421 replies to this topic

[hmm]

I got achilles tendonitis years ago, big time, before anyone heard of resveratrol. It looked like a golf-ball attached to my heel. The doctor laughed and called it the best example he'd ever seen, took pictures. I got it running up hills in Georgia. Lots of stretching, ice and rest, some ibuprofen and in two weeks I could run again. It hasn't recurred. Not even with large doses of resveratrol. If you are active, and you increase your activity level, or do something different, like running hills when you are used to flat, you can get tendonitis. If taking resveratrol makes you feel stronger, you are likely to increase your activity level. Treat it like any other injury.

Mine didn't respond to stretching or special balance exercises performed on steps or to running backwards a half-mile a day, but it was never that bad (guys I play hoops with, who are my age, seem to have it much worse). When I injured a knee playing basketball, I also stopped running for a few months and within a couple weeks there wasn't any tendinitis pain at all. But last February, when I started playing hoops and running again, the tendinitis came right back. By the time I got as high as 200 mg (50%) RSV, once in the morning and once at night, the pain/inflammation was negligible. Not only that pain but other miscellaneous aches and pains associated with a once-a-week hoops game that formerly left me limping about for 2 or 3 days afterward.
All the tendinitis discussion in here could lead to an "anti-placebo" effect and generate gratuitous reports of tendinitis. As well, the Long**** guy might be further tempted to continue to try to exploit them. But if these tendinitis reports are groundlessly associated with RSV, then in time, this should bear itself out....

[maxwatt]

...snip...
All the tendinitis discussion in here could lead to an "anti-placebo" effect and generate gratuitous reports of tendinitis. As well, the Long**** guy might be further tempted to continue to try to exploit them. But if these tendinitis reports are groundlessly associated with RSV, then in time, this should bear itself out....

You mean "BS"? Those are his initials.

[hmm]

...snip...
All the tendinitis discussion in here could lead to an "anti-placebo" effect and generate gratuitous reports of tendinitis. As well, the Long**** guy might be further tempted to continue to try to exploit them. But if these tendinitis reports are groundlessly associated with RSV, then in time, this should bear itself out....

You mean "BS"? Those are his initials.

It just seems weird that BS is a low-dosage proponent, backing up his position with warnings about tendonitis, and yet most of the complaints I remember seeing seem to be coming from people taking very small doses...

[maxwatt]

...snip...
All the tendinitis discussion in here could lead to an "anti-placebo" effect and generate gratuitous reports of tendinitis. As well, the Long**** guy might be further tempted to continue to try to exploit them. But if these tendinitis reports are groundlessly associated with RSV, then in time, this should bear itself out....

You mean "BS"? Those are his initials.

It just seems weird that BS is a low-dosage proponent, backing up his position with warnings about tendonitis, and yet most of the complaints I remember seeing seem to be coming from people taking very small doses...

hmm...

[Meenute]

Obviously you are not reading my post! I STOPPED taking it, al together because I now have issues with my feet. You can believe what you want, but I know my body VERY well and am considered normally to be VERY healthy. As for BS and his claims, if anything....I believe he is rash in throwing this into the market and it may come back to bite him.

As for you, you seem rather desperate to push this forward and discount all of the claims. I think either side of this...both yours and BS's are irresponsible, because neither can be backed with controlled human studies and seem discount the claims of the other without substantial evidence. This being said, if your go to the FDA website, you will see that human trials are going on. And, if you google a variety of illnesses say....fibroids and resveratrol, .edu etc. you will find many studies. I suggest you read the data.

As for everyone reading this forum, I believe you should listen to your body most of all. Know that the pharma's will lose alot should these Resveratrol claims be accurate...so they have people posted on these boards to discount claims of Resveratrol success and the makers of Resveratrol products are looking to make a dollar.

####################################################

It just seems weird that BS is a low-dosage proponent, backing up his position with warnings about tendonitis, and yet most of the complaints I remember seeing seem to be coming from people taking very small doses...
[/quote]

hmm...
[/quote]

[missminni]

Obviously you are not reading my post! I STOPPED taking it, al together because I now have issues with my feet. You can believe what you want, but I know my body VERY well and am considered normally to be VERY healthy. As for BS and his claims, if anything....I believe he is rash in throwing this into the market and it may come back to bite him.

As for you, you seem rather desperate to push this forward and discount all of the claims. I think either side of this...both yours and BS's are irresponsible, because neither can be backed with controlled human studies and seem discount the claims of the other without substantial evidence. This being said, if your go to the FDA website, you will see that human trials are going on. And, if you google a variety of illnesses say....fibroids and resveratrol, .edu etc. you will find many studies. I suggest you read the data.

As for everyone reading this forum, I believe you should listen to your body most of all. Know that the pharma's will lose alot should these Resveratrol claims be accurate...so they have people posted on these boards to discount claims of Resveratrol success and the makers of Resveratrol products are looking to make a dollar.

####################################################

It just seems weird that BS is a low-dosage proponent, backing up his position with warnings about tendonitis, and yet most of the complaints I remember seeing seem to be coming from people taking very small doses...


hmm...

THE BEST ADVICE!!

[jCole]

While I am waiting for my 99% RSV from RevGen to come, I decided to get some 50% RSV from NOW.

Taking only 100mg's for about 5 days now and a few subtle effects like mood enhancement a bit and a bit more intense training sessions.....but one thing I did get was (and excuse how graphic this is) realllly really bad diarrhea.

I've never had problems in this area even for other supps that are known to cause diarrhea, but this 50% crap is really taking a toll on me. I'm going to discontinue until I get my 99% from RevGen.

[hmm]

Obviously you are not reading my post! I STOPPED taking it, al together because I now have issues with my feet. You can believe what you want, but I know my body VERY well and am considered normally to be VERY healthy. As for BS and his claims, if anything....I believe he is rash in throwing this into the market and it may come back to bite him.

As for you, you seem rather desperate to push this forward and discount all of the claims. I think either side of this...both yours and BS's are irresponsible, because neither can be backed with controlled human studies and seem discount the claims of the other without substantial evidence. This being said, if your go to the FDA website, you will see that human trials are going on. And, if you google a variety of illnesses say....fibroids and resveratrol, .edu etc. you will find many studies. I suggest you read the data.

As for everyone reading this forum, I believe you should listen to your body most of all. Know that the pharma's will lose alot should these Resveratrol claims be accurate...so they have people posted on these boards to discount claims of Resveratrol success and the makers of Resveratrol products are looking to make a dollar.

####################################################


hmm...

Meenute,
actually, I did read your post, though I did not respond to it, so it seems strange to be chided for not reading it. I am making a claim quite similar to yours (tendinitis soon after taking a small amount of RSV) so I am not sure how that comes across as "desperate to push this forward and discount all claims". Actually, if I was in your circumstances, I wouldn't bother with RSV either. At your age I don't think I would have noticed any big benefits, and (who knows?) I might have gotten tendinitis then as well. But at age 52 I am making a judgment that the risks in taking RSV (based on studies that have already been completed) when weighed against the benefits of taking RSV, make it worthwhile for me. So far, in my estimation, the jury is still out as far as whether I have won or lost in my gamble...Has your tendinitis shown any signs of abating?

[jCole]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

[missminni]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

Emodin is a substance found in the knotweed plant that has a laxative effect.
When the Res is purified to 98 or 99% the emodin content is minimal, if at all.

Edited by missminni, 09 August 2008 - 03:00 PM.

[Hedgehog]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

Try "emodin"


Anthraquinones represent a large family of compounds having diverse biological properties. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Earlier studies have documented mutagenic/genotoxic effects of emodin, mainly in bacterial system. Emodin, first assigned to be a specific inhibitor of the protein tyrosine kinase p65lck, has now a number of cellular targets interacting with it. Its inhibitory effect on mammalian cell cycle modulation in specific oncogene overexpressed cells formed the basis of using this compound as an anticancer agent. Identification of apoptosis as a mechanism of elimination of cells treated with cytotoxic agents initiated new studies deciphering the mechanism of apoptosis induced by emodin. At present, its role in combination chemotherapy with standard drugs to reduce toxicity and to enhance efficacy is pursued vigorously. Its additional inhibitory effects on angiogenic and metastasis regulatory processes make emodin a sensible candidate as a specific blocker of tumor-associated events. Additionally, because of its quinone structure, emodin may interfere with electron transport process and in altering cellular redox status, which may account for its cytotoxic properties in different systems. However, there is no documentation available which reviews the biological activities of emodin, in particular, its growth inhibitory effects. This review is an attempt to analyze the biological properties of emodin, a molecule offering a broad therapeutic window, which in future may become a member of anticancer armamentarium. © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 5, 591-608, 2007

[jCole]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

Try "emodin"

Haha, I suppose the correct spelling would of helped me a bit.

Thanks guys!

[sUper GeNius]

For those with dogs, try some resveratrol mixed in with his regular toothpaste. I'm trying it with my dog. He has gingivitis, and if it responds to t-res like mine has, I may not have to have his teeth cleaned.

Tried some on hi yesterday, and his breath seemed much better today.

[ptvan]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

jCole's post has inspired me to post my own experience with resv side effects. I started my regime without any diet or life style changes, and without having read any reports about side effects. I'm an active 44 year old male in good health. I have been using 300 mg capsules which are advertised as 99% pure. My aim has been to reach a daily dose of about a gram. I began with a daily morning dose of 300 mg. Effects were as follows:

1. "slight aggression and mild, constant agitation," just as jCole described (and others have mentioned on this forum)
2. in competition with the above, mild euphoria
3. sense of increased physical energy

The feeling of agitation was unpleasant but not overwhelming. It concerned me but I persisted with taking the supplement. After about 5 days on 300 mg the agitation/aggression subsided completely leaving the sense of mild euphoria in tact. A week later I doubled the dose to 600 mg, one cap with breakfast, the other with lunch. The agitated feeling returned, seemingly more pronounced than initially. With the additon of the second cap I noted a final side effect, the complete lack of desire for my evening glass of wine (I consume a glass or two daily). I persisted just 2 (dry -- no desire for alchol second evening either) days with the 600 mg dose divided between breakfast and lunch and the agitation persisted. It continued to persist when I took the whole dose in the morning the following day. I dropped back to 300 mg and have continued on this dose happily now for going on about 8 or 9 weeks. At some stage I'll try increasing the dose again. Incidentally, my parents (both in their mid 70's) began taking resveratrol at the same time as I did. Both of them are now taking 1200 grams daily. Neither of them have noticed side effects as they have increased their doses through the weeks. My mother has observed one striking effect in that during stretches of time when she's sleeping badly, her energy and sense of well being has not been hampered as it is typically when she is fighting insomnia.

On a side note, the resveratrol I'm using has a very strong, sharp earthy smell, and is a dark greenish brown in color. My understanding has been than 99% pure resveratrol is close to white in color and without much in the way of odour. Is this typical? Does the color/smell of resveratrol vary to a degree? I am wondering whehter I should be concerned about these features.

[maxwatt]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

jCole's post has inspired me to post my own experience with resv side effects. I started my regime without any diet or life style changes, and without having read any reports about side effects. I'm an active 44 year old male in good health. I have been using 300 mg capsules which are advertised as 99% pure. My aim has been to reach a daily dose of about a gram. I began with a daily morning dose of 300 mg. Effects were as follows:

1. "slight aggression and mild, constant agitation," just as jCole described (and others have mentioned on this forum)
2. in competition with the above, mild euphoria
3. sense of increased physical energy

The feeling of agitation was unpleasant but not overwhelming. It concerned me but I persisted with taking the supplement. After about 5 days on 300 mg the agitation/aggression subsided completely leaving the sense of mild euphoria in tact. A week later I doubled the dose to 600 mg, one cap with breakfast, the other with lunch. The agitated feeling returned, seemingly more pronounced than initially. With the additon of the second cap I noted a final side effect, the complete lack of desire for my evening glass of wine (I consume a glass or two daily). I persisted just 2 (dry -- no desire for alchol second evening either) days with the 600 mg dose divided between breakfast and lunch and the agitation persisted. It continued to persist when I took the whole dose in the morning the following day. I dropped back to 300 mg and have continued on this dose happily now for going on about 8 or 9 weeks. At some stage I'll try increasing the dose again. Incidentally, my parents (both in their mid 70's) began taking resveratrol at the same time as I did. Both of them are now taking 1200 grams daily. Neither of them have noticed side effects as they have increased their doses through the weeks. My mother has observed one striking effect in that during stretches of time when she's sleeping badly, her energy and sense of well being has not been hampered as it is typically when she is fighting insomnia.

On a side note, the resveratrol I'm using has a very strong, sharp earthy smell, and is a dark greenish brown in color. My understanding has been than 99% pure resveratrol is close to white in color and without much in the way of odour. Is this typical? Does the color/smell of resveratrol vary to a degree? I am wondering whehter I should be concerned about these features.

I think your supplement maker is using a "99% pure 50% extract." The color and smell are typical of a 50% extract.

[jCole]

Well, after a week of 50% extract and having extremely bad side effects everyday, one being diarrhea and another slight aggression and mild, constant agitation.... a good 24 hours after I stopped taking the 50% extract, all symptoms are gone.

Definitely the 50% extract is a no go for me. Probably the Amodin correct?

Can someone explain to me what Amodin is? I seem to be having a hard time finding decent information online about this.

jCole's post has inspired me to post my own experience with resv side effects. I started my regime without any diet or life style changes, and without having read any reports about side effects. I'm an active 44 year old male in good health. I have been using 300 mg capsules which are advertised as 99% pure. My aim has been to reach a daily dose of about a gram. I began with a daily morning dose of 300 mg. Effects were as follows:

1. "slight aggression and mild, constant agitation," just as jCole described (and others have mentioned on this forum)
2. in competition with the above, mild euphoria
3. sense of increased physical energy

The feeling of agitation was unpleasant but not overwhelming. It concerned me but I persisted with taking the supplement. After about 5 days on 300 mg the agitation/aggression subsided completely leaving the sense of mild euphoria in tact. A week later I doubled the dose to 600 mg, one cap with breakfast, the other with lunch. The agitated feeling returned, seemingly more pronounced than initially. With the additon of the second cap I noted a final side effect, the complete lack of desire for my evening glass of wine (I consume a glass or two daily). I persisted just 2 (dry -- no desire for alchol second evening either) days with the 600 mg dose divided between breakfast and lunch and the agitation persisted. It continued to persist when I took the whole dose in the morning the following day. I dropped back to 300 mg and have continued on this dose happily now for going on about 8 or 9 weeks. At some stage I'll try increasing the dose again. Incidentally, my parents (both in their mid 70's) began taking resveratrol at the same time as I did. Both of them are now taking 1200 grams daily. Neither of them have noticed side effects as they have increased their doses through the weeks. My mother has observed one striking effect in that during stretches of time when she's sleeping badly, her energy and sense of well being has not been hampered as it is typically when she is fighting insomnia.

On a side note, the resveratrol I'm using has a very strong, sharp earthy smell, and is a dark greenish brown in color. My understanding has been than 99% pure resveratrol is close to white in color and without much in the way of odour. Is this typical? Does the color/smell of resveratrol vary to a degree? I am wondering whehter I should be concerned about these features.

I think your supplement maker is using a "99% pure 50% extract." The color and smell are typical of a 50% extract.

Yeh, the 50% extract I used from NOW had a extremely strong smell and had a dark greenish color also...

Edited by jCole, 11 August 2008 - 11:37 PM.

[niner]

I think your supplement maker is using a "99% pure 50% extract." The color and smell are typical of a 50% extract.

The side effects that were noted are also entirely consistent with a 50% extract, and quite inconsistent with pure resveratrol.

[rhc124]

Meenute,
I may hve missed it somewhere, but can you tell me more about the problems you where having with your feet. We may have had the same issues.

Edited by rhc124, 12 August 2008 - 04:05 AM.

[notox]

I recently spend two weeks of holiday with sunshine every day and
playing with my kinds on the beach.

I enriched my bodymilk with several grams of 99% resveratrol and used
it every morning and afternoon before/after sun exposure. All the time there was
not the slightest sign of sun burn of skin irritation due to sun exposure.

Now after one week at home there was no sign of skin peeling and my intensive
tan persists until today.

This is very unusual for me with regard to my previous experiences where my
skin starts peeling after the first full bath at home.

[missminni]

I recently spend two weeks of holiday with sunshine every day and
playing with my kinds on the beach.

I enriched my bodymilk with several grams of 99% resveratrol and used
it every morning and afternoon before/after sun exposure. All the time there was
not the slightest sign of sun burn of skin irritation due to sun exposure.

Now after one week at home there was no sign of skin peeling and my intensive
tan persists until today.

This is very unusual for me with regard to my previous experiences where my
skin starts peeling after the first full bath at home.

How interesting. Please tell the amount of Resveratrol you but in your body milk
and the name and ingredients of your body milk.

[maxwatt]

I recently spend two weeks of holiday with sunshine every day and
playing with my kinds on the beach.

I enriched my bodymilk with several grams of 99% resveratrol and used
it every morning and afternoon before/after sun exposure. All the time there was
not the slightest sign of sun burn of skin irritation due to sun exposure.

Now after one week at home there was no sign of skin peeling and my intensive
tan persists until today.

This is very unusual for me with regard to my previous experiences where my
skin starts peeling after the first full bath at home.

Same experience here with sun exposure this summer. Unfortunately I now have one hell of a farmer's tan. Resveratrol stimulates melanocytes.

[notox]

I recently spend two weeks of holiday with sunshine every day and
playing with my kinds on the beach.

I enriched my bodymilk with several grams of 99% resveratrol and used
it every morning and afternoon before/after sun exposure. All the time there was
not the slightest sign of sun burn of skin irritation due to sun exposure.

Now after one week at home there was no sign of skin peeling and my intensive
tan persists until today.

This is very unusual for me with regard to my previous experiences where my
skin starts peeling after the first full bath at home.

How interesting. Please tell the amount of Resveratrol you but in your body milk
and the name and ingredients of your body milk.

I used around 1.5-2g per 150 ml, it was florena body milk with olive oil and vitamin E

[rhc124]

Obviously you are not reading my post! I STOPPED taking it, al together because I now have issues with my feet.

I think there is something going on here. As many of you know I have posted about some mild side effect going all the way back to late last year. However, there is one thing that I have not mentioned because I was hoping it would go away like the other symptoms. About 4 months ago when I was taking about 3 grams a day of 98% Vita Prime, the highest dose that I have taken, my feet starting hurting. It was really odd because this has never happened before. I was and am wearing the same shoes that I have for the past two years and I do very little walking. After about two months of this it kind of went away but I had also reduced my Resv down to around 1.5 g/day. Lately my feet have started hurting again but not as bad as previously. My current intake is around 1.5 to 2.0 g. Anyone got any ideas?

[missminni]

Obviously you are not reading my post! I STOPPED taking it, al together because I now have issues with my feet.

I think there is something going on here. As many of you know I have posted about some mild side effect going all the way back to late last year. However, there is one thing that I have not mentioned because I was hoping it would go away like the other symptoms. About 4 months ago when I was taking about 3 grams a day of 98% Vita Prime, the highest dose that I have taken, my feet starting hurting. It was really odd because this has never happened before. I was and am wearing the same shoes that I have for the past two years and I do very little walking. After about two months of this it kind of went away but I had also reduced my Resv down to around 1.5 g/day. Lately my feet have started hurting again but not as bad as previously. My current intake is around 1.5 to 2.0 g. Anyone got any ideas?

Funny, because Resvertrol actually cleared a condition I had called Mortons Nueroma, which felt like burning feet, only by the toes. However burning feet can be a sign of a vitamin B5 (Pantothenic acid) deficiency.

[maxwatt]

Obviously you are not reading my post! I STOPPED taking it, al together because I now have issues with my feet.

I think there is something going on here. As many of you know I have posted about some mild side effect going all the way back to late last year. However, there is one thing that I have not mentioned because I was hoping it would go away like the other symptoms. About 4 months ago when I was taking about 3 grams a day of 98% Vita Prime, the highest dose that I have taken, my feet starting hurting. It was really odd because this has never happened before. I was and am wearing the same shoes that I have for the past two years and I do very little walking. After about two months of this it kind of went away but I had also reduced my Resv down to around 1.5 g/day. Lately my feet have started hurting again but not as bad as previously. My current intake is around 1.5 to 2.0 g. Anyone got any ideas?

How old are you? Do you have arthritis? Osteo or rheumatoid? Did you have it before taking resveratrol?

There has been some speculation that resveratrol's activation of Sirt1 may not be desirable in cases of autoimmune diseases, like rheumatoid arthritis. Niacinamide is shown to block Sirt1 in vitro, and thus might help rheumatoid arthritis.

Sometimes pain in the feet can be caused by collapsed arches, or neuromas, or new shoes. Does any of this ring a bell?

Edited by maxwatt, 16 August 2008 - 01:24 AM.

[rhc124]

I'm 42 and been on resveratrol about one year. The only autoimmune issues that I have are allergies, that I know about. Never had any type of joint problem before taking resveratrol except for the left shouder that has bothered me on and off since my 20's (Most likely a result of high school football). I don't know if you guys remember me posting about joint pain in the hips way back in December. Again that was something I have never had but after about 2 months that went away. This thing with the feet is different, it really hurts when I take my shores off and walk in my bare feet, mostly on the ball and heal area. Also, as I am sitting here the feet feel heavy and there is some very mild discomfort.

I guess I should just drop Resv and see what happens. But you got to admit that it is very interesting that someone else would mention such a rare thing (ie. feet start hurting for no reason).

[niner]

I'm 42 and been on resveratrol about one year. The only autoimmune issues that I have are allergies, that I know about. Never had any type of joint problem before taking resveratrol except for the left shouder that has bothered me on and off since my 20's (Most likely a result of high school football). I don't know if you guys remember me posting about joint pain in the hips way back in December. Again that was something I have never had but after about 2 months that went away. This thing with the feet is different, it really hurts when I take my shores off and walk in my bare feet, mostly on the ball and heal area. Also, as I am sitting here the feet feel heavy and there is some very mild discomfort.

I guess I should just drop Resv and see what happens. But you got to admit that it is very interesting that someone else would mention such a rare thing (ie. feet start hurting for no reason).

rhc124, this sounds a bit like something that I experienced a long while ago, which eventually went away when I started exercising more and got into better cardiovascular shape. Or it might be a plantar fasciitis. Does it respond to anti-inflammatories? Do you notice it first thing in the morning? There'd be no harm in stopping resveratrol for a while to see what happens. What sort of shape are you in, in terms of weight and cardio fitness?

[krillin]

New theory: resveratrol is a calcium channel blocker. Amlodipine, a calcium channel blocker, causes foot pain. (I assume it's caused by swelling.)

Sheng Li Xue Bao. 2008 Apr 25;60(2):279-83.
Resveratrol inhibits electrical activity of paraventricular nucleus neurons in rat hypothalamic slices.
Wang R, Xiao L, Ma HJ, Zhang LH, He RR, Wu YM.
Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China. E-mail: wuym@hebmu.edu.cn.

To study the role of resveratrol in the discharges of neurons in paraventricular nucleus (PVN) in hypothalamic slices, extracellular single-unit discharge recording technique was used. The effects of resveratrol were examined with glass microelectrodes in the rat PVN neurons at resting potential level. The results were as follows: (1) In response to the application of resveratrol (0.05, 0.5, 5.0 mumol/L, n=29) to the superfusate for 2 min, the spontaneous discharge rate (SDR) of neurons in 28/29 (96.6%) hypothalamic slices significantly decreased in a dose-dependent manner; (2) Pretreatment with L-glutamate (0.2 mmol/L) led to a marked increase in the SDR in all 8/8 (100%) slices in an epileptiform pattern. The increased discharges were suppressed by the application of resveratrol (5.0 mmol/L) in all 8 slices; (3) In 8 slices, perfusion of the selective L-type calcium channel agonist, Bay K8644 (0.1 mumol/L), induced a significant increase in the discharge rate in 8/8 (100%) slices. Resveratrol (5.0 mumol/L) significantly attenuated the increased SDR in all 8 slices; (4) Pretreatment with the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME, 50 mumol/L) increased SDR in 7/8 (87.5%) slices, but did not affect the inhibitory effect of resveratrol (5.0 mumol/L). These results suggest that resveratrol inhibits the electrical activity of PVN neurons and exerts neuroprotective actions on central neurons. The inhibitory effect of resveratrol is possibly related to the blockade of L-type calcium channel, but not due to NO release.

PMID: 18425319

Hokey smokes! Amlodipine can cause achilles tendinitis too.

http://www.nature.co...df/1000872a.pdf

[jCole]

Day three of taking 99% RevGen P99.

500mg first thing in the morning, then another 500mg just before bed via Buccal delivery.

One thing I noticed, is I definitely get a very noticeable rush or buzz via this method, but if I mix it into a protein drink mixed with soy milk, I do not. Not sure if that's a indicator Buccal is far more effective for me or if there is some other mechanism at work happening here when absorbed via the mouth.

Dream recall and lucidity is amazingly better. I never remember my dreams, ever... but the last couple of nights have been pretty intense. One dream last night was visiting TFI after he beat his cancer.


Have not worked out yet, as I am on a week break, which I do every 7 weeks. Will see what happens on Monday.

[rhc124]

).[/quote]
rhc124, this sounds a bit like something that I experienced a long while ago, which eventually went away when I started exercising more and got into better cardiovascular shape. Or it might be a plantar fasciitis. Does it respond to anti-inflammatories? Do you notice it first thing in the morning? There'd be no harm in stopping resveratrol for a while to see what happens. What sort of shape are you in, in terms of weight and cardio fitness?
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Unfortunatly I am not in great shape. I'm 6'1" and about 205 lbs and I get little to no exercise. I did go on a two day camping trip back in May, when the feet were at their worst, and all the walking I did seemed to help. I never really tried any antiinflammatories for this so I could not tell you about that. The pain was at its worst later in the day.

I think for right now I am going to reduce Resv intake to 750mg. My concern is that this may be a copper deficiency. From my limited research, it seems copper deficiencies could result in the same symptoms. Anyone out there got some good research on Resv's chelation of copper? I seem to remember Maxwatt saying that is was not more of a copper chelator than asprin. But is that on a mg to mg basis? 3gm of asprin a day would be a whole lot over a three month period, which is how much resv I was taking when the feet were at their worst.