbilty and the amount of resveratrol you need to take to reap any benefits. The way I tend to think about is that you may not need a huge amount of this stuff in your system to have a beneficial effect:

Anyone who has taken LSD can attest to the fact that ingesting a very miniscule amount of a compound can produce profound effects.

Resveratrol has pretty significant effects when fed to mice. I could be wrong, and if so someone please correct me, but from what I’ve read there is no reason to believe that resveratrol is inherently more bioavailble in mice than humans.

Something is responsible for the “French paradox” and resveratrol is a good candidate for playing a role. I would be willing to bet if you took the resveratrol out of wine the “French paradox” would disappear. The concentration of resveratrol in wine is not that high.

George

[dannov]

True George, however, one must not ignore the host of polyphenols and antioxidants that are abundant in Red Wine. It seems a more plausible explanation that the French Paradox is attributed to the polyphenols than the Res inside, but as you said, it may very well be like LSD in humans. Scientific work has shown very little traces of Res post-liver in human blood, which encourages folks to take a large dose to ensure that some circulates past the liver.

I plan on taking my res when it arrives with Bioperine (Piperine), and hope that it assists my body into getting more Res into my circulatory system.

[maxwatt]

hmmm...

I know this might seem out there, but how about an injectable solution?

I think it will be an issue with solubility even if maxwatt was comfortable with a synthetic or pure source. As usually the IV liquid that is used when adding something to an IV is isotonic saline or 5% dextrose solution in water, and we all know how soluble resveratrol is in water...

A

I suppose one could try snorting it then. [bl:)]

[beefytaco]

hmmm...

I know this might seem out there, but how about an injectable solution?

I think it will be an issue with solubility even if maxwatt was comfortable with a synthetic or pure source. As usually the IV liquid that is used when adding something to an IV is isotonic saline or 5% dextrose solution in water, and we all know how soluble resveratrol is in water...

A

I suppose one could try snorting it then. [bl:)]

.... rolling up a $100 bill ....

[niner]

True George, however, one must not ignore the host of polyphenols and antioxidants that are abundant in Red Wine. It seems a more plausible explanation that the French Paradox is attributed to the polyphenols than the Res inside, but as you said, it may very well be like LSD in humans. Scientific work has shown very little traces of Res post-liver in human blood, which encourages folks to take a large dose to ensure that some circulates past the liver.

I agree with all of this except the LSD part. There is neither evidence nor theory that would indicate significant resveratrol activity from sub-milligram doses. A more reasonable open question would consider the activity or lack thereof of the sulfate and glucuronide conjugates.