You're not alone someone else on the Life extension forums mentioned that they had pain after talking trans res. If Res is at fault perhaps people should consult doctors before they begin using these supplements (as most bottles tell you to do). This is why I only take the well researched Vitamins and Minerals, since there isn't enough studies on these newer supplements when it comes to humans (the only res I get is from red grapes).
Consult doctors and ask them what? Should I take resveratrol? Doctors are not hugely likely to even know what it is, so they will say "no, you should not take that". If you were to ask the doctor if you had any autoimmune conditions, at least that is something they understand and could tell you something about. These days, resveratrol is starting to be pretty well researched. It is a drug with some significant actions, so I'm not arguing that it should be taken lightly, but it is rapidly developing a track record.
Most of the studies are on lower animals or cell cultures and the results have been mixed.
Linus Pauling Institute at Oregon State University
Micronutrient Research for Optimum Health
http://lpi.oregonsta...ls/resveratrol/
ResveratrolResveratrol has been found to exert a number of potentially cardioprotective effects
in vitro, including inhibition of platelet aggregation
(47, 48,
68), promotion of vasodilation by enhancing the production of NO
(46,
69) and inhibition of inflammatory enzymes
(34,
70, 71). However, the concentrations of resveratrol required to produce these effects are often higher than those that have been measured in human
plasma after oral consumption of resveratrol
(7). The results of some animal studies suggest that high oral doses of resveratrol could decrease the risk of thrombosis (clot formation) and
atherosclerosis (72, 73), but at least one study found increased atherosclerosis in animals fed resveratrol
(74). Although its presence in red wine has stimulated a great deal of interest in the potential for resveratrol to prevent cardiovascular disease, there is currently no convincing evidence that resveratrol has cardioprotective effects in humans, particularly in the amounts present in 1-2 glasses of red wine (see
Sources).
CancerResveratrol has been found to inhibit the <A href="
http://lpi.oregonsta...proliferation">proliferation of a variety of human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic, and thyroid cancers
(2). In animal models, oral administration of resveratrol inhibited the development of esophageal
(75), intestinal
(76), and mammary (breast) cancer
(20,
77) induced by chemical carcinogens. However, oral resveratrol was not effective in inhibiting the development of lung cancer induced by carcinogens in cigarette smoke
(78, 79). The effects of oral resveratrol administration on mice that are genetically predisposed to colon cancer have been mixed
(80, 81), and a few studies have documented that oral resveratrol protects against colon cancer development in rats administered the carcinogen, 1,2-dimethylhydrazine
(82-84). It is not known whether high intakes of resveratrol can help prevent cancer in humans. Clinical trials are currently underway to address this question and to also determine whether resveratrol might be beneficial in cancer treatment
(85). Studies on human metabolism of resveratrol suggest that even very high dietary intakes of resveratrol may not result in tissue levels that are high enough to realize most of the protective effects demonstrated in cell culture studies
(7,
12).
LongevityCaloric restriction is known to extend the lifespans of a number of species, including mammals
(86). In yeast, caloric restriction stimulates the activity of an
enzyme known as Sir2
(87). Providing resveratrol to yeast increased Sir2 activity in the absence of caloric restriction and extended the replicative lifespan of yeast by 70%
(6). Resveratrol feeding also extended the lifespans of worms (
C. elegans) and fruit flies (
D. melanogaster) by a similar mechanism
(88). Additionally, resveratrol dose-dependently increased the lifespan of a vertebrate fish (
N. furzeri)
(89). However, it is not known whether resveratrol will have similar effects in higher animals. A recent study reported that resveratrol extended lifespan of mice on a high-calorie diet such that their lifespan was similar to that of mice fed a standard diet
(90). Although resveratrol increased the activity of the
homologous human enzyme (Sirt1) in the test tube
(6), it is not known whether resveratrol can extend the human lifespan. Moreover, the resveratrol concentrations required to increase human Sirt1 activity were considerably higher than concentrations that have been measured in human
plasma after oral consumption. Interestingly, a recent aging study in mice found that a low dose of dietary resveratrol altered gene expression in heart, brain, and skeletal muscle similar to that induced by caloric restriction
(91). Like caloric restriction, resveratrol also blunted the age-related decline in heart function in this study. Clinical trials will be needed to determine if these findings are relevant to humans.
