33 replies to this topic

[niner]

I just read this article . Creatine inhibits sarcopenia and according to this article, lipofuscin too
Recently, creatine has been found to significantly lower the accumulation of a recognized marker of aging called lipofuscin in the brains of aging mice.1 As a result, creatine-fed mice lived an average of 9% longer than control animals thats equivalent to more than seven years for an average human!1

http://www.lef.org/m...ch&key=creatine

Thoughts ?

 

In the article from LEF, they attribute creatine's slowing of lipofuscin accumulation to improved mitochondrial function.  If true, this suggests that other mitochondrial enhancers would be equally good, or perhaps better.  Whatever the case, it's a lot easier to extend the lifespan of mice than of humans, so don't expect an extra seven years from creatine.  That's unlikely.   That doesn't mean that it wouldn't improve health.  It may well do that.  I wish creatine didn't make my hair fall out...

[Kevnzworld]

I just read this article . Creatine inhibits sarcopenia and according to this article, lipofuscin too
Recently, creatine has been found to significantly lower the accumulation of a recognized marker of aging called lipofuscin in the brains of aging mice.1 As a result, creatine-fed mice lived an average of 9% longer than control animals thats equivalent to more than seven years for an average human!1

http://www.lef.org/m...ch&key=creatine

Thoughts ?

 
In the article from LEF, they attribute creatine's slowing of lipofuscin accumulation to improved mitochondrial function.  If true, this suggests that other mitochondrial enhancers would be equally good, or perhaps better.  Whatever the case, it's a lot easier to extend the lifespan of mice than of humans, so don't expect an extra seven years from creatine.  That's unlikely.   That doesn't mean that it wouldn't improve health.  It may well do that.  I wish creatine didn't make my hair fall out...

Creatine makes your hair fall out? Does it raise DHT ? I haven't noticed that side effect. Yikes!

[niner]

Creatine makes your hair fall out? Does it raise DHT ? I haven't noticed that side effect. Yikes!

 

Yeah, I definitely noticed a WTF level of hair loss when I started taking it, and it stopped when I made the connection and stopped taking it.  There are a lot of people who have experienced it, and there are also some people on the net that say it's a myth.  I guess a myth is a side effect that one hasn't personally suffered.  Most people don't have a problem with it, judging by the number of "I don't have a problem" posts.

[Kevnzworld]

I found one study that showed that Australian rugby players taking 25 g per day of creatine experienced elevated DHT.
I'm taking 3.2 g. I just received a blood test that showed my DHT being very elevated 250. I do take testosterone replacement, and my free testosterone was also high at 24. I'm backing off the testosterone and beginning finasteride.

I've also began taking piracetam for cognition! and found this added benefit. I do drink alcohol, so piracetam's potential ability to also ameliorate lipofuscin accumulation is an added bonus
" The effects of piracetam on lipofuscin of the rat cerebellar and hippocampal neurons after long-term alcohol treatment and withdrawal: a quantitative study."
Conclusion " Piracetam was found to markedly decrease the formation of neuronal lipofuscin."
http://www.ncbi.nlm....tam, lipofuscin