The Latest Alzheimer's Research
#511
Posted 15 December 2015 - 04:40 AM
#512
Posted 15 December 2015 - 04:41 AM
Our loved one has some seizure activity.
This is somewhat common in dementia.
#513
Posted 15 December 2015 - 04:44 AM
I keep thinking that I shall too but not yet. It hurts.
#514
Posted 15 December 2015 - 04:45 AM
What is your MMSE score?
The test is available online.
#515
Posted 15 December 2015 - 05:11 AM
#516
Posted 15 December 2015 - 05:17 AM
Don't take it so bad.
Chocolate is probably not really overly horrible.
It actually has a lot of antioxidants.
As I said what they have really found is that it is a whole bunch of things that converge together.
If it was as simple as eating too much chocolate causes AD they would have known that years ago.
#517
Posted 15 December 2015 - 05:36 AM
Don't take it so bad.
Chocolate is probably not really overly horrible.
It actually has a lot of antioxidants.
As I said what they have really found is that it is a whole bunch of things that converge together.
If it was as simple as eating too much chocolate causes AD they would have known that years ago.
Exactly !
At 1kg of dark chocolate per week, Madame Calment did pretty good mentally-wise so I think this "(dark) chocolate is bad" meme is a red herring and it should be ignored.
Now red meat is whole another matter.
You need a "perfect storm" of confluent factors (genetic, environmental and dietary, in that order) to get a full-blown early-onset AD pathology.
#518
Posted 15 December 2015 - 05:55 AM
#519
Posted 15 December 2015 - 06:11 AM
#520
Posted 15 December 2015 - 06:13 AM
#521
Posted 15 December 2015 - 06:20 AM
#522
Posted 15 December 2015 - 08:05 AM
#523
Posted 15 December 2015 - 10:22 AM
One doesn't need to consume all the calories of chocolate to get its benefits, as the active ingredients can be had from other sources--Acacia Catechu extract, for instance. I find that a couple of caps of the extract (Swanson, 580 mg each) goes very well with a few grams of piracetam. See Cocoa Flavanols Boost Memory.
#524
Posted 15 December 2015 - 11:06 AM
#525
Posted 15 December 2015 - 11:13 AM
#526
Posted 15 December 2015 - 05:53 PM
I suppose that I'd only sound a little crazier if I were to say I think we are up against a conscious living virus? I think this disease is intelligent
So what your doctor have said and prescribed about your symptoms?
For such serious complications, you have not reported much medical background.
#527
Posted 15 December 2015 - 06:48 PM
Nilotinib for Alzheimer's?
...c-Abl activation is associated with many neurodegenerative disorders such as Alzheimer's disease...
http://www.ncbi.nlm....les/PMC4007078/
...Abl inhibition enhances survival of DA neurons in PD models (14). Phosphorylated Abl is present in neuronal cell bodies in Alzheimer's disease...
http://www.ncbi.nlm....les/PMC3723316/
Some easier reading:
http://www.npr.org/s...se-and-dementia
These guys did the study:
...Study participants with earlier stage disease responded best, as did those diagnosed with Lewy body dementia, often described as a combination of Parkinson’s and Alzheimer’s diseases,” Pagan says...
https://gumc.georget...-Clinical-Trial
It did wonders for Allan's, and others, Parkinson's:
Alan Hoffman, PhD, a retired professor of social science education at Georgia State University, was diagnosed with Parkinson’s disease in 1997 and has participated in several clinical trials with no benefit, he says, until he enrolled in Pagan’s study.
“Before the nilotinib, I did almost nothing around the house. Now, I empty the garbage, unload the dishwasher, load the washer and the dryer, set the table, even take responsibility for grilling,” he says.
In the three weeks prior to enrolling in the study, Hoffman says he fell eight times, but only fell once during six months on the study. His speech has improved, as has his thinking.
“My wife says it’s life-changing for her and for my children and grandchildren,” Hoffman says. “To say that nilotinib has made a change in our lives is a huge understatement.”
Hoffman and other patients in the clinical trial can continue taking nilotinib (provided by Novartis) as part of an expanded access study.
https://gumc.georget...-Clinical-Trial
Edited by Logic, 15 December 2015 - 06:53 PM.
#528
Posted 15 December 2015 - 07:05 PM
#529
Posted 15 December 2015 - 07:19 PM
The copper causation makes perfect sense to me but I also wondered if this is a low level infection that can stay dormant for decades as my Aunt looked after me when I was a baby.
I have raised copper,homocystine and cholesterol.
#530
Posted 15 December 2015 - 07:22 PM
#531
Posted 15 December 2015 - 07:31 PM
#532
Posted 15 December 2015 - 10:10 PM
#533
Posted 15 December 2015 - 10:32 PM
#534
Posted 16 December 2015 - 12:05 AM
The article that started this recent topic greatly helped clarify the copper-2 connection to AD.
However, things usually are more complicated.
For instance, in this clinical trial in AD patients giving a copper-2 supplement did not have a negative effect on cognition versus placebo.
http://www.ncbi.nlm....ubmed/18587525/
This seems quite surprising.
If copper-2 is so bad, then why was there not a reduction in cognition?
Life is complex.
Researchers have been working on the metals hypothesis of AD for many years now without a successful product.
Some of the research that I read mentioned that in severe Alzhiemer`s there is actually a copper deficit.
It might be that causing the dementia pandemic with copper-2 over decades might be understandable enough.
Yet, creating a pharmaceutically profitable therapeutic intervention that for copper dementia once clinical symptoms have emerged
might be nearly impossible.
Edited by mag1, 16 December 2015 - 12:08 AM.
#535
Posted 17 December 2015 - 02:21 AM
I sincerely doubt that the copper-2 content in dark chocolate is anything to be concerned about. It should be tightly bound to the epicatechins. Fundamentally, we should be looking at the epidemiology for clues here. How many dark chocolate addicts are coming down with dementia at any given age, as opposed to people who don't eat chocolate? I don't know, but I do know that cocoa powder assists the dentate gyrus in its function. And at her advanced age, I don't expect that any amount of good genes would have defended Jean Calment against a century of copper-2 insult, if it were truly free copper-2. Surely, some other person with equally good genes would have lived longer by avoiding chocolate.
That said, milk chocolate is another story entirely, because it's loaded with sugar and dairy protein, both of which are surely contributors to AD. Here in America, milk chocolate (and chocolate milk, and chocolate-covered potato chips, etc.) is a pillar of the SAD diet.
#536
Posted 17 December 2015 - 02:58 AM
I was staying away from chocolate for some other reason that I cannot quite remember at this time.
It appears to be loaded with iron which might not be great.
I thought there must be something else.
This article gives some background on metals in chocolate.
They found no concern with aluminium nor copper.
Though they were talking about 25g of chocolate intake.
Let's face it,some people when they go on a chocoholic bender are going to go past 25g.
Even I in my weaker moments have went well past 25 g.
I see to recall buying one of those big delicious holiday chocolate boxes and eating them all!
The copper in chocolate apparently is sourced from the pesticides they use.
http://www.sciencedi...889157511000287
I would be so interested in knowing places besides Japan that have avoided copper plumbing.
Perhaps 10% of Americans do not have copper plumbing, I would love to know there dementia rates.
Wow, are you kidding chocolate covered potato chips?!
That simply seems too too nuts for me to believe.
Sure, it would be massively addictive, though just because we can invent such yummy treats, should we?
Edited by mag1, 17 December 2015 - 03:34 AM.
#537
Posted 17 December 2015 - 03:22 AM
I am so disappointed that we are now facing this uncertainty about copper-2 and Alzheimer's!
How could we have been so reckless to have essentially a global consensus on copper plumbing when research had never
clearly established that it would not result in dementia? (Especially given the thousands of years of history related to other
dementogenic metals in plumbing systems.) Somewhere such as California could have chosen a different path and we would
already have a long term comparison group.
As it is, about all we have to look forward to is the potential for truly massive class action lawsuits, if this copper-2 Alzheimer
connection could be firmly established.
Edited by mag1, 17 December 2015 - 03:41 AM.
#538
Posted 17 December 2015 - 04:10 AM
I was staying away from chocolate for some other reason that I cannot quite remember at this time.
It appears to be loaded with iron which might not be great.
I thought there must be something else.
This article gives some background on metals in chocolate.
They found no concern with aluminium nor copper.
Though they were talking about 25g of chocolate intake.
Let's face it,some people when they go on a chocoholic bender are going to go past 25g.
Even I in my weaker moments have went well past 25 g.
I see to recall buying one of those big delicious holiday chocolate boxes and eating them all!
The copper in chocolate apparently is sourced from the pesticides they use.
http://www.sciencedi...889157511000287
I would be so interested in knowing places besides Japan that have avoided copper plumbing.
Perhaps 10% of Americans do not have copper plumbing, I would love to know there dementia rates.
Wow, are you kidding chocolate covered potato chips?!
That simply seems too too nuts for me to believe.
Sure, it would be massively addictive, though just because we can invent such yummy treats, should we?
I am also guilty as charged - just gobbled 50g+ of 90 % Lindt dark chocolate ...and 15ml of C60oo - to hypothetically counteract the iron ROS reactivity.
I am not worried about copper toxicity coming from chocolate, though.
My tap water is filtered through the Berkey filtration system so that should remove most of the copper coming from the plumbing here and it is a reasonably priced alternative to reverse osmosis systems..
Heavy Metals: Greater than 95% reduction for most metals
Including: Aluminum (> 75%). Antimony (>97.5%), Barium (>80%), Cadmium (>99.5%), Cobalt (>95%), Chromium (>95%), Chromium 6 (>99.85%), Copper (>95%), Lead (>97.5%), Mercury (>98%), Molybdenum (>90%), Nickel (>95%), Vanadium (>87.5%)
#539
Posted 17 December 2015 - 05:25 PM
"The copper in chocolate apparently is sourced from the pesticides they use." -- How do you conclude that? This is paywalled. That said, pesticides probably didn't even exist for most of Jean Calment's life. It also seems likely that her cacao would have been sourced from West Africa, which pretty much until her death in 1997 was not the polluted nightmare that it is today. There is also a second possibility: enhanced cerebral circulation which assists in the removal of brain plaque, even if the copper content causes some degree of accelerated aggregation. We know, based on a wealth of evidence at this point, that dark chocolate is broadly protective of the cardiovascular system for reasons other than merely its caffeine content. Remember, too, that she consumed enough olive oil for an elephant, which means that her HDL must have been fantastic, which again reinforces the vascular hypothesis. This would be consistent with the original c60oo study, showing that olive oil, moreso than c60 itself, was responsible for the observed life extension.
25 g isn't much. I think Jean was eating 100 g a day, which is a standard sized chocolate bar, and would jive with the approximation of "a quarter pound a day" in the anecdotes. Now that I think about it, I do not believe it was a kilogram a week. At her weight, 100 g might be like a man eating 140 g.
In any event, you've raised an important point about potential toxicity. I suggest moving to an organic brand, for example, Green and Black's. (Lindt is a chemical blob in fancy packaging; look at the ingredients.) You could also make hot chocolate from one of the many organic cacao powder brands available. (Personally, I find it overpowering and intolerable, given the absence of a lethicin buffer, but if you can take it, go for it.)
While I don't think there are many plumbed places in the world without ubiquitous copper pipes, there are obviously plenty of places with no plumbing. Rural India is a prime example, and as we've seen, it's also a model of low dementia rates. Likewise for the Inuit in Alaska, who historically had no plumbing, plenty of seafood, and essentially no dementia. I can't think of any place on Earth, for that matter, which has Western levels of dementia yet no significant plumbing installation, apart from war zones where the dementia is induced by severe stress. Can you?
Edited by resveratrol_guy, 17 December 2015 - 05:36 PM.
#540
Posted 17 December 2015 - 05:41 PM
Yeah, that was the chocolate company I was thinking about.
I once ate a whole box of their yummy products.
Would that be about a kilo?
Good point about the caffeine.
Research has found that coffee drinking can have large anti-dementia effects.
Perhaps this is another anti-dementia aspect of chocolate.
I went behind the paywall on the article.
The article talked about the copper content of chocolate originating from copper pesticides.
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