Ok, well I was reading about different types of medical mushrooms, just to see what they could do. Anyways, it is starting to seem they might act in some ways as Resveratrol, i left in all the links from what i copied from wikipedia, since that might help some
The Effects of Resveratrol:
Well, there is a lot but resveratrol increases MnSOD which reduces peroxides, lowers oxidative stress, has antitumor properties, helps with glucose, insulin and other things. Im pretty sure most of you know everything about it.. if not, the wikipedia of it is a decent start
http://en.wikipedia....iki/Resveratrol
The Effects of Maitake:
"..to enhance the immune system. Researchers have also indicated that whole maitake has the ability to regulate blood pressure, glucose, insulin, and both serum and liver lipids, such as cholesterol, triglycerides, and phospholipids, and may also be useful for weight loss."
The Effects of shiitake: "..Shiitake mushrooms have been researched for their medicinal benefits, most notably their anti-tumor properties in laboratory mice. These studies have also identified the polysaccharide lentinan, a (1-3) β-D-glucan, as the active compound responsible for the anti-tumor effects.[5]
Extracts from shiitake mushrooms have also been researched for many other immunological benefits, ranging from anti-viral properties to possible treatments for severe allergies, as well as arthritis.[6]
Lenthionine, a key flavour compound of shiitake, also inhibits platelet aggregation, so it is a promising treatment for thrombosis.[citation needed]
Shiitake are also one of a few known natural sources of vegan and kosher vitamin D (vitamin D2).
A patented chemical derived from shiitake is reputed to reverse cellular aging and is sold as a moisturizer by the company Aveeno."
The Effects of chaga:
"In 1998 there was a study in Poland that demonstrated Chaga's inhibiting effects on tumor growth.[3] Noda et. al found that betulin seems to work highly selectively on tumor cells because the interior pH of tumor tissues is generally lower than that of normal tissues, and betulinic acid is only active at those lower levels. Fulda et al. found in 1997 that once inside the cells, betulinic acid induces apoptosis (programmed cell death) in the tumors.[4] In 2005 there was a study done at Department of Medical Nutrition in South Korea. The Chaga Mushroom was evaluated for their potential for protecting against oxidative damage to DNA in human lymphocytes. The study found that the polyphenolic extract protected these cells against hydrogen peroxide-induced oxidative stress.[5] Another study that year found the endo-polysaccharide of Chaga produced indirect anti-cancer effects via immuno-stimulation. The mycelial endo-polysaccharide of I. obliquus was identified as a candidate for use as an immune response modifier and indicate that the anti-cancer effect of endo-polysaccharide is not directly tumorcidal but rather is immuno-stimulating.[6][7] It has also been demonstrated as anti-inflammatory.[8] Saitoh Akiko published on the antimutagenic effects of Chaga in 1996, and Mizuno et al. published on the anti tumor and hypoglycemic activities of the polysaccharides from the sclerotia and mycelia of Chaga.
Chaga grows in birch forests of Russia, Korea, Eastern Europe, Northern areas of the United States[9] and in the North Carolina mountains."
The Effects of reishi:
"Lingzhi may possess some anti-tumor, immunomodulatory and immunotherapeutic activities, supported by some studies on polysaccharides, terpenes, and other bioactive compounds isolated from fruiting bodies and mycelia of this fungus (reviewed by R. R. Paterson[5]). However, the efficacy of these compounds in the treatment of cancer has not yet been shown in clinical trials.[6] Moreover, as with any herb, variation between preparations and potential negative side effects cannot be ruled out. It is understood as adaptogenic, anti-allergenic and anti-hypertensive due to the presence of triterpenes. Apart from these properties, lingzhi has been found to be anti-inflammatory, antiviral, anti-parasitic, anti-fungal, antidiabetic, anti-hypotensive, and protective of the liver. It has also been found to inhibit platelet aggregation, and to lower blood pressure, cholesterol and blood sugar. [7][8][9]
Because of these properties, lingzhi has been regarded as blood pressure stabilizer, antioxidant, analgesic, a kidney and nerve tonic. It has been used in bronchitis prevention and in cardiovascular treatment, and in the treatment of high triglycerides, high blood pressure, hepatitis, allergies, chemotherapy support, HIV support, and even for fatigue and altitude sickness. [10][11][12]
Some peer-reviewed studies indicate that ganoderic acid has some protective effects against liver injury by viruses and other toxic agents in mice, suggesting a potential benefit of this compound in the treatment of liver diseases in humans.[13]
Although the experiences in fighting cancer are more inconsistent, the extract has been claimed to be effective in regressing tumors. The results depend on the type of cancer and the severity of the condition. It is usually recommended that it be used in combination with other prescribed medical treatments and as part of a fu zheng formula with a variety of supporting herbs. The Ganoderma extract has been employed to help substantially reduce or eliminate the side-effects of radio- and chemotherapies if it is taken before, during and after the treatments. It has been found clinically to reduce side-effects like hair loss, nausea, vomiting, stomatitis, sore throat, loss of appetite and insomnia."
All of this was found on wikipedia.
What i am Concluding:
These all have very similar effects to resveratrol, and likely milk thistle since it is also a sirt1 activator. I find it unlikley that there is another compound working on a totally different way, with nearly the same effects. so, wouldnt it make sense that the chemicals in these mushrooms, and likely others also can activate sirt1? However the chemicals that i think would do this, look quite a bit different, however it looks like there metabolites could do something good. What do you guys think?
Maybe i am crazy, but who can spot the Resveratrol look a like in this picture? it seems like there are a few options to hydrolise/metabolisize it into smaller compounds, that work like resveratrol: http://en.wikipedia....ge:Lentinan.png
If this is true, maybe it improves bioavalability? eh.. haha sorry i might be doing a little to much wishful thinking
Edited by kclo4x, 29 March 2008 - 03:44 AM.
