A Complex Dietary Supplement Extends
Longevity of Mice
Key factors implicated in aging include reactive oxygen species, inflammatory processes, insulin
resistance, and mitochondrial dysfunction. All are exaggerated in transgenic growth hormone mice
(TGM), which display a syndrome resembling accelerated aging. We formulated a complex
dietary supplement containing 31 ingredients known to ameliorate all of the above features. We
previously showed that this supplement completely abolished the severe age-related cognitive
decline expressed by untreated TGM. Here we report that longevity of both TGM and normal mice
is extended by this supplement. Treated TGM showed a 28% increase ( p , .00008) in mean
longevity. An 11% increase in mean longevity was also significant ( p , .002093) for treated
normal mice, compared to untreated normal mice. These data support the hypothesis that TGM are
a model of accelerated aging, and demonstrate that complex dietary supplements may be effective
in ameliorating aging or age-related pathologies where simpler formulations have generally failed.
Supplement Dosage
Vitamin B1 b 0.72 mg/day
Vitamin B3 b 0.72 mg/day
Vitamin B6 b 0.72 mg/day
Vitamin B12 b 0.72 mcg/day
Vitamin C b 3.6 mg/day
Vitamin D b 2.5 IU/day
Vitamin E b 1.44 IU/day
Acetyl L-carnitine c 14.4 mg/day
Alpha-lipoic acid e 0.72 mg/day
ASAd 2.5 mg/day
Beta carotene b 50.0 IU/day
Bioflavinoids h 4.32 mg/day
Chromium picolinate i 1.44 mcg/day
Cod liver oil b 5.04 IU/day
CoEnzyme Q10 h 0.44 mg/day
DHEA g 0.15 mg/day
Flax seed oilh 21.6 mg/day
Folic acid b 0.01 mg/day
Garlic b 21.6 mcg/day
Gingerh 7.2 mg/day
Gingko biloba h 1.44 mg/day
Ginseng (Canadian) h 8.64 mg/day
Green tea extracts f 7.2 mg/day
L-Glutathione a 0.36 mg/day
Magnesium b 0.72 mg/day
Melatonin g 0.01 mg/day
N-Acetyl cysteine e 7.2 mg/day
Potassium b 0.36 mg/day
Rutin h 0.72 mg/day
Selenium h 1.08 mcg/day
Zinc (chelated) b 0.14 mg/day
Notes:
Vitamin brands are as follows: a ¼ Cell Life; b ¼ Jamieson vitamins;
c ¼ Jarrow Formulas; d ¼ Lifebrand; e ¼ Natural Factors; f ¼ Naka; g ¼ Pro-
matrix; h ¼ Swiss vitamins; i ¼ Vitamin Power Inc.
ASA ¼ acetylsalicylic acid; DHEA ¼ dehydroepiandrosterone.
https://sci-hub.ru/1...gerona/60.3.275
NB that Sci-Hub very often has the full paper you cant find.
