50 replies to this topic

[jessicantique]

i have been using carrier oils and essential oils as skincare for some time. then, nothing has actually penetrate my skin?

[Eva Victoria]

i have been using carrier oils and essential oils as skincare for some time. then, nothing has actually penetrate my skin?

If you mean Carrier oils for Essential oils like Wheat Germ oil or Grape Seed Oil then not really. They have too big molecular size to be able to penetrate into the skin. Although they can be used for diluting Essential oils. Essential oils have smaller molecular weight hence they can penetrate into the skin easier. (Of course the question remains: is it good to have essential oils penetrating into the skin? They can trigger allergies since they also contain fragrance molecules).

[TheFountain]

Where do you guys purchase your topical niacinimide? I'm thinking this looks like a good buy.

http://www.lifelinkn...ts/Metazene.asp

Edited by TheFountain, 11 May 2009 - 11:48 PM.

[Chaos Theory]

Where do you guys purchase your topical niacinimide? I'm thinking this looks like a good buy.

http://www.lifelinkn...ts/Metazene.asp

What's the verdict on topical niacinamide for preventing/repairing UV damage and aging? I get more than my fair share of UV.

I was considering the metazene also, is that company reputable?

[TheFountain]

Where do you guys purchase your topical niacinimide? I'm thinking this looks like a good buy.

http://www.lifelinkn...ts/Metazene.asp

What's the verdict on topical niacinamide for preventing/repairing UV damage and aging? I get more than my fair share of UV.

I was considering the metazene also, is that company reputable?

The brand name metazene is quite reputable. As for the company, probably one of several selling it. But the website seems to have many hits and no negative reviews so, I think it is worth a try.

[Chaos Theory]

So has anyone actually used the metazene? I've never heard of that website, company, or product. If nobody here can vouch for it I'm going to make an appointment with my dermatologist and see if he's willing to write me a script for the niacinamide topical.

[happy lemon]

Just read this thread from EDS:

Recommended by Leslie Baumann:

http://www.essential...d.php?tid=35359

I will buy some & just mix it with distilled water & apply on my skin before taz.

Any comments?

[Cirkeline]

Just read this thread from EDS:

Recommended by Leslie Baumann:

http://www.essential...d.php?tid=35359

I will buy some & just mix it with distilled water & apply on my skin before taz.

Any comments?

I would not mix the two or prep my skin with a niacinamide cream before applying Tazorac unless you find that Tazorac irritates your skin. Remember that whatever you mix into Tazorac will dilute the concentration of tazarotene.

Instead, I would use a niacinamide product AM, or more precisely, a product containing Myristyl Nicotinate (MN), a lipophilic derivative of niacin. MN penetrates skin far better than niacinamide.

In this study, MN is shown to strengthen skin barrier and mitigate barrier impairment caused by retinoid therapy.

Quote: These results show that prior and concurrent use of MN can mitigate barrier impairment and improve tolerability of retinoic acid therapy for facial photodamage without interfering with efficacy.

PMID: 17927576

http://www.ncbi.nlm....pubmed/17927576

The study below shows that MN has the ability to strengthen skin barrier regardless of the use of retinoids.

Quote: The results indicate that MN enhances epidermal differentiation and barrier function in skin, suggesting that this method of nicotinic acid delivery may prove useful in limiting progression of actinic skin damage and possibly in treating other conditions involving skin barrier impairment.

PMID: 17518989

http://www.ncbi.nlm....ogdbfrom=pubmed

Myristyl Nicotinate is found in the skin care lines NIA24 and Canyon Ranch in a concentration of 5 % in most of the products. (I just mentioned those in a thread about UV spots on this forum).

[happy lemon]

I would not mix the two or prep my skin with a niacinamide cream before applying Tazorac unless you find that Tazorac irritates your skin. Remember that whatever you mix into Tazorac will dilute the concentration of tazarotene......

Hi Cirkeline,

Thx for your comment!

I do have irritation towards taz (I know it is due to overdosage).

http://www.imminst.o...Taz-t32437.html

However, is it still a bad idea if I just apply the solution (water + niacinamide) on my face and then wait 30 mins before taz?

[Cirkeline]

I would not mix the two or prep my skin with a niacinamide cream before applying Tazorac unless you find that Tazorac irritates your skin. Remember that whatever you mix into Tazorac will dilute the concentration of tazarotene......

Hi Cirkeline,

Thx for your comment!

I do have irritation towards taz (I know it is due to overdosage).

http://www.imminst.o...Taz-t32437.html

However, is it still a bad idea if I just apply the solution (water + niacinamide) on my face and then wait 30 mins before taz?

Hi, lemon.

I don't know about the niacinamide and water solution... I think I would rather mix it in a gel (t.ex. aloe vera gel) in a 1-3 % concentration if you are going to make your own. I don't know very much about DIY skin care, but they have receipts in the DIY skin care online stores. Then you can either prep your face with the gel, or mix it with Tazorac in the palm of your hand, as suggested by Dr Baumann.

[VesperLynd]

I've read through this thread carefully a few times and want to make sure I understand this correctly -

Myristyl Nicotinate (MN) is preferrred over niacimamide since it better penetrates the skin and doesn't have the potential to be pro-aging as mentioned in the first post?

Thanks, VL

[TheFountain]

I wouldn't want to mess around with something homemade here. Does anyone know of any good niacinamide containing creams or moisturizers, that preferably incorporate other antioxidants / useful ingredients?

Olay of Ulay has a line: Regenerist that is based on Niacinamide in higher concentration (please see the previously attached document from P&G). The serum also contains: Di-Peptide 3, Sodium Ascorbic Acid, Vit.E.
It is light and does not contain much fragrance. In the US it is possible to buy the day creme (Spf15) without fragrance.

http://www.olay.com/...rand=regenerist

Does anyone have a direct link to this particular product?

[TheFountain]

Does anyone know if you apply vitamin C serum before or after the niacinamide?

[someidiot]

Does anyone know if you apply vitamin C serum before or after the niacinamide?

I have read that Vitamin C needs to have a pH of 3.5 to penetrate skin. Niacinamide is most efficacious at pH 6.0-7. try doing C in the AM and Nia in the PM

[ElSenor]

Ok now I am confused. I just received my bottle of metazene, and noticed that one of the ingredients was meythlparaben which according to Wikipedia " Studies indicate that methylparaben applied on the skin reacts with UVB leading to increased skin aging and DNA damage" Could I get niacinimide(sp) without these ingredients??

Edited by ElSenor, 20 March 2010 - 04:30 AM.

[aikikai]

I am using Olays Total Effect series which has B3.

http://www.amazon.co...A...3897&sr=8-3

[miklu]

Question: is niacinamide useful in cleansers? That is,

1) does it benefit the skin during the short contact of the cleanser (e.g., 30–60 seconds); or

2) does it deposit on the skin, so that it can provide skin-benefits later?

[GhostBuster]

This is interesting…

both oral and topical niacinamide have proven to protect against UV induced immunosupression, that contributes to the development of the skin cancer. Most sunscreens protect against sun burn but not against immunosupression. Topical niacinamide also works well as an after sun –lotion.

Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans.
http://www.ncbi.nlm....pubmed/19028705

UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide
http://www.ncbi.nlm....pubmed/17882270

Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans.
http://www.ncbi.nlm....pubmed/19804594

Downregulation of NF-kappaB activation in human keratinocytes by melanogenic inhibitors.
http://www.ncbi.nlm....pubmed/12727023

[TheFountain]

I am using Olays Total Effect series which has B3.

http://www.amazon.co...A...3897&sr=8-3

And your results so far?

[chrono]

I avoid topical Niacinamide, just like dietary. It will be absorbed and will inhibit SIRT1 in surrounding tissues by altering the NAD/NAD+ ratio.

This seems like it might be the most important point to the original question. Does anyone have any data on whether topical niacinamide (with proper vehicle?) would be absorbed systemically? I couldn't find anything with a quick pubmed search.

Whatever its proven benefits to the skin, a large daily transdermal dose might be ultimately counterproductive if it's significantly inhibiting SIRT1.

[smithx]

I was looking for a source of myristyl nicotinate and only came up with Chinese chemical companies offering it by the kilogram. Does anyone know of a source that sells smaller quantities?

While looking, I came across this low cost source for niacinamide powder at $2.85 an ounce: http://www.amazon.co...z/dp/B0051VE5DQ