25 replies to this topic

[unbreakable]

Reversing Atherosclerosis Naturally

About a year and a half after commencing daily supplementation with GliSODin®, measurable decreases in subjects’ IMT were detected. Approximately two years after starting GliSODin® supplementation, decreases in IMT values became statistically significant. In dramatic contrast, control subjects not receiving GliSODin® experienced increased IMT values over the same period.21 There were no reported side effects in either group.

This remarkable study demonstrated that reversal of atherosclerosis in adults with multiple risk factors for future cardiovascular disease is possible through a combination of healthy diet and daily intake of GliSODin® (orally bioavailable superoxide dismutase). These findings were confirmed by monitoring of clinical and biological health parameters, and measurements of carotid IMT. The GliSODin® regimen, “improves, significantly, the anti-oxidant status,” noted investigators, “and diminishes, remarkably, carotid artery IMT.”

Cloarec M, Caillard P, Provost JC, et al. GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging. Allerg Immunol.(Paris). 2007 Feb;39(2):45-50.

[DukeNukem]

I've been taking (and recommending) GliSODin since it first came out several years ago. LEF has a new formulation that I now take (two caps per day): Endothelial Defense
http://www.lef.org/n.../item00997.html

Background:
http://www.glisodini...ackgrounder.htm

[roxanne]

Does this appear to be more effective than pomegranate extract?

[curious_sle]

Does this appear to be more effective than pomegranate extract?

LEF recommends to combine it with pommegrenate AFAIK

[unbreakable]

On www.glisodin.org you find many studies about this interesting supplement.

[lucid]

Hippocampal Long-term Potentiation, Memory, and Longevity in Mice that Overexpress Mitochondrial Superoxide Dismutase
http://www.pubmedcen...z&artid=1847321

Superoxide has been shown to be critically involved in several pathological manifestations of aging animals. In contrast, superoxide can act as a signaling molecule to modulate signal transduction cascades required for hippocampal synaptic plasticity. Mitochondrial superoxide dismutase (SOD-2 or Mn-SOD) is a key antioxidant enzyme that scavenges superoxide. Thus, SOD-2 may not only prevent aging-related oxidative stress, but may also regulate redox signaling in young animals. We used transgenic mice overexpressing SOD-2 to study the role of mitochondrial superoxide in aging, synaptic plasticity and memory-associated behavior. We found that overexpression of SOD-2 had no obvious effect on synaptic plasticity and memory formation in young mice, and could not rescue the age-related impairments in either synaptic plasticity or memory in old mice. However, SOD-2 overexpression did decrease mitochondrial superoxide in hippocampal neurons, and extended the lifespan of the mice. These findings increase our knowledge of the role of mitochondrial superoxide in physiological and pathological processes in the brain.

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1847321&blobname=nihms19175f8.jpg

[quixote]

Hello,

Any new research into Glisodin vs. arteries since 2007? I'm considering getting a couple of bottles of LEF's Endothelial Defense, but before I pull the trigger I'd love to get some fresh intel on whether it's actually worth its salt. Thank you

[Richard McGee]

I've been taking the LEF Endothelial Defense for 3 months, to help protect my cardiovascular system. Unexpectedly, I have experienced a complete cessation of all arthritis pains. These arthritis pains had previously been growing in severity the past several years - affecting my hands, hips and knees. Walking was painful. Now, there is no pain at all. (I don't take any arthritis-targeted supplements like glucosamine.) Whatever the reason (action of SOD?), it is a welcome relief.

Edited by Richard McGee, 12 November 2016 - 03:36 AM.

[Oakman]

After looking at the LEF product I rather favored the SwansonSOD Gliadin Complex with GliSODin, as it contains more GliSODin per capsule (300mg vs. 250mg), then combines it with Catalase 100mg and L-Glutathione 50mg. What makes this special??  Well, my intital interest was due to its ability to counteract UV exposure (I'm outside a lot). But then after reading up on the subject, and because of this ​from the manufacturer's site :

 

"The body’s antioxidant supply can be classified into two groups:

* Primary antioxidants are made by the body, thus internally provided. This internal antioxidant defense system includes Superoxide Dismutase (SOD), Catalase and Glutathione Peroxidase (Gpx), which are the first, and most powerful, line of defense against oxidative stress."

 

 > http://www.plthealth...oducts/glisodin

 

Based on that, it would seem that the Swanson product, which contains these exact primary antioxidants is the superior choice. Beyond that the discounted price of the Swanson is ~$20 vs $30 (both 60 caps) for the LEF product.

 

[quixote]

Thank you both @Richard and @Oakman for taking the time to reply. Since apparently both LEF's Endothelial Defense and Swanson's SOD Gliadin Complex have some science behind them and since I know pretty much nothing about the underlying biochemistry, it appears as though I'll have to try both (not at the same time obviousl) to see if (hopefully) either works for me.

[Richard McGee]

http://www.sciencedi...899900714004444

 

"A research study on individuals at risk for developing atherosclerosis demonstrated a striking difference between the control and the protected SOD–supplemented group when examining carotid thickness [16]. Individuals receiving SOD–gliadin daily (500 U SOD activity) or placebo for a period of 2 y were subjected to B-scan ultrasonography to measure the intima media thickness (IMT), a standard detection method for atherosclerotic lesions. Decreased carotid IMT measurements were seen in patients after 365 d of treatment with SOD–gliadin. Moreover, the supplemented group registered an increase in SOD and CAT levels in the blood compared with the placebo group. Additionally, lipid peroxidation, used as a measurement of oxidative stress, was reduced after SOD–gliadin intake. Together, these data suggest a potential role for SOD–gliadin supplementation in the prevention of atherosclerotic lesions, possibly through its general antioxidant action."

 

It looks like you would need a year or two of continuous gliSODin supplementation to observe atherosclerotic reversal.

[quixote]

Thank you for the link, Richard.

 

I've read pretty much the entire article, and I just want to make sure that, say, GliSODin in LEF's Endothelial Defense is the very same stuff as ‘500 U SOD-Gliadin’ mentioned in the article, right? There's no catch, I hope. Thanks!

 

[Richard McGee]

The gliSODin website:

 

What is GliSODin?

GliSODin is a cantaloupe melon extract rich in vegetal superoxide dismutase (SOD) covered by polymeric films of wheat matrix gliadin. This is the only proven orally effective delivery of SOD.

http://www.glisodin.org/?page_id=14

 

Also, "currently there are two patents awarded for GliSODin.  The combination of SOD and Gliadin as an orally delivery is patented, and therapeutic uses of the combination of ingredients is patented."

 

The study I posted has this to say about the compound:

 

"...the terms protected SOD, encapsulated SOD, coated SOD, and bioactive SOD are used interchangeably and refer to the SOD–gliadin formulation that resists gastrointestinal inactivation...

...The intake of melon superoxide dismutase (SOD) combined with gliadin increases endogenous antioxidant levels."

 

I'm certain this is the same formulation cited in the study.

 

 

Edited by Richard McGee, 17 November 2016 - 08:00 PM.

[Daniel Cooper]

A study that looked at coronary calcium scores rather than carotid  IMT would be very interesting.  Both are proxies for the state of coronary artery disease but calcium scores seem like the better proxy.  

 

Is anyone aware of any follow up studies since 2007?

 

 

 

Edited by Daniel Cooper, 17 November 2016 - 08:22 PM.

[quixote]

Thank you for your thorough answer, it's much appreciated!

[Richard McGee]

Radiation dosage is troubling for CT. With a Cardiac CT for Calcium Scoring, an adult's approximate effective radiation dosage is 3 mSv (equal to 1 year of normal background radiation). I would be wary of using this for normal tracking of atherosclerosis.

 

http://www.radiology...?pg=safety-xray

 

There is some interesting work being done to improve the consistency and accuracy of sonography to assess atherosclerosis. "New quantitative methods beyond backscatter (to include speed of sound, attenuation, strain, temperature, and high order statistics) will be developed to evaluate vascular tissues. These image methods may offer opportunities for the early detection and treatment of the disease [52]. Once the methodology and analysis have been standardized, the stage will be set for future prospective randomized trials to evaluate whether quantitative tissue characterization-based information on plaque vulnerability can be used to tailor risk and treatment in patients with clinically symptomatic and high-risk asymptomatic atherosclerosis."

 

https://www.ncbi.nlm...les/PMC4463636/

Edited by Richard McGee, 17 November 2016 - 11:25 PM.

[Daniel Cooper]

Well, what I'd like to see is a couple of CAC scores a couple of years apart as a party of a study, not for routine monitoring for the general population.  I agree that any ionizing radiation is not ideal, but 3 mSv is fairly minimal (about a quarter of an abdominal CT).  You can see that magnitude variation in yearly radiation dosage between two people based solely upon where they live quite easily.  Airline pilots and crew logging 700hrs a year can see between 2 and 5 mSv additional dose per year every year they fly.  And we are trying to find the truth here.  Does this stuff really slow or reverse coronary artery disease? Carotid IMT does appear to be correlated to coronary artery disease but not as closely as we might like.  Right now CAC scores are about the best we have that is minimally invasive. 

 

There have been studies done that evaluated various proposed agents for slowing or reversing coronary artery disease that used CAC scores as the metric.  Ultrasound IMT has been used in other studies mainly because it's just such a cheaper test.

 

  I do hope these advanced ultrasound techniques pan out, but I'm a little skeptical.  The wavelengths you typically see in these scans are rather large relative to the feature sizes we'd like to see.  Unless they are pushing the frequencies up quite a bit (maybe they are, I haven't kept up).  There has also been some work done in using NMR techniques to access coronary artery disease but so far these also have difficulty picking up the fairly small features we'd like to look at.

 

I certainly don't mean to disparage this study or the possibility of using Glisodin to treat coronary artery disease. I'm quite interested in it and will be surveying the literature.  If other studies have been done since that 2007 study I'd like to hear about it.

 

Thanks for the info..

 

 

 

 

 

 

[Daniel Cooper]

So I'll bring up a concern that was around back when I took GliSODin a few years ago.  Forgive me if I don't have studies to cite, this is just a recollection from discussions here on longecity.

 

There was some concern that raising exogenous SOD could damp down endogenous production of SOD while at the same time not getting into all the cellular spaces that we want it to go, thus leaving you in some cases worse off for taking the supplement.  I don't remember if there was ever any conclusion to this speculation but my recollection was that someone had a study or two that might support this conclusion.

 

Anyone remember this or recall what the outcome was?

 

I'm looking for something to slow or reverse atherosclerosis so I'd really rather this not be an issue.

 

 

Edited by Daniel Cooper, 18 November 2016 - 02:06 AM.

[RWhigham]

 

 

Radiation dosage is troubling for CT. With a Cardiac CT for Calcium Scoring, an adult's approximate effective radiation dosage is 3 mSv (equal to 1 year of normal background radiation). I would be wary of using this for normal tracking of atherosclerosis.

http://www.newportbo...ebt-procedures/  "Radiaton Dosage of EBT Procedures"  Electron Beam CT (EBT) Coronary Artery Calcium Score (FDA approved)……………………………….50-63 mrem   (0.5-0.63 mSv) " the Electron Beam CT scanner is essentially a fast shuttered camera only turning on for brief periods of 50 to 100 milli-seconds as needed to acquire the images."  EBT machines are scarce (no longer made) because cardiologists and hospitals didn't want the competition with their cath labs. But quite a few are in use around the USA. It's worthwhile finding one.

 

http://abcnews.go.co...=6801216&page=1

Conventional CT Scan:  "Authors studied almost 2,000 patients who had a cardiac CTA, and they found that the average radiation dose from these CT scans was 12 mSv." Hospitals and radiologists want to keep their general purpose CT machines as busy as possible. They can't be held responsible for cancer that may, or may not, occur in a patient years later.

Edited by RWhigham, 18 November 2016 - 02:23 AM.

[Daniel Cooper]

That 12 mSv is for a CT angiogram not a CAC score.  Richard's 3 mSv number is the correct number for a CAC. 

 

I'd love to have an electron beam machine in my area, but the last one was taken out of service some years ago.  It is a shame that that technology is no longer available to us.

 

 

 

[RWhigham]

GlisSODin sounds like a worthwhile prevention for atherosclerosis. Unfortunately, it's not advisable for those of us who are gluten sensitive.

 

When I was a child, and for most of my adult life, I was uncomfortable holding my stomach in. Month-long gluten-free trials had no effect. But about a year of gluten-free diet worked - no more discomfort.

 

Take away - gluten sensitivity may not be obvious, and recovery can take a long time.

[ryukenden]

Any of you still taking this?

[ryukenden]

I am taking two capsules of GlisSODin per day as well as Nattokinase one capsule.

Who else is taking such combination?

[Forever21]

I ceased taking it after reading that the body relies on it too much and if you cease taking it, you'll no longer as strong as before as your body is incapable of producing its own SOD.

[ryukenden]

I ceased taking it after reading that the body relies on it too much and if you cease taking it, you'll no longer as strong as before as your body is incapable of producing its own SOD.

 

Yes, I became aware of it while taking it. However I am not sure about whether the body can still produce the same amount, less or more of SOD after long term use of GlisSoDin. It is the same as other substances/hormones due to body's feedback system, IMO. Once we stop taking it, the body may go back to producing SOD as before.

[Forever21]

It took me about 1 month to gain the energy levels back. But I'd been taking GliSODin for only a few months before I quit.