19 replies to this topic

[tham]

I posted this in another forum, so I'd thought I'd post
it here too for informative purposes.

Oleuropein and hydroxytyrosol, olive leaf's polyphenols,
apparently block gp41.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


HIV docks, or binds, with the CD4 receptors on the surface of
our T-helper cells and macrophages vide gp120, the flower-like
structure on its surface. After attaching to CD4, gp120 detaches
to allow gp41, the "stalk" embedded in its lipid membrane, to
fuse with or lock onto CD4. Once fused, the virus's capsid is
free to enter the cell and replicate itself.

http://en.wikipedia....e:HIV_Viron.png

http://en.wikipedia....and_genome#gp41

http://www.niaid.nih...eets/howhiv.htm

http://www.tthhivcli.../lifecycle1.htm


In effect, olive leaf extract acts as a fusion inhibitor. The only
drugs currently being used as fusion inhibitors are enfuvirtide
(Fuzeon) and maraviroc (Selzentry). Enfuvirtide also acts by
interfering with gp41.

http://en.wikipedia....iki/Enfuvirtide


Olive leaf extract also has other significant mechanisms of
antiviral action against HIV:

http://www.ncbi.nlm....l=pubmed_docsum


The docking receptor, gp120, is itself blocked by the EGCG.
EGCG has an affinity for CD4, thus competing and interfering
with gp120.

EGCG also has other direct activities against HIV by inhibiting
protease and reverse transcriptase, the replication enzymes
targeted by standard anti-HIV drugs, and destruction of viral
particles.


http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


EGCG also inhibits HIV-associated dementia :

http://www.ncbi.nlm....l=pubmed_docsum

Edited by tham, 22 December 2007 - 06:35 PM.

[MP11]

Thanks for getting this all together.

[meat250]

good info tham


meat

[tham]

After reverse transcription of RNA to DNA, HIV requires the
enzyme integrase to insert it into the host cell's DNA.

http://www.mcld.co.uk/hiv/?q=Integrase

The first integrase inhibitor drug, raltegravir, has only just
been approved.

http://en.wikipedia....iki/Raltegravir


Oleuropein and hydroxytyrosol also inhibits integrase.

http://www.ncbi.nlm....bmedid=17261269

[tham]

The most potent olive leaf extract on the market is
probably Nature's Plus Oliceutic-20, with up to 25%
oleuropein and 4.5 mg hydroxytyrosol.

http://www.betterlif...sp?prod_id=2394

http://www.evitamins...ct.asp?pid=9051

[mike250]

The most potent olive leaf extract on the market is
probably Nature's Plus Oliceutic-20, with up to 25%
oleuropein and 4.5 mg hydroxytyrosol.

http://www.betterlif...sp?prod_id=2394

http://www.evitamins...ct.asp?pid=9051

would this product suffice

http://www.iherb.com...c...d=4735&at=0

[tham]

would this product suffice

http://www.iherb.com...c...d=4735&at=0

It looks potent enough in terms of the oleuropein content.

Nature's Plus's product appears to be the only one standardized
for hydroxytyrosol, though it is still miniscule at only 4.5 mg per
capsule. The amounts used in the above in vitro lab tests achieved
much higher concentrations, of course.

Combined with arabinogalactan from larch tree, this is even
more potent and cost-effective :

http://www.betterlif...sp?prod_id=5883


This is almost similar in potency to the Paradise Herb product
and half the cost. It also has some lemon balm, another virus
fighter, as an added bonus :

http://www.betterlif...p?prod_id=16207

http://www.ncbi.nlm....l=pubmed_docsum


This is also quite potent, and twice the strength at 500 mg.
I keep this in my office and take it when I have the flu, etc.

http://www.betterlif...p?prod_id=14241


Solaray's product is also quite potent :

http://www.betterlif...p?prod_id=27436


If you are fighting a disease, however, I think it is best to take
the Nature's Plus product.

Edited by tham, 28 December 2007 - 02:42 PM.

[mike250]

would the nature plus product be still good enough to use for general immune health

[caston]

I've been taking NutraLife Oliviral and it has seems to have helped me clear up some mens health issues.

http://health.nutral...uct.aspx?id=850

Edited by caston, 28 December 2007 - 01:40 PM.

[mike250]

I've been taking NutraLife Oliviral and it has seems to have helped me clear up some mens health issues.

http://health.nutral...uct.aspx?id=850

wouldn't have thought that it was a reputable brand.

[tham]

would the nature plus product be still good enough to use for general immune health

It should be. It's the most potent on the market.

If one had HIV and had just three supplements to choose
from, I would consider these the most important :

http://www.betterlif...sp?prod_id=5883

http://www.betterlif...p?prod_id=27647

http://www.betterlif...sp?prod_id=1060


For general immune support, any of the olive leaf extracts
should be good enough. The oleuropein content range from
6 to 25 %. The Nutralife product above has 12% and also
looks good with other synergistic herbs like astragalus,
pau d'arco and elderberry.

I took this when recovering from a cellulitis infection in my
left foot a few years ago.

http://www.betterlif...sp?prod_id=9528

[tham]

Rosemary's compounds, rosmarinic acid, carnosic acid and
carnosol have activity against HIV.

http://www.betterlif...p?prod_id=10390

Rosmarinic acid inhibits integrase :

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


Carnosic acid and carnosol inhibits protease :

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

Edited by tham, 28 December 2007 - 05:13 PM.

[mike250]

would the extract be syngergistic with oregano oil

[tham]

would the extract be syngergistic with oregano oil

Here's one with rosemary and oregano oil.

http://www.betterlif...sp?prod_id=5699

[Otterley]

I'm positive. And since being off med's I've tried many different supplements. And the one supplement that I can say has truly worked is Olive Leaf. I've changed my regimen many times, but have never taken out Olive Leaf. I've used OLE (Olive Leaf Extract) along with other natural supplements that claim to have antiviral qualities, and seems I can never get my viral below 29,000. When I went off my med's my viral went from undetectable to 200,000. OLE brought my viral load down from 200,000 to the lowest of 29,000. And has kept it around that for 4 years now. So that shows it does work...

The OLE I've been using is Roex Olive Leaf

I recently found another supplement that has made a significant impact on my T-cell count. Between July 2010 & April 2011 my T-cell count dropped from 850 to 599. I began to panic and started researching. I then came across an ultra strength powder form of Cell Forte's IP-6 & Inositol. I had used IP-6 & Inositol in the past, but in a lower dose pill form. So, on April 21, 2011 I began using Cell Forte IP-6 & Inositol Ultra Strength Powder. On June 20, 2011 I went for my lab work and found my T-cells went from 599 to 845. I was ecstatic! ...So I'll be keeping IP-6 with Inositol in my regimen and hope that my numbers from my lab work was not just a fluke. (I'll be letting you know at the end of October..)

I recently started a Blog of my journey using Alternative Natural Supplements called My Primitive Cocktail If anyone would like to visit..

And thanks for all the info everyone has put up! I'm going to add the Sodium Selenite to my regimen!

[tham]

It's good to know that olive leaf extract is helping you.

The full text of the gp41 blockade properties.

http://www.sciencedi...014579307005571



You could add in one of the mint plants -
lemon balm, sage, selfheal, peppermint, basil.

http://www.ncbi.nlm....cles/PMC2288616

http://www.ncbi.nlm....t_uids=21513560

[kilgoretrout]

If you are HIV+ and trying to manage the infection with natural supplements you are living out a fool's fantasy. My late partner and I tried this till he died from pneumonia (yes, PCP) and my T-Cells fell to 50 and it almost killed me. Thank God I was lucky enough to get a good job with insurance and started on ATRIPLA (one pill once a day) in 2006... after 6 months I was undetectable, I am still undetectable (under 20), zero health problems or toxicities (though possibly all my antioxidants and liver supports etc have helped with that) a T-CELL count is up in 750-800 range, about normal.

If you have HIV seek proper medical care by experts, and if you dont have insurance contact your local health department... even though there is a waiting list for ADAP, they still have Ryan White Act funds to pay for meds outside of that, and/or pay insurance premiums and co-pays, even COBRA premiums if you are laid off. Seek professional help. HIV is nothing to try self-treating with no matter how "promising" this or that test tube study might look. You will kill yourself doing that. You need to be on a medically supervised cocktail.

[Anthony_Loera]

If you are HIV+ and trying to manage the infection with natural supplements you are living out a fool's fantasy. My late partner and I tried this till he died from pneumonia (yes, PCP) and my T-Cells fell to 50 and it almost killed me. Thank God I was lucky enough to get a good job with insurance and started on ATRIPLA (one pill once a day) in 2006... after 6 months I was undetectable, I am still undetectable (under 20), zero health problems or toxicities (though possibly all my antioxidants and liver supports etc have helped with that) a T-CELL count is up in 750-800 range, about normal.

If you have HIV seek proper medical care by experts, and if you dont have insurance contact your local health department... even though there is a waiting list for ADAP, they still have Ryan White Act funds to pay for meds outside of that, and/or pay insurance premiums and co-pays, even COBRA premiums if you are laid off. Seek professional help. HIV is nothing to try self-treating with no matter how "promising" this or that test tube study might look. You will kill yourself doing that. You need to be on a medically supervised cocktail.

I agree with you kilgoretrout,

HIV is devastating and I would not know how to react if I was in your shoes. In 2008 there was a person by the name of Fauce that did a presentation at UCLA that I am attaching, it has some information regarding HIV blood that was used in this presentation. Unfortunately I do not have the audio, just the slides. I have attached it here. I am not saying that it may be a solution of any kind for anyone. I simply hope that it leads to something manageable for folks who have limited resources, as it was done in a University which tend to be unbiased. Again, I don't think this is a solution for anyone at this time, and agree that when dealing with HIV you need to be on a medically supervised cocktail that has been proven to help.

To clarify:
In this presentation we know that TAT2 is Cycloastragenol, from the humble plant Astragalus.

A

Attached Files

•  SFauce-2008-Presentation.pdf   1.81MB   29 downloads

Edited by Anthony_Loera, 30 July 2011 - 03:52 PM.

[Otterley]

If you are HIV+ and trying to manage the infection with natural supplements you are living out a fool's fantasy. My late partner and I tried this till he died from pneumonia (yes, PCP) and my T-Cells fell to 50 and it almost killed me. Thank God I was lucky enough to get a good job with insurance and started on ATRIPLA (one pill once a day) in 2006... after 6 months I was undetectable, I am still undetectable (under 20), zero health problems or toxicities (though possibly all my antioxidants and liver supports etc have helped with that) a T-CELL count is up in 750-800 range, about normal.

If you have HIV seek proper medical care by experts, and if you dont have insurance contact your local health department... even though there is a waiting list for ADAP, they still have Ryan White Act funds to pay for meds outside of that, and/or pay insurance premiums and co-pays, even COBRA premiums if you are laid off. Seek professional help. HIV is nothing to try self-treating with no matter how "promising" this or that test tube study might look. You will kill yourself doing that. You need to be on a medically supervised cocktail.

1st off, I'm very sorry to hear about your partner... I did med's for 7 years.. I began to feel toxic... So.. I knew MY BODY well enough to know I'd be ok trying natural supplements.. I was poz for 4 years before I found out my numbers.. My viral was 200,000, but my Tcells were 1800.. I know the med's wrecked my body... I know my body would be in much better condition if I had never started them... I want to say this is MY path.. Everyone is different when it comes to HIV.. It's a big part of your gene make up, and the mutated type of HIV virus you have.. I'm very glad the drugs are out there.. And I would not hesitate to go on them if needed.. But as long as I keep my numbers in good levels, I'll stay off the med's.... So, I go to my infectious decease doctor every 3-4 months to keep tabs on it all.... And maybe my doctor will learn some from me. Rather prescribing a drug (that is toxic) to lower a patients viral, hopefully she'll suggest Olive Leaf.. Or some other natural supplement...

http://myprimitiveco...l.blogspot.com/

Edited by Otterley, 03 August 2011 - 08:59 PM.

[Lufega]

There is a strong link between alpha-1 antitrypsin deficiency and the tendency to go from HIV to AIDS at a faster rate. So it seems like increasing the levels of this serum protein is therapeutic. It's available to COPD patients as augmentation therapy. Maybe you could show your doctor some studies.

Lastly, there was that study showing that Manganese inhibits the replication of the virus while magnesium stimulates it. Search the board for it. I'd be using 20 mg manganese daily if that was in case. In fact, one of the HAART meds, forget which one, is antiviral simply because it increases manganese concentrations in the body.

So, have your Doctor check your levels of this protein. If low, then you qualify for augmentation therapy.

I want to do my residency in infectious disease so this is a topic of interest to me. Keep us posted.

HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations.
Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L.
Source
Department of Medicine, Denver Veterans Affairs Medical Center, 1055 Clermont Street, Denver, CO 80220, USA.


Abstract

PURPOSE:
Several observations suggest the presence of HIV-suppressive factors in the fluid phase of blood. Alpha-1-antitrypsin (AAT), the most abundant serine protease inhibitor in the circulation, has potent anti-HIV activity in vitro, and may function as an endogenous HIV suppressor. Therefore, we assessed serum AAT concentrations for association with HIV infection.


METHODS:
In this cross-sectional study, serum AAT concentrations were measured in 66 persons with HIV infection and in 45 healthy persons (Controls). In the HIV-infected group, antiretroviral therapy (ART) use was assessed and CD4+ T cell levels and plasma HIV RNA were quantified.


RESULTS:
Median AAT concentration was significantly lower in the HIV-infected group (1.64 mg/mL) in comparison with Controls (1.94 mg/mL; p=0.001). AAT reduction was most pronounced in the HIV-infected subgroup with CD4+ T cell levels > 200 cells/µL in comparison with Controls (p < 0.01). Serum AAT concentrations < 1.0 mg/mL are clinically significant, and concentrations below this level were identified in 4.5% of the HIV-infected group and in no Control subjects. No association between AAT levels and viral load or use of ART was observed in HIV-infected subjects.


CONCLUSION:
The association between reduced serum AAT concentration and HIV infection is consistent with a role for AAT as an endogenous HIV suppressor.