67 replies to this topic

[NeuroGeneration]

Adding my account with CoQ10 and derivatives to this string.

 

I'm 30 years old, in great physical shape and overall health, and eat a very healthy diet of moderately high carb Paleo (because of how active I am in the gym).

 

I had been taking ubiquinol, ubiquinone and/or idebenone for more than 6 months. My dosages were 100mg, up to 300mg, max.

 

It was only recently that I made a correlation to CoQ10 for the following symptoms:

 

•Brain fog: Difficulty focusing. Looking at my computer / the work I had to do, and being somewhat puzzled. Not knowing what I should do next, unless I devoted a ton of energy towards focusing (not normal for me), at which point, I would quickly get distracted and lose track of what I should be doing, once again.

 

•Mental fatigue: After a few hours (I'd have my vitamins between 9am-11am each morning), I'd have to take a nap (12-3pm). The need was extreme – without it, I'd be wasting the day away, and have absolutely no chance of getting any work done. More often than not, I felt 60+% better after the nap. I also noticed that I could remedy the brain fog / mental fatigue by going to the gym. I would have to lift heavy or run intensely for more than 2 miles, before the symptoms were totally lifted.

 

•High blood glucose: I can't definitively attribute this to the CoQ10 yet, but after seeing some other posts in this thread, I think I can owe the following to it. I got a sleep study done, as a result of my 8-9 hours of sleep still requiring habitual naps (this was before I came to realize that it's probably CoQ10, which was relatively recent). During the time, I also got back to measuring my blood glucose. I had purchased the glucometer to measure my ketones while experimenting with a ketogenic diet for ~3 months. I noticed back then (I was taking CoQ10 at the time) that my fasting blood glucose (FBG) was 110-120; I attributed it to the notorious "physiological insulin resistance". When I got the sleep study done, I randomly decided to pick up the glucometer again, for the first time since keto; I noticed that my FBG was still 110+!. This concerned me, because I eat very "clean", and am extremely active in the gym. I had an endocrinologist run tests on me, and I made a point to not take any supplements for the three days leading up to it. My 12-hour FBG level? 70! Was it the CoQ10 causing the spike? I don't know for sure, but the only other supplements I was taking during the time (as well as during the ketosis period) were ThorneFX AM/PM, magnesium glycinate, zinc, PQQ, matcha green tea & astaxanthin. I'm currently still taking all of these, except for the ThorneFX multi, PQQ & CoQ10.

 

Assuming I have test strips, I'll run a few more FBG tests in the coming days, since I haven't been on ubiquinol/one/idebenone for 2 weeks now. Speaking of which, I haven't had to take any naps during these two weeks, for the first time in months!!

 

If it makes any difference, I seem to have similar reactions (brain fog, high blood glucose) to choline and cholinergics (CDP, inositol, UMP, etc.). Believe it or not, I actually suspect having too many eggs may even throw me off somewhat – but, I don't know for sure, since I've been hesitant to reintroduce eggs in a methodical fashion, in order to measure my reaction. Any connections, or totally off?

 

Also, as for my 23andMe profile, my rs6323 SNP is G.

[xtronics]

Sleepiness is the side effect I've had as well.  Just tried taking a much smaller dose - 50mg - by the 4th day I kept forgetting what I was doing, falling asleep.

 

I've found this effect on numerous forums, yet no explanation of why it effects some people this way.

[geo12the]

The thing I wonder is if the conflicting results with CoQ10 might have to do with differential effects of the two forms of it that you can take?  I don't know how much this question has been researched. Everyone seems to assumes the ubiquinone (oxidized) and ubiquinol (reduced) forms are more or less the same in-terms of biological effects. Many of the clinical trials studies I have read don't even mention the form used. But wouldn't the ubiquinone form be more oxidizing while the ubiquinol is anti-oxidant?  I take the ubiquinol form for this reason.

 

 

[Tom Andre F. (ex shinobi)]

Sorry to bump this topic, but Im wondering how it can have such conflicting information ?

 

Many study show how great coQ10 is. Also, what about mitoQ since its just a more bioavailable form of coQ10 but was shown to increase lifespan ?

 

 

[Kabb]

Sorry to bump this topic, but Im wondering how it can have such conflicting information ?

 

Many study show how great coQ10 is. Also, what about mitoQ since its just a more bioavailable form of coQ10 but was shown to increase lifespan ?

 

 

Hi Tom.  CoQ10 has several effects.  It has a unique effect which other compounds cannot replicate of shuttling electrons in mitochondria to create a usable source of energy for the cell.  Mitochondria are in almost every cell and if your cells a malfunctioning due to lack of energy then CoQ10 can be a big help (although there are compounds other than CoQ10 whose deficiency may be causing trouble).  If your cells are not short of CoQ10 for energy shuttling then adding more is not going to help.

 

CoQ10 is also an antioxidant.  Antioxidants give electrons to free radicals to neutralise them.  An antioxidant which has given up its electrons may then becomes similar in nature to the free radical it just neutralised and become a problem itself.  For this reason it is worth making sure additional antioxidants are not excessive.  (Some people try to make sure the antioxidants they are taking in redox pairs to limit this.)  So supplementary CoQ10 might have this effect although generally it is not reported to do this much.

 

MitoQ is CoQ10 dissolved in a more effective delivery mechanism designed to get a larger proportion of CoQ10 absorbed than usual.  I believe this means that MitoQ can achieve higher concentrations of CoQ10 than even the highest dose of regular CoQ10.  A lot of scientific marketing talk accompanies discussions of these more effective versions of CoQ10 which do work but it can be hard to see exactly how much additional benefit they truly provide.  A lot can be at stake here on account of the high cost of these proprietary versions.

Edited by Kabb, 25 March 2016 - 06:03 PM.

[DbCooper]

2016

 

 

https://www.ncbi.nlm...pubmed/26910885

 

https://www.ncbi.nlm...pubmed/26957943

Edited by DbCooper, 26 March 2016 - 01:56 PM.

[vrain]

Sorry to bump, but has anyone experienced a decrease in libido with coq10? I can't be certain yet, but it's starting to look like it might be having this affect on me consistently. Odd, considering it should do the opposite if anything.

[kurdishfella]

The body contains about 1000mg of coq10 more than anything else afaik so that should validate its importance and also has 2 precursor on top of being made in the body.