Why did you make these changes stephen? How are you feeling on these supplements?
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Stephen_B's supplement regimen
Started by
stephen_b
, Jan 26 2008 08:07 PM
32 replies to this topic
#32 Guest_Funiture2_*
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Posted 10 April 2014 - 02:15 PM
Is this true? Can you confirm that B2 in such small doses fixes problems associated with the MTHFR gene? over at phoenix rising.me the general consensus seems to be that 5-MTHF is used for people with the defects in metabolizing folate or folic acid. I didn't know the answer was as simple as supplementing b2.
Here's an exercise for people to try: compare the cost per methyl group of methylfolate and TMG. You'll find that the only reason to take methylfolate is to bypass the rate-limiting conversion of folic acid to dihydrofolate, and folinic acid does it cheaper. I'll need to see some proof that methylfolate in reasonable doses can treat the MTHFR polymorphism: the biological lifetime of a folic acid molecule is a heck of a lot longer than the lifetime of its methyl group, so bypassing MTHFR just once per molecule won't do you much good. (Besides, that polymorphism can be rendered harmless by single-digit milligram doses of B2.)
Is this true? Can you confirm that B2 in such small doses fixes problems associated with the MTHFR gene? over at phoenix rising.me the general consensus seems to be that 5-MTHF is used for people with the defects in metabolizing folate or folic acid. I didn't know the answer was as simple as supplementing b2.
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#33
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Posted 10 April 2014 - 04:11 PM
The benefits of 5-MTHF are probably from bypassing DHFR. This enzyme is damaged by peroxynitrite (elevated in ME) and is only needed to process folic acid and dihydrofolic acid during intake metabolism and after making dTMP for DNA synthesis.
http://www.ncbi.nlm....pubmed/14759604
http://www.ncbi.nlm....pubmed/15639221
http://www.lipidworl...5/1/1/figure/F1
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