Over in the Supplementation section lots of members are talking about avoiding niacinamide/nicotinamide like the plague as, and I quote, "it has been proven to be a potent INHIBITOR or SIRT1, one of the key genes related to aging". Yet, I am seeing niacinamide in a lot of skin care products. Also, Dr. Leslie Baumann author of The Skin Type Solution and chief of the Division of Cosmetic Dermatology at the University of Miami School of Medicine states:
"There aren't a lot of ingredients that I unequivocally recommend to just about every skin type - but topical niacinamide is one of 'em!"
Also:
D. L. Bissett, K. Miyamoto, P. Sun, J. Li, C. A. Berge (2004) Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin1
International Journal of Cosmetic Science 26 (5) , 231–238 doi:10.1111/j.1467-2494.2004.00228.x
Previous clinical testing of topical niacinamide (vitamin B3) has revealed a broad array of improvements in the appearance of aging facial skin. The study reported here was done to confirm some of those previous observations and to evaluate additional end points such as skin anti-yellowing. Caucasian female subjects (n = 50, aged 40–60 years) participated in a 12-week, double-blind, placebo-controlled, split-face, left–right randomized clinical study assessing two topical products: moisturizer control product versus the same moisturizer product containing 5% niacinamide. Niacinamide was well tolerated by the skin and provided significant improvements versus control in end points evaluated previously: fine lines/wrinkles, hyperpigmentation spots, texture, and red blotchiness. In addition, skin yellowing (sallowness) versus control was significantly improved. The mechanism by which this array of benefits is achieved with niacinamide is discussed.
Sirtuins or niacinamide? Comments?