I just discovered that Minni has canine viral papilloma between her toes. This is very common
among puppies whose immune systems are not fully developed, very contagious among dogs, and usually clears up in one to five months without treatment. However since Minni is almost ten, it is unusual. When it occcurs in older dogs it usually indicates a challenged immune system.
Since Minni is taking Resveratrol, and it is an immune supressant I am concerned that it won't go away on its own and will spread.
I don't want to take her off of Resveratrol, and the canine viral papilloma is benign so it is not imminently threatening to her, but
I would like to get rid of them since she does pick at them and they might get infected. It's spread to three of the crevices in her toes
already. I've been trying to keep them clean with peroxide and alcohol. Should I lower her Resveratrol dose? I'd hate to take a chance
on the cancer coming back if I do. I have lowered it from what I was giving her at first. She's at 3g a day now.
Any and all suggestions are appreciated. Thanks
This doesn't seem quite right, especially as resveratrol kills many viruses and is effective against papilloma in mice. See below.
One way resveratrol is effective against tumors is to prevent angiogenesis, in effect killing them by starvaton, preventing them from establishing a blood supply to allow them to grow. It is also possible that this reduces the blood flow to the toes enough that the natural immune response does not destroy the papilloma, allowing it to grow.
You might consider reducing Minni's resveratrol intake by 50%; given that she is in remission from cancer, this should be a sufficient maintenance dose. At the same time, apply resveratrol in a cream base to her toes. Something edible, she will lick them, but enough will be applied to be absorbed by the papilloma. I think resveratrol applied this way will kill them, as it does in mice and to viruses in test tubes. It should be worth trying.
Ai Zheng. 2004 Aug;23(8):869-73. Links
[Chemopreventive effect of resveratrol to cancer][Article in Chinese]
Fu ZD, Cao Y, Wang KF, Xu SF, Han R.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
BACKGROUND & OBJECTIVE: Carcinogenesis is a complex process and at least 3 stages, including initiation, promotion, and progression, have been proposed in the process of carcinogenesis. Resveratrol has attracted considerable attention due to its low toxicity and unique chemical structure. This study was designed to test chemopreventive effect of resveratrol to cancer using various animal models. METHODS:Ames assay and micronucleus formation assay were used to test the antimutagenic activities of resveratrol. Croton oil-induced enhancement of ornithine decarboxylase (ODC) activities of dorsal epidermis cells in mouse and mouse ear edema model were used to investigate the anti-promotion effect of resveratrol. In addition,7,12-dimenthylbenz[a]anthracene (DMBA)/croton oil-induced mouse skin tumor model was used to evaluate chemopreventive effect of resveratrol to cancer in vivo. RESULTS: In Ames test,100 microg/plate of resveratrol exhibited 42.2% of inhibition on the reversion of Salmonella typhimurium TA100 induced by methylmethansulfonate, and 200 microg/plate of resveratrol exhibited 91.8% of inhibition on the reversion induced by benzopyrene.Pretreatment of resveratrol prevented cyclophosphamide (CTX)-induced micronucleus formation of polychromatic erythrocytes of mice bone marrow in dose-dependent manner. Mice treated with 30 mg/kg of resveratrol for 6 days before croton oil exposure have palliative ear edema. Treatment of 180 mg/kg resveratrol for 3 days caused 69.3% decrease of ODC activities in croton oil-induced dorsal epidermis. It was shown that resveratrol could inhibit DMBA/croton oil-induced mouse skin papilloma, which includes prolonging the latent period of tumor occurrence, decreasing the incidence of papilloma, and reducing tumor number per mouse in dose-dependent manner. CONCLUSION: Resveratrol has the ability of anti-mutation and anti-promotion of cancer and merit further studies as a potential cancer chemopreventive agent.